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Professor Pedro Alzari

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. East A, Mechaly AE, Huysmans GHM, Bernarde C, Tello-Manigne D, Nadeau N, Pugsley AP, Buschiazzo A, Alzari PM, Bond PJ, Francetic O. Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis. Structure. 2016 Jan 05; 24(1):92-104. PMID: 26688215.
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    2. Mori G, Chiarelli LR, Esposito M, Makarov V, Bellinzoni M, Hartkoorn RC, Degiacomi G, Boldrin F, Ekins S, de Jesus Lopes Ribeiro AL, Marino LB, Centárová I, Svetlíková Z, Blaško J, Kazakova E, Lepioshkin A, Barilone N, Zanoni G, Porta A, Fondi M, Fani R, Baulard AR, Mikušová K, Alzari PM, Manganelli R, de Carvalho LP, Riccardi G, Cole ST, Pasca MR. Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chem Biol. 2015 Jul 23; 22(7):917-27. PMID: 26097035; PMCID: PMC4521081.
    3. Lisa MN, Gil M, André-Leroux G, Barilone N, Durán R, Biondi RM, Alzari PM. Molecular Basis of the Activity and the Regulation of the Eukaryotic-like S/T Protein Kinase PknG from Mycobacterium tuberculosis. Structure. 2015 Jun 02; 23(6):1039-48. PMID: 25960409.
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    4. Wagner T, Alexandre M, Duran R, Barilone N, Wehenkel A, Alzari PM, Bellinzoni M. The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation. Proteins. 2015 May; 83(5):982-8. PMID: 25586004.
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    5. Giganti D, Albesa-Jové D, Urresti S, Rodrigo-Unzueta A, Martínez MA, Comino N, Barilone N, Bellinzoni M, Chenal A, Guerin ME, Alzari PM. Secondary structure reshuffling modulates glycosyltransferase function at the membrane. Nat Chem Biol. 2015 Jan; 11(1):16-8. PMID: 25402770.
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    6. Bellinzoni M, Haouz A, Miras I, Magnet S, André-Leroux G, Mukherjee R, Shepard W, Cole ST, Alzari PM. Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c. J Struct Biol. 2014 Nov; 188(2):156-64. PMID: 25260828.
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    7. Giganti D, Bouillon A, Tawk L, Robert F, Martinez M, Crublet E, Weber P, Girard-Blanc C, Petres S, Haouz A, Hernandez JF, Mercereau-Puijalon O, Alzari PM, Barale JC. A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase. Nat Commun. 2014 Sep 10; 5:4833. PMID: 25204226.
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    8. Correa A, Pacheco S, Mechaly AE, Obal G, Béhar G, Mouratou B, Oppezzo P, Alzari PM, Pecorari F. Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins). PLoS One. 2014; 9(5):e97438. PMID: 24823716; PMCID: PMC4019568.
    9. Correa A, Ortega C, Obal G, Alzari P, Vincentelli R, Oppezzo P. Generation of a vector suite for protein solubility screening. Front Microbiol. 2014; 5:67. PMID: 24616717; PMCID: PMC3934309.
    10. Wagner T, Barilone N, Alzari PM, Bellinzoni M. A dual conformation of the post-decarboxylation intermediate is associated with distinct enzyme states in mycobacterial KGD (a-ketoglutarate decarboxylase). Biochem J. 2014 Feb 01; 457(3):425-34. PMID: 24171907.
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    11. Mechaly AE, Sassoon N, Betton JM, Alzari PM. Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation. PLoS Biol. 2014 Jan; 12(1):e1001776. PMID: 24492262; PMCID: PMC3904827.
    12. Albesa-Jové D, Giganti D, Jackson M, Alzari PM, Guerin ME. Structure-function relationships of membrane-associated GT-B glycosyltransferases. Glycobiology. 2014 Feb; 24(2):108-24. PMID: 24253765; PMCID: PMC3907083.
    13. Ventura M, Rieck B, Boldrin F, Degiacomi G, Bellinzoni M, Barilone N, Alzaidi F, Alzari PM, Manganelli R, O'Hare HM. GarA is an essential regulator of metabolism in Mycobacterium tuberculosis. Mol Microbiol. 2013 Oct; 90(2):356-66. PMID: 23962235.
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    14. Gil M, Graña M, Schopfer FJ, Wagner T, Denicola A, Freeman BA, Alzari PM, Batthyány C, Durán R. Inhibition of Mycobacterium tuberculosis PknG by non-catalytic rubredoxin domain specific modification: reaction of an electrophilic nitro-fatty acid with the Fe-S center. Free Radic Biol Med. 2013 Dec; 65:150-61. PMID: 23792274; PMCID: PMC4061738.
    15. Béhar G, Bellinzoni M, Maillasson M, Paillard-Laurance L, Alzari PM, He X, Mouratou B, Pecorari F. Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G Affitins. Protein Eng Des Sel. 2013 Apr; 26(4):267-75. PMID: 23315487.
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    16. Albanesi D, Reh G, Guerin ME, Schaeffer F, Debarbouille M, Buschiazzo A, Schujman GE, de Mendoza D, Alzari PM. Structural basis for feed-forward transcriptional regulation of membrane lipid homeostasis in Staphylococcus aureus. PLoS Pathog. 2013 Jan; 9(1):e1003108. PMID: 23300457; PMCID: PMC3536700.
    17. Busschots K, Lopez-Garcia LA, Lammi C, Stroba A, Zeuzem S, Piiper A, Alzari PM, Neimanis S, Arencibia JM, Engel M, Schulze JO, Biondi RM. Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site. Chem Biol. 2012 Sep 21; 19(9):1152-63. PMID: 22999883.
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    18. Urresti S, Albesa-Jové D, Schaeffer F, Pham HT, Kaur D, Gest P, van der Woerd MJ, Carreras-González A, López-Fernández S, Alzari PM, Brennan PJ, Jackson M, Guerin ME. Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria. J Biol Chem. 2012 Jul 13; 287(29):24649-61. PMID: 22637481; PMCID: PMC3397893.
    19. Mechaly AE, Haouz A, Miras I, Barilone N, Weber P, Shepard W, Alzari PM, Bellinzoni M. Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis. FEBS Lett. 2012 Jun 04; 586(11):1606-11. PMID: 22561013.
