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Professor Christine Elizabeth Clayton

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    For an overview of my research please visit my web page.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Clayton CE. Gene expression in Kinetoplastids. Curr Opin Microbiol. 2016 Aug; 32:46-51. PMID: 27177350.
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    2. Antwi EB, Haanstra JR, Ramasamy G, Jensen B, Droll D, Rojas F, Minia I, Terrao M, Mercé C, Matthews K, Myler PJ, Parsons M, Clayton C. Integrative analysis of the Trypanosoma brucei gene expression cascade predicts differential regulation of mRNA processing and unusual control of ribosomal protein expression. BMC Genomics. 2016 Apr 26; 17:306. PMID: 27118143; PMCID: PMC4845500.
    3. Mulindwa J, Mercé C, Matovu E, Enyaru J, Clayton C. Transcriptomes of newly-isolated Trypanosoma brucei rhodesiense reveal hundreds of mRNAs that are co-regulated with stumpy-form markers. BMC Genomics. 2015 Dec 29; 16:1118. PMID: 26715446; PMCID: PMC4696300.
    4. Klein C, Terrao M, Inchaustegui Gil D, Clayton C. Polysomes of Trypanosoma brucei: Association with Initiation Factors and RNA-Binding Proteins. PLoS One. 2015; 10(8):e0135973. PMID: 26287607; PMCID: PMC4545788.
    5. Loureiro I, Faria J, Clayton C, Macedo-Ribeiro S, Santarém N, Roy N, Cordeiro-da-Siva A, Tavares J. Ribose 5-phosphate isomerase B knockdown compromises Trypanosoma brucei bloodstream form infectivity. PLoS Negl Trop Dis. 2015 Jan; 9(1):e3430. PMID: 25568941; PMCID: PMC4287489.
    6. Fadda A, Ryten M, Droll D, Rojas F, Färber V, Haanstra JR, Merce C, Bakker BM, Matthews K, Clayton C. Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels. Mol Microbiol. 2014 Oct; 94(2):307-26. PMID: 25145465; PMCID: PMC4285177.
    7. Begolo D, Erben E, Clayton C. Drug target identification using a trypanosome overexpression library. Antimicrob Agents Chemother. 2014 Oct; 58(10):6260-4. PMID: 25049244; PMCID: PMC4187942.
    8. Clayton CE. Networks of gene expression regulation in Trypanosoma brucei. Mol Biochem Parasitol. 2014 Jul; 195(2):96-106. PMID: 24995711.
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    9. Erben ED, Fadda A, Lueong S, Hoheisel JD, Clayton C. A genome-wide tethering screen reveals novel potential post-transcriptional regulators in Trypanosoma brucei. PLoS Pathog. 2014 Jun; 10(6):e1004178. PMID: 24945722; PMCID: PMC4055773.
    10. Mulindwa J, Fadda A, Merce C, Matovu E, Enyaru J, Clayton C. Methods to determine the transcriptomes of trypanosomes in mixtures with mammalian cells: the effects of parasite purification and selective cDNA amplification. PLoS Negl Trop Dis. 2014 Apr; 8(4):e2806. PMID: 24743343; PMCID: PMC3990519.
    11. Jha BA, Fadda A, Merce C, Mugo E, Droll D, Clayton C. Depletion of the Trypanosome Pumilio domain protein PUF2 or of some other essential proteins causes transcriptome changes related to coding region length. Eukaryot Cell. 2014 May; 13(5):664-74. PMID: 24681684; PMCID: PMC4060476.
    12. Nyambega B, Helbig C, Masiga DK, Clayton C, Levin MJ. Proteins associated with SF3a60 in T. brucei. PLoS One. 2014; 9(3):e91956. PMID: 24651488; PMCID: PMC3961280.
    13. Singh A, Minia I, Droll D, Fadda A, Clayton C, Erben E. Trypanosome MKT1 and the RNA-binding protein ZC3H11: interactions and potential roles in post-transcriptional regulatory networks. Nucleic Acids Res. 2014 Apr; 42(7):4652-68. PMID: 24470144; PMCID: PMC3985637.
