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Dr Emad Ibrahim M. Khater

TitleAssociate Professor
InstitutionAin Shams University
DepartmentDepartment of Entomology, Faculty of Science
AddressCairo
Egypt
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    Collapse Overview 
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    My permanent position is Associate Professor of medical entomology and molecular biology at the Department of Entomology, Faculty of Science, Ain Shams University, Egypt.
    Currently, (December, 2014-March, 2018), I am the Director of the Public Health Pests Laboratory of Jeddah Governorate (PHPL), Saudi Arabia.
    I worked as Assist. Prof. and Vice-Director of the research chair on vectors of diseases, College of Food and agricultural Sciences, King Saud University (KSU), Riyadh, Saudi Arabia (Oct.2008-Dec.2014).

    I have extended and broad professional research, teaching and training experiences (25 years) in basic and modern biology and ecology of major disease vectors for the control of vector-borne diseases. During my university career as undergraduate, postgraduate and active faculty member, I was introduced to various theoretical aspects of biology, ecology and molecular biology and phylogenetics of mosquitoes and other disease vectors. These have been supported by a broad range of practical skills in molecular and cellular biology, light and electron microscopy, functional genomics and bioinformatics and bioethics.

    I obtained my PhD and Diploma of Imperial College London (DIC) from at Imperial College London (1999-2004) (Bob Sinden`s lab). During this period I obtained high-level training in the subject of malaria transmission-blocking strategies and interventions using the rodent malaria model, Plasmodium berghei and the mosquito vector Anopheles stephensi. I have good experience in various basic cellular and molecular biological and functional genomics of malaria parasite and mosquito vectors. Since the start of my PhD study I have excellent opportunities to interact and collaborate with world labs in malaria research, especially the BioMalPar-EviMalaR network of excellence.

    During my work in Saudi Arabia, my main research focus has been on understanding the ecology and phylogenetics and functional genomic of major mosquito vectors of malaria and arboviruses. This has been through a number of nationally-funded research projects, mainly by the National Science, Technology and Innovation Plan (MAARIFAH), KACST and KSU, Saudi Arabia. One of the major projects was the functional genomic analysis of the nutrient sensor, the target-of-rapamycin (TOR) metabolic pathway in the mosquito vector. The research results (in-preparation for re-submission) using RNAi-gene silencing, helped to understand the potential but variable roles of mosquito TOR pathway genes (TOR and S6K) in malaria parasite infectivity to the mosquito vector and regulation of its immune responses to infection and lifespan. This project has been the means to enhance my collaboration with Prof. G. K. Christophides (Imperial College London) as a consultant to the project and Dr Janet Midega (KEMRI and Imperial College London and currently, Oxford University).
    The second is the molecular phylogenetic analysis of Aedes aegypti, the major vector of arboviral diseases, and dengue vector in Saudi Arabia and Yemen, in collaboration with Prof. Jeff Powell, Yale University. The research results provide better understanding of the global diversity of Ae. aegypti and its role in dengue transmission dynamics (one manuscript submitted to Molecular Ecology and two others are in preparation for publication).
    I have long good teaching and research experience with field research and control of mosquitoes and sandflies.

    Through my current responsibilities as director of PHPL, Jeddah, I manage and plan various aspects of research and control of public health pests, the most important of which are Aedes and Culex mosquito vectors of arboviruses (Dengue and RFV) in Saudi Arabia. This is to understand the dynamics of disease transmission in the city and develop effective and new approaches of prevention and control and national early-warning system of disease risk using GIS/RS technology. Work also includes testing the efficacy of various pesticides used in operational control programmes.

    I supervised five MSc theses and advisor to two PhD theses, all of which on the ecology, molecular biology and insecticide resistance in mosquitoes (Culex pipiens complex, Cx. tritaenyorhynchus, An. stephensi and An. arabiensis) and sandflies. Students were from Egypt, Saudi Arabia and Pakistan. This includes good collaboration with experts in the field such as Prof. H. Savage (the CDC, Fort Collins, USA).
    I recently developed some interest in public health issues as shown in the list of publications in collaboration with Dr E. Tambo (Cameroon, Africa DIScoR).