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    20. Lopez-Garcia LA, Schulze JO, Fröhner W, Zhang H, Süss E, Weber N, Navratil J, Amon S, Hindie V, Zeuzem S, Jørgensen TJ, Alzari PM, Neimanis S, Engel M, Biondi RM. Allosteric regulation of protein kinase PKC? by the N-terminal C1 domain and small compounds to the PIF-pocket. Chem Biol. 2011 Nov 23; 18(11):1463-73. PMID: 22118680.
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    21. Wagner T, Bellinzoni M, Wehenkel A, O'Hare HM, Alzari PM. Functional plasticity and allosteric regulation of a-ketoglutarate decarboxylase in central mycobacterial metabolism. Chem Biol. 2011 Aug 26; 18(8):1011-20. PMID: 21867916.
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    22. Bellinzoni M, Bastard K, Perret A, Zaparucha A, Perchat N, Vergne C, Wagner T, de Melo-Minardi RC, Artiguenave F, Cohen GN, Weissenbach J, Salanoubat M, Alzari PM. 3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation. J Biol Chem. 2011 Aug 05; 286(31):27399-405. PMID: 21632536; PMCID: PMC3149333.
    23. Oppezzo P, Obal G, Baraibar MA, Pritsch O, Alzari PM, Buschiazzo A. Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity. Biochim Biophys Acta. 2011 Sep; 1814(9):1154-61. PMID: 21570497.
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    24. Manina G, Bellinzoni M, Pasca MR, Neres J, Milano A, Ribeiro AL, Buroni S, Skovierová H, Dianišková P, Mikušová K, Marák J, Makarov V, Giganti D, Haouz A, Lucarelli AP, Degiacomi G, Piazza A, Chiarelli LR, De Rossi E, Salina E, Cole ST, Alzari PM, Riccardi G. Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance. Mol Microbiol. 2010 Sep; 77(5):1172-85. PMID: 20624223.
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    25. Guerin ME, Korduláková J, Alzari PM, Brennan PJ, Jackson M. Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria. J Biol Chem. 2010 Oct 29; 285(44):33577-83. PMID: 20801880; PMCID: PMC2962455.
    26. Martinez MA, Zaballa ME, Schaeffer F, Bellinzoni M, Albanesi D, Schujman GE, Vila AJ, Alzari PM, de Mendoza D. A novel role of malonyl-ACP in lipid homeostasis. Biochemistry. 2010 Apr 13; 49(14):3161-7. PMID: 20201588.
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    27. Graña M, Bellinzoni M, Bellalou J, Haouz A, Miras I, Buschiazzo A, Winter N, Alzari PM. Crystal structure of Mycobacterium tuberculosis LppA, a lipoprotein confined to pathogenic mycobacteria. Proteins. 2010 Feb 15; 78(3):769-72. PMID: 19899167.
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    28. Bellinzoni M, Buroni S, Schaeffer F, Riccardi G, De Rossi E, Alzari PM. Structural plasticity and distinct drug-binding modes of LfrR, a mycobacterial efflux pump regulator. J Bacteriol. 2009 Dec; 191(24):7531-7. PMID: 19820093; PMCID: PMC2786614.
    29. Graña M, Bellinzoni M, Miras I, Fiez-Vandal C, Haouz A, Shepard W, Buschiazzo A, Alzari PM. Structure of Mycobacterium tuberculosis Rv2714, a representative of a duplicated gene family in Actinobacteria. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 01; 65(Pt 10):972-7. PMID: 19851001; PMCID: PMC2765880.
    30. Albanesi D, Martín M, Trajtenberg F, Mansilla MC, Haouz A, Alzari PM, de Mendoza D, Buschiazzo A. Structural plasticity and catalysis regulation of a thermosensor histidine kinase. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16185-90. PMID: 19805278; PMCID: PMC2738621.
    31. Hindie V, Stroba A, Zhang H, Lopez-Garcia LA, Idrissova L, Zeuzem S, Hirschberg D, Schaeffer F, Jørgensen TJ, Engel M, Alzari PM, Biondi RM. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol. 2009 Oct; 5(10):758-64. PMID: 19718043.
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    32. Boucontet L, Grana M, Alzari PM, Pereira P. Mechanisms determining cell membrane expression of different gammadelta TCR chain pairings. Eur J Immunol. 2009 Jul; 39(7):1937-46. PMID: 19585514.
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    33. Guerin ME, Schaeffer F, Chaffotte A, Gest P, Giganti D, Korduláková J, van der Woerd M, Jackson M, Alzari PM. Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria: implications for catalysis. J Biol Chem. 2009 Aug 07; 284(32):21613-25. PMID: 19520856; PMCID: PMC2755885.
    34. Bellinzoni M, Alzari PM. Bacterial metabolism under FHA control. Structure. 2009 Apr 15; 17(4):487-8. PMID: 19368881.
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    35. Martín M, Albanesi D, Alzari PM, de Mendoza D. Functional in vitro assembly of the integral membrane bacterial thermosensor DesK. Protein Expr Purif. 2009 Jul; 66(1):39-45. PMID: 19233289.
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    36. Sala C, Haouz A, Saul FA, Miras I, Rosenkrands I, Alzari PM, Cole ST. Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis. Mol Microbiol. 2009 Mar; 71(5):1102-16. PMID: 19154333.
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    37. England P, Wehenkel A, Martins S, Hoos S, André-Leroux G, Villarino A, Alzari PM. The FHA-containing protein GarA acts as a phosphorylation-dependent molecular switch in mycobacterial signaling. FEBS Lett. 2009 Jan 22; 583(2):301-7. PMID: 19114043.
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    38. Neres J, Brewer ML, Ratier L, Botti H, Buschiazzo A, Edwards PN, Mortenson PN, Charlton MH, Alzari PM, Frasch AC, Bryce RA, Douglas KT. Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):589-96. PMID: 19144516.
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    39. O'Hare HM, Durán R, Cerveñansky C, Bellinzoni M, Wehenkel AM, Pritsch O, Obal G, Baumgartner J, Vialaret J, Johnsson K, Alzari PM. Regulation of glutamate metabolism by protein kinases in mycobacteria. Mol Microbiol. 2008 Dec; 70(6):1408-23. PMID: 19019160.
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    40. Buschiazzo A, Alzari PM. Structural insights into sialic acid enzymology. Curr Opin Chem Biol. 2008 Oct; 12(5):565-72. PMID: 18625334.
