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Dr Modest Mulenga

TitleExecutive Director
InstitutionTropical Diseases Research Centre
AddressNdola
Zambia
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    I am the Director, Chief Executive Officer Senior Health Research of the Tropical Diseases Research Centre in, Ndola, Zambia. The Centre is the main national health research institution in Zambia which is mandated to conduct research in major diseases of public health importance. The institution has an authorized establishment of 200 staff including senior scientific staff, technical and support staff. I have held this position for seven years following my other appointments as deputy director and head of Clinical Sciences Department. I retain the position of Honorary Senior Lecturer of Biomedical sciences in the school of medicine of the Copperbelt University. In addition, I supervise PhD students in their research training work for various universities locally and internationally.

    I also belong to a number of important national and international research advisory committees or boards, some of which I have been able to take leadership roles in various capacities. One of the roles as a member of the national health research advisory committee is to advice government of the republic of Zambia on matters concerning health research and disease control in Zambia. Other similar important international appointments and engagements are indicated below. At country level I am involved as a key person in the setting up of the national public health institute and played a key role in the setting up of the CBU-school of medicine. I am currently leading a team that has been designated as SADC malaria reference laboratory for surveillance and control of malaria in the borders areas of the member states. I head programmes for disease surveillance for the northern part of Zambia. I am a guest Author and reviewer for various Journals such as The Lancet Infectious Diseases. I still hold a sizable portfolio of research programme grants for disease control through research and surveillance.

    My main research career achievement has been in the development of appropriate medicines for malaria treatment in Zambia. I was one of the lead persons that started the mapping of chloroquine resistance in Zambia and which led to the change in policy to save life from malaria. Zambia has recently added another effective drug for first line malaria treatment (ß-dihydroartemisinin-piperaquine) as a result of a series of clinical trials sponsored by the EDCTP, which I led in conducting over the past ten years.

    We have conducted studies with colleagues at Johns Hopkins University that have unveiled pockets of high malaria burden in Zambia despite extensive scale up of interventions. From this research we have thus proposed different approaches to malaria control including Mass Drug Administration in different parts of the country. Under this programme we are supervising a number of students conducting various research training activities in the country.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Pringle JC, Carpi G, Almagro-Garcia J, Zhu SJ, Kobayashi T, Mulenga M, Bobanga T, Chaponda M, Moss WJ, Norris DE. RTS,S/AS01 malaria vaccine mismatch observed among Plasmodium falciparum isolates from southern and central Africa and globally. Sci Rep. 2018 04 26; 8(1):6622. PMID: 29700348.
      View in: PubMed
    2. Ippolito MM, Kamavu LK, Kabuya JB, Tente C, Chileshe E, Wapachole M, Thuma PE, Muleba M, Chaponda M, Mulenga M, Moss WJ. Risk Factors for Mortality in Children Hospitalized with Severe Malaria in Northern Zambia: A Retrospective Case-Control Study. Am J Trop Med Hyg. 2018 06; 98(6):1699-1704. PMID: 29692306.
      View in: PubMed
    3. Kanyangarara M, Hamapumbu H, Mamini E, Lupiya J, Stevenson JC, Mharakurwa S, Chaponda M, Thuma PE, Gwanzura L, Munyati S, Mulenga M, Norris DE, Moss WJ. Malaria knowledge and bed net use in three transmission settings in southern Africa. Malar J. 2018 Jan 19; 17(1):41. PMID: 29351795.
