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Professor Mirko Zimic

TitleHead Bioinformatics Group
InstitutionFARVET SAC
DepartmentVaccines Development
AddressChincha
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    Collapse Overview 
    Collapse overview
    Physicist graduated from the prestigious National University of Engineering in Lima, Peru, Dr Zimic is also a biostatistician and a PhD in International Health from the Johns Hopkins Bloomberg School of Public Health. He also has a Masters of Genetics from the JHSPH and a Masters in Biochemistry from the UPCH. He trained at the UNI in theoretical physics. Mirko Zimic is a tenured Principal Professor of Biochemistry and Bioinformatics at the UPCH. Dr Zimic's innovative capacities have already produced an automated system for tuberculosis culture video surveillance and interpretation, which is now being adopted by the Peruvian Ministry of Health, and is also developing a series of initiatives in telemedicine and telediagnostics.  Dr. Zimic heads the Bioinformatics laboratory at UPCH.  His research besides the imaging algorithms is also very much involved the genetics of T. solium and using it to develop diagnostics especially for single cyst neurocysticercosis. His group studies the mechanism of action and resistance to pyrazinamide in Mycobacterium tuberculosis, and recently is starting to apply immunoinformatics techniques to analyze whole pathogen genomes in order to rationally develop novel immunodiagnostics antigens and potential vaccines. 
    Dr. Zimic leads the Bioinformatics and Molecular Biology laboratory at UPCH.  His research besides the imaging algorithms is also very much involved in development of alternate and cost-effective hardware for diagnostics. His group developed an under $500 inverted microscope and an automatic MODS plate reader for automation of TB diagnostics. Most recently, Zimic´s group has proven the utility of lens-free microscopy for TB diagnostics, developing an affordable system to be used in developing countries.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Proaño A, Bravard MA, Tracey BH, López JW, Comina G, Zimic M, Coronel J, O'Neill Lee G, Caviedes L, Luis Cabrera J, Salas A, Ticona E, Kirwan DE, Friedland JS, Evans CA, Moore DA, Gilman RH. Protocol for studying cough frequency in people with pulmonary tuberculosis. BMJ Open. 2016 Apr 22; 6(4):e010365. PMID: 27105713; PMCID: PMC4853990.
    2. Pajuelo MJ, Eguiluz M, Dahlstrom E, Requena D, Guzmán F, Ramirez M, Sheen P, Frace M, Sammons S, Cama V, Anzick S, Bruno D, Mahanty S, Wilkins P, Nash T, Gonzalez A, García HH, Gilman RH, Porcella S, Zimic M. Identification and Characterization of Microsatellite Markers Derived from the Whole Genome Analysis of Taenia solium. PLoS Negl Trop Dis. 2015 Dec; 9(12):e0004316. PMID: 26697878; PMCID: PMC4689449.
    3. Cangalaya C, Zimic M, Marzal M, González AE, Guerra-Giraldez C, Mahanty S, Nash TE, García HH. Inflammation Caused by Praziquantel Treatment Depends on the Location of the Taenia solium Cysticercus in Porcine Neurocysticercosis. PLoS Negl Trop Dis. 2015 Dec; 9(12):e0004207. PMID: 26658257; PMCID: PMC4689503.
    4. Castro JC, Maddox JD, Cobos M, Requena D, Zimic M, Bombarely A, Imán SA, Cerdeira LA, Medina AE. De novo assembly and functional annotation of Myrciaria dubia fruit transcriptome reveals multiple metabolic pathways for L-ascorbic acid biosynthesis. BMC Genomics. 2015 Nov 24; 16:997. PMID: 26602763; PMCID: PMC4658800.
    5. Valdivia-Olarte H, Requena D, Ramirez M, Saravia LE, Izquierdo R, Falconi-Agapito F, Zavaleta M, Best I, Fernández-Díaz M, Zimic M. Design of a predicted MHC restricted short peptide immunodiagnostic and vaccine candidate for Fowl adenovirus C in chicken infection. Bioinformation. 2015; 11(10):460-5. PMID: 26664030.
