Loading...
Header Logo
Keywords
Last Name
Institution

Dr Karl Werbovetz

Title[no position]
Institution[no institution name]
Address[no address]
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Zhu X, Van Horn KS, Barber MM, Yang S, Wang MZ, Manetsch R, Werbovetz KA. SAR refinement of antileishmanial N(2),N(4)-disubstituted quinazoline-2,4-diamines. Bioorg Med Chem. 2015 Aug 15; 23(16):5182-9. PMID: 25749014; PMCID: PMC4536136.
    2. Van Horn KS, Zhu X, Pandharkar T, Yang S, Vesely B, Vanaerschot M, Dujardin JC, Rijal S, Kyle DE, Wang MZ, Werbovetz KA, Manetsch R. Antileishmanial activity of a series of N²,N4-disubstituted quinazoline-2,4-diamines. J Med Chem. 2014 Jun 26; 57(12):5141-56. PMID: 24874647; PMCID: PMC4216219.
    3. Pandharkar T, Zhu X, Mathur R, Jiang J, Schmittgen TD, Shaha C, Werbovetz KA. Studies on the antileishmanial mechanism of action of the arylimidamide DB766: azole interactions and role of CYP5122A1. Antimicrob Agents Chemother. 2014 Aug; 58(8):4682-9. PMID: 24890590; PMCID: PMC4135980.
    4. Patrick DA, Bakunov SA, Bakunova SM, Jones SK, Wenzler T, Barszcz T, Kumar A, Boykin DW, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives. Eur J Med Chem. 2013 Sep; 67:310-24. PMID: 23871911.
      View in: PubMed
    5. Patrick DA, Ismail MA, Arafa RK, Wenzler T, Zhu X, Pandharkar T, Jones SK, Werbovetz KA, Brun R, Boykin DW, Tidwell RR. Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives. J Med Chem. 2013 Jul 11; 56(13):5473-94. PMID: 23795673.
      View in: PubMed
    6. Soeiro MN, Werbovetz K, Boykin DW, Wilson WD, Wang MZ, Hemphill A. Novel amidines and analogues as promising agents against intracellular parasites: a systematic review. Parasitology. 2013 Jul; 140(8):929-51. PMID: 23561006; PMCID: PMC3815587.
    7. Yi B, Long S, González-Cestari TF, Henderson BJ, Pavlovicz RE, Werbovetz K, Li C, McKay DB. Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: pharmacophore modeling and structure-activity relationship studies. Bioorg Med Chem. 2013 Aug 01; 21(15):4730-43. PMID: 23757208; PMCID: PMC4347880.
    8. Endeshaw M, Zhu X, He S, Pandharkar T, Cason E, Mahasenan KV, Agarwal H, Li C, Munde M, Wilson WD, Bahar M, Doskotch RW, Kinghorn AD, Kaiser M, Brun R, Drew ME, Werbovetz KA. 8,8-dialkyldihydroberberines with potent antiprotozoal activity. J Nat Prod. 2013 Mar 22; 76(3):311-5. PMID: 23167812.
      View in: PubMed
    9. Banerjee M, Farahat AA, Kumar A, Wenzler T, Brun R, Munde MM, Wilson WD, Zhu X, Werbovetz KA, Boykin DW. Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides. Eur J Med Chem. 2012 Sep; 55:449-54. PMID: 22840696; PMCID: PMC3560421.
    10. Reid CS, Farahat AA, Zhu X, Pandharkar T, Boykin DW, Werbovetz KA. Antileishmanial bis-arylimidamides: DB766 analogs modified in the linker region and bis-arylimidamide structure-activity relationships. Bioorg Med Chem Lett. 2012 Nov 15; 22(22):6806-10. PMID: 22765899.
      View in: PubMed
    11. Zhu X, Liu Q, Yang S, Parman T, Green CE, Mirsalis JC, de Nazaré Correia Soeiro M, Mello de Souza E, da Silva CF, da Gama Jaen Batista D, Stephens CE, Banerjee M, Farahat AA, Munde M, Wilson WD, Boykin DW, Wang MZ, Werbovetz KA. Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies. Antimicrob Agents Chemother. 2012 Jul; 56(7):3690-9. PMID: 22508306; PMCID: PMC3393454.