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    41. Krehenbrink M, Chami M, Guilvout I, Alzari PM, Pécorari F, Pugsley AP. Artificial binding proteins (Affitins) as probes for conformational changes in secretin PulD. J Mol Biol. 2008 Nov 28; 383(5):1058-68. PMID: 18822295.
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    42. Balganesh TS, Alzari PM, Cole ST. Rising standards for tuberculosis drug development. Trends Pharmacol Sci. 2008 Nov; 29(11):576-81. PMID: 18799223.
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    43. Damager I, Buchini S, Amaya MF, Buschiazzo A, Alzari P, Frasch AC, Watts A, Withers SG. Kinetic and mechanistic analysis of Trypanosoma cruzi trans-sialidase reveals a classical ping-pong mechanism with acid/base catalysis. Biochemistry. 2008 Mar 18; 47(11):3507-12. PMID: 18284211.
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    44. Ahmed F, André-Leroux G, Haouz A, Boutonnier A, Delepierre M, Qadri F, Nato F, Fournier JM, Alzari PM. Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1. Proteins. 2008 Jan 01; 70(1):284-8. PMID: 17876834.
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    45. Mouratou B, Schaeffer F, Guilvout I, Tello-Manigne D, Pugsley AP, Alzari PM, Pecorari F. Remodeling a DNA-binding protein as a specific in vivo inhibitor of bacterial secretin PulD. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):17983-8. PMID: 17984049; PMCID: PMC2084283.
    46. Cole ST, Alzari PM. Towards new tuberculosis drugs. Biochem Soc Trans. 2007 Nov; 35(Pt 5):1321-4. PMID: 17956342.
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    47. Wehenkel A, Bellinzoni M, Schaeffer F, Villarino A, Alzari PM. Structural and binding studies of the three-metal center in two mycobacterial PPM Ser/Thr protein phosphatases. J Mol Biol. 2007 Dec 07; 374(4):890-8. PMID: 17961594.
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    48. Fernandez P, Haouz A, Pereira CA, Aguilar C, Alzari PM. The crystal structure of Trypanosoma cruzi arginine kinase. Proteins. 2007 Oct 01; 69(1):209-12. PMID: 17623863.
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    49. Wehenkel A, Bellinzoni M, Graña M, Duran R, Villarino A, Fernandez P, Andre-Leroux G, England P, Takiff H, Cerveñansky C, Cole ST, Alzari PM. Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential. Biochim Biophys Acta. 2008 Jan; 1784(1):193-202. PMID: 17869195.
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    50. Graña M, Haouz A, Buschiazzo A, Miras I, Wehenkel A, Bondet V, Shepard W, Schaeffer F, Cole ST, Alzari PM. The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria. Protein Sci. 2007 Sep; 16(9):1896-904. PMID: 17660248; PMCID: PMC2206960.
    51. Stadthagen G, Sambou T, Guerin M, Barilone N, Boudou F, Korduláková J, Charles P, Alzari PM, Lemassu A, Daffé M, Puzo G, Gicquel B, Rivière M, Jackson M. Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis. J Biol Chem. 2007 Sep 14; 282(37):27270-6. PMID: 17640872.
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    52. Topalis D, Kumamoto H, Amaya Velasco MF, Dugué L, Haouz A, Alexandre JA, Gallois-Montbrun S, Alzari PM, Pochet S, Agrofoglio LA, Deville-Bonne D. Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives -- a screening based on affinity for the UMP-CMP binding site. FEBS J. 2007 Jul; 274(14):3704-14. PMID: 17608725.
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    53. Bellinzoni M, Wehenkel A, Shepard W, Alzari PM. Insights into the catalytic mechanism of PPM Ser/Thr phosphatases from the atomic resolution structures of a mycobacterial enzyme. Structure. 2007 Jul; 15(7):863-72. PMID: 17637345.
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    54. Guerin ME, Kordulakova J, Schaeffer F, Svetlikova Z, Buschiazzo A, Giganti D, Gicquel B, Mikusova K, Jackson M, Alzari PM. Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria. J Biol Chem. 2007 Jul 13; 282(28):20705-14. PMID: 17510062.
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    55. Ingvarsson H, Maté MJ, Högbom M, Portnoï D, Benaroudj N, Alzari PM, Ortiz-Lombardía M, Unge T. Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1. Acta Crystallogr D Biol Crystallogr. 2007 Feb; 63(Pt 2):249-59. PMID: 17242518.
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    56. Shepard W, Haouz A, Graña M, Buschiazzo A, Betton JM, Cole ST, Alzari PM. The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria. J Bacteriol. 2007 Mar; 189(5):1899-904. PMID: 17172346; PMCID: PMC1855704.
    57. Neres J, Bonnet P, Edwards PN, Kotian PL, Buschiazzo A, Alzari PM, Bryce RA, Douglas KT. Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase. Bioorg Med Chem. 2007 Mar 01; 15(5):2106-19. PMID: 17218104.
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    58. Engel M, Hindie V, Lopez-Garcia LA, Stroba A, Schaeffer F, Adrian I, Imig J, Idrissova L, Nastainczyk W, Zeuzem S, Alzari PM, Hartmann RW, Piiper A, Biondi RM. Allosteric activation of the protein kinase PDK1 with low molecular weight compounds. EMBO J. 2006 Nov 29; 25(23):5469-80. PMID: 17110931; PMCID: PMC1679772.
    59. Costabel MD, Ermácora MR, Santomé JA, Alzari PM, Guérin DM. Structure of armadillo ACBP: a new member of the acyl-CoA-binding protein family. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Oct 01; 62(Pt 10):958-61. PMID: 17012783; PMCID: PMC2225200.
    60. Fogg MJ, Alzari P, Bahar M, Bertini I, Betton JM, Burmeister WP, Cambillau C, Canard B, Corrondo MA, Carrondo M, Coll M, Daenke S, Dym O, Egloff MP, Enguita FJ, Geerlof A, Haouz A, Jones TA, Ma Q, Manicka SN, Migliardi M, Nordlund P, Owens RJ, Peleg Y, Schneider G, Schnell R, Stuart DI, Tarbouriech N, Unge T, Wilkinson AJ, Wilmanns M, Wilson KS, Zimhony O, Grimes JM. Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens. Acta Crystallogr D Biol Crystallogr. 2006 Oct; 62(Pt 10):1196-207. PMID: 17001096.