      View in: PubMed
    6. Ramírez-Salinas GL, García-Machorro J, Quiliano M, Zimic M, Briz V, Rojas-Hernández S, Correa-Basurto J. Molecular modeling studies demonstrate key mutations that could affect the ligand recognition by influenza AH1N1 neuraminidase. J Mol Model. 2015 Nov; 21(11):292. PMID: 26499499.
      View in: PubMed
    7. Gonzalez AE, Bustos JA, Garcia HH, Rodriguez S, Zimic M, Castillo Y, Praet N, Gabriël S, Gilman RH, Dorny P. Successful Antiparasitic Treatment for Cysticercosis is Associated with a Fast and Marked Reduction of Circulating Antigen Levels in a Naturally Infected Pig Model. Am J Trop Med Hyg. 2015 Dec; 93(6):1305-10. PMID: 26392159.
      View in: PubMed
    8. Adaui V, Lye LF, Akopyants NS, Zimic M, Llanos-Cuentas A, Garcia L, Maes I, De Doncker S, Dobson DE, Arevalo J, Dujardin JC, Beverley SM. Association of the Endobiont Double-Stranded RNA Virus LRV1 With Treatment Failure for Human Leishmaniasis Caused by Leishmania braziliensis in Peru and Bolivia. J Infect Dis. 2016 Jan 01; 213(1):112-21. PMID: 26123565; PMCID: PMC4676543 [Available on 01/01/17].
    9. Grandjean L, Iwamoto T, Lithgow A, Gilman RH, Arikawa K, Nakanishi N, Martin L, Castillo E, Alarcon V, Coronel J, Solano W, Aminian M, Guezala C, Rastogi N, Couvin D, Sheen P, Zimic M, Moore DA. The Association between Mycobacterium Tuberculosis Genotype and Drug Resistance in Peru. PLoS One. 2015; 10(5):e0126271. PMID: 25984723; PMCID: PMC4435908.
    10. García PJ, Egoavil MS, Blas MM, Alvarado-Vásquez E, Curioso WH, Zimic M, Castagnetto JM, Lescano AG, Lopez DM, Cárcamo CP. [Development and institutionalization of the first online certificate and Master Program of Biomedical Informatics in global health in Peru]. Rev Peru Med Exp Salud Publica. 2015 Apr-Jun; 32(2):356-60. PMID: 26338399.
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    11. Rueda D, Sheen P, Gilman RH, Bueno C, Santos M, Pando-Robles V, Batista CV, Zimic M. Nicotinamidase/pyrazinamidase of Mycobacterium tuberculosis forms homo-dimers stabilized by disulfide bonds. Tuberculosis (Edinb). 2014 Dec; 94(6):644-8. PMID: 25199451; PMCID: PMC4258149.
    12. Salazar-Salinas K, Baldera-Aguayo PA, Encomendero-Risco JJ, Orihuela M, Sheen P, Seminario JM, Zimic M. Metal-ion effects on the polarization of metal-bound water and infrared vibrational modes of the coordinated metal center of Mycobacterium tuberculosis pyrazinamidase via quantum mechanical calculations. J Phys Chem B. 2014 Aug 28; 118(34):10065-75. PMID: 25055049; PMCID: PMC4514207.
    13. Garcia HH, Gonzales I, Lescano AG, Bustos JA, Zimic M, Escalante D, Saavedra H, Gavidia M, Rodriguez L, Najar E, Umeres H, Pretell EJ. Efficacy of combined antiparasitic therapy with praziquantel and albendazole for neurocysticercosis: a double-blind, randomised controlled trial. Lancet Infect Dis. 2014 Aug; 14(8):687-95. PMID: 24999157; PMCID: PMC4157934.
    14. Rodríguez L, Alva A, Coronel J, Caviedes L, Mendoza-Ticona A, Gilman R, Sheen P, Zimic M. [Implementation of a telediagnostic system for tuberculosis and determination of multi-drug resistance based in the MODS method in Trujillo, Peru]. Rev Peru Med Exp Salud Publica. 2014 Jul-Sep; 31(3):445-53. PMID: 25418641.
      View in: PubMed
    15. Carrasco Pro S, Zimic M, Nielsen M. Improved pan-specific MHC class I peptide-binding predictions using a novel representation of the MHC-binding cleft environment. Tissue Antigens. 2014 Feb; 83(2):94-100. PMID: 24447175; PMCID: PMC3925504.
