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Professor Eric Oldfield

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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Feng X, Zhu W, Schurig-Briccio LA, Lindert S, Shoen C, Hitchings R, Li J, Wang Y, Baig N, Zhou T, Kim BK, Crick DC, Cynamon M, McCammon JA, Gennis RB, Oldfield E. Antiinfectives targeting enzymes and the proton motive force. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):E7073-82. PMID: 26644565; PMCID: PMC4697371.
    2. Li J, Feng X, Zhu W, Oskolkov N, Zhou T, Kim BK, Baig N, McMahon MT, Oldfield E. Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI. Chemistry. 2016 Jan 04; 22(1):264-71. PMID: 26616530; PMCID: PMC4715718 [Available on 01/04/17].
    3. Yang G, Zhu W, Kim K, Byun SY, Choi G, Wang K, Cha JS, Cho HS, Oldfield E, No JH. In Vitro and In Vivo Investigation of the Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates. Antimicrob Agents Chemother. 2015 Dec; 59(12):7530-9. PMID: 26392508; PMCID: PMC4649187.
    4. Oldfield E. Tuberculosis terpene targets. Chem Biol. 2015 Apr 23; 22(4):437-8. PMID: 25910241.
      View in: PubMed
    5. Liu YL, Cao R, Wang Y, Oldfield E. Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries. ACS Med Chem Lett. 2015 Mar 12; 6(3):349-54. PMID: 25815158; PMCID: PMC4360152.
    6. Zhu W, Wang Y, Li K, Gao J, Huang CH, Chen CC, Ko TP, Zhang Y, Guo RT, Oldfield E. Antibacterial drug leads: DNA and enzyme multitargeting. J Med Chem. 2015 Feb 12; 58(3):1215-27. PMID: 25574764; PMCID: PMC4513954.
    7. Veiga-Santos P, Li K, Lameira L, de Carvalho TM, Huang G, Galizzi M, Shang N, Li Q, Gonzalez-Pacanowska D, Hernandez-Rodriguez V, Benaim G, Guo RT, Urbina JA, Docampo R, de Souza W, Oldfield E. SQ109, a new drug lead for Chagas disease. Antimicrob Agents Chemother. 2015 Apr; 59(4):1950-61. PMID: 25583723; PMCID: PMC4356821.
    8. Feng X, Hu Y, Zheng Y, Zhu W, Li K, Huang CH, Ko TP, Ren F, Chan HC, Nega M, Bogue S, López D, Kolter R, Götz F, Guo RT, Oldfield E. Structural and functional analysis of Bacillus subtilis YisP reveals a role of its product in biofilm production. Chem Biol. 2014 Nov 20; 21(11):1557-63. PMID: 25308276; PMCID: PMC4252625.
    9. Sinko W, Wang Y, Zhu W, Zhang Y, Feixas F, Cox CL, Mitchell DA, Oldfield E, McCammon JA. Undecaprenyl diphosphate synthase inhibitors: antibacterial drug leads. J Med Chem. 2014 Jul 10; 57(13):5693-701. PMID: 24827744; PMCID: PMC4096218.
    10. Liu YL, Lindert S, Zhu W, Wang K, McCammon JA, Oldfield E. Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):E2530-9. PMID: 24927548; PMCID: PMC4078810.
    11. Shang N, Li Q, Ko TP, Chan HC, Li J, Zheng Y, Huang CH, Ren F, Chen CC, Zhu Z, Galizzi M, Li ZH, Rodrigues-Poveda CA, Gonzalez-Pacanowska D, Veiga-Santos P, de Carvalho TM, de Souza W, Urbina JA, Wang AH, Docampo R, Li K, Liu YL, Oldfield E, Guo RT. Squalene synthase as a target for Chagas disease therapeutics. PLoS Pathog. 2014 May; 10(5):e1004114. PMID: 24789335; PMCID: PMC4006925.
    12. Li K, Schurig-Briccio LA, Feng X, Upadhyay A, Pujari V, Lechartier B, Fontes FL, Yang H, Rao G, Zhu W, Gulati A, No JH, Cintra G, Bogue S, Liu YL, Molohon K, Orlean P, Mitchell DA, Freitas-Junior L, Ren F, Sun H, Jiang T, Li Y, Guo RT, Cole ST, Gennis RB, Crick DC, Oldfield E. Multitarget drug discovery for tuberculosis and other infectious diseases. J Med Chem. 2014 Apr 10; 57(7):3126-39. PMID: 24568559; PMCID: PMC4084622.