    14. Erben E, Chakraborty C, Clayton C. The CAF1-NOT complex of trypanosomes. Front Genet. 2014 Jan 02; 4:299. PMID: 24427169; PMCID: PMC3877767.
    15. Achcar F, Fadda A, Haanstra JR, Kerkhoven EJ, Kim DH, Leroux AE, Papamarkou T, Rojas F, Bakker BM, Barrett MP, Clayton C, Girolami M, Krauth-Siegel RL, Matthews KR, Breitling R. The silicon trypanosome: a test case of iterative model extension in systems biology. Adv Microb Physiol. 2014; 64:115-43. PMID: 24797926; PMCID: PMC4773886.
    16. Loureiro I, Faria J, Clayton C, Ribeiro SM, Roy N, Santarém N, Tavares J, Cordeiro-da-Silva A. Knockdown of asparagine synthetase A renders Trypanosoma brucei auxotrophic to asparagine. PLoS Negl Trop Dis. 2013; 7(12):e2578. PMID: 24340117; PMCID: PMC3854871.
    17. Clayton C. The regulation of trypanosome gene expression by RNA-binding proteins. PLoS Pathog. 2013; 9(11):e1003680. PMID: 24244152; PMCID: PMC3820711.
    18. Jha BA, Archer SK, Clayton CE. The trypanosome Pumilio domain protein PUF5. PLoS One. 2013; 8(10):e77371. PMID: 24167571; PMCID: PMC3805580.
    19. Klein CA, Droll D, Clayton C. SUMOylation in Trypanosoma brucei. PeerJ. 2013; 1:e180. PMID: 24133638; PMCID: PMC3796365.
    20. Fadda A, Färber V, Droll D, Clayton C. The roles of 3'-exoribonucleases and the exosome in trypanosome mRNA degradation. RNA. 2013 Jul; 19(7):937-47. PMID: 23697549; PMCID: PMC3683928.
    21. Droll D, Minia I, Fadda A, Singh A, Stewart M, Queiroz R, Clayton C. Post-transcriptional regulation of the trypanosome heat shock response by a zinc finger protein. PLoS Pathog. 2013; 9(4):e1003286. PMID: 23592996; PMCID: PMC3616968.
    22. Colasante C, Voncken F, Manful T, Ruppert T, Tielens AGM, van Hellemond JJ, Clayton C. Proteins and lipids of glycosomal membranes from Leishmania tarentolae and Trypanosoma brucei. F1000Res. 2013; 2:27. PMID: 24358884; PMCID: PMC3814921.
    23. Färber V, Erben E, Sharma S, Stoecklin G, Clayton C. Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAs. Nucleic Acids Res. 2013 Jan; 41(2):1211-22. PMID: 23221646; PMCID: PMC3553956.
    24. Ouna BA, Nyambega B, Manful T, Helbig C, Males M, Fadda A, Clayton C. Depletion of trypanosome CTR9 leads to gene expression defects. PLoS One. 2012; 7(4):e34256. PMID: 22532828; PMCID: PMC3332058.
    25. Ouna BA, Stewart M, Helbig C, Clayton C. The Trypanosoma brucei CCCH zinc finger proteins ZC3H12 and ZC3H13. Mol Biochem Parasitol. 2012 Jun; 183(2):184-8. PMID: 22366391.
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    26. Wurst M, Seliger B, Jha BA, Klein C, Queiroz R, Clayton C. Expression of the RNA recognition motif protein RBP10 promotes a bloodstream-form transcript pattern in Trypanosoma brucei. Mol Microbiol. 2012 Mar; 83(5):1048-63. PMID: 22296558.
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    27. Manful T, Fadda A, Clayton C. The role of the 5'-3' exoribonuclease XRNA in transcriptome-wide mRNA degradation. RNA. 2011 Nov; 17(11):2039-47. PMID: 21947264; PMCID: PMC3198596.
    28. Delhi P, Queiroz R, Inchaustegui D, Carrington M, Clayton C. Is there a classical nonsense-mediated decay pathway in trypanosomes? PLoS One. 2011; 6(9):e25112. PMID: 21957477; PMCID: PMC3177853.