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    61. Alzari PM, Berglund H, Berrow NS, Blagova E, Busso D, Cambillau C, Campanacci V, Christodoulou E, Eiler S, Fogg MJ, Folkers G, Geerlof A, Hart D, Haouz A, Herman MD, Macieira S, Nordlund P, Perrakis A, Quevillon-Cheruel S, Tarandeau F, van Tilbeurgh H, Unger T, Luna-Vargas MP, Velarde M, Willmanns M, Owens RJ. Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE. Acta Crystallogr D Biol Crystallogr. 2006 Oct; 62(Pt 10):1103-13. PMID: 17001088.
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    62. Albeck S, Alzari P, Andreini C, Banci L, Berry IM, Bertini I, Cambillau C, Canard B, Carter L, Cohen SX, Diprose JM, Dym O, Esnouf RM, Felder C, Ferron F, Guillemot F, Hamer R, Ben Jelloul M, Laskowski RA, Laurent T, Longhi S, Lopez R, Luchinat C, Malet H, Mochel T, Morris RJ, Moulinier L, Oinn T, Pajon A, Peleg Y, Perrakis A, Poch O, Prilusky J, Rachedi A, Ripp R, Rosato A, Silman I, Stuart DI, Sussman JL, Thierry JC, Thompson JD, Thornton JM, Unger T, Vaughan B, Vranken W, Watson JD, Whamond G, Henrick K. SPINE bioinformatics and data-management aspects of high-throughput structural biology. Acta Crystallogr D Biol Crystallogr. 2006 Oct; 62(Pt 10):1184-95. PMID: 17001095.
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    63. Fernandez P, Saint-Joanis B, Barilone N, Jackson M, Gicquel B, Cole ST, Alzari PM. The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth. J Bacteriol. 2006 Nov; 188(22):7778-84. PMID: 16980473; PMCID: PMC1636329.
    64. Schujman GE, Guerin M, Buschiazzo A, Schaeffer F, Llarrull LI, Reh G, Vila AJ, Alzari PM, de Mendoza D. Structural basis of lipid biosynthesis regulation in Gram-positive bacteria. EMBO J. 2006 Sep 06; 25(17):4074-83. PMID: 16932747; PMCID: PMC1560364.
    65. Pehar M, Vargas MR, Robinson KM, Cassina P, England P, Beckman JS, Alzari PM, Barbeito L. Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons. Free Radic Biol Med. 2006 Dec 01; 41(11):1632-44. PMID: 17145551.
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    66. Neres J, Buschiazzo A, Alzari PM, Walsh L, Douglas KT. Continuous fluorimetric assay for high-throughput screening of inhibitors of trans-sialidase from Trypanosoma cruzi. Anal Biochem. 2006 Oct 15; 357(2):302-4. PMID: 16930524.
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    67. Bellinzoni M, Haouz A, Graña M, Munier-Lehmann H, Shepard W, Alzari PM. The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer. Protein Sci. 2006 Jun; 15(6):1489-93. PMID: 16672241; PMCID: PMC2242552.
    68. Wehenkel A, Fernandez P, Bellinzoni M, Catherinot V, Barilone N, Labesse G, Jackson M, Alzari PM. The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria. FEBS Lett. 2006 May 29; 580(13):3018-22. PMID: 16674948.
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    69. Buschiazzo A, Goytia M, Schaeffer F, Degrave W, Shepard W, Grégoire C, Chamond N, Cosson A, Berneman A, Coatnoan N, Alzari PM, Minoprio P. Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1705-10. PMID: 16446443; PMCID: PMC1413642.
    70. Watts AG, Oppezzo P, Withers SG, Alzari PM, Buschiazzo A. Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase. J Biol Chem. 2006 Feb 17; 281(7):4149-55. PMID: 16298994.
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    71. Girardin SE, Jéhanno M, Mengin-Lecreulx D, Sansonetti PJ, Alzari PM, Philpott DJ. Identification of the critical residues involved in peptidoglycan detection by Nod1. J Biol Chem. 2005 Nov 18; 280(46):38648-56. PMID: 16172124.
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    72. Durán R, Villarino A, Bellinzoni M, Wehenkel A, Fernandez P, Boitel B, Cole ST, Alzari PM, Cerveñansky C. Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases. Biochem Biophys Res Commun. 2005 Aug 05; 333(3):858-67. PMID: 15967413.
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    73. Villarino A, Duran R, Wehenkel A, Fernandez P, England P, Brodin P, Cole ST, Zimny-Arndt U, Jungblut PR, Cerveñansky C, Alzari PM. Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions. J Mol Biol. 2005 Jul 29; 350(5):953-63. PMID: 15978616.
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    74. Guimarães BG, Souchon H, Honoré N, Saint-Joanis B, Brosch R, Shepard W, Cole ST, Alzari PM. Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress. J Biol Chem. 2005 Jul 08; 280(27):25735-42. PMID: 15886207.
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    75. Guerin ME, Buschiazzo A, Korduláková J, Jackson M, Alzari PM. Crystallization and preliminary crystallographic analysis of PimA, an essential mannosyltransferase from Mycobacterium smegmatis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 May 01; 61(Pt 5):518-20. PMID: 16511084; PMCID: PMC1952298.
    76. Paris G, Ratier L, Amaya MF, Nguyen T, Alzari PM, Frasch AC. A sialidase mutant displaying trans-sialidase activity. J Mol Biol. 2005 Jan 28; 345(4):923-34. PMID: 15588836.
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    77. Cole ST, Alzari PM. Microbiology. TB--a new target, a new drug. Science. 2005 Jan 14; 307(5707):214-5. PMID: 15653490.
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    78. Alzari PM. First structural glimpse at a bacterial Ser/Thr protein phosphatase. Structure. 2004 Nov; 12(11):1923-4. PMID: 15530356.
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    79. Freire T, Fernández C, Chalar C, Maizels RM, Alzari P, Osinaga E, Robello C. Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus. Biochem J. 2004 Sep 01; 382(Pt 2):501-10. PMID: 15142032; PMCID: PMC1133806.
    80. Buschiazzo A, Ugalde JE, Guerin ME, Shepard W, Ugalde RA, Alzari PM. Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation. EMBO J. 2004 Aug 18; 23(16):3196-205. PMID: 15272305; PMCID: PMC514502.
    81. Amaya MF, Watts AG, Damager I, Wehenkel A, Nguyen T, Buschiazzo A, Paris G, Frasch AC, Withers SG, Alzari PM. Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase. Structure. 2004 May; 12(5):775-84. PMID: 15130470.