    13. Aripirala S, Gonzalez-Pacanowska D, Oldfield E, Kaiser M, Amzel LM, Gabelli SB. Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates. Acta Crystallogr D Biol Crystallogr. 2014 Mar; 70(Pt 3):802-10. PMID: 24598749; PMCID: PMC3949514.
    14. Chan HC, Feng X, Ko TP, Huang CH, Hu Y, Zheng Y, Bogue S, Nakano C, Hoshino T, Zhang L, Lv P, Liu W, Crick DC, Liang PH, Wang AH, Oldfield E, Guo RT. Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. J Am Chem Soc. 2014 Feb 19; 136(7):2892-6. PMID: 24475925; PMCID: PMC3986019.
    15. Benaim G, Casanova P, Hernandez-Rodriguez V, Mujica-Gonzalez S, Parra-Gimenez N, Plaza-Rojas L, Concepcion JL, Liu YL, Oldfield E, Paniz-Mondolfi A, Suarez AI. Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy. Antimicrob Agents Chemother. 2014; 58(4):2295-303. PMID: 24492373; PMCID: PMC4023776.
    16. Ziniel PD, Desai J, Cass CL, Gatto C, Oldfield E, Williams DL. Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni. Antimicrob Agents Chemother. 2013 Dec; 57(12):5969-76. PMID: 24041901; PMCID: PMC3837879.
    17. Lindert S, Zhu W, Liu YL, Pang R, Oldfield E, McCammon JA. Farnesyl diphosphate synthase inhibitors from in silico screening. Chem Biol Drug Des. 2013 Jun; 81(6):742-8. PMID: 23421555; PMCID: PMC3671582.
    18. Li J, Wang K, Smirnova TI, Khade RL, Zhang Y, Oldfield E. Isoprenoid biosynthesis: ferraoxetane or allyl anion mechanism for IspH catalysis? Angew Chem Int Ed Engl. 2013 Jun 17; 52(25):6522-5. PMID: 23649534; PMCID: PMC3821072.
    19. Span I, Wang K, Wang W, Jauch J, Eisenreich W, Bacher A, Oldfield E, Groll M. Structures of fluoro, amino, and thiol inhibitors bound to the [Fe4S4] protein IspH. Angew Chem Int Ed Engl. 2013 Feb 11; 52(7):2118-21. PMID: 23307751; PMCID: PMC3734547.
    20. Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, Nizet V, McCammon JA, Oldfield E. Antibacterial drug leads targeting isoprenoid biosynthesis. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):123-8. PMID: 23248302; PMCID: PMC3538244.
    21. Wang W, Wang K, Span I, Jauch J, Bacher A, Groll M, Oldfield E. Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation. J Am Chem Soc. 2012 Jul 11; 134(27):11225-34. PMID: 22687151; PMCID: PMC3394908.
    22. El Moll H, Zhu W, Oldfield E, Rodriguez-Albelo LM, Mialane P, Marrot J, Vila N, Mbomekallé IM, Rivière E, Duboc C, Dolbecq A. Polyoxometalates functionalized by bisphosphonate ligands: synthesis, structural, magnetic, and spectroscopic characterizations and activity on tumor cell lines. Inorg Chem. 2012 Jul 16; 51(14):7921-31. PMID: 22725619; PMCID: PMC3412544.
    23. Liu YL, Guerra F, Wang K, Wang W, Li J, Huang C, Zhu W, Houlihan K, Li Z, Zhang Y, Nair SK, Oldfield E. Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8558-63. PMID: 22586085; PMCID: PMC3365180.
    24. Lin FY, Liu YL, Li K, Cao R, Zhu W, Axelson J, Pang R, Oldfield E. Head-to-head prenyl tranferases: anti-infective drug targets. J Med Chem. 2012 May 10; 55(9):4367-72. PMID: 22486710; PMCID: PMC3349777.
    25. No JH, de Macedo Dossin F, Zhang Y, Liu YL, Zhu W, Feng X, Yoo JA, Lee E, Wang K, Hui R, Freitas-Junior LH, Oldfield E. Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity. Proc Natl Acad Sci U S A. 2012 Mar 13; 109(11):4058-63. PMID: 22392982; PMCID: PMC3306666.