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    4. Auld AF, Shiraishi RW, Oboho I, Ross C, Bateganya M, Pelletier V, Dee J, Francois K, Duval N, Antoine M, Delcher C, Desforges G, Griswold M, Domercant JW, Joseph N, Deyde V, Desir Y, Van Onacker JD, Robin E, Chun H, Zulu I, Pathmanathan I, Dokubo EK, Lloyd S, Pati R, Kaplan J, Raizes E, Spira T, Mitruka K, Couto A, Gudo ES, Mbofana F, Briggs M, Alfredo C, Xavier C, Vergara A, Hamunime N, Agolory S, Mutandi G, Shoopala NN, Sawadogo S, Baughman AL, Bashorun A, Dalhatu I, Swaminathan M, Onotu D, Odafe S, Abiri OO, Debem HH, Tomlinson H, Okello V, Preko P, Ao T, Ryan C, Bicego G, Ehrenkranz P, Kamiru H, Nuwagaba-Biribonwoha H, Kwesigabo G, Ramadhani AA, Ng'wangu K, Swai P, Mfaume M, Gongo R, Carpenter D, Mastro TD, Hamilton C, Denison J, Wabwire-Mangen F, Koole O, Torpey K, Williams SG, Colebunders R, Kalamya JN, Namale A, Adler MR, Mugisa B, Gupta S, Tsui S, van Praag E, Nguyen DB, Lyss S, Le Y, Abdul-Quader AS, Do NT, Mulenga M, Hachizovu S, Mugurungi O, Barr BAT, Gonese E, Mutasa-Apollo T, Balachandra S, Behel S, Bingham T, Mackellar D, Lowrance D, Ellerbrock TV. Trends in Prevalence of Advanced HIV Disease at Antiretroviral Therapy Enrollment - 10 Countries, 2004-2015. MMWR Morb Mortal Wkly Rep. 2017 Jun 02; 66(21):558-563. PMID: 28570507.
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    5. Nambozi M, Kabuya JB, Hachizovu S, Mwakazanga D, Mulenga J, Kasongo W, Buyze J, Mulenga M, Van Geertruyden JP, D'Alessandro U. Artemisinin-based combination therapy in pregnant women in Zambia: efficacy, safety and risk of recurrent malaria. Malar J. 2017 05 16; 16(1):199. PMID: 28511713.
      View in: PubMed
    6. Mwanza S, Joshi S, Nambozi M, Chileshe J, Malunga P, Kabuya JB, Hachizovu S, Manyando C, Mulenga M, Laufer M. The return of chloroquine-susceptible Plasmodium falciparum malaria in Zambia. Malar J. 2016 Dec 05; 15(1):584. PMID: 27919256.
      View in: PubMed
    7. Stevenson JC, Pinchoff J, Muleba M, Lupiya J, Chilusu H, Mwelwa I, Mbewe D, Simubali L, Jones CM, Chaponda M, Coetzee M, Mulenga M, Pringle JC, Shields T, Curriero FC, Norris DE. Spatio-temporal heterogeneity of malaria vectors in northern Zambia: implications for vector control. Parasit Vectors. 2016 Sep 21; 9(1):510. PMID: 27655231.
      View in: PubMed
    8. Four artemisinin-based treatments in African pregnant women with malaria. Malawi Med J. 2016 09; 28(3):139-149. PMID: 27895848.
      View in: PubMed
    9. Pinchoff J, Chaponda M, Shields TM, Sichivula J, Muleba M, Mulenga M, Kobayashi T, Curriero FC, Moss WJ. Individual and Household Level Risk Factors Associated with Malaria in Nchelenge District, a Region with Perennial Transmission: A Serial Cross-Sectional Study from 2012 to 2015. PLoS One. 2016; 11(6):e0156717. PMID: 27281028.
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    10. Four Artemisinin-Based Treatments in African Pregnant Women with Malaria. N Engl J Med. 2016 Mar 10; 374(10):913-27. PMID: 26962727.
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    11. Mulenga M, Manyando C. Mounting evidence for use of artemisinin derivatives for malaria in early pregnancy. Lancet Infect Dis. 2016 05; 16(5):513-515. PMID: 26869379.
      View in: PubMed
    12. Koole O, Denison JA, Menten J, Tsui S, Wabwire-Mangen F, Kwesigabo G, Mulenga M, Auld A, Agolory S, Mukadi YD, van Praag E, Torpey K, Williams S, Kaplan J, Zee A, Bangsberg DR, Colebunders R. Reasons for Missing Antiretroviral Therapy: Results from a Multi-Country Study in Tanzania, Uganda, and Zambia. PLoS One. 2016; 11(1):e0147309. PMID: 26788919.
      View in: PubMed
    13. Auld AF, Shiraishi RW, Mbofana F, Couto A, Fetogang EB, El-Halabi S, Lebelonyane R, Pilatwe PT, Hamunime N, Okello V, Mutasa-Apollo T, Mugurungi O, Murungu J, Dzangare J, Kwesigabo G, Wabwire-Mangen F, Mulenga M, Hachizovu S, Ettiegne-Traore V, Mohamed F. Lower Levels of Antiretroviral Therapy Enrollment Among Men with HIV Compared with Women - 12 Countries, 2002-2013. MMWR Morb Mortal Wkly Rep. 2015 Nov 27; 64(46):1281-6. PMID: 26605861.