    16. Alva A, Aquino F, Gilman RH, Olivares C, Requena D, Gutiérrez AH, Caviedes L, Coronel J, Larson S, Sheen P, Moore DA, Zimic M. Morphological characterization of Mycobacterium tuberculosis in a MODS culture for an automatic diagnostics through pattern recognition. PLoS One. 2013; 8(12):e82809. PMID: 24358227; PMCID: PMC3865090.
    17. Saito M, Goel-Apaza S, Espetia S, Velasquez D, Cabrera L, Loli S, Crabtree JE, Black RE, Kosek M, Checkley W, Zimic M, Bern C, Cama V, Gilman RH. Multiple norovirus infections in a birth cohort in a Peruvian Periurban community. Clin Infect Dis. 2014 Feb; 58(4):483-91. PMID: 24300042; PMCID: PMC3905757.
    18. Quiliano M, Valdivia-Olarte H, Olivares C, Requena D, Gutiérrez AH, Reyes-Loyola P, Tolentino-Lopez LE, Sheen P, Briz V, Muñoz-Fernández MA, Correa-Basurto J, Zimic M. Molecular distribution of amino acid substitutions on neuraminidase from the 2009 (H1N1) human influenza pandemic virus. Bioinformation. 2013; 9(13):673-9. PMID: 23930018; PMCID: PMC3732439.
    19. Sheen P, Lozano K, Gilman RH, Valencia HJ, Loli S, Fuentes P, Grandjean L, Zimic M. pncA gene expression and prediction factors on pyrazinamide resistance in Mycobacterium tuberculosis. Tuberculosis (Edinb). 2013 Sep; 93(5):515-22. PMID: 23867321; PMCID: PMC3755357.
    20. León N, Padilla C, Pajuelo M, Sheen P, Zimic M. [Cathepsin L cysteine protease from Taenia solium: its biological role in the infection and potential use for the immunodiagnosis of neurocysticercosis]. Rev Peru Med Exp Salud Publica. 2013 Jul; 30(3):446-54. PMID: 24100821.
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    21. Bertani S, Pineau P, Loli S, Moura J, Zimic M, Deharo E, Ruiz E. An atypical age-specific pattern of hepatocellular carcinoma in Peru: a threat for Andean populations. PLoS One. 2013; 8(6):e67756. PMID: 23840771; PMCID: PMC3695993.
    22. Sheen P, Couvin D, Grandjean L, Zimic M, Dominguez M, Luna G, Gilman RH, Rastogi N, Moore DA. Genetic diversity of Mycobacterium tuberculosis in Peru and exploration of phylogenetic associations with drug resistance. PLoS One. 2013; 8(6):e65873. PMID: 23826083; PMCID: PMC3691179.
    23. Requena D, Chumbe A, Torres M, Alzamora O, Ramirez M, Valdivia-Olarte H, Gutierrez AH, Izquierdo-Lara R, Saravia LE, Zavaleta M, Tataje-Lavanda L, Best I, Fernández-Sánchez M, Icochea E, Zimic M, Fernández-Díaz M. Genome sequence and comparative analysis of Avibacterium paragallinarum. Bioinformation. 2013; 9(10):528-36. PMID: 23861570; PMCID: PMC3705629.
    24. Loyola PK, Campos-Rodríguez R, Bello M, Rojas-Hernández S, Zimic M, Quiliano M, Briz V, Muñoz-Fernández MA, Tolentino-López L, Correa-Basurto J. Theoretical analysis of the neuraminidase epitope of the Mexican A H1N1 influenza strain, and experimental studies on its interaction with rabbit and human hosts. Immunol Res. 2013 May; 56(1):44-60. PMID: 23371837.
      View in: PubMed
    25. Tolentino-Lopez L, Segura-Cabrera A, Reyes-Loyola P, Zimic M, Quiliano M, Briz V, Muñoz-Fernández A, Rodríguez-Pérez M, Ilizaliturri-Flores I, Correa-Basurto J. Outside-binding site mutations modify the active site's shapes in neuraminidase from influenza A H1N1. Biopolymers. 2013 Jan; 99(1):10-21. PMID: 23097226.