    26. Lin FY, Zhang Y, Hensler M, Liu YL, Chow OA, Zhu W, Wang K, Pang R, Thienphrapa W, Nizet V, Oldfield E. Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics. ChemMedChem. 2012 Apr; 7(4):561-4. PMID: 22290830; PMCID: PMC3471559.
    27. Oldfield E, Lin FY. Terpene biosynthesis: modularity rules. Angew Chem Int Ed Engl. 2012 Jan 27; 51(5):1124-37. PMID: 22105807; PMCID: PMC3769779.
    28. Wylie BJ, Sperling LJ, Nieuwkoop AJ, Franks WT, Oldfield E, Rienstra CM. Ultrahigh resolution protein structures using NMR chemical shift tensors. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):16974-9. PMID: 21969532; PMCID: PMC3193204.
    29. Durrant JD, Cao R, Gorfe AA, Zhu W, Li J, Sankovsky A, Oldfield E, McCammon JA. Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design. Chem Biol Drug Des. 2011 Sep; 78(3):323-32. PMID: 21696546; PMCID: PMC3155669.
    30. Wang W, Wang K, Li J, Nellutla S, Smirnova TI, Oldfield E. An ENDOR and HYSCORE investigation of a reaction intermediate in IspG (GcpE) catalysis. J Am Chem Soc. 2011 Jun 08; 133(22):8400-3. PMID: 21574560; PMCID: PMC3116442.
    31. Wang W, Li J, Wang K, Smirnova TI, Oldfield E. Pyridine inhibitor binding to the 4Fe-4S protein A. aeolicus IspH (LytB): a HYSCORE Investigation. J Am Chem Soc. 2011 May 04; 133(17):6525-8. PMID: 21486034; PMCID: PMC3092291.
    32. Sinko W, de Oliveira C, Williams S, Van Wynsberghe A, Durrant JD, Cao R, Oldfield E, McCammon JA. Applying molecular dynamics simulations to identify rarely sampled ligand-bound conformational states of undecaprenyl pyrophosphate synthase, an antibacterial target. Chem Biol Drug Des. 2011 Jun; 77(6):412-20. PMID: 21294851; PMCID: PMC3095679.
    33. Lin FY, Liu CI, Liu YL, Zhang Y, Wang K, Jeng WY, Ko TP, Cao R, Wang AH, Oldfield E. Mechanism of action and inhibition of dehydrosqualene synthase. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21337-42. PMID: 21098670; PMCID: PMC3003041.
    34. Oldfield E. Targeting isoprenoid biosynthesis for drug discovery: bench to bedside. Acc Chem Res. 2010 Sep 21; 43(9):1216-26. PMID: 20560544; PMCID: PMC2943567.
    35. Cao R, Zhang Y, Mann FM, Huang C, Mukkamala D, Hudock MP, Mead ME, Prisic S, Wang K, Lin FY, Chang TK, Peters RJ, Oldfield E. Diterpene cyclases and the nature of the isoprene fold. Proteins. 2010 Aug 15; 78(11):2417-32. PMID: 20602361; PMCID: PMC3805035.
    36. Ramos IB, Miranda K, Pace DA, Verbist KC, Lin FY, Zhang Y, Oldfield E, Machado EA, De Souza W, Docampo R. Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP. Biochem J. 2010 Aug 01; 429(3):485-95. PMID: 20497125; PMCID: PMC2907711.
    37. Wang W, Li J, Wang K, Huang C, Zhang Y, Oldfield E. Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG). Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11189-93. PMID: 20534554; PMCID: PMC2895101.
    38. Wang K, Wang W, No JH, Zhang Y, Zhang Y, Oldfield E. Inhibition of the Fe(4)S(4)-cluster-containing protein IspH (LytB): electron paramagnetic resonance, metallacycles, and mechanisms. J Am Chem Soc. 2010 May 19; 132(19):6719-27. PMID: 20426416; PMCID: PMC2874468.
    39. Singh AP, Zhang Y, No JH, Docampo R, Nussenzweig V, Oldfield E. Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth. Antimicrob Agents Chemother. 2010 Jul; 54(7):2987-93. PMID: 20457823; PMCID: PMC2897311.
    40. Huang CH, Gabelli SB, Oldfield E, Amzel LM. Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer. Proteins. 2010 Mar; 78(4):888-99. PMID: 19876942; PMCID: PMC3018326.
    41. Wang W, Wang K, Liu YL, No JH, Li J, Nilges MJ, Oldfield E. Bioorganometallic mechanism of action, and inhibition, of IspH. Proc Natl Acad Sci U S A. 2010 Mar 09; 107(10):4522-7. PMID: 20173096; PMCID: PMC2842026.