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    14. Pinchoff J, Chaponda M, Shields T, Lupiya J, Kobayashi T, Mulenga M, Moss WJ, Curriero FC. Predictive Malaria Risk and Uncertainty Mapping in Nchelenge District, Zambia: Evidence of Widespread, Persistent Risk and Implications for Targeted Interventions. Am J Trop Med Hyg. 2015 Dec; 93(6):1260-7. PMID: 26416106.
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    15. Pfeil J, Borrmann S, Bassat Q, Mulenga M, Talisuna A, Tozan Y. An Economic Evaluation of the Posttreatment Prophylactic Effect of Dihydroartemisinin-Piperaquine Versus Artemether-Lumefantrine for First-Line Treatment of Plasmodium falciparum Malaria Across Different Transmission Settings in Africa. Am J Trop Med Hyg. 2015 Nov; 93(5):961-6. PMID: 26240155.
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    16. Zumla A, Maeurer M. Towards host-directed therapies for tuberculosis. Nat Rev Drug Discov. 2015 Aug; 14(8):511-2. PMID: 26184493.
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    17. Denison JA, Koole O, Tsui S, Menten J, Torpey K, van Praag E, Mukadi YD, Colebunders R, Auld AF, Agolory S, Kaplan JE, Mulenga M, Kwesigabo GP, Wabwire-Mangen F, Bangsberg DR. Incomplete adherence among treatment-experienced adults on antiretroviral therapy in Tanzania, Uganda and Zambia. AIDS. 2015 Jan 28; 29(3):361-71. PMID: 25686684.
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    18. Nambozi M, Mulenga M, Halidou T, Tagbor H, Mwapasa V, Phiri LK, Kalanda G, Valea I, Traore M, Mwakazanga D, Claeys Y, Schurmans C, De Crop M, Menten J, Ravinetto R, Thriemer K, Van Geertruyden JP, Mutabingwa T, D'Alessandro U. Safe and efficacious artemisinin-based combination treatments for African pregnant women with malaria: a multicentre randomized control trial. Reprod Health. 2015 Jan 15; 12:5. PMID: 25592254.
      View in: PubMed
    19. Auld AF, Agolory SG, Shiraishi RW, Wabwire-Mangen F, Kwesigabo G, Mulenga M, Hachizovu S, Asadu E, Tuho MZ, Ettiegne-Traore V, Mbofana F, Okello V, Azih C, Denison JA, Tsui S, Koole O, Kamiru H, Nuwagaba-Biribonwoha H, Alfredo C, Jobarteh K, Odafe S, Onotu D, Ekra KA, Kouakou JS, Ehrenkranz P, Bicego G, Torpey K, Mukadi YD, van Praag E, Menten J, Mastro T, Dukes Hamilton C, Swaminathan M, Dokubo EK, Baughman AL, Spira T, Colebunders R, Bangsberg D, Marlink R, Zee A, Kaplan J, Ellerbrock TV. Antiretroviral therapy enrollment characteristics and outcomes among HIV-infected adolescents and young adults compared with older adults--seven African countries, 2004-2013. MMWR Morb Mortal Wkly Rep. 2014 Nov 28; 63(47):1097-103. PMID: 25426651.
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    20. Sagara I, Oduro AR, Mulenga M, Dieng Y, Ogutu B, Tiono AB, Mugyenyi P, Sie A, Wasunna M, Kain KC, Djimdé AA, Sarkar S, Chandra R, Robbins J, Dunne MW. Efficacy and safety of a combination of azithromycin and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multi-country randomised clinical trials in African adults. Malar J. 2014 Nov 25; 13:458. PMID: 25425434.
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    21. Koole O, Tsui S, Wabwire-Mangen F, Kwesigabo G, Menten J, Mulenga M, Auld A, Agolory S, Mukadi YD, Colebunders R, Bangsberg DR, van Praag E, Torpey K, Williams S, Kaplan J, Zee A, Denison J. Retention and risk factors for attrition among adults in antiretroviral treatment programmes in Tanzania, Uganda and Zambia. Trop Med Int Health. 2014 Dec; 19(12):1397-410. PMID: 25227621.
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    22. Nambozi M, Malunga P, Mulenga M, Van Geertruyden JP, D'Alessandro U. Defining the malaria burden in Nchelenge District, northern Zambia using the World Health Organization malaria indicators survey. Malar J. 2014 Jun 05; 13:220. PMID: 24902708.