    29. Archer SK, Inchaustegui D, Queiroz R, Clayton C. The cell cycle regulated transcriptome of Trypanosoma brucei. PLoS One. 2011 Mar 31; 6(3):e18425. PMID: 21483801; PMCID: PMC3069104.
    30. Benz C, Mulindwa J, Ouna B, Clayton C. The Trypanosoma brucei zinc finger protein ZC3H18 is involved in differentiation. Mol Biochem Parasitol. 2011 Jun; 177(2):148-51. PMID: 21354218.
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    31. Clayton C, Estevez A. The exosomes of trypanosomes and other protists. Adv Exp Med Biol. 2011; 702:39-49. PMID: 21713676.
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    32. Haanstra JR, Kerkhoven EJ, van Tuijl A, Blits M, Wurst M, van Nuland R, Albert MA, Michels PA, Bouwman J, Clayton C, Westerhoff HV, Bakker BM. A domino effect in drug action: from metabolic assault towards parasite differentiation. Mol Microbiol. 2011 Jan; 79(1):94-108. PMID: 21166896.
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    33. Clayton C, Michaeli S. 3' processing in protists. Wiley Interdiscip Rev RNA. 2011 Mar-Apr; 2(2):247-55. PMID: 21957009.
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    34. Clayton C. Repetitive elements in parasitic protozoa. BMC Biol. 2010 May 24; 8:64. PMID: 20529240; PMCID: PMC2875222.
    35. Bakker BM, Krauth-Siegel RL, Clayton C, Matthews K, Girolami M, Westerhoff HV, Michels PA, Breitling R, Barrett MP. The silicon trypanosome. Parasitology. 2010 Aug; 137(9):1333-41. PMID: 20444304.
      View in: PubMed
    36. Stewart M, Haile S, Jha BA, Cristodero M, Li CH, Clayton C. Processing of a phosphoglycerate kinase reporter mRNA in Trypanosoma brucei is not coupled to transcription by RNA polymerase II. Mol Biochem Parasitol. 2010 Aug; 172(2):99-106. PMID: 20363263.
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    37. Manful T, Mulindwa J, Frank FM, Clayton CE, Matovu E. A search for Trypanosoma brucei rhodesiense diagnostic antigens by proteomic screening and targeted cloning. PLoS One. 2010 Mar 10; 5(3):e9630. PMID: 20224787; PMCID: PMC2835760.
    38. Droll D, Archer S, Fenn K, Delhi P, Matthews K, Clayton C. The trypanosome Pumilio-domain protein PUF7 associates with a nuclear cyclophilin and is involved in ribosomal RNA maturation. FEBS Lett. 2010 Mar 19; 584(6):1156-62. PMID: 20153321; PMCID: PMC2855960.
    39. Kramer S, Queiroz R, Ellis L, Hoheisel JD, Clayton C, Carrington M. The RNA helicase DHH1 is central to the correct expression of many developmentally regulated mRNAs in trypanosomes. J Cell Sci. 2010 Mar 01; 123(Pt 5):699-711. PMID: 20124414; PMCID: PMC2823576.
    40. Clayton C, Estevez A. The exosomes of trypanosomes and other protists. Adv Exp Med Biol. 2010; 702:39-49. PMID: 21618873.
      View in: PubMed
    41. Benz C, Engstler M, Hillmer S, Clayton C. Depletion of 14-3-3 proteins in bloodstream-form Trypanosoma brucei inhibits variant surface glycoprotein recycling. Int J Parasitol. 2010 Apr; 40(5):629-34. PMID: 19925803.
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    42. Queiroz R, Benz C, Fellenberg K, Hoheisel JD, Clayton C. Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons. BMC Genomics. 2009 Oct 26; 10:495. PMID: 19857263; PMCID: PMC2772864.
    43. Archer SK, Luu VD, de Queiroz RA, Brems S, Clayton C. Trypanosoma brucei PUF9 regulates mRNAs for proteins involved in replicative processes over the cell cycle. PLoS Pathog. 2009 Aug; 5(8):e1000565. PMID: 19714224; PMCID: PMC2727004.
    44. Schwede A, Manful T, Jha BA, Helbig C, Bercovich N, Stewart M, Clayton C. The role of deadenylation in the degradation of unstable mRNAs in trypanosomes. Nucleic Acids Res. 2009 Sep; 37(16):5511-28. PMID: 19596809; PMCID: PMC2760810.
