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Dr Maria Isabel Nogueira Cano

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Moretti NS, da Silva Augusto L, Clemente TM, Antunes RP, Yoshida N, Torrecilhas AC, Cano MI, Schenkman S. Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease. Antimicrob Agents Chemother. 2015 Aug; 59(8):4669-79. PMID: 26014945.
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    2. Pariona-Llanos R, Pavani RS, Reis M, Noël V, Silber AM, Armelin HA, Cano MI, Elias MC. Glyceraldehyde 3-phosphate dehydrogenase-telomere association correlates with redox status in Trypanosoma cruzi. PLoS One. 2015; 10(3):e0120896. PMID: 25775131.
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    3. Pavani RS, Fernandes C, Perez AM, Vasconcelos EJ, Siqueira-Neto JL, Fontes MR, Cano MI. RPA-1 from Leishmania amazonensis (LaRPA-1) structurally differs from other eukaryote RPA-1 and interacts with telomeric DNA via its N-terminal OB-fold domain. FEBS Lett. 2014 Dec 20; 588(24):4740-8. PMID: 25451229.
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    4. Vasconcelos EJ, Nunes VS, da Silva MS, Segatto M, Myler PJ, Cano MI. The putative Leishmania telomerase RNA (LeishTER) undergoes trans-splicing and contains a conserved template sequence. PLoS One. 2014; 9(11):e112061. PMID: 25391020.
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    5. Giardini MA, Segatto M, da Silva MS, Nunes VS, Cano MI. Telomere and telomerase biology. Prog Mol Biol Transl Sci. 2014; 125:1-40. PMID: 24993696.
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    6. da Silva MS, Monteiro JP, Nunes VS, Vasconcelos EJ, Perez AM, Freitas-Júnior Lde H, Elias MC, Cano MI. Leishmania amazonensis promastigotes present two distinct modes of nucleus and kinetoplast segregation during cell cycle. PLoS One. 2013; 8(11):e81397. PMID: 24278433.
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    7. Lima FM, Souza RT, Santori FR, Santos MF, Cortez DR, Barros RM, Cano MI, Valadares HM, Macedo AM, Mortara RA, da Silveira JF. Interclonal variations in the molecular karyotype of Trypanosoma cruzi: chromosome rearrangements in a single cell-derived clone of the G strain. PLoS One. 2013; 8(5):e63738. PMID: 23667668.
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    8. Da Silveira Rde C, Da Silva MS, Nunes VS, Perez AM, Cano MI. The natural absence of RPA1N domain did not impair Leishmania amazonensis RPA-1 participation in DNA damage response and telomere protection. Parasitology. 2013 Apr; 140(4):547-59. PMID: 23388105.
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    9. Fessel MR, Lira CB, Giorgio S, Ramos CH, Cano MI. Sir2-Related Protein 1 from Leishmania amazonensis is a glycosylated NAD+-dependent deacetylase. Parasitology. 2011 Sep; 138(10):1245-58. PMID: 21819639.
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    10. Monteiro JP, Cano MI. SIRT1 deacetylase activity and the maintenance of protein homeostasis in response to stress: an overview. Protein Pept Lett. 2011 Feb; 18(2):167-73. PMID: 21121893.
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    11. Giardini MA, Fernández MF, Lira CB, Cano MI. Leishmania amazonensis: partial purification and study of the biochemical properties of the telomerase reverse transcriptase activity from promastigote-stage. Exp Parasitol. 2011 Jan; 127(1):243-8. PMID: 20692257.
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    12. da Silva MS, Perez AM, da Silveira Rde C, de Moraes CE, Siqueira-Neto JL, Freitas Lde H, Cano MI. The Leishmania amazonensis TRF (TTAGGG repeat-binding factor) homologue binds and co-localizes with telomeres. BMC Microbiol. 2010 May 07; 10:136. PMID: 20459667.
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    13. Lira CB, Gui KE, Perez AM, da Silveira RC, Gava LM, Ramos CH, Cano MI. DNA and heparin chaperone the refolding of purified recombinant replication protein A subunit 1 from Leishmania amazonensis. Biochim Biophys Acta. 2009 Feb; 1790(2):119-25. PMID: 19056467.