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    23. Manyando C, Njunju EM, Mwakazanga D, Chongwe G, Mkandawire R, Champo D, Mulenga M, De Crop M, Claeys Y, Ravinetto RM, van Overmeir C, Alessandro UD, Van Geertruyden JP. Safety of daily co-trimoxazole in pregnancy in an area of changing malaria epidemiology: a phase 3b randomized controlled clinical trial. PLoS One. 2014; 9(5):e96017. PMID: 24830749.
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    24. Mukonka VM, Chanda E, Haque U, Kamuliwo M, Mushinge G, Chileshe J, Chibwe KA, Norris DE, Mulenga M, Chaponda M, Muleba M, Glass GE, Moss WJ. High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia. Malar J. 2014 Apr 23; 13:153. PMID: 24755108.
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    25. Talisuna AO, Karema C, Ogutu B, Juma E, Logedi J, Nyandigisi A, Mulenga M, Mbacham WF, Roper C, Guerin PJ, D'Alessandro U, Snow RW. Mitigating the threat of artemisinin resistance in Africa: improvement of drug-resistance surveillance and response systems. Lancet Infect Dis. 2012 Nov; 12(11):888-96. PMID: 23099083.
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    26. Moss WJ, Norris DE, Mharakurwa S, Scott A, Mulenga M, Mason PR, Chipeta J, Thuma PE. Challenges and prospects for malaria elimination in the Southern Africa region. Acta Trop. 2012 Mar; 121(3):207-11. PMID: 21871864.
      View in: PubMed
    27. Mharakurwa S, Thuma PE, Norris DE, Mulenga M, Chalwe V, Chipeta J, Munyati S, Mutambu S, Mason PR. Malaria epidemiology and control in Southern Africa. Acta Trop. 2012 Mar; 121(3):202-6. PMID: 21756864.
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    28. Cirimotich CM, Dong Y, Clayton AM, Sandiford SL, Souza-Neto JA, Mulenga M, Dimopoulos G. Natural microbe-mediated refractoriness to Plasmodium infection in Anopheles gambiae. Science. 2011 May 13; 332(6031):855-8. PMID: 21566196.
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    29. Nambozi M, Van Geertruyden JP, Hachizovu S, Chaponda M, Mukwamataba D, Mulenga M, Ubben D, D'Alessandro U. Safety and efficacy of dihydroartemisinin-piperaquine versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Zambian children. Malar J. 2011 Feb 28; 10:50. PMID: 21352609.
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    30. Aklamati EK, Mulenga M, Dueker SR, Buchholz BA, Peerson JM, Kafwembe E, Brown KH, Haskell MJ. Accelerator mass spectrometry can be used to assess vitamin A metabolism quantitatively in boys in a community setting. J Nutr. 2010 Sep; 140(9):1588-94. PMID: 20660280.
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    31. Van Geertruyden JP, Van Eijk E, Yosaatmadja F, Kasongo W, Mulenga M, D'Alessandro U, Rogerson S. The relationship of Plasmodium falciparum humeral immunity with HIV-1 immunosuppression and treatment efficacy in Zambia. Malar J. 2009 Nov 18; 8:258. PMID: 19922664.
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    32. Bassat Q, Mulenga M, Tinto H, Piola P, Borrmann S, Menéndez C, Nambozi M, Valéa I, Nabasumba C, Sasi P, Bacchieri A, Corsi M, Ubben D, Talisuna A, D'Alessandro U. Dihydroartemisinin-piperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trial. PLoS One. 2009 Nov 17; 4(11):e7871. PMID: 19936217.
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    33. Chalwe V, Van geertruyden JP, Mukwamataba D, Menten J, Kamalamba J, Mulenga M, D'Alessandro U. Increased risk for severe malaria in HIV-1-infected adults, Zambia. Emerg Infect Dis. 2009 May; 15(5):749; quiz 858. PMID: 19402961.
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    34. Alker AP, Juliano JJ, Meshnick SR, Owen A, Ochong E, Bell DJ, Johnson DJ, d'Alessandro U, Mulenga M, Muangnoicharoen S, Van Geertruyden JP, Winstanley PA, Bray PG, Ward SA. Plasmodium falciparum and dihydrofolate reductase I164L mutations in Africa. Antimicrob Agents Chemother. 2009 Apr; 53(4):1722; author reply 1722-3. PMID: 19299520.