    45. Colasante C, Peña Diaz P, Clayton C, Voncken F. Mitochondrial carrier family inventory of Trypanosoma brucei brucei: Identification, expression and subcellular localisation. Mol Biochem Parasitol. 2009 Oct; 167(2):104-17. PMID: 19463859.
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    46. Bercovich N, Levin MJ, Clayton C, Vazquez MP. Identification of core components of the exon junction complex in trypanosomes. Mol Biochem Parasitol. 2009 Aug; 166(2):190-3. PMID: 19450736.
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    47. Manful T, Cristodero M, Clayton C. DRBD1 is the Trypanosoma brucei homologue of the spliceosome-associated protein 49. Mol Biochem Parasitol. 2009 Aug; 166(2):186-9. PMID: 19450735.
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    48. Wurst M, Robles A, Po J, Luu VD, Brems S, Marentije M, Stoitsova S, Quijada L, Hoheisel J, Stewart M, Hartmann C, Clayton C. An RNAi screen of the RRM-domain proteins of Trypanosoma brucei. Mol Biochem Parasitol. 2009 Jan; 163(1):61-5. PMID: 18840477.
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    49. Kramer S, Queiroz R, Ellis L, Webb H, Hoheisel JD, Clayton C, Carrington M. Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2(alpha) phosphorylation at Thr169. J Cell Sci. 2008 Sep 15; 121(Pt 18):3002-14. PMID: 18713834; PMCID: PMC2871294.
    50. Clayton C, Schwede A, Stewart M, Robles A, Benz C, Po J, Wurst M, Queiroz R, Quieroz R, Archer S. Control of mRNA degradation in trypanosomes. Biochem Soc Trans. 2008 Jun; 36(Pt 3):520-1. PMID: 18481995.
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    51. Schwede A, Ellis L, Luther J, Carrington M, Stoecklin G, Clayton C. A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cells. Nucleic Acids Res. 2008 Jun; 36(10):3374-88. PMID: 18442996; PMCID: PMC2425496.
    52. Cristodero M, Böttcher B, Diepholz M, Scheffzek K, Clayton C. The Leishmania tarentolae exosome: purification and structural analysis by electron microscopy. Mol Biochem Parasitol. 2008 May; 159(1):24-9. PMID: 18279979.
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    53. Archer S, Queiroz R, Stewart M, Clayton C. Trypanosomes as a model to investigate mRNA decay pathways. Methods Enzymol. 2008; 448:359-77. PMID: 19111185.
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    54. Haanstra JR, Stewart M, Luu VD, van Tuijl A, Westerhoff HV, Clayton C, Bakker BM. Control and regulation of gene expression: quantitative analysis of the expression of phosphoglycerate kinase in bloodstream form Trypanosoma brucei. J Biol Chem. 2008 Feb 01; 283(5):2495-507. PMID: 17991737.
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    55. Cristodero M, Clayton CE. Trypanosome MTR4 is involved in rRNA processing. Nucleic Acids Res. 2007; 35(20):7023-30. PMID: 17940093; PMCID: PMC2175323.
    56. Hartmann C, Clayton C. Regulation of a transmembrane protein gene family by the small RNA-binding proteins TbUBP1 and TbUBP2. Mol Biochem Parasitol. 2008 Jan; 157(1):112-5. PMID: 18022708.
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    57. Robles A, Clayton C. Regulation of an amino acid transporter mRNA in Trypanosoma brucei. Mol Biochem Parasitol. 2008 Jan; 157(1):102-6. PMID: 17996963.
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    58. Hartmann C, Benz C, Brems S, Ellis L, Luu VD, Stewart M, D'Orso I, Busold C, Fellenberg K, Frasch AC, Carrington M, Hoheisel J, Clayton CE. Small trypanosome RNA-binding proteins TbUBP1 and TbUBP2 influence expression of F-box protein mRNAs in bloodstream trypanosomes. Eukaryot Cell. 2007 Nov; 6(11):1964-78. PMID: 17873084; PMCID: PMC2168414.