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    14. Dossin Fde M, Dufour A, Dusch E, Siqueira-Neto JL, Moraes CB, Yang GS, Cano MI, Genovesio A, Freitas-Junior LH. Automated nuclear analysis of Leishmania major telomeric clusters reveals changes in their organization during the parasite's life cycle. PLoS One. 2008 Jun 11; 3(6):e2313. PMID: 18545650.
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    15. Lira CB, de Siqueira Neto JL, Khater L, Cagliari TC, Peroni LA, dos Reis JR, Ramos CH, Cano MI. LaTBP1: a Leishmania amazonensis DNA-binding protein that associates in vivo with telomeres and GT-rich DNA using a Myb-like domain. Arch Biochem Biophys. 2007 Sep 15; 465(2):399-409. PMID: 17678615.
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    16. Lira CB, Giardini MA, Neto JL, Conte FF, Cano MI. Telomere biology of trypanosomatids: beginning to answer some questions. Trends Parasitol. 2007 Aug; 23(8):357-62. PMID: 17580124.
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    17. Lira CB, Siqueira Neto JL, Giardini MA, Winck FV, Ramos CH, Cano MI. LaRbp38: a Leishmania amazonensis protein that binds nuclear and kinetoplast DNAs. Biochem Biophys Res Commun. 2007 Jul 06; 358(3):854-60. PMID: 17506988.
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    18. Neto JL, Lira CB, Giardini MA, Khater L, Perez AM, Peroni LA, dos Reis JR, Freitas-Junior LH, Ramos CH, Cano MI. Leishmania replication protein A-1 binds in vivo single-stranded telomeric DNA. Biochem Biophys Res Commun. 2007 Jun 29; 358(2):417-23. PMID: 17498665.
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    19. Giardini MA, Lira CB, Conte FF, Camillo LR, de Siqueira Neto JL, Ramos CH, Cano MI. The putative telomerase reverse transcriptase component of Leishmania amazonensis: gene cloning and characterization. Parasitol Res. 2006 Apr; 98(5):447-54. PMID: 16416120.
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    20. Conte FF, Cano MI. Genomic organization of telomeric and subtelomeric sequences of Leishmania (Leishmania) amazonensis. Int J Parasitol. 2005 Nov; 35(13):1435-43. PMID: 16126212.
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    21. Fernández MF, Castellari RR, Conte FF, Gozzo FC, Sabino AA, Pinheiro H, Novello JC, Eberlin MN, Cano MI. Identification of three proteins that associate in vitro with the Leishmania (Leishmania) amazonensis G-rich telomeric strand. Eur J Biochem. 2004 Jul; 271(14):3050-63. PMID: 15233802.
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    22. do Carmo MS, dos Santos MR, Cano MI, Araya JE, Yoshida N, da Silveira JF. Expression and genome-wide distribution of the gene family encoding a 90 kDa surface glycoprotein of metacyclic trypomastigotes of Trypanosoma cruzi. Mol Biochem Parasitol. 2002 Nov-Dec; 125(1-2):201-6. PMID: 12467988.
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    23. Cano MI, Blake JJ, Blackburn EH, Agabian N. A Trypanosoma brucei protein complex that binds G-overhangs and co-purifies with telomerase activity. J Biol Chem. 2002 Jan 11; 277(2):896-906. PMID: 11673453.
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    24. Cano MI. Telomere biology of trypanosomatids: more questions than answers. Trends Parasitol. 2001 Sep; 17(9):425-9. PMID: 11530354.
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    25. Cano MI, Dungan JM, Agabian N, Blackburn EH. Telomerase in kinetoplastid parasitic protozoa. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3616-21. PMID: 10097086.
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    26. Carmo MS, Araya JE, Ramirez MI, Boscardin S, Cano MI, Baida RP, Ruiz RC, Santos MR, Chiurillo MA, Ramirez JL, Yoshida N, Silveira JF. Organization and expression of a multigene family encoding the surface glycoproteins of Trypanosoma cruzi metacyclic trypomastigotes involved in the cell invasion. Mem Inst Oswaldo Cruz. 1999; 94 Suppl 1:169-71. PMID: 10677708.
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    27. Cano MI, Cisalpino PS, Galindo I, Ramírez JL, Mortara RA, da Silveira JF. Electrophoretic karyotypes and genome sizing of the pathogenic fungus Paracoccidioides brasiliensis. J Clin Microbiol. 1998 Mar; 36(3):742-7. PMID: 9508305.