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    35. Van Geertruyden JP, Mulenga M, Chalwe V, Michael N, Moerman F, Mukwamataba D, Colebunders R, D'alessandro U. Impact of HIV-1 infection on the hematological recovery after clinical malaria. J Acquir Immune Defic Syndr. 2009 Feb 01; 50(2):200-5. PMID: 19131887.
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    36. Ochong E, Bell DJ, Johnson DJ, D'Alessandro U, Mulenga M, Muangnoicharoen S, Van Geertruyden JP, Winstanley PA, Bray PG, Ward SA, Owen A. Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure. Antimicrob Agents Chemother. 2008 Nov; 52(11):3883-8. PMID: 18725445.
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    37. Hamer DH, Mwanakasale V, Macleod WB, Chalwe V, Mukwamataba D, Champo D, Mwananyanda L, Chilengi R, Mubikayi L, Mulele CK, Mulenga M, Thea DM, Gill CJ. Two-dose versus monthly intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine in HIV-seropositive pregnant Zambian women. J Infect Dis. 2007 Dec 01; 196(11):1585-94. PMID: 18008241.
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    38. Mulenga M, Malunga F, Bennett S, Thuma PE, Shulman C, Fielding K, Alloueche A, Greenwood BM. A randomised, double-blind, placebo-controlled trial of atovaquone-proguanil vs. sulphadoxine-pyrimethamine in the treatment of malarial anaemia in Zambian children. Trop Med Int Health. 2006 Nov; 11(11):1643-52. PMID: 17054743.
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    39. Van Geertruyden JP, Mulenga M, Kasongo W, Polman K, Colebunders R, Kestens L, D'Alessandro U. CD4 T-cell count and HIV-1 infection in adults with uncomplicated malaria. J Acquir Immune Defic Syndr. 2006 Nov 01; 43(3):363-7. PMID: 17079994.
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    40. Van Geertruyden JP, Mulenga M, Mwananyanda L, Chalwe V, Moerman F, Chilengi R, Kasongo W, Van Overmeir C, Dujardin JC, Colebunders R, Kestens L, D'Alessandro U. HIV-1 immune suppression and antimalarial treatment outcome in Zambian adults with uncomplicated malaria. J Infect Dis. 2006 Oct 01; 194(7):917-25. PMID: 16960779.
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    41. Mulenga M, VangGeertruyden JP, Mwananyanda L, Chalwe V, Moerman F, Chilengi R, Van Overmeir C, Dujardin JC, D'Alessandro U. Safety and efficacy of lumefantrine-artemether (Coartem) for the treatment of uncomplicated Plasmodium falciparum malaria in Zambian adults. Malar J. 2006 Aug 21; 5:73. PMID: 16923176.
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    42. Mulenga M, Malunga P, Bennett S, Thuma P, Shulman C, Fielding K, Greenwood B. Folic acid treatment of Zambian children with moderate to severe malaria anemia. Am J Trop Med Hyg. 2006 Jun; 74(6):986-90. PMID: 16760508.
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    43. Na-Bangchang K, Manyando C, Ruengweerayut R, Kioy D, Mulenga M, Miller GB, Konsil J. The pharmacokinetics and pharmacodynamics of atovaquone and proguanil for the treatment of uncomplicated falciparum malaria in third-trimester pregnant women. Eur J Clin Pharmacol. 2005 Sep; 61(8):573-82. PMID: 16041597.
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    44. Mulenga M, Malunga P, Bennett S, Thuma PE, Shulman C, Fielding K, Greenwood BM. Factors associated with severe anaemia in Zambian children admitted with Plasmodium falciparum malarial anaemia. Ann Trop Paediatr. 2005 Jun; 25(2):87-90. PMID: 15949196.
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    45. Mulenga M, Sukwa TY, Canfield CJ, Hutchinson DB. Atovaquone and proguanil versus pyrimethamine/sulfadoxine for the treatment of acute falciparum malaria in Zambia. Clin Ther. 1999 May; 21(5):841-52. PMID: 10397379.
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    46. Sukwa TY, Mulenga M, Chisdaka N, Roskell NS, Scott TR. A randomized, double-blind, placebo-controlled field trial to determine the efficacy and safety of Malarone (atovaquone/proguanil) for the prophylaxis of malaria in Zambia. Am J Trop Med Hyg. 1999 Apr; 60(4):521-5. PMID: 10348223.
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