    12. He S, Dayton A, Kuppusamy P, Werbovetz KA, Drew ME. Induction of oxidative stress in Trypanosoma brucei by the antitrypanosomal dihydroquinoline OSU-40. Antimicrob Agents Chemother. 2012 May; 56(5):2428-34. PMID: 22314522; PMCID: PMC3346584.
    13. Zhu X, Pandharkar T, Werbovetz K. Identification of new antileishmanial leads from hits obtained by high-throughput screening. Antimicrob Agents Chemother. 2012 Mar; 56(3):1182-9. PMID: 22143523; PMCID: PMC3294885.
    14. Collar CJ, Zhu X, Werbovetz K, Boykin DW, Wilson WD. Molecular factors governing inhibition of arylimidamides against Leishmania: conservative computational modeling to improve chemotherapies. Bioorg Med Chem. 2011 Aug 01; 19(15):4552-61. PMID: 21741248; PMCID: PMC3164838.
    15. Turabekova MA, Vinogradova VI, Werbovetz KA, Capers J, Rasulev BF, Levkovich MG, Rakhimov SB, Abdullaev ND. Structure-activity relationship investigations of leishmanicidal N-benzylcytisine derivatives. Chem Biol Drug Des. 2011 Jul; 78(1):183-9. PMID: 21457471.
      View in: PubMed
    16. Salem MM, Capers J, Rito S, Werbovetz KA. Antiparasitic activity of C-geranyl flavonoids from Mimulus bigelovii. Phytother Res. 2011 Aug; 25(8):1246-9. PMID: 21796699.
      View in: PubMed
    17. Bahar M, Deng Y, Zhu X, He S, Pandharkar T, Drew ME, Navarro-Vázquez A, Anklin C, Gil RR, Doskotch RW, Werbovetz KA, Kinghorn AD. Potent antiprotozoal activity of a novel semi-synthetic berberine derivative. Bioorg Med Chem Lett. 2011 May 01; 21(9):2606-10. PMID: 21474310.
      View in: PubMed
    18. Gershkovich P, Wasan KM, Sivak O, Lysakowski S, Reid C, Premalatha K, Werbovetz KA. Simultaneous determination of a novel antitrypanosomal compound (OSU-36) and its ester derivative (OSU-40) in plasma by HPLC: application to first pharmacokinetic study in rats. J Pharm Pharm Sci. 2011; 14(1):36-45. PMID: 21501551.
      View in: PubMed
    19. Wasan EK, Gershkovich P, Zhao J, Zhu X, Werbovetz K, Tidwell RR, Clement JG, Thornton SJ, Wasan KM. A novel tropically stable oral amphotericin B formulation (iCo-010) exhibits efficacy against visceral Leishmaniasis in a murine model. PLoS Negl Trop Dis. 2010 Dec 07; 4(12):e913. PMID: 21151883; PMCID: PMC2998436.
    20. Reid CS, Patrick DA, He S, Fotie J, Premalatha K, Tidwell RR, Wang MZ, Liu Q, Gershkovich P, Wasan KM, Wenzler T, Brun R, Werbovetz KA. Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation. Bioorg Med Chem. 2011 Jan 01; 19(1):513-23. PMID: 21112788.
      View in: PubMed
    21. Lyons-Abbott S, Sackett DL, Wloga D, Gaertig J, Morgan RE, Werbovetz KA, Morrissette NS. a-Tubulin mutations alter oryzalin affinity and microtubule assembly properties to confer dinitroaniline resistance. Eukaryot Cell. 2010 Dec; 9(12):1825-34. PMID: 20870876; PMCID: PMC3008275.
    22. Endeshaw MM, Li C, de Leon J, Yao N, Latibeaudiere K, Premalatha K, Morrissette N, Werbovetz KA. Synthesis and evaluation of oryzalin analogs against Toxoplasma gondii. Bioorg Med Chem Lett. 2010 Sep 01; 20(17):5179-83. PMID: 20675138; PMCID: PMC2922421.
    23. Richard JV, Werbovetz KA. New antileishmanial candidates and lead compounds. Curr Opin Chem Biol. 2010 Aug; 14(4):447-55. PMID: 20400358.