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    26. Sheen P, Ferrer P, Gilman RH, Christiansen G, Moreno-Román P, Gutiérrez AH, Sotelo J, Evangelista W, Fuentes P, Rueda D, Flores M, Olivera P, Solis J, Pesaresi A, Lamba D, Zimic M. Role of metal ions on the activity of Mycobacterium tuberculosis pyrazinamidase. Am J Trop Med Hyg. 2012 Jul; 87(1):153-61. PMID: 22764307; PMCID: PMC3391041.
    27. Gutiérrez AH, Spero DM, Gay C, Zimic M, De Groot AS. New vaccines needed for pathogens infecting animals and humans: One Health. Hum Vaccin Immunother. 2012 Jul; 8(7):971-8. PMID: 22485046.
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    28. Valencia C, Arévalo J, Dujardin JC, Llanos-Cuentas A, Chappuis F, Zimic M. Prediction score for antimony treatment failure in patients with ulcerative leishmaniasis lesions. PLoS Negl Trop Dis. 2012; 6(6):e1656. PMID: 22720098; PMCID: PMC3373623.
    29. Kosek M, Yori PP, Gilman RH, Calderon M, Zimic M, Chuquiyauri R, Jeri C, Pinedo-Cancino V, Matthias MA, Llanos-Cuentas A, Vinetz JM. High degree of Plasmodium vivax diversity in the Peruvian Amazon demonstrated by tandem repeat polymorphism analysis. Am J Trop Med Hyg. 2012 Apr; 86(4):580-6. PMID: 22492139; PMCID: PMC3403772.
    30. Zimic M, Loli S, Gilman RH, Gutierrez A, Fuentes P, Cotrina M, Kirwan D, Sheen P. A new approach for pyrazinamide susceptibility testing in Mycobacterium tuberculosis. Microb Drug Resist. 2012 Aug; 18(4):372-5. PMID: 22372927; PMCID: PMC3462410.
    31. Zimic M, Pajuelo M, Gilman RH, Gutiérrez AH, Rueda LD, Flores M, Chile N, Verástegui M, Gonzalez A, García HH, Sheen P. The highly antigenic 53/25 kDa Taenia solium protein fraction with cathepsin-L like activity is present in the oncosphere/cysticercus and induces non-protective IgG antibodies in pigs. Vet Immunol Immunopathol. 2012 Jan 15; 145(1-2):171-8. PMID: 22119017; PMCID: PMC3273550.
    32. Zimic M, Fuentes P, Gilman RH, Gutiérrez AH, Kirwan D, Sheen P. Pyrazinoic acid efflux rate in Mycobacterium tuberculosis is a better proxy of pyrazinamide resistance. Tuberculosis (Edinb). 2012 Jan; 92(1):84-91. PMID: 22004792; PMCID: PMC3269536.
    33. Chew R, Calderón C, Schumacher SG, Sherman JM, Caviedes L, Fuentes P, Coronel J, Valencia T, Hererra B, Zimic M, Huaroto L, Sabogal I, Escombe AR, Gilman RH, Evans CA. Evaluation of bleach-sedimentation for sterilising and concentrating Mycobacterium tuberculosis in sputum specimens. BMC Infect Dis. 2011 Oct 11; 11:269. PMID: 21985457; PMCID: PMC3213181.
    34. Rueda A, Sifuentes C, Gilman RH, Gutiérrez AH, Piña R, Chile N, Carrasco S, Larson S, Mayta H, Verástegui M, Rodriguez S, Gutiérrez-Correa M, García HH, Sheen P, Zimic M. TsAg5, a Taenia solium cysticercus protein with a marginal trypsin-like activity in the diagnosis of human neurocysticercosis. Mol Biochem Parasitol. 2011 Dec; 180(2):115-9. PMID: 21893105; PMCID: PMC3196780.
    35. Quiliano M, Gutierrez AH, Gilman RH, López C, Evangelista W, Sotelo J, Sheen P, Zimic M. Structure-Activity relationship in mutated pyrazinamidases from Mycobacterium tuberculosis. Bioinformation. 2011; 6(9):335-9. PMID: 21814390; PMCID: PMC3143395.
