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Dr Michelle Wykes

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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Panikkar A, Smith C, Hislop A, Tellam N, Dasari V, Hogquist KA, Wykes M, Moss DJ, Rickinson A, Balfour HH, Khanna R. Impaired Epstein-Barr Virus-Specific Neutralizing Antibody Response during Acute Infectious Mononucleosis Is Coincident with Global B-Cell Dysfunction. J Virol. 2015 Sep; 89(17):9137-41. PMID: 26109734.
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    2. Panikkar A, Smith C, Hislop A, Tellam N, Dasari V, Hogquist KA, Wykes M, Moss DJ, Rickinson A, Balfour HH, Khanna R. Cytokine-Mediated Loss of Blood Dendritic Cells During Epstein-Barr Virus-Associated Acute Infectious Mononucleosis: Implication for Immune Dysregulation. J Infect Dis. 2015 Dec 15; 212(12):1957-61. PMID: 26080368.
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    3. Wykes MN, Horne-Debets JM, Leow CY, Karunarathne DS. Malaria drives T cells to exhaustion. Front Microbiol. 2014; 5:249. PMID: 24904561.
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    4. Horne-Debets JM, Faleiro R, Karunarathne DS, Liu XQ, Lineburg KE, Poh CM, Grotenbreg GM, Hill GR, MacDonald KP, Good MF, Renia L, Ahmed R, Sharpe AH, Wykes MN. PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria. Cell Rep. 2013 Dec 12; 5(5):1204-13. PMID: 24316071.
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    5. Wykes MN. Why haven't we made an efficacious vaccine for malaria? EMBO Rep. 2013 Aug; 14(8):661. PMID: 23846309.
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    6. Pandey M, Wykes MN, Hartas J, Good MF, Batzloff MR. Long-term antibody memory induced by synthetic peptide vaccination is protective against Streptococcus pyogenes infection and is independent of memory T cell help. J Immunol. 2013 Mar 15; 190(6):2692-701. PMID: 23401589.
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    7. Liu XQ, Stacey KJ, Horne-Debets JM, Cridland JA, Fischer K, Narum D, Mackay F, Pierce SK, Wykes MN. Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival. Eur J Immunol. 2012 Dec; 42(12):3291-301. PMID: 22936176.
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    8. Cridland JA, Curley EZ, Wykes MN, Schroder K, Sweet MJ, Roberts TL, Ragan MA, Kassahn KS, Stacey KJ. The mammalian PYHIN gene family: phylogeny, evolution and expression. BMC Evol Biol. 2012 Aug 07; 12:140. PMID: 22871040.
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    9. Wykes MN, Horne-Debets J. Dendritic cells: the Trojan horse of malaria? Int J Parasitol. 2012 May 15; 42(6):583-7. PMID: 22726753.
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    10. Wykes MN. Are plasmacytoid dendritic cells the misguided sentinels of malarial immunity? Trends Parasitol. 2012 May; 28(5):182-6. PMID: 22365902.
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    11. Wykes MN, Kay JG, Manderson A, Liu XQ, Brown DL, Richard DJ, Wipasa J, Jiang SH, Jones MK, Janse CJ, Waters AP, Pierce SK, Miller LH, Stow JL, Good MF. Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice. Proc Natl Acad Sci U S A. 2011 Jul 05; 108(27):11205-10. PMID: 21690346.
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    12. Wykes MN, Good MF. What have we learnt from mouse models for the study of malaria? Eur J Immunol. 2009 Aug; 39(8):2004-7. PMID: 19672886.
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    13. Phillipps KS, Wykes MN, Liu XQ, Brown M, Blanchfield J, Toth I. A novel synthetic adjuvant enhances dendritic cell function. Immunology. 2009 Sep; 128(1 Suppl):e582-8. PMID: 19740319.
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    14. Liu XQ, Hart DN, MacPherson GG, Good MF, Wykes MN. Soluble CD38 significantly prolongs the lifespan of memory B-cell responses. Immunology. 2008 Sep; 125(1):14-20. PMID: 18798916.
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    15. Wykes MN, Good MF. What really happens to dendritic cells during malaria? Nat Rev Microbiol. 2008 Nov; 6(11):864-70. PMID: 18711429.
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    16. Wykes MN, Liu XQ, Jiang S, Hirunpetcharat C, Good MF. Systemic tumor necrosis factor generated during lethal Plasmodium infections impairs dendritic cell function. J Immunol. 2007 Sep 15; 179(6):3982-7. PMID: 17785836.
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    17. Wykes MN, Liu XQ, Beattie L, Stanisic DI, Stacey KJ, Smyth MJ, Thomas R, Good MF. Plasmodium strain determines dendritic cell function essential for survival from malaria. PLoS Pathog. 2007 Jul; 3(7):e96. PMID: 17616976.