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    82. Ribard C, Rochet M, Labedan B, Daignan-Fornier B, Alzari P, Scazzocchio C, Oestreicher N. Sub-families of alpha/beta barrel enzymes: a new adenine deaminase family. J Mol Biol. 2003 Dec 12; 334(5):1117-31. PMID: 14643670.
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    83. Boitel B, Ortiz-Lombardía M, Durán R, Pompeo F, Cole ST, Cerveñansky C, Alzari PM. PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis. Mol Microbiol. 2003 Sep; 49(6):1493-508. PMID: 12950916.
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    84. Watts AG, Damager I, Amaya ML, Buschiazzo A, Alzari P, Frasch AC, Withers SG. Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile. J Am Chem Soc. 2003 Jun 25; 125(25):7532-3. PMID: 12812490.
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    85. Guerin ME, Buschiazzo A, Ugalde JE, Ugalde RA, Alzari PM. Preliminary crystallographic studies of glycogen synthase from Agrobacterium tumefaciens. Acta Crystallogr D Biol Crystallogr. 2003 Mar; 59(Pt 3):526-8. PMID: 12595715.
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    86. Babino A, Tello D, Rojas A, Bay S, Osinaga E, Alzari PM. The crystal structure of a plant lectin in complex with the Tn antigen. FEBS Lett. 2003 Feb 11; 536(1-3):106-10. PMID: 12586347.
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    87. Ortiz-Lombardía M, Pompeo F, Boitel B, Alzari PM. Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis. J Biol Chem. 2003 Apr 11; 278(15):13094-100. PMID: 12551895.
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    88. Amaya MF, Buschiazzo A, Nguyen T, Alzari PM. The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase. J Mol Biol. 2003 Jan 24; 325(4):773-84. PMID: 12507479.
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    89. Buschiazzo A, Amaya MF, Cremona ML, Frasch AC, Alzari PM. The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis. Mol Cell. 2002 Oct; 10(4):757-68. PMID: 12419220.
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    90. Mo F, Mathiesen RH, Alzari PM, Lescar J, Rasmussen B. Physical estimation of triplet phases from two new proteins. Acta Crystallogr D Biol Crystallogr. 2002 Oct; 58(Pt 10 Pt 2):1780-6. PMID: 12351821.
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    91. Schmidt A, Gonzalez A, Morris RJ, Costabel M, Alzari PM, Lamzin VS. Advantages of high-resolution phasing: MAD to atomic resolution. Acta Crystallogr D Biol Crystallogr. 2002 Sep; 58(Pt 9):1433-41. PMID: 12198299.
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    92. Guimarães BG, Souchon H, Lytle BL, David Wu JH, Alzari PM. The crystal structure and catalytic mechanism of cellobiohydrolase CelS, the major enzymatic component of the Clostridium thermocellum Cellulosome. J Mol Biol. 2002 Jul 12; 320(3):587-96. PMID: 12096911.
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    93. Montagna G, Cremona ML, Paris G, Amaya MF, Buschiazzo A, Alzari PM, Frasch AC. The trans-sialidase from the african trypanosome Trypanosoma brucei. Eur J Biochem. 2002 Jun; 269(12):2941-50. PMID: 12071958.
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    94. Maté MJ, Ortiz-Lombardía M, Boitel B, Haouz A, Tello D, Susin SA, Penninger J, Kroemer G, Alzari PM. The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol. 2002 Jun; 9(6):442-6. PMID: 11967568.
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    95. Smith SP, Béguin P, Alzari PM, Gehring K. 1H, 13C, 15N NMR sequence-specific resonance assignment of a Clostridium thermocellum type II cohesin module. J Biomol NMR. 2002 May; 23(1):73-4. PMID: 12061722.
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    96. Carpena X, Guarné A, Ferrer JC, Alzari PM, Fita I, Loewen PC. Crystallization and preliminary X-ray analysis of the hydroperoxidase I C-terminal domain from Escherichia coli. Acta Crystallogr D Biol Crystallogr. 2002 May; 58(Pt 5):853-5. PMID: 11976501.
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    97. Mowat CG, Leys D, McLean KJ, Rivers SL, Richmond A, Munro AW, Ortiz Lombardia M, Alzari PM, Reid GA, Chapman SK, Walkinshaw MD. Crystallization and preliminary crystallographic analysis of a novel cytochrome P450 from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr. 2002 Apr; 58(Pt 4):704-5. PMID: 11914502.
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    98. Chernyak A, Kondo S, Wade TK, Meeks MD, Alzari PM, Fournier JM, Taylor RK, Kovác P, Wade WF. Induction of protective immunity by synthetic Vibrio cholerae hexasaccharide derived from V. cholerae O1 Ogawa lipopolysaccharide bound to a protein carrier. J Infect Dis. 2002 Apr 01; 185(7):950-62. PMID: 11920320.
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    99. Guérin DM, Lascombe MB, Costabel M, Souchon H, Lamzin V, Béguin P, Alzari PM. Atomic (0.94 A) resolution structure of an inverting glycosidase in complex with substrate. J Mol Biol. 2002 Mar 08; 316(5):1061-9. PMID: 11884144.
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    100. Schaeffer F, Matuschek M, Guglielmi G, Miras I, Alzari PM, Béguin P. Duplicated dockerin subdomains of Clostridium thermocellum endoglucanase CelD bind to a cohesin domain of the scaffolding protein CipA with distinct thermodynamic parameters and a negative cooperativity. Biochemistry. 2002 Feb 19; 41(7):2106-14. PMID: 11841200.
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    101. Miras I, Schaeffer F, Béguin P, Alzari PM. Mapping by site-directed mutagenesis of the region responsible for cohesin-dockerin interaction on the surface of the seventh cohesin domain of Clostridium thermocellum CipA. Biochemistry. 2002 Feb 19; 41(7):2115-9. PMID: 11841201.
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    102. Eckenberg R, Rose T, Moreau JL, Weil R, Gesbert F, Dubois S, Tello D, Bossus M, Gras H, Tartar A, Bertoglio J, Chouaïb S, Jacques Y, Alzari PM, Thèze J. Characterization of an IL-2 mimetic with therapeutic potential. Cell Mol Biol (Noisy-le-grand). 2001 Jun; 47(4):703-7. PMID: 11502078.