    36. Zimic M, Gutiérrez AH, Gilman RH, López C, Quiliano M, Evangelista W, Gonzales A, García HH, Sheen P. Immunoinformatics prediction of linear epitopes from Taenia solium TSOL18. Bioinformation. 2011; 6(7):271-4. PMID: 21738328; PMCID: PMC3124692.
    37. Barea C, Pabón A, Castillo D, Zimic M, Quiliano M, Galiano S, Pérez-Silanes S, Monge A, Deharo E, Aldana I. New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities. Bioorg Med Chem Lett. 2011 Aug 01; 21(15):4498-502. PMID: 21724395.
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    38. Piña R, Gutiérrez AH, Gilman RH, Rueda D, Sifuentes C, Flores M, Sheen P, Rodriguez S, García HH, Zimic M. A dot-ELISA using a partially purified cathepsin-L-like protein fraction from Taenia solium cysticerci, for the diagnosis of human neurocysticercosis. Ann Trop Med Parasitol. 2011 Jun; 105(4):311-8. PMID: 21871167; PMCID: PMC3368245.
    39. Adaui V, Castillo D, Zimic M, Gutierrez A, Decuypere S, Vanaerschot M, De Doncker S, Schnorbusch K, Maes I, Van der Auwera G, Maes L, Llanos-Cuentas A, Arevalo J, Dujardin JC. Comparative gene expression analysis throughout the life cycle of Leishmania braziliensis: diversity of expression profiles among clinical isolates. PLoS Negl Trop Dis. 2011 May 10; 5(5):e1021. PMID: 21572980; PMCID: PMC3091834.
    40. Caballero J, Quiliano M, Alzate-Morales JH, Zimic M, Deharo E. Docking and quantitative structure-activity relationship studies for 3-fluoro-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yloxy)aniline, 3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline, and 4-(4-amino-2-fluorophenoxy)-2-pyridinylamine derivatives as c-Met kinase inhibitors. J Comput Aided Mol Des. 2011 Apr; 25(4):349-69. PMID: 21487786.
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    41. Mendoza A, Pérez-Silanes S, Quiliano M, Pabón A, Galiano S, González G, Garavito G, Zimic M, Vaisberg A, Aldana I, Monge A, Deharo E. Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure-activity relationships. Exp Parasitol. 2011 Jun; 128(2):97-103. PMID: 21354139.
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    42. Estevez Y, Quiliano M, Burguete A, Cabanillas B, Zimic M, Málaga E, Verástegui M, Pérez-Silanes S, Aldana I, Monge A, Castillo D, Deharo E. Trypanocidal properties, structure-activity relationship and computational studies of quinoxaline 1,4-di-N-oxide derivatives. Exp Parasitol. 2011 Apr; 127(4):745-51. PMID: 21272583.
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    43. Comina G, Mendoza D, Velazco A, Coronel J, Sheen P, Gilman RH, Moore DA, Zimic M. Development of an automated MODS plate reader to detect early growth of Mycobacterium tuberculosis. J Microsc. 2011 Jun; 242(3):325-30. PMID: 21250995.
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    44. Blas MM, Curioso WH, Garcia PJ, Zimic M, Carcamo CP, Castagnetto JM, Lescano AG, Lopez DM. Training the biomedical informatics workforce in Latin America: results of a needs assessment. BMJ Open. 2011 Jan 01; 1(2):e000233. PMID: 22080537; PMCID: PMC3208899.
    45. Curioso WH, García PJ, Castillo GM, Blas MM, Perez-Brumer A, Zimic M. [Strengthening global health informatics research within the andean region through international collaboration]. Rev Peru Med Exp Salud Publica. 2010 Sep; 27(3):449-57. PMID: 21152740; PMCID: PMC3130124.
    46. Adaui V, Schnorbusch K, Zimic M, Gutiérrez A, Decuypere S, Vanaerschot M, DE Doncker S, Maes I, Llanos-Cuentas A, Chappuis F, Arévalo J, Dujardin JC. Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony. Parasitology. 2011 Feb; 138(2):183-93. PMID: 20678296.