      View in: PubMed
    24. Wang MZ, Zhu X, Srivastava A, Liu Q, Sweat JM, Pandharkar T, Stephens CE, Riccio E, Parman T, Munde M, Mandal S, Madhubala R, Tidwell RR, Wilson WD, Boykin DW, Hall JE, Kyle DE, Werbovetz KA. Novel arylimidamides for treatment of visceral leishmaniasis. Antimicrob Agents Chemother. 2010 Jun; 54(6):2507-16. PMID: 20368397; PMCID: PMC2876428.
    25. Fotie J, Kaiser M, Delfín DA, Manley J, Reid CS, Paris JM, Wenzler T, Maes L, Mahasenan KV, Li C, Werbovetz KA. Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives. J Med Chem. 2010 Feb 11; 53(3):966-82. PMID: 20047276.
      View in: PubMed
    26. Ma C, Tran J, Gu F, Ochoa R, Li C, Sept D, Werbovetz K, Morrissette N. Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin. Antimicrob Agents Chemother. 2010 Apr; 54(4):1453-60. PMID: 20145086; PMCID: PMC2849357.
    27. Bakunov SA, Bakunova SM, Wenzler T, Ghebru M, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles. J Med Chem. 2010 Jan 14; 53(1):254-72. PMID: 19928900; PMCID: PMC3113660.
    28. Sackett DL, Werbovetz KA, Morrissette NS. Isolating tubulin from nonneural sources. Methods Cell Biol. 2010; 95:17-32. PMID: 20466127.
      View in: PubMed
    29. Gershkovich P, Wasan EK, Sivak O, Li R, Zhu X, Werbovetz KA, Tidwell RR, Clement JG, Thornton SJ, Wasan KM. Visceral leishmaniasis affects liver and spleen concentrations of amphotericin B following administration to mice. J Antimicrob Chemother. 2010 Mar; 65(3):535-7. PMID: 20026611.
      View in: PubMed
    30. Bakunov SA, Bakunova SM, Bridges AS, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal properties of pentamidine congeners bearing the benzofuran motif. J Med Chem. 2009 Sep 24; 52(18):5763-7. PMID: 19757840.
      View in: PubMed
    31. Bakunova SM, Bakunov SA, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine. J Med Chem. 2009 Aug 13; 52(15):4657-67. PMID: 19606902.
      View in: PubMed
    32. Wasan KM, Wasan EK, Gershkovich P, Zhu X, Tidwell RR, Werbovetz KA, Clement JG, Thornton SJ. Highly effective oral amphotericin B formulation against murine visceral leishmaniasis. J Infect Dis. 2009 Aug 01; 200(3):357-60. PMID: 19545212.
      View in: PubMed
    33. Bakunova SM, Bakunov SA, Patrick DA, Kumar EV, Ohemeng KA, Bridges AS, Wenzler T, Barszcz T, Jones SK, Werbovetz KA, Brun R, Tidwell RR. Structure-activity study of pentamidine analogues as antiprotozoal agents. J Med Chem. 2009 Apr 09; 52(7):2016-35. PMID: 19267462.
      View in: PubMed
    34. Patrick DA, Bakunov SA, Bakunova SM, Kumar EV, Chen H, Jones SK, Wenzler T, Barzcz T, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes. Eur J Med Chem. 2009 Sep; 44(9):3543-51. PMID: 19409677.
      View in: PubMed
    35. Morgan RE, Ahn S, Nzimiro S, Fotie J, Phelps MA, Cotrill J, Yakovich AJ, Sackett DL, Dalton JT, Werbovetz KA. Inhibitors of tubulin assembly identified through screening a compound library. Chem Biol Drug Des. 2008 Dec; 72(6):513-24. PMID: 19090918; PMCID: PMC3677961.
    36. Joshi MS, Bauer JA, Werbovetz KA, Barszcz T, Patil PN. Pharmacological and biological screening of ascorbigen: protection against glucose-induced endothelial cell toxicity. Phytother Res. 2008 Dec; 22(12):1581-6. PMID: 18844288.
      View in: PubMed
    37. Delfín DA, Morgan RE, Zhu X, Werbovetz KA. Redox-active dinitrodiphenylthioethers against Leishmania: synthesis, structure-activity relationships and mechanism of action studies. Bioorg Med Chem. 2009 Jan 15; 17(2):820-9. PMID: 19058972.
      View in: PubMed
    38. Bakunov SA, Bakunova SM, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans. J Med Chem. 2008 Nov 13; 51(21):6927-44. PMID: 18841956.