    59. Benz C, Clayton CE. The F-box protein CFB2 is required for cytokinesis of bloodstream-form Trypanosoma brucei. Mol Biochem Parasitol. 2007 Dec; 156(2):217-24. PMID: 17920137.
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    60. Clayton C, Shapira M. Post-transcriptional regulation of gene expression in trypanosomes and leishmanias. Mol Biochem Parasitol. 2007 Dec; 156(2):93-101. PMID: 17765983.
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    61. Colasante C, Robles A, Li CH, Schwede A, Benz C, Voncken F, Guilbride DL, Clayton C. Regulated expression of glycosomal phosphoglycerate kinase in Trypanosoma brucei. Mol Biochem Parasitol. 2007 Feb; 151(2):193-204. PMID: 17187872.
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    62. Haile S, Cristodero M, Clayton C, Estévez AM. The subcellular localisation of trypanosome RRP6 and its association with the exosome. Mol Biochem Parasitol. 2007 Jan; 151(1):52-8. PMID: 17118470.
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    63. Li CH, Irmer H, Gudjonsdottir-Planck D, Freese S, Salm H, Haile S, Estévez AM, Clayton C. Roles of a Trypanosoma brucei 5'->3' exoribonuclease homolog in mRNA degradation. RNA. 2006 Dec; 12(12):2171-86. PMID: 17077271; PMCID: PMC1664730.
    64. Luu VD, Brems S, Hoheisel JD, Burchmore R, Guilbride DL, Clayton C. Functional analysis of Trypanosoma brucei PUF1. Mol Biochem Parasitol. 2006 Dec; 150(2):340-9. PMID: 17052765.
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    65. Colasante C, Alibu VP, Kirchberger S, Tjaden J, Clayton C, Voncken F. Characterization and developmentally regulated localization of the mitochondrial carrier protein homologue MCP6 from Trypanosoma brucei. Eukaryot Cell. 2006 Aug; 5(8):1194-205. PMID: 16896205; PMCID: PMC1539146.
    66. De Gaudenzi J, Frasch AC, Clayton C. RNA-binding domain proteins in Kinetoplastids: a comparative analysis. Eukaryot Cell. 2005 Dec; 4(12):2106-14. PMID: 16339728; PMCID: PMC1317496.
    67. Alibu VP, Richter C, Voncken F, Marti G, Shahi S, Renggli CK, Seebeck T, Brun R, Clayton C. The role of Trypanosoma brucei MRPA in melarsoprol susceptibility. Mol Biochem Parasitol. 2006 Mar; 146(1):38-44. PMID: 16343658.
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    68. Benz C, Nilsson D, Andersson B, Clayton C, Guilbride DL. Messenger RNA processing sites in Trypanosoma brucei. Mol Biochem Parasitol. 2005 Oct; 143(2):125-34. PMID: 15993496.
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    69. Ivens AC, Peacock CS, Worthey EA, Murphy L, Aggarwal G, Berriman M, Sisk E, Rajandream MA, Adlem E, Aert R, Anupama A, Apostolou Z, Attipoe P, Bason N, Bauser C, Beck A, Beverley SM, Bianchettin G, Borzym K, Bothe G, Bruschi CV, Collins M, Cadag E, Ciarloni L, Clayton C, Coulson RM, Cronin A, Cruz AK, Davies RM, De Gaudenzi J, Dobson DE, Duesterhoeft A, Fazelina G, Fosker N, Frasch AC, Fraser A, Fuchs M, Gabel C, Goble A, Goffeau A, Harris D, Hertz-Fowler C, Hilbert H, Horn D, Huang Y, Klages S, Knights A, Kube M, Larke N, Litvin L, Lord A, Louie T, Marra M, Masuy D, Matthews K, Michaeli S, Mottram JC, Müller-Auer S, Munden H, Nelson S, Norbertczak H, Oliver K, O'neil S, Pentony M, Pohl TM, Price C, Purnelle B, Quail MA, Rabbinowitsch E, Reinhardt R, Rieger M, Rinta J, Robben J, Robertson L, Ruiz JC, Rutter S, Saunders D, Schäfer M, Schein J, Schwartz DC, Seeger K, Seyler A, Sharp S, Shin H, Sivam D, Squares R, Squares S, Tosato V, Vogt C, Volckaert G, Wambutt R, Warren T, Wedler H, Woodward J, Zhou S, Zimmermann W, Smith DF, Blackwell JM, Stuart KD, Barrell B, Myler PJ. The genome of the kinetoplastid parasite, Leishmania major. Science. 2005 Jul 15; 309(5733):436-42. PMID: 16020728; PMCID: PMC1470643.