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    47. Zimic M, Velazco A, Comina G, Coronel J, Fuentes P, Luna CG, Sheen P, Gilman RH, Moore DA. Development of low-cost inverted microscope to detect early growth of Mycobacterium tuberculosis in MODS culture. PLoS One. 2010 Mar 23; 5(3):e9577. PMID: 20351778; PMCID: PMC2843629.
    48. Aponte JC, Vaisberg AJ, Castillo D, Gonzalez G, Estevez Y, Arevalo J, Quiliano M, Zimic M, Verástegui M, Málaga E, Gilman RH, Bustamante JM, Tarleton RL, Wang Y, Franzblau SG, Pauli GF, Sauvain M, Hammond GB. Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines. Bioorg Med Chem. 2010 Apr 15; 18(8):2880-6. PMID: 20356752.
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    49. Cordova J, Shiloh R, Gilman RH, Sheen P, Martin L, Arenas F, Caviedes L, Kawai V, Soto G, Williams DL, Zimic M, Escombe AR, Evans CA. Evaluation of molecular tools for detection and drug susceptibility testing of Mycobacterium tuberculosis in stool specimens from patients with pulmonary tuberculosis. J Clin Microbiol. 2010 May; 48(5):1820-6. PMID: 20200293; PMCID: PMC2863910.
    50. Zimic M, Sheen P, Quiliano M, Gutierrez A, Gilman RH. Peruvian and globally reported amino acid substitutions on the Mycobacterium tuberculosis pyrazinamidase suggest a conserved pattern of mutations associated to pyrazinamide resistance. Infect Genet Evol. 2010 Mar; 10(2):346-9. PMID: 19963078; PMCID: PMC2845309.
    51. Cabrera L, De Witte J, Victor B, Vermeiren L, Zimic M, Brandt J, Geysen D. Specific detection and identification of African trypanosomes in bovine peripheral blood by means of a PCR-ELISA assay. Vet Parasitol. 2009 Oct 14; 164(2-4):111-7. PMID: 19619947.
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    52. Sheen P, Méndez M, Gilman RH, Peña L, Caviedes L, Zimic MJ, Zhang Y, Moore DA, Evans CA. Sputum PCR-single-strand conformational polymorphism test for same-day detection of pyrazinamide resistance in tuberculosis patients. J Clin Microbiol. 2009 Sep; 47(9):2937-43. PMID: 19535526; PMCID: PMC2738130.
    53. Zimic M, Pajuelo M, Rueda D, López C, Arana Y, Castillo Y, Calderón M, Rodriguez S, Sheen P, Vinetz JM, Gonzales A, García HH, Gilman RH. Utility of a protein fraction with cathepsin L-Like activity purified from cysticercus fluid of Taenia solium in the diagnosis of human cysticercosis. Am J Trop Med Hyg. 2009 Jun; 80(6):964-70. PMID: 19478259; PMCID: PMC2762273.
    54. Sheen P, Ferrer P, Gilman RH, López-Llano J, Fuentes P, Valencia E, Zimic MJ. Effect of pyrazinamidase activity on pyrazinamide resistance in Mycobacterium tuberculosis. Tuberculosis (Edinb). 2009 Mar; 89(2):109-13. PMID: 19249243; PMCID: PMC2691962.
    55. Wolf H, Mendez M, Gilman RH, Sheen P, Soto G, Velarde AK, Zimic M, Escombe AR, Montenegro S, Oberhelman RA, Evans CA. Diagnosis of pediatric pulmonary tuberculosis by stool PCR. Am J Trop Med Hyg. 2008 Dec; 79(6):893-8. PMID: 19052299; PMCID: PMC2912504.
    56. Zimic M, Coronel J, Gilman RH, Luna CG, Curioso WH, Moore DA. Can the power of mobile phones be used to improve tuberculosis diagnosis in developing countries? Trans R Soc Trop Med Hyg. 2009 Jun; 103(6):638-40. PMID: 19036392.
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    57. Herrera PM, Mendez M, Velapatiño B, Velapatiõ B, Santivañez L, Santivaez L, Balqui J, Finger SA, Sherman J, Zimic M, Cabrera L, Watanabe J, Rodríguez C, Gilman RH, Berg DE. DNA-level diversity and relatedness of Helicobacter pylori strains in shantytown families in Peru and transmission in a developing-country setting. J Clin Microbiol. 2008 Dec; 46(12):3912-8. PMID: 18842944; PMCID: PMC2593267.