    42. Zhang Y, Cao R, Yin F, Lin FY, Wang H, Krysiak K, No JH, Mukkamala D, Houlihan K, Li J, Morita CT, Oldfield E. Lipophilic pyridinium bisphosphonates: potent gammadelta T cell stimulators. Angew Chem Int Ed Engl. 2010 Feb 01; 49(6):1136-8. PMID: 20039246; PMCID: PMC2819003.
    43. Song Y, Liu CI, Lin FY, No JH, Hensler M, Liu YL, Jeng WY, Low J, Liu GY, Nizet V, Wang AH, Oldfield E. Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results. J Med Chem. 2009 Jul 09; 52(13):3869-80. PMID: 19456099; PMCID: PMC2753857.
    44. Mukherjee S, Huang C, Guerra F, Wang K, Oldfield E. Thermodynamics of bisphosphonates binding to human bone: a two-site model. J Am Chem Soc. 2009 Jun 24; 131(24):8374-5. PMID: 19489581; PMCID: PMC2753405.
    45. Zhang Y, Cao R, Yin F, Hudock MP, Guo RT, Krysiak K, Mukherjee S, Gao YG, Robinson H, Song Y, No JH, Bergan K, Leon A, Cass L, Goddard A, Chang TK, Lin FY, Van Beek E, Papapoulos S, Wang AH, Kubo T, Ochi M, Mukkamala D, Oldfield E. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J Am Chem Soc. 2009 Apr 15; 131(14):5153-62. PMID: 19309137; PMCID: PMC2753403.
    46. Song Y, Lin FY, Yin F, Hensler M, Rodrígues Poveda CA, Mukkamala D, Cao R, Wang H, Morita CT, González Pacanowska D, Nizet V, Oldfield E. Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem. 2009 Feb 26; 52(4):976-88. PMID: 19191557; PMCID: PMC2765255.
    47. Wylie BJ, Schwieters CD, Oldfield E, Rienstra CM. Protein structure refinement using 13C alpha chemical shift tensors. J Am Chem Soc. 2009 Jan 28; 131(3):985-92. PMID: 19123862; PMCID: PMC2751586.
    48. Mukkamala D, No JH, Cass LM, Chang TK, Oldfield E. Bisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme data. J Med Chem. 2008 Dec 25; 51(24):7827-33. PMID: 19053772; PMCID: PMC2765246.
    49. Rekittke I, Wiesner J, Röhrich R, Demmer U, Warkentin E, Xu W, Troschke K, Hintz M, No JH, Duin EC, Oldfield E, Jomaa H, Ermler U. Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. J Am Chem Soc. 2008 Dec 24; 130(51):17206-7. PMID: 19035630; PMCID: PMC2756146.
    50. Cao R, Chen CK, Guo RT, Wang AH, Oldfield E. Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases. Proteins. 2008 Nov 01; 73(2):431-9. PMID: 18442135; PMCID: PMC2580052.
    51. K-M Chen C, Hudock MP, Zhang Y, Guo RT, Cao R, No JH, Liang PH, Ko TP, Chang TH, Chang SC, Song Y, Axelson J, Kumar A, Wang AH, Oldfield E. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25; 51(18):5594-607. PMID: 18800762; PMCID: PMC2552397.
    52. Song Y, Chan JM, Tovian Z, Secrest A, Nagy E, Krysiak K, Bergan K, Parniak MA, Oldfield E. Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR investigation. Bioorg Med Chem. 2008 Oct 01; 16(19):8959-67. PMID: 18789701; PMCID: PMC2586422.
    53. Zhang Y, Oldfield E. NMR hyperfine shifts in blue copper proteins: a quantum chemical investigation. J Am Chem Soc. 2008 Mar 26; 130(12):3814-23. PMID: 18314973; PMCID: PMC2761745.
    54. Liu CI, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V, Wang AH, Oldfield E. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science. 2008 Mar 07; 319(5868):1391-4. PMID: 18276850; PMCID: PMC2747771.
    55. Mukherjee S, Song Y, Oldfield E. NMR investigations of the static and dynamic structures of bisphosphonates on human bone: a molecular model. J Am Chem Soc. 2008 Jan 30; 130(4):1264-73. PMID: 18173269.