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    28. Araya J, Cano MI, Gomes HB, Novak EM, Requena JM, Alonso C, Levin MJ, Guevara P, Ramirez JL, Da Silveira JF. Characterization of an interspersed repetitive DNA element in the genome of Trypanosoma cruzi. Parasitology. 1997 Dec; 115 ( Pt 6):563-70. PMID: 9488867.
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    29. Santos MR, Cano MI, Schijman A, Lorenzi H, Vázquez M, Levin MJ, Ramirez JL, Brandão A, Degrave WM, da Silveira JF. The Trypanosoma cruzi genome project: nuclear karyotype and gene mapping of clone CL Brener. Mem Inst Oswaldo Cruz. 1997 Nov-Dec; 92(6):821-8. PMID: 9580491.
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    30. Zingales B, Pereira ME, Oliveira RP, Almeida KA, Umezawa ES, Souto RP, Vargas N, Cano MI, da Silveira JF, Nehme NS, Morel CM, Brener Z, Macedo A. Trypanosoma cruzi genome project: biological characteristics and molecular typing of clone CL Brener. Acta Trop. 1997 Nov; 68(2):159-73. PMID: 9386791.
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    31. Lesénéchal M, Duret L, Cano MI, Mortara RA, Jolivet M, Camargo ME, da Silveira JF, Paranhos-Baccalà G. Cloning and characterization of a gene encoding a novel immunodominant antigen of Trypanosoma cruzi. Mol Biochem Parasitol. 1997 Aug; 87(2):193-204. PMID: 9247930.
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    32. Cisalpino PS, Puccia R, Yamauchi LM, Cano MI, da Silveira JF, Travassos LR. Cloning, characterization, and epitope expression of the major diagnostic antigen of Paracoccidioides brasiliensis. J Biol Chem. 1996 Feb 23; 271(8):4553-60. PMID: 8626811.
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    33. Cano MI, Gruber A, Vazquez M, Cortés A, Levin MJ, González A, Degrave W, Rondinelli E, Zingales B, Ramirez JL, et al. Molecular karyotype of clone CL Brener chosen for the Trypanosoma cruzi genome project. Mol Biochem Parasitol. 1995 May; 71(2):273-8. PMID: 7477112.
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    34. Cotrim PC, Paranhos-Baccala G, Santos MR, Mortensen C, Cano MI, Jolivet M, Camargo ME, Mortara RA, Da Silveira JF. Organization and expression of the gene encoding an immunodominant repetitive antigen associated to the cytoskeleton of Trypanosoma cruzi. Mol Biochem Parasitol. 1995 Apr; 71(1):89-98. PMID: 7630386.
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    35. Araya JE, Cano MI, Yoshida N, da Silveira JF. Cloning and characterization of a gene for the stage-specific 82-kDa surface antigen of metacyclic trypomastigotes of Trypanosoma cruzi. Mol Biochem Parasitol. 1994 May; 65(1):161-9. PMID: 7935622.
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    36. Lirio Vde S, de Assis CM, Cano MI, Lacaz Cda S. [The isolation and evaluation of Aspergillus fumigatus antigens]. Rev Inst Med Trop Sao Paulo. 1992 Jul-Aug; 34(4):359-65. PMID: 1342095.
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    37. Del Negro GM, Garcia NM, Rodrigues EG, Cano MI, de Aguiar MS, Lírio Vde S, Lacaz Cda S. The sensitivity, specificity and efficiency values of some serological tests used in the diagnosis of paracoccidioidomycosis. Rev Inst Med Trop Sao Paulo. 1991 Jul-Aug; 33(4):277-80. PMID: 1844949.
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    38. Cano MI, de Aguiar MS. [Utilization of aminoacids in the study of the growth of Paracoccidioides brasiliensis. Influence on dimorphism]. Rev Inst Med Trop Sao Paulo. 1991 Jul-Aug; 33(4):319-24. PMID: 1844955.
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    39. Cano MI, Livramento JA. Coagglutination test (COA) for Cryptococcus neoformans circulating antigen detection in cerebral spinal fluid (CSF). Rev Inst Med Trop Sao Paulo. 1990 Nov-Dec; 32(6):456-60. PMID: 2135493.
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