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    18. Wykes M, Good MF. A case for whole-parasite malaria vaccines. Int J Parasitol. 2007 Jun; 37(7):705-12. PMID: 17408673.
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    19. Wykes M, Keighley C, Pinzon-Charry A, Good MF. Dendritic cell biology during malaria. Cell Microbiol. 2007 Feb; 9(2):300-5. PMID: 17217425.
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    20. Beattie L, Engwerda CR, Wykes M, Good MF. CD8+ T lymphocyte-mediated loss of marginal metallophilic macrophages following infection with Plasmodium chabaudi chabaudi AS. J Immunol. 2006 Aug 15; 177(4):2518-26. PMID: 16888013.
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    21. Wykes M, Good MF. Memory B cell responses and malaria. Parasite Immunol. 2006 Jan-Feb; 28(1-2):31-4. PMID: 16438674.
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    22. Wykes MN, Zhou YH, Liu XQ, Good MF. Plasmodium yoelii can ablate vaccine-induced long-term protection in mice. J Immunol. 2005 Aug 15; 175(4):2510-6. PMID: 16081823.
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    23. Good MF, Xu H, Wykes M, Engwerda CR. Development and regulation of cell-mediated immune responses to the blood stages of malaria: implications for vaccine research. Annu Rev Immunol. 2005; 23:69-99. PMID: 15771566.
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    24. Wykes MN, Beattie L, Macpherson GG, Hart DN. Dendritic cells and follicular dendritic cells express a novel ligand for CD38 which influences their maturation and antibody responses. Immunology. 2004 Nov; 113(3):318-27. PMID: 15500618.
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    25. Good MF, Stanisic D, Xu H, Elliott S, Wykes M. The immunological challenge to developing a vaccine to the blood stages of malaria parasites. Immunol Rev. 2004 Oct; 201:254-67. PMID: 15361246.
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    26. Wykes M. Why do B cells produce CD40 ligand? Immunol Cell Biol. 2003 Aug; 81(4):328-31. PMID: 12848855.
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    27. Wykes M, MacDonald KP, Tran M, Quin RJ, Xing PX, Gendler SJ, Hart DN, McGuckin MA. MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells. J Leukoc Biol. 2002 Oct; 72(4):692-701. PMID: 12377938.
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    28. Tone M, Tone Y, Fairchild PJ, Wykes M, Waldmann H. Regulation of CD40 function by its isoforms generated through alternative splicing. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1751-6. PMID: 11172023.
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    29. Macpherson G, Wykes M, Huang FP, Jenkins C. Isolation of dendritic cells from rat intestinal lymph and spleen. Methods Mol Med. 2001; 64:29-41. PMID: 21374247.
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    30. Wykes M, MacPherson G. Dendritic cell-B-cell interaction: dendritic cells provide B cells with CD40-independent proliferation signals and CD40-dependent survival signals. Immunology. 2000 May; 100(1):1-3. PMID: 10809952.
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    31. Huang FP, Platt N, Wykes M, Major JR, Powell TJ, Jenkins CD, MacPherson GG. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J Exp Med. 2000 Feb 07; 191(3):435-44. PMID: 10662789.
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    32. MacPherson G, Kushnir N, Wykes M. Dendritic cells, B cells and the regulation of antibody synthesis. Immunol Rev. 1999 Dec; 172:325-34. PMID: 10631957.
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    33. Wykes M, Pombo A, Jenkins C, MacPherson GG. Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response. J Immunol. 1998 Aug 01; 161(3):1313-9. PMID: 9686593.
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    34. Wykes M, Poudrier J, Lindstedt R, Gray D. Regulation of cytoplasmic, surface and soluble forms of CD40 ligand in mouse B cells. Eur J Immunol. 1998 Feb; 28(2):548-59. PMID: 9521065.
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    35. Gray D, Bergthorsdottir S, van Essen D, Wykes M, Poudrier J, Siepmann K. Observations on memory B-cell development. Semin Immunol. 1997 Aug; 9(4):249-54. PMID: 9237931.
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    36. Gray D, Siepmann K, van Essen D, Poudrier J, Wykes M, Jainandunsing S, Bergthorsdottir S, Dullforce P. B-T lymphocyte interactions in the generation and survival of memory cells. Immunol Rev. 1996 Apr; 150:45-61. PMID: 8782701.
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    37. Wykes MN, Shellam GR, McCluskey J, Kast WM, Dallas PB, Price P. Murine cytomegalovirus interacts with major histocompatibility complex class I molecules to establish cellular infection. J Virol. 1993 Jul; 67(7):4182-9. PMID: 8389923.
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