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    56. Babu PK, Lewera A, Chung JH, Hunger R, Jaegermann W, Alonso-Vante N, Wieckowski A, Oldfield E. Selenium becomes metallic in Ru-Se fuel cell catalysts: an EC-NMR and XPS investigation. J Am Chem Soc. 2007 Dec 12; 129(49):15140-1. PMID: 18004862.
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    57. Zhang Y, Hudock MP, Krysiak K, Cao R, Bergan K, Yin F, Leon A, Oldfield E. Activity of sulfonium bisphosphonates on tumor cell lines. J Med Chem. 2007 Nov 29; 50(24):6067-79. PMID: 17963374.
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    58. Ling Y, Li ZH, Miranda K, Oldfield E, Moreno SN. The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates. J Biol Chem. 2007 Oct 19; 282(42):30804-16. PMID: 17724033.
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    59. Guo RT, Cao R, Liang PH, Ko TP, Chang TH, Hudock MP, Jeng WY, Chen CK, Zhang Y, Song Y, Kuo CJ, Yin F, Oldfield E, Wang AH. Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A. 2007 Jun 12; 104(24):10022-7. PMID: 17535895; PMCID: PMC1877987.
    60. Mukkamala D, Zhang Y, Oldfield E. A solid state 13C NMR, crystallographic, and quantum chemical investigation of phenylalanine and tyrosine residues in dipeptides and proteins. J Am Chem Soc. 2007 Jun 13; 129(23):7385-92. PMID: 17506558.
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    61. Sanz-Rodríguez CE, Concepción JL, Pekerar S, Oldfield E, Urbina JA. Bisphosphonates as inhibitors of Trypanosoma cruzi hexokinase: kinetic and metabolic studies. J Biol Chem. 2007 Apr 27; 282(17):12377-87. PMID: 17329254.
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    62. Leon A, Liu L, Yang Y, Hudock MP, Hall P, Yin F, Studer D, Puan KJ, Morita CT, Oldfield E. Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin. J Med Chem. 2006 Dec 14; 49(25):7331-41. PMID: 17149863.
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    63. Kotsikorou E, Sahota G, Oldfield E. Bisphosphonate inhibition of phosphoglycerate kinase: quantitative structure-activity relationship and pharmacophore modeling investigation. J Med Chem. 2006 Nov 16; 49(23):6692-703. PMID: 17154500.
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    64. Mao J, Mukherjee S, Zhang Y, Cao R, Sanders JM, Song Y, Zhang Y, Meints GA, Gao YG, Mukkamala D, Hudock MP, Oldfield E. Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes. J Am Chem Soc. 2006 Nov 15; 128(45):14485-97. PMID: 17090032.
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    65. Zhang Y, Leon A, Song Y, Studer D, Haase C, Koscielski LA, Oldfield E. Activity of nitrogen-containing and non-nitrogen-containing bisphosphonates on tumor cell lines. J Med Chem. 2006 Sep 21; 49(19):5804-14. PMID: 16970405.
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    66. Zhang Y, Song Y, Yin F, Broderick E, Siegel K, Goddard A, Nieves E, Pasa-Tolic L, Tanaka Y, Wang H, Morita CT, Oldfield E. Structural studies of Vgamma2Vdelta2 T cell phosphoantigens. Chem Biol. 2006 Sep; 13(9):985-92. PMID: 16984888.
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    67. Yin F, Cao R, Goddard A, Zhang Y, Oldfield E. Enthalpy versus entropy-driven binding of bisphosphonates to farnesyl diphosphate synthase. J Am Chem Soc. 2006 Mar 22; 128(11):3524-5. PMID: 16536518.
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    68. Benaim G, Sanders JM, Garcia-Marchán Y, Colina C, Lira R, Caldera AR, Payares G, Sanoja C, Burgos JM, Leon-Rossell A, Concepcion JL, Schijman AG, Levin M, Oldfield E, Urbina JA. Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole. J Med Chem. 2006 Feb 09; 49(3):892-9. PMID: 16451055.
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    69. Hudock MP, Sanz-Rodríguez CE, Song Y, Chan JM, Zhang Y, Odeh S, Kosztowski T, Leon-Rossell A, Concepción JL, Yardley V, Croft SL, Urbina JA, Oldfield E. Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates. J Med Chem. 2006 Jan 12; 49(1):215-23. PMID: 16392806.
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    70. Zhang Y, Oldfield E. 31P NMR chemical shifts in hypervalent oxyphosphoranes and polymeric orthophosphates. J Phys Chem B. 2006 Jan 12; 110(1):579-86. PMID: 16471570.