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    103. Paris G, Cremona ML, Amaya MF, Buschiazzo A, Giambiagi S, Frasch AC, Alzari PM. Probing molecular function of trypanosomal sialidases: single point mutations can change substrate specificity and increase hydrolytic activity. Glycobiology. 2001 Apr; 11(4):305-11. PMID: 11358879.
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    104. Pitcovsky TA, Mucci J, Alvarez P, Leguizamón MS, Burrone O, Alzari PM, Campetella O. Epitope mapping of trans-sialidase from Trypanosoma cruzi reveals the presence of several cross-reactive determinants. Infect Immun. 2001 Mar; 69(3):1869-75. PMID: 11179365; PMCID: PMC98094.
    105. Pritsch O, Magnac C, Dumas G, Bouvet JP, Alzari P, Dighiero G. Can isotype switch modulate antigen-binding affinity and influence clonal selection? Eur J Immunol. 2000 Dec; 30(12):3387-95. PMID: 11093156.
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    106. Villeneuve S, Souchon H, Riottot MM, Mazie JC, Lei P, Glaudemans CP, Kovác P, Fournier JM, Alzari PM. Crystal structure of an anti-carbohydrate antibody directed against Vibrio cholerae O1 in complex with antigen: molecular basis for serotype specificity. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8433-8. PMID: 10880560; PMCID: PMC26965.
    107. Lascombe MB, Grégoire C, Poncet P, Tavares GA, Rosinski-Chupin I, Rabillon J, Goubran-Botros H, Mazié JC, David B, Alzari PM. Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopes. J Biol Chem. 2000 Jul 14; 275(28):21572-7. PMID: 10787420.
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    108. Oppezzo P, Osinaga E, Tello D, Bay S, Cantacuzene D, Irigoín F, Ferreira A, Roseto A, Cayota A, Alzari P, Pritsch O. Production and functional characterization of two mouse/human chimeric antibodies with specificity for the tumor-associated Tn-antigen. Hybridoma. 2000 Jun; 19(3):229-39. PMID: 10952411.
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    109. Osinaga E, Bay S, Tello D, Babino A, Pritsch O, Assemat K, Cantacuzene D, Nakada H, Alzari P. Analysis of the fine specificity of Tn-binding proteins using synthetic glycopeptide epitopes and a biosensor based on surface plasmon resonance spectroscopy. FEBS Lett. 2000 Mar 03; 469(1):24-8. PMID: 10708749.
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    110. Medeiros A, Bianchi S, Calvete JJ, Balter H, Bay S, Robles A, Cantacuzène D, Nimtz M, Alzari PM, Osinaga E. Biochemical and functional characterization of the Tn-specific lectin from Salvia sclarea seeds. Eur J Biochem. 2000 Mar; 267(5):1434-40. PMID: 10691981.
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    111. Eckenberg R, Rose T, Moreau JL, Weil R, Gesbert F, Dubois S, Tello D, Bossus M, Gras H, Tartar A, Bertoglio J, Chouaïb S, Goldberg M, Jacques Y, Alzari PM, Thèze J. The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells. J Exp Med. 2000 Feb 07; 191(3):529-40. PMID: 10662798; PMCID: PMC2195822.
    112. Buschiazzo A, Tavares GA, Campetella O, Spinelli S, Cremona ML, París G, Amaya MF, Frasch AC, Alzari PM. Structural basis of sialyltransferase activity in trypanosomal sialidases. EMBO J. 2000 Jan 04; 19(1):16-24. PMID: 10619840; PMCID: PMC1171773.
    113. Barale JC, Blisnick T, Fujioka H, Alzari PM, Aikawa M, Braun-Breton C, Langsley G. Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite surface protein 1-42 maturase. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6445-50. PMID: 10339607; PMCID: PMC26901.
    114. Grégoire C, Tavares GA, Lorenzo HK, Dandeu JP, David B, Alzari PM. Crystallization and preliminary crystallographic analysis of the major horse allergen Equ c 1. Acta Crystallogr D Biol Crystallogr. 1999 Apr; 55(Pt 4):880-2. PMID: 10089322.
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    115. Marina A, Alzari PM, Bravo J, Uriarte M, Barcelona B, Fita I, Rubio V. Carbamate kinase: New structural machinery for making carbamoyl phosphate, the common precursor of pyrimidines and arginine. Protein Sci. 1999 Apr; 8(4):934-40. PMID: 10211841; PMCID: PMC2144312.
    116. Saint-Joanis B, Souchon H, Wilming M, Johnsson K, Alzari PM, Cole ST. Use of site-directed mutagenesis to probe the structure, function and isoniazid activation of the catalase/peroxidase, KatG, from Mycobacterium tuberculosis. Biochem J. 1999 Mar 15; 338 ( Pt 3):753-60. PMID: 10051449; PMCID: PMC1220113.
    117. Maté MJ, Zamocky M, Nykyri LM, Herzog C, Alzari PM, Betzel C, Koller F, Fita I. Structure of catalase-A from Saccharomyces cerevisiae. J Mol Biol. 1999 Feb 12; 286(1):135-49. PMID: 9931255.
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    118. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Brenner C, Larochette N, Prévost MC, Alzari PM, Kroemer G. Mitochondrial release of caspase-2 and -9 during the apoptotic process. J Exp Med. 1999 Jan 18; 189(2):381-94. PMID: 9892620; PMCID: PMC2192979.
    119. Terenzi H, Alzari PM, Zakin MM. Structural features involved in the formation of a complex between the monomeric or the dimeric form of the rev-erb beta DNA-binding domain and its DNA reactive sites. Biochemistry. 1998 Aug 18; 37(33):11488-95. PMID: 9708984.
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    120. Béguin P, Alzari PM. The cellulosome of Clostridium thermocellum. Biochem Soc Trans. 1998 May; 26(2):178-85. PMID: 9649744.
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    121. Demangel C, Rouyre S, Alzari PM, Nato F, Longacre S, Lafaye P, Mazie JC. Phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate. Biol Chem. 1998 Jan; 379(1):65-70. PMID: 9504719.
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    122. Guillouard I, Alzari PM, Saliou B, Cole ST. The carboxy-terminal C2-like domain of the alpha-toxin from Clostridium perfringens mediates calcium-dependent membrane recognition. Mol Microbiol. 1997 Dec; 26(5):867-76. PMID: 9426125.