    I trust that all my academic and professional and multi-country expertise will offer me the opportunity to actively participate and serve the vision and goals for develop novel research and control tools to control the transmission of important vector-borne diseases.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tambo E, El Dessouky AG, Khater EIM. Innovative Preventive and Resilience Approaches Against Aedes-linked Vector-borne Arboviral Diseases Threat and Epidemics Burden in Gulf Council Countries. Oman Med J. 2019 Sep; 34(5):391-396. PMID: 31555414.
      View in: PubMed
    2. Tambo E, Madjou G, Khayeka-Wandabwa C, Olalubi OA, Chengho CF, Khater EIM. Ethical, legal and societal considerations on Zika virus epidemics complications in scaling-up prevention and control strategies. Philos Ethics Humanit Med. 2017 08 25; 12(1):3. PMID: 28841899.
      View in: PubMed
    3. Tambo E, Khayeka-Wandabwa C, Olalubi OA, Adedeji AA, Ngogang JY, Khater EI. Addressing knowledge gaps in molecular, sero-surveillance and monitoring approaches on Zika epidemics and other arbovirus co-infections: A structured review. Parasite Epidemiol Control. 2017 May; 2(2):50-60. PMID: 29774281.
      View in: PubMed
    4. Gloria-Soria A, Ayala D, Bheecarry A, Calderon-Arguedas O, Chadee DD, Chiappero M, Coetzee M, Elahee KB, Fernandez-Salas I, Kamal HA, Kamgang B, Khater EI, Kramer LD, Kramer V, Lopez-Solis A, Lutomiah J, Martins A, Micieli MV, Paupy C, Ponlawat A, Rahola N, Rasheed SB, Richardson JB, Saleh AA, Sanchez-Casas RM, Seixas G, Sousa CA, Tabachnick WJ, Troyo A, Powell JR. Global genetic diversity of Aedes aegypti. Mol Ecol. 2016 11; 25(21):5377-5395. PMID: 27671732.
      View in: PubMed
    5. Tambo E, Chen JH, Zhou XN, Khater EI. Outwitting dengue threat and epidemics resurgence in Asia-Pacific countries: strengthening integrated dengue surveillance, monitoring and response systems. Infect Dis Poverty. 2016 May 27; 5(1):56. PMID: 27233238.
      View in: PubMed
    6. Tambo E, Chuisseu PD, Ngogang JY, Khater EI. Deciphering emerging Zika and dengue viral epidemics: Implications for global maternal-child health burden. J Infect Public Health. 2016 May-Jun; 9(3):240-50. PMID: 27052794.
      View in: PubMed
    7. Tambo E, Khater EI, Chen JH, Bergquist R, Zhou XN. Nobel prize for the artemisinin and ivermectin discoveries: a great boost towards elimination of the global infectious diseases of poverty. Infect Dis Poverty. 2015 Dec 28; 4:58. PMID: 26708575.
      View in: PubMed
    8. Khater EI, Sowilem MM, Sallam MF, Alahmed AM. Ecology and habitat characterization of mosquitoes in Saudi Arabia. Trop Biomed. 2013 Sep; 30(3):409-27. PMID: 24189671.
      View in: PubMed
    9. Sowilem MM, Kamal HA, Khater EI. Life table characteristics of Aedes aegypti (Diptera:Culicidae) from Saudi Arabia. Trop Biomed. 2013 Jun; 30(2):301-14. PMID: 23959496.
      View in: PubMed
    10. Kamal HA, Khater EI. Potency and persistence of the bacterial mosquitocide Bacillus sphaericus against culicine mosquitoes under field conditions. J Egypt Soc Parasitol. 2013 Apr; 43(1):115-24. PMID: 23697020.
      View in: PubMed
    11. Abdel-Badei NM, Khater EI, Daba S, Shehata MG. Morphometrics and protein profiles of the salivary glands of Phlebotomus papatasi and Phlebotomus langeroni sand flies. Trans R Soc Trop Med Hyg. 2012 Apr; 106(4):235-42. PMID: 22341687.
      View in: PubMed
    12. Kamal HA, Khater EI. The biological effects of the insect growth regulators; pyriproxyfen and diflubenzuron on the mosquito Aedes aegypti. J Egypt Soc Parasitol. 2010 Dec; 40(3):565-74. PMID: 21268527.
      View in: PubMed
    13. Fallatah SA, Khater EI. Potential of medicinal plants in mosquito control. J Egypt Soc Parasitol. 2010 Apr; 40(1):1-26. PMID: 20503582.
      View in: PubMed
    14. Tremp AZ, Khater EI, Dessens JT. IMC1b is a putative membrane skeleton protein involved in cell shape, mechanical strength, motility, and infectivity of malaria ookinetes. J Biol Chem. 2008 Oct 10; 283(41):27604-11. PMID: 18650444.
      View in: PubMed
    15. Khater EI, Sinden RE, Dessens JT. A malaria membrane skeletal protein is essential for normal morphogenesis, motility, and infectivity of sporozoites. J Cell Biol. 2004 Nov 08; 167(3):425-32. PMID: 15533999.
      View in: PubMed
    16. Dessens JT, Sidén-Kiamos I, Mendoza J, Mahairaki V, Khater E, Vlachou D, Xu XJ, Kafatos FC, Louis C, Dimopoulos G, Sinden RE. SOAP, a novel malaria ookinete protein involved in mosquito midgut invasion and oocyst development. Mol Microbiol. 2003 Jul; 49(2):319-29. PMID: 12828632.
      View in: PubMed
    17. Dessens JT, Mendoza J, Claudianos C, Vinetz JM, Khater E, Hassard S, Ranawaka GR, Sinden RE. Knockout of the rodent malaria parasite chitinase pbCHT1 reduces infectivity to mosquitoes. Infect Immun. 2001 Jun; 69(6):4041-7. PMID: 11349074.
      View in: PubMed
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