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    71. Gabelli SB, McLellan JS, Montalvetti A, Oldfield E, Docampo R, Amzel LM. Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design. Proteins. 2006 Jan 01; 62(1):80-8. PMID: 16288456.
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    72. Kobayashi T, Babu PK, Gancs L, Chung JH, Oldfield E, Wieckowski A. An NMR determination of CO diffusion on platinum electrocatalysts. J Am Chem Soc. 2005 Oct 19; 127(41):14164-5. PMID: 16218593.
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    73. Kotsikorou E, Song Y, Chan JM, Faelens S, Tovian Z, Broderick E, Bakalara N, Docampo R, Oldfield E. Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase. J Med Chem. 2005 Sep 22; 48(19):6128-39. PMID: 16162013.
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    74. Babu PK, Kim HS, Kuk ST, Chung JH, Oldfield E, Wieckowski A, Smotkin ES. Activation of nanoparticle Pt-Ru fuel cell catalysts by heat treatment: a 195Pt NMR and electrochemical study. J Phys Chem B. 2005 Sep 15; 109(36):17192-6. PMID: 16853193.
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    75. Cheng F, Sun H, Zhang Y, Mukkamala D, Oldfield E. A solid state 13C NMR, crystallographic, and quantum chemical investigation of chemical shifts and hydrogen bonding in histidine dipeptides. J Am Chem Soc. 2005 Sep 14; 127(36):12544-54. PMID: 16144402.
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    76. Oldfield E. Quantum chemical studies of protein structure. Philos Trans R Soc Lond B Biol Sci. 2005 Jun 29; 360(1458):1347-61. PMID: 16147526; PMCID: PMC1569496.
    77. Ling Y, Sahota G, Odeh S, Chan JM, Araujo FG, Moreno SN, Oldfield E. Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations. J Med Chem. 2005 May 05; 48(9):3130-40. PMID: 15857119.
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    78. Sanders JM, Song Y, Chan JM, Zhang Y, Jennings S, Kosztowski T, Odeh S, Flessner R, Schwerdtfeger C, Kotsikorou E, Meints GA, Gómez AO, González-Pacanowska D, Raker AM, Wang H, van Beek ER, Papapoulos SE, Morita CT, Oldfield E. Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption. J Med Chem. 2005 Apr 21; 48(8):2957-63. PMID: 15828834.
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    79. Zhang Y, Sun H, Oldfield E. Solid-state NMR fermi contact and dipolar shifts in organometallic complexes and metalloporphyrins. J Am Chem Soc. 2005 Mar 23; 127(11):3652-3. PMID: 15771472.
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    80. Cheng F, Oldfield E. Inhibition of isoprene biosynthesis pathway enzymes by phosphonates, bisphosphonates, and diphosphates. J Med Chem. 2004 Oct 07; 47(21):5149-58. PMID: 15456258.
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    81. Mao J, Gao YG, Odeh S, Robinson H, Montalvetti A, Docampo R, Oldfield E. Crystallization and preliminary X-ray diffraction study of the farnesyl diphosphate synthase from Trypanosoma brucei. Acta Crystallogr D Biol Crystallogr. 2004 Oct; 60(Pt 10):1863-6. PMID: 15388934.
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    82. Seufferheld M, Lea CR, Vieira M, Oldfield E, Docampo R. The H(+)-pyrophosphatase of Rhodospirillum rubrum is predominantly located in polyphosphate-rich acidocalcisomes. J Biol Chem. 2004 Dec 03; 279(49):51193-202. PMID: 15371423.
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    83. Yajima S, Hara K, Sanders JM, Yin F, Ohsawa K, Wiesner J, Jomaa H, Oldfield E. Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes. J Am Chem Soc. 2004 Sep 08; 126(35):10824-5. PMID: 15339150.
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    84. Song Y, Zhang Y, Wang H, Raker AM, Sanders JM, Broderick E, Clark A, Morita CT, Oldfield E. Synthesis of chiral phosphoantigens and their activity in gamma delta T cell stimulation. Bioorg Med Chem Lett. 2004 Sep 06; 14(17):4471-7. PMID: 15357974.
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    85. Ruiz FA, Lea CR, Oldfield E, Docampo R. Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes. J Biol Chem. 2004 Oct 22; 279(43):44250-7. PMID: 15308650.