    58. Aponte JC, Verástegui M, Málaga E, Zimic M, Quiliano M, Vaisberg AJ, Gilman RH, Hammond GB. Synthesis, cytotoxicity, and anti-Trypanosoma cruzi activity of new chalcones. J Med Chem. 2008 Oct 09; 51(19):6230-4. PMID: 18798609.
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    59. Donroe JA, Maurtua-Neumann PJ, Gilman RH, Acosta AT, Cain G, Parker JE, Carhuaricra JC, Padilla JJ, Mendoza D, Zimic M, Moore DA. Surveillance for early silicosis in high altitude miners using pulse oximetry. Int J Occup Environ Health. 2008 Jul-Sep; 14(3):187-92. PMID: 18686718.
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    60. Gamboa D, Torres K, De Doncker S, Zimic M, Arevalo J, Dujardin JC. Evaluation of an in vitro and in vivo model for experimental infection with Leishmania (Viannia) braziliensis and L. (V.) peruviana. Parasitology. 2008 Mar; 135(3):319-26. PMID: 17961284.
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    61. Zimic MJ, Infantes J, López C, Velásquez J, Farfán M, Pajuelo M, Sheen P, Verastegui M, Gonzalez A, Garciá HH, Gilman RH. Comparison of the peptidase activity in the oncosphere excretory/secretory products of Taenia solium and Taenia saginata. J Parasitol. 2007 Aug; 93(4):727-34. PMID: 17918349.
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    62. Arevalo J, Ramirez L, Adaui V, Zimic M, Tulliano G, Miranda-Verástegui C, Lazo M, Loayza-Muro R, De Doncker S, Maurer A, Chappuis F, Dujardin JC, Llanos-Cuentas A. Influence of Leishmania (Viannia) species on the response to antimonial treatment in patients with American tegumentary leishmaniasis. J Infect Dis. 2007 Jun 15; 195(12):1846-51. PMID: 17492601.
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    63. Adaui V, Verdonck K, Best I, González E, Tipismana M, Arévalo J, Vanham G, Campos M, Zimic M, Gotuzzo E. SYBR Green-based quantitation of human T-lymphotropic virus type 1 proviral load in Peruvian patients with neurological disease and asymptomatic carriers: influence of clinical status, sex, and familial relatedness. J Neurovirol. 2006 Dec; 12(6):456-65. PMID: 17162661.
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    64. Oberhelman RA, Gilman RH, Sheen P, Cordova J, Zimic M, Cabrera L, Meza R, Perez J. An intervention-control study of corralling of free-ranging chickens to control Campylobacter infections among children in a Peruvian periurban shantytown. Am J Trop Med Hyg. 2006 Jun; 74(6):1054-9. PMID: 16760519.
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    65. Pelly TF, Santillan CF, Gilman RH, Cabrera LZ, Garcia E, Vidal C, Zimic MJ, Moore DA, Evans CA. Tuberculosis skin testing, anergy and protein malnutrition in Peru. Int J Tuberc Lung Dis. 2005 Sep; 9(9):977-84. PMID: 16161252; PMCID: PMC2912519.
    66. Chinga-Alayo E, Villena J, Evans AT, Zimic M. Thyroid hormone levels improve the prediction of mortality among patients admitted to the intensive care unit. Intensive Care Med. 2005 Oct; 31(10):1356-61. PMID: 16012806.
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    67. Oberhelman RA, Gilman RH, Sheen P, Cordova J, Taylor DN, Zimic M, Meza R, Perez J, LeBron C, Cabrera L, Rodgers FG, Woodward DL, Price LJ. Campylobacter transmission in a Peruvian shantytown: a longitudinal study using strain typing of campylobacter isolates from chickens and humans in household clusters. J Infect Dis. 2003 Jan 15; 187(2):260-9. PMID: 12552450.
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    68. Zimic MJ, Guerra D, Arévalo J. DNA thermodynamic pressure: a potential contributor to genome evolution. Trans R Soc Trop Med Hyg. 2002 Apr; 96 Suppl 1:S15-20. PMID: 12055830.
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