    70. Brems S, Guilbride DL, Gundlesdodjir-Planck D, Busold C, Luu VD, Schanne M, Hoheisel J, Clayton C. The transcriptomes of Trypanosoma brucei Lister 427 and TREU927 bloodstream and procyclic trypomastigotes. Mol Biochem Parasitol. 2005 Feb; 139(2):163-72. PMID: 15664651.
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    71. Schlecker T, Schmidt A, Dirdjaja N, Voncken F, Clayton C, Krauth-Siegel RL. Substrate specificity, localization, and essential role of the glutathione peroxidase-type tryparedoxin peroxidases in Trypanosoma brucei. J Biol Chem. 2005 Apr 15; 280(15):14385-94. PMID: 15664987.
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    72. Alibu VP, Storm L, Haile S, Clayton C, Horn D. A doubly inducible system for RNA interference and rapid RNAi plasmid construction in Trypanosoma brucei. Mol Biochem Parasitol. 2005 Jan; 139(1):75-82. PMID: 15610821.
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    73. Clayton CE, Estévez AM, Hartmann C, Alibu VP, Field M, Horn D. Down-regulating gene expression by RNA interference in Trypanosoma brucei. Methods Mol Biol. 2005; 309:39-60. PMID: 15990397.
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    74. Ding M, Kwok LY, Schlüter D, Clayton C, Soldati D. The antioxidant systems in Toxoplasma gondii and the role of cytosolic catalase in defence against oxidative injury. Mol Microbiol. 2004 Jan; 51(1):47-61. PMID: 14651610.
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    75. Estévez AM, Haile S, Steinbüchel M, Quijada L, Clayton C. Effects of depletion and overexpression of the Trypanosoma brucei ribonuclease L inhibitor homologue. Mol Biochem Parasitol. 2004 Jan; 133(1):137-41. PMID: 14668021.
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    76. Biebinger S, Helfert S, Steverding D, Ansorge I, Clayton C. Impaired dimerization and trafficking of ESAG6 lacking a glycosyl-phosphatidylinositol anchor. Mol Biochem Parasitol. 2003 Dec; 132(2):93-6. PMID: 14599669.
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    77. Haile S, Estevez AM, Clayton C. A role for the exosome in the in vivo degradation of unstable mRNAs. RNA. 2003 Dec; 9(12):1491-501. PMID: 14624005; PMCID: PMC1370503.
    78. Voncken F, van Hellemond JJ, Pfisterer I, Maier A, Hillmer S, Clayton C. Depletion of GIM5 causes cellular fragility, a decreased glycosome number, and reduced levels of ether-linked phospholipids in trypanosomes. J Biol Chem. 2003 Sep 12; 278(37):35299-310. PMID: 12829709.
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    79. Estévez AM, Lehner B, Sanderson CM, Ruppert T, Clayton C. The roles of intersubunit interactions in exosome stability. J Biol Chem. 2003 Sep 12; 278(37):34943-51. PMID: 12821657.
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    80. Mussmann R, Janssen H, Calafat J, Engstler M, Ansorge I, Clayton C, Borst P. The expression level determines the surface distribution of the transferrin receptor in Trypanosoma brucei. Mol Microbiol. 2003 Jan; 47(1):23-35. PMID: 12492851.
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    81. Schmidt A, Clayton CE, Krauth-Siegel RL. Silencing of the thioredoxin gene in Trypanosoma brucei brucei. Mol Biochem Parasitol. 2002 Nov-Dec; 125(1-2):207-10. PMID: 12467989.
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    82. Quijada L, Guerra-Giraldez C, Drozdz M, Hartmann C, Irmer H, Ben-Dov C, Cristodero M, Ding M, Clayton C