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    86. Zhang Y, Oldfield E. On the Mössbauer spectra of isopenicillin N synthase and a model (FeNO)7 (S = 3/2) system. J Am Chem Soc. 2004 Aug 11; 126(31):9494-5. PMID: 15291525.
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    87. Zhang Y, Oldfield E. Cytochrome P450: an investigation of the Mössbauer spectra of a reaction intermediate and an Fe(IV)[double bond]O model system. J Am Chem Soc. 2004 Apr 14; 126(14):4470-1. PMID: 15070336.
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    88. Sun H, Oldfield E. Tryptophan chemical shift in peptides and proteins: a solid state carbon-13 nuclear magnetic resonance spectroscopic and quantum chemical investigation. J Am Chem Soc. 2004 Apr 14; 126(14):4726-34. PMID: 15070392.
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    89. Garzoni LR, Waghabi MC, Baptista MM, de Castro SL, Meirelles Mde N, Britto CC, Docampo R, Oldfield E, Urbina JA. Antiparasitic activity of risedronate in a murine model of acute Chagas' disease. Int J Antimicrob Agents. 2004 Mar; 23(3):286-90. PMID: 15164970.
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    90. Garzoni LR, Caldera A, Meirelles Mde N, de Castro SL, Docampo R, Meints GA, Oldfield E, Urbina JA. Selective in vitro effects of the farnesyl pyrophosphate synthase inhibitor risedronate on Trypanosoma cruzi. Int J Antimicrob Agents. 2004 Mar; 23(3):273-85. PMID: 15164969.
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    91. Sanders JM, Ghosh S, Chan JM, Meints G, Wang H, Raker AM, Song Y, Colantino A, Burzynska A, Kafarski P, Morita CT, Oldfield E. Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates. J Med Chem. 2004 Jan 15; 47(2):375-84. PMID: 14711309.
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    92. Ghosh S, Chan JM, Lea CR, Meints GA, Lewis JC, Tovian ZS, Flessner RM, Loftus TC, Bruchhaus I, Kendrick H, Croft SL, Kemp RG, Kobayashi S, Nozaki T, Oldfield E. Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. J Med Chem. 2004 Jan 01; 47(1):175-87. PMID: 14695831.
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    93. Zhang Y, Gossman W, Oldfield E. A density functional theory investigation of Fe-N-O bonding in heme proteins and model systems. J Am Chem Soc. 2003 Dec 31; 125(52):16387-96. PMID: 14692781.
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    94. Sanders JM, Gómez AO, Mao J, Meints GA, Van Brussel EM, Burzynska A, Kafarski P, González-Pacanowska D, Oldfield E. 3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates. J Med Chem. 2003 Nov 20; 46(24):5171-83. PMID: 14613320.
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    95. Kotsikorou E, Oldfield E. A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents. J Med Chem. 2003 Jul 03; 46(14):2932-44. PMID: 12825934.
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    96. Montalvetti A, Fernandez A, Sanders JM, Ghosh S, Van Brussel E, Oldfield E, Docampo R. Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies. J Biol Chem. 2003 May 09; 278(19):17075-83. PMID: 12618430.
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    97. Van Brussel EM, Gossman WL, Wilson SR, Oldfield E. Hydronium (cycloheptylammonio)methylene-1,1-bisphosphonate (hydronium incadronate). Acta Crystallogr C. 2003 Feb; 59(Pt 2):o93-4. PMID: 12574666.
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    98. Gossman WL, Wilson SR, Oldfield E. Three hydrates of the bisphosphonate risedronate, consisting of one molecular and two ionic structures. Acta Crystallogr C. 2003 Feb; 59(Pt 2):m33-6. PMID: 12574640.
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    99. Gossman WL, Wilson SR, Oldfield E. Monosodium [1-hydroxy-2-(1H-imidazol-3-ium-4-yl)ethane-1,1-diyl]bis(phosphonate) tetrahydrate (monosodium isozoledronate). Acta Crystallogr C. 2002 Dec; 58(Pt 12):m599-600. PMID: 12466610.
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    100. Zhang Y, Mao J, Godbout N, Oldfield E. Mössbauer quadrupole splittings and electronic structure in heme proteins and model systems: a density functional theory investigation. J Am Chem Soc. 2002 Nov 20; 124(46):13921-30. PMID: 12431124.
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    101. Mao J, Zhang Y, Oldfield E. Nuclear magnetic resonance shifts in paramagnetic metalloporphyrins and metalloproteins. J Am Chem Soc. 2002 Nov 20; 124(46):13911-20. PMID: 12431123.