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    123. Tavares GA, Béguin P, Alzari PM. The crystal structure of a type I cohesin domain at 1.7 A resolution. J Mol Biol. 1997 Oct 31; 273(3):701-13. PMID: 9402065.
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    124. Babino A, Pritsch O, Oppezzo P, Du Pasquier R, Roseto A, Osinaga E, Alzari PM. Molecular cloning of a monoclonal anti-tumor antibody specific for the Tn antigen and expression of an active single-chain Fv fragment. Hybridoma. 1997 Aug; 16(4):317-24. PMID: 9309422.
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    125. Osinaga E, Tello D, Batthyany C, Bianchet M, Tavares G, Durán R, Cerveñansky C, Camoin L, Roseto A, Alzari PM. Amino acid sequence and three-dimensional structure of the Tn-specific isolectin B4 from Vicia villosa. FEBS Lett. 1997 Jul 21; 412(1):190-6. PMID: 9257718.
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    126. Lorenzo HK, Farber D, Germain V, Acuto O, Alzari PM. The MBP fusion protein restores the activity of the first phosphatase domain of CD45. FEBS Lett. 1997 Jul 14; 411(2-3):231-5. PMID: 9271211.
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    127. Eckenberg R, Xu D, Moreau JL, Bossus M, Mazie JC, Tartar A, Liu XY, Alzari PM, Bertoglio J, Theze J. Analysis of human IL-2/IL-2 receptor beta chain interactions: monoclonal antibody H2-8 and new IL-2 mutants define the critical role of alpha helix-A of IL-2. Cytokine. 1997 Jul; 9(7):488-98. PMID: 9237811.
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    128. Berthet S, Nykyri LM, Bravo J, Mate MJ, Berthet-Colominas C, Alzari PM, Koller F, Fita I. Crystallization and preliminary structural analysis of catalase A from Saccharomyces cerevisiae. Protein Sci. 1997 Feb; 6(2):481-3. PMID: 9041655; PMCID: PMC2143643.
    129. Diaw L, Magnac C, Pritsch O, Buckle M, Alzari PM, Dighiero G. Structural and affinity studies of IgM polyreactive natural autoantibodies. J Immunol. 1997 Jan 15; 158(2):968-76. PMID: 8993018.
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    130. Gregoire C, Rosinski-Chupin I, Rabillon J, Alzari PM, David B, Dandeu JP. cDNA cloning and sequencing reveal the major horse allergen Equ c1 to be a glycoprotein member of the lipocalin superfamily. J Biol Chem. 1996 Dec 20; 271(51):32951-9. PMID: 8955138.
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    131. Thèze J, Alzari PM, Bertoglio J. Interleukin 2 and its receptors: recent advances and new immunological functions. Immunol Today. 1996 Oct; 17(10):481-6. PMID: 8908814.
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    132. Béguin P, Raynaud O, Chaveroche MK, Dridi A, Alzari PM. Subcloning of a DNA fragment encoding a single cohesin domain of the Clostridium thermocellum cellulosome-integrating protein CipA: purification, crystallization, and preliminary diffraction analysis of the encoded polypeptide. Protein Sci. 1996 Jun; 5(6):1192-4. PMID: 8762152; PMCID: PMC2143444.
    133. Souchon H, Béguin P, Alzari PM. Crystallization of a family 8 cellulase from Clostridium thermocellum. Proteins. 1996 May; 25(1):134-6. PMID: 8727326.
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    134. Domínguez R, Souchon H, Lascombe M, Alzari PM. The crystal structure of a family 5 endoglucanase mutant in complexed and uncomplexed forms reveals an induced fit activation mechanism. J Mol Biol. 1996 Apr 19; 257(5):1042-51. PMID: 8632467.
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    135. Alzari PM, Souchon H, Dominguez R. The crystal structure of endoglucanase CelA, a family 8 glycosyl hydrolase from Clostridium thermocellum. Structure. 1996 Mar 15; 4(3):265-75. PMID: 8805535.
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    136. Strynadka NC, Jensen SE, Alzari PM, James MN. A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex. Nat Struct Biol. 1996 Mar; 3(3):290-7. PMID: 8605632.
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    137. Saul FA, Alzari PM. Crystallographic studies of antigen-antibody interactions. Methods Mol Biol. 1996; 66:11-23. PMID: 8959700.
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    138. Assemat K, Alzari PM, Clément-Métral J. Conservative substitutions in the hydrophobic core of Rhodobacter sphaeroides thioredoxin produce distinct functional effects. Protein Sci. 1995 Dec; 4(12):2510-6. PMID: 8580841; PMCID: PMC2143044.
    139. Lescar J, Pellegrini M, Souchon H, Tello D, Poljak RJ, Peterson N, Greene M, Alzari PM. Crystal structure of a cross-reaction complex between Fab F9.13.7 and guinea fowl lysozyme. J Biol Chem. 1995 Jul 28; 270(30):18067-76. PMID: 7629116.
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    140. Dominguez R, Souchon H, Spinelli S, Dauter Z, Wilson KS, Chauvaux S, Béguin P, Alzari PM. A common protein fold and similar active site in two distinct families of beta-glycanases. Nat Struct Biol. 1995 Jul; 2(7):569-76. PMID: 7664125.
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    141. Chitarra V, Souchon H, Spinelli S, Juy M, Béguin P, Alzari PM. Multiple crystal forms of endoglucanase CelD: signal peptide residues modulate lattice formation. J Mol Biol. 1995 Apr 28; 248(2):225-32. PMID: 7739036.
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    142. Chauvaux S, Souchon H, Alzari PM, Chariot P, Beguin P. Structural and functional analysis of the metal-binding sites of Clostridium thermocellum endoglucanase CelD. J Biol Chem. 1995 Apr 28; 270(17):9757-62. PMID: 7730353.
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    143. Heym B, Alzari PM, Honoré N, Cole ST. Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis. Mol Microbiol. 1995 Jan; 15(2):235-45. PMID: 7746145.
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    144. Guelpa-Fonlupt V, Bossy D, Alzari P, Fumoux F, Fougereau M, Schiff C. The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain. Mol Immunol. 1994 Oct; 31(14):1099-108. PMID: 7935499.
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    145. Dominguez R, Souchon H, Alzari PM. Characterization of two crystal forms of Clostridium thermocellum endoglucanase CelC. Proteins. 1994 Jun; 19(2):158-60. PMID: 8090710.