      View in: PubMed
    39. Rosypal AC, Werbovetz KA, Salem M, Stephens CE, Kumar A, Boykin DW, Hall JE, Tidwell RR. Inhibition by Dications of in vitro growth of Leishmania major and Leishmania tropica: causative agents of old world cutaneous leishmaniasis. J Parasitol. 2008 Jun; 94(3):743-9. PMID: 18605790.
      View in: PubMed
    40. Morgan RE, Werbovetz KA. Selective lead compounds against kinetoplastid tubulin. Adv Exp Med Biol. 2008; 625:33-47. PMID: 18365657.
      View in: PubMed
    41. Hu L, Arafa RK, Ismail MA, Wenzler T, Brun R, Munde M, Wilson WD, Nzimiro S, Samyesudhas S, Werbovetz KA, Boykin DW. Azaterphenyl diamidines as antileishmanial agents. Bioorg Med Chem Lett. 2008 Jan 01; 18(1):247-51. PMID: 18006310.
      View in: PubMed
    42. Bakunova SM, Bakunov SA, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Hall JE, Tidwell RR. Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations. J Med Chem. 2007 Nov 15; 50(23):5807-23. PMID: 17948982.
      View in: PubMed
    43. George TG, Endeshaw MM, Morgan RE, Mahasenan KV, Delfín DA, Mukherjee MS, Yakovich AJ, Fotie J, Li C, Werbovetz KA. Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents. Bioorg Med Chem. 2007 Sep 15; 15(18):6071-9. PMID: 17618122; PMCID: PMC1994923.
    44. Gutteridge CE, Vo JV, Tillett CB, Vigilante JA, Dettmer JR, Patterson SL, Werbovetz KA, Capers J, Nichols DA, Bhattacharjee AK, Gerena L. Antileishmanial and antimalarial chalcones: synthesis, efficacy and cytotoxicity of pyridinyl and naphthalenyl analogs. Med Chem. 2007 Mar; 3(2):115-9. PMID: 17348849.
      View in: PubMed
    45. Gonzalez JL, Stephens CE, Wenzler T, Brun R, Tanious FA, Wilson WD, Barszcz T, Werbovetz KA, Boykin DW. Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes. Eur J Med Chem. 2007 Apr; 42(4):552-7. PMID: 17178177.
      View in: PubMed
    46. Delfín DA, Bhattacharjee AK, Yakovich AJ, Werbovetz KA. Activity of and initial mechanistic studies on a novel antileishmanial agent identified through in silico pharmacophore development and database searching. J Med Chem. 2006 Jul 13; 49(14):4196-207. PMID: 16821779.
      View in: PubMed
    47. Yakovich AJ, Ragone FL, Alfonzo JD, Sackett DL, Werbovetz KA. Leishmania tarentolae: purification and characterization of tubulin and its suitability for antileishmanial drug screening. Exp Parasitol. 2006 Dec; 114(4):289-96. PMID: 16753146; PMCID: PMC1986769.
    48. George TG, Johnsamuel J, Delfín DA, Yakovich A, Mukherjee M, Phelps MA, Dalton JT, Sackett DL, Kaiser M, Brun R, Werbovetz KA. Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides. Bioorg Med Chem. 2006 Aug 15; 14(16):5699-710. PMID: 16675220.
      View in: PubMed
    49. Das U, Gul HI, Alcorn J, Shrivastav A, George T, Sharma RK, Nienaber KH, De Clercq E, Balzarini J, Kawase M, Kan N, Tanaka T, Tani S, Werbovetz KA, Yakovich AJ, Manavathu EK, Stables JP, Dimmock JR. Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds. Eur J Med Chem. 2006 May; 41(5):577-85. PMID: 16581158.
      View in: PubMed
    50. Wu D, George TG, Hurh E, Werbovetz KA, Dalton JT. Pre-systemic metabolism prevents in vivo antikinetoplastid activity of N1,N4-substituted 3,5-dinitro sulfanilamide, GB-II-150. Life Sci. 2006 Aug 08; 79(11):1081-93. PMID: 16643960.
      View in: PubMed
    51. Li PK, Pandit B, Sackett DL, Hu Z, Zink J, Zhi J, Freeman D, Robey RW, Werbovetz K, Lewis A, Li C. A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities. Mol Cancer Ther. 2006 Feb; 5(2):450-6. PMID: 16505120.
      View in: PubMed
    52. Werbovetz K. Diamidines as antitrypanosomal, antileishmanial and antimalarial agents. Curr Opin Investig Drugs. 2006 Feb; 7(2):147-57. PMID: 16499285.
      View in: PubMed
    53. Salem MM, Werbovetz KA. Natural products from plants as drug candidates and lead compounds against leishmaniasis and trypanosomiasis. Curr Med Chem. 2006; 13(21):2571-98. PMID: 17017912.
      View in: PubMed
    54. Salem MM, Werbovetz KA. Isoflavonoids and other compounds from Psorothamnus arborescens with antiprotozoal activities. J Nat Prod. 2006 Jan; 69(1):43-9. PMID: 16441066.
      View in: PubMed
    55. Li PK, Xiao Z, Hu Z, Pandit B, Sun Y, Sackett DL, Werbovetz K, Lewis A, Johnsamuel J. Conformationally restricted analogs of Combretastatin A-4 derived from SU5416. Bioorg Med Chem Lett. 2005 Dec 15; 15(24):5382-5. PMID: 16213720.
      View in: PubMed
    56. Salem MM, Werbovetz KA. Antiprotozoal compounds from Psorothamnus polydenius. J Nat Prod. 2005 Jan; 68(1):108-11. PMID: 15679330.
      View in: PubMed
    57. Cottrell DM, Capers J, Salem MM, DeLuca-Fradley K, Croft SL, Werbovetz KA. Antikinetoplastid activity of 3-aryl-5-thiocyanatomethyl-1,2,4-oxadiazoles. Bioorg Med Chem. 2004 Jun 01; 12(11):2815-24. PMID: 15142541.
      View in: PubMed
    58. Jiang DW, Werbovetz KA, Varadhachary A, Cole RN, Englund PT. Purification and identification of a fatty acyl-CoA synthetase from Trypanosoma brucei. Mol Biochem Parasitol. 2004 May; 135(1):149-52. PMID: 15287596.
      View in: PubMed
    59. Bhattacharya G, Herman J, Delfín D, Salem MM, Barszcz T, Mollet M, Riccio G, Brun R, Werbovetz KA. Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania. J Med Chem. 2004 Mar 25; 47(7):1823-32. PMID: 15027874.
      View in: PubMed
    60. Werbovetz KA, Sackett DL, Delfín D, Bhattacharya G, Salem M, Obrzut T, Rattendi D, Bacchi C. Selective antimicrotubule activity of N1-phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (GB-II-5) against kinetoplastid parasites. Mol Pharmacol. 2003 Dec; 64(6):1325-33. PMID: 14645662.
      View in: PubMed
    61. Hua DH, Tamura M, Egi M, Werbovetz K, Delfín D, Salem M, Chiang PK. Antiprotozoal activities of symmetrical bishydroxamic acids. Bioorg Med Chem. 2003 Oct 01; 11(20):4357-61. PMID: 13129572.
      View in: PubMed
    62. Stephens CE, Brun R, Salem MM, Werbovetz KA, Tanious F, Wilson WD, Boykin DW. The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani. Bioorg Med Chem Lett. 2003 Jun 16; 13(12):2065-9. PMID: 12781196.
      View in: PubMed
    63. Werbovetz KA. Tubulin as an antiprotozoal drug target. Mini Rev Med Chem. 2002 Dec; 2(6):519-29. PMID: 12370037.
      View in: PubMed
    64. Bhattacharya G, Salem MM, Werbovetz KA. Antileishmanial dinitroaniline sulfonamides with activity against parasite tubulin. Bioorg Med Chem Lett. 2002 Sep 02; 12(17):2395-8. PMID: 12161141.
      View in: PubMed
    65. Werbovetz KA. Promising therapeutic targets for antileishmanial drugs. Expert Opin Ther Targets. 2002 Aug; 6(4):407-22. PMID: 12223057.
      View in: PubMed
    66. Bhattacharjee AK, Skanchy DJ, Jennings B, Hudson TH, Brendle JJ, Werbovetz KA. Analysis of stereoelectronic properties, mechanism of action and pharmacophore of synthetic indolo[2,1-b]quinazoline-6,12-dione derivatives in relation to antileishmanial activity using quantum chemical, cyclic voltammetry and 3-D-QSAR CATALYST procedures. Bioorg Med Chem. 2002 Jun; 10(6):1979-89. PMID: 11937358.
      View in: PubMed
    67. Brendle JJ, Outlaw A, Kumar A, Boykin DW, Patrick DA, Tidwell RR, Werbovetz KA. Antileishmanial activities of several classes of aromatic dications. Antimicrob Agents Chemother. 2002 Mar; 46(3):797-807. PMID: 11850264; PMCID: PMC127500.
    68. Havens CG, Bryant N, Asher L, Lamoreaux L, Perfetto S, Brendle JJ, Werbovetz KA. Cellular effects of leishmanial tubulin inhibitors on L. donovani. Mol Biochem Parasitol. 2000 Oct; 110(2):223-36. PMID: 11071278.
      View in: PubMed
    69. Werbovetz KA. Target-based drug discovery for malaria, leishmaniasis, and trypanosomiasis. Curr Med Chem. 2000 Aug; 7(8):835-60. PMID: 10828290.
      View in: PubMed
    70. Werbovetz KA, Bhattacharjee AK, Brendle JJ, Scovill JP. Analysis of stereoelectronic properties of camptothecin analogues in relation to biological activity. Bioorg Med Chem. 2000 Jul; 8(7):1741-7. PMID: 10976522.
      View in: PubMed
    71. Werbovetz KA, Brendle JJ, Sackett DL. Purification, characterization, and drug susceptibility of tubulin from Leishmania. Mol Biochem Parasitol. 1999 Jan 05; 98(1):53-65. PMID: 10029309.
      View in: PubMed
    72. Pitzer KK, Werbovetz KA, Brendle JJ, Scovill JP. Synthesis and biological evaluation of 4-chloro-3, 5-dinitrobenzotrifluoride analogues as antileishmanial agents. J Med Chem. 1998 Nov 19; 41(24):4885-9. PMID: 9822557.
      View in: PubMed
    73. Madalengoitia JS, Tepe JJ, Werbovetz KA, Lehnert EK, Macdonald TL. Structure-activity relationship for DNA topoisomerase II-induced DNA cleavage by azatoxin analogues. Bioorg Med Chem. 1997 Sep; 5(9):1807-15. PMID: 9354236.
      View in: PubMed
    74. Werbovetz KA, Englund PT. Glycosyl phosphatidylinositol myristoylation in African trypanosomes. Mol Biochem Parasitol. 1997 Mar; 85(1):1-7. PMID: 9108544.
      View in: PubMed
    75. Werbovetz KA, Bacchi CJ, Englund PT. Trypanocidal analogs of myristate and myristoyllysophosphatidylcholine. Mol Biochem Parasitol. 1996 Oct 18; 81(1):115-8. PMID: 8892311.
      View in: PubMed
    76. Werbovetz KA, Englund PT. Lipid metabolism in Trypanosoma brucei: utilization of myristate and myristoyllysophosphatidylcholine for myristoylation of glycosyl phosphatidylinositols. Biochem J. 1996 Sep 01; 318 ( Pt 2):575-81. PMID: 8809049; PMCID: PMC1217659.
    77. Buxbaum LU, Milne KG, Werbovetz KA, Englund PT. Myristate exchange on the Trypanosoma brucei variant surface glycoprotein. Proc Natl Acad Sci U S A. 1996 Feb 06; 93(3):1178-83. PMID: 8577736; PMCID: PMC40052.
    78. Doering TL, Lu T, Werbovetz KA, Gokel GW, Hart GW, Gordon JI, Englund PT. Toxicity of myristic acid analogs toward African trypanosomes. Proc Natl Acad Sci U S A. 1994 Oct 11; 91(21):9735-9. PMID: 7937882; PMCID: PMC44891.
    79. Werbovetz KA, Spoors PG, Pearson RD, Macdonald TL. Cleavable complex formation in Leishmania chagasi treated with anilinoacridines. Mol Biochem Parasitol. 1994 May; 65(1):1-10. PMID: 7935616.
      View in: PubMed
    80. Werbovetz KA, Lehnert EK, Macdonald TL, Pearson RD. Cytotoxicity of acridine compounds for Leishmania promastigotes in vitro. Antimicrob Agents Chemother. 1992 Feb; 36(2):495-7. PMID: 1318684; PMCID: PMC188468.
    Werbovetz's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description