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    102. Gossman W, Oldfield E. Quantitative structure--activity relations for gammadelta T cell activation by phosphoantigens. J Med Chem. 2002 Oct 24; 45(22):4868-74. PMID: 12383012.
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    103. Moreno B, Rodrigues CO, Bailey BN, Urbina JA, Moreno SN, Docampo R, Oldfield E. Magic-angle spinning (31)P NMR spectroscopy of condensed phosphates in parasitic protozoa: visualizing the invisible. FEBS Lett. 2002 Jul 17; 523(1-3):207-12. PMID: 12123833.
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    104. Martin MB, Sanders JM, Kendrick H, de Luca-Fradley K, Lewis JC, Grimley JS, Van Brussel EM, Olsen JR, Meints GA, Burzynska A, Kafarski P, Croft SL, Oldfield E. Activity of bisphosphonates against Trypanosoma brucei rhodesiense. J Med Chem. 2002 Jul 04; 45(14):2904-14. PMID: 12086478.
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    105. Szabo CM, Martin MB, Oldfield E. An investigation of bone resorption and Dictyostelium discoideum growth inhibition by bisphosphonate drugs. J Med Chem. 2002 Jul 04; 45(14):2894-903. PMID: 12086477.
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    106. Zhang Y, Mao J, Oldfield E. (57)Fe Mössbauer isomer shifts of heme protein model systems: electronic structure calculations. J Am Chem Soc. 2002 Jul 03; 124(26):7829-39. PMID: 12083937.
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    107. Rodriguez N, Bailey BN, Martin MB, Oldfield E, Urbina JA, Docampo R. Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate. J Infect Dis. 2002 Jul 01; 186(1):138-40. PMID: 12089677.
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    108. Szabo CM, Matsumura Y, Fukura S, Martin MB, Sanders JM, Sengupta S, Cieslak JA, Loftus TC, Lea CR, Lee HJ, Koohang A, Coates RM, Sagami H, Oldfield E. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem. 2002 May 23; 45(11):2185-96. PMID: 12014956.
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    109. Sun H, Sanders LK, Oldfield E. Carbon-13 NMR shielding in the twenty common amino acids: comparisons with experimental results in proteins. J Am Chem Soc. 2002 May 15; 124(19):5486-95. PMID: 11996591.
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    110. Yardley V, Khan AA, Martin MB, Slifer TR, Araujo FG, Moreno SN, Docampo R, Croft SL, Oldfield E. In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii. Antimicrob Agents Chemother. 2002 Mar; 46(3):929-31. PMID: 11850291; PMCID: PMC127510.
    111. Tong Y, Kim HS, Babu PK, Waszczuk P, Wieckowski A, Oldfield E. An NMR investigation of CO tolerance in a Pt/Ru fuel cell catalyst. J Am Chem Soc. 2002 Jan 23; 124(3):468-73. PMID: 11792218.
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    112. Oldfield E. Chemical shifts in amino acids, peptides, and proteins: from quantum chemistry to drug design. Annu Rev Phys Chem. 2002; 53:349-78. PMID: 11972012.
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    113. Montalvetti A, Bailey BN, Martin MB, Severin GW, Oldfield E, Docampo R. Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. J Biol Chem. 2001 Sep 07; 276(36):33930-7. PMID: 11435429.
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    114. Martin MB, Grimley JS, Lewis JC, Heath HT, Bailey BN, Kendrick H, Yardley V, Caldera A, Lira R, Urbina JA, Moreno SN, Docampo R, Croft SL, Oldfield E. Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy. J Med Chem. 2001 Mar 15; 44(6):909-16. PMID: 11300872.
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    115. Bowler WA, Weiss PJ, Hill HE, Hoffmeister KA, Fleck RP, Blacky AR, Oldfield EC. Risk of ventricular dysrhythmias during 1-hour infusions of amphotericin B in patients with preserved renal function. Antimicrob Agents Chemother. 1992 Nov; 36(11):2542-3. PMID: 1489202; PMCID: PMC284371.
    116. Oldfield EC, Garst PD, Hostettler C, White M, Samuelson D. Randomized, double-blind trial of 1- versus 4-hour amphotericin B infusion durations. Antimicrob Agents Chemother. 1990 Jul; 34(7):1402-6. PMID: 2201256; PMCID: PMC175990.
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