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    146. Lescar J, Souchon H, Alzari PM. Crystal structures of pheasant and guinea fowl egg-white lysozymes. Protein Sci. 1994 May; 3(5):788-98. PMID: 8061608; PMCID: PMC2142728.
    147. Hoog SS, Pawlowski JE, Alzari PM, Penning TM, Lewis M. Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily. Proc Natl Acad Sci U S A. 1994 Mar 29; 91(7):2517-21. PMID: 8146147; PMCID: PMC43400.
    148. Souchon H, Spinelli S, Béguin P, Alzari PM. Crystallization and preliminary diffraction analysis of the catalytic domain of xylanase Z from Clostridium thermocellum. J Mol Biol. 1994 Jan 28; 235(4):1348-50. PMID: 8308898.
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    149. Spinelli S, Alzari PM. Structural implications of somatic mutations during the immune response to 2-phenyloxazolone. Res Immunol. 1994 Jan; 145(1):41-5. PMID: 7516564.
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    150. Chitarra V, Alzari PM, Bentley GA, Bhat TN, Eiselé JL, Houdusse A, Lescar J, Souchon H, Poljak RJ. Three-dimensional structure of a heteroclitic antigen-antibody cross-reaction complex. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7711-5. PMID: 8356074; PMCID: PMC47212.
    151. Eiselé JL, Tello D, Osinaga E, Roseto A, Alzari PM. Crystallization and preliminary crystallographic analysis of a tetrameric isolectin from Vicia villosa, specific for the Tn antigen. J Mol Biol. 1993 Mar 20; 230(2):670-2. PMID: 8464073.
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    152. Lescar J, Riottot MM, Souchon H, Chitarra V, Bentley GA, Navaza J, Alzari PM, Poljak RJ. Crystallization, preliminary X-ray diffraction study, and crystal packing of a complex between anti-hen lysozyme antibody F9.13.7 and guinea-fowl lysozyme. Proteins. 1993 Feb; 15(2):209-12. PMID: 7680133.
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    153. Lascombe MB, Alzari PM, Poljak RJ, Nisonoff A. Three-dimensional structure of two crystal forms of FabR19.9 from a monoclonal anti-arsonate antibody. Proc Natl Acad Sci U S A. 1992 Oct 15; 89(20):9429-33. PMID: 1409652; PMCID: PMC50145.
    154. Spinelli S, Liu QZ, Alzari PM, Hirel PH, Poljak RJ. The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU. Biochimie. 1991 Nov; 73(11):1391-6. PMID: 1799632.
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    155. Brunel F, Alzari PM, Ferrara P, Zakin MM. Cloning and sequencing of PYBP, a pyrimidine-rich specific single strand DNA-binding protein. Nucleic Acids Res. 1991 Oct 11; 19(19):5237-45. PMID: 1681508; PMCID: PMC328882.
    156. Devaux C, Defendini ML, Alzari PM, Abergel C, Granier C, Fontecilla-Camps JC, Alzar PM. Crystallization and preliminary X-ray diffraction data of the Fab fragment of a monoclonal antibody against apamin, a bee venom neurotoxin. FEBS Lett. 1991 Jul 29; 286(1-2):64-6. PMID: 1747157.
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    157. Jores R, Alzari PM, Meo T. Resolution of hypervariable regions in T-cell receptor beta chains by a modified Wu-Kabat index of amino acid diversity. Proc Natl Acad Sci U S A. 1990 Dec; 87(23):9138-42. PMID: 2251255; PMCID: PMC55119.
    158. Alzari PM, Spinelli S, Mariuzza RA, Boulot G, Poljak RJ, Jarvis JM, Milstein C. Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response. EMBO J. 1990 Dec; 9(12):3807-14. PMID: 2123450; PMCID: PMC552147.
    159. González-Quintial R, Baccalà R, Alzari PM, Nahmias C, Mazza G, Fougereau M, Avrameas S. Poly(Glu60Ala30Tyr10) (GAT)-induced IgG monoclonal antibodies cross-react with various self and non-self antigens through the complementarity determining regions. Comparison with IgM monoclonal polyreactive natural antibodies. Eur J Immunol. 1990 Nov; 20(11):2383-7. PMID: 2253678.
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    160. Bentley GA, Alzari PM, Amit AG, Boulot G, Guillon-Chitarra V, Fischmann T, Lascombe MB, Mariuzza RA, Poljak RJ, Riottot MM, et al. Studies of structure and specificity of some antigen-antibody complexes. Philos Trans R Soc Lond B Biol Sci. 1989 Jun 12; 323(1217):487-94. PMID: 2569206.
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    161. Leroy P, Alzari P, Sassoon D, Wolgemuth D, Fellous M. The protein encoded by a murine male germ cell-specific transcript is a putative ATP-dependent RNA helicase. Cell. 1989 May 19; 57(4):549-59. PMID: 2720782.
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    162. Lascombe MB, Alzari PM, Boulot G, Saludjian P, Tougard P, Berek C, Haba S, Rosen EM, Nisonoff A, Poljak RJ. Three-dimensional structure of Fab R19.9, a monoclonal murine antibody specific for the p-azobenzenearsonate group. Proc Natl Acad Sci U S A. 1989 Jan; 86(2):607-11. PMID: 2911596; PMCID: PMC286521.
    163. Alzari PM, Lascombe MB, Poljak RJ. Three-dimensional structure of antibodies. Annu Rev Immunol. 1988; 6:555-80. PMID: 2454644.
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    164. Guillon V, Alzari PM, Poljak RJ. Preliminary crystallographic study of a complex between an heteroclitic anti-hen egg-white lysozyme antibody and the heterologous antigen pheasant egg-white lysozyme. J Mol Biol. 1987 Sep 20; 197(2):375-6. PMID: 3682000.
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    165. Guillon V, Alzari PM, Grognet JM. Preliminary crystallographic study of the Fab fragment of a monoclonal antibody directed against a cobra cardiotoxin. J Mol Biol. 1986 Jun 20; 189(4):723-4. PMID: 3783690.
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    166. Joliff G, Béguin P, Millet J, Aubert JP, Alzari P, Juy M, Poljak RJ. Crystallization and preliminary X-ray diffraction study of an endoglucanase from Clostridium thermocellum. J Mol Biol. 1986 May 05; 189(1):249-50. PMID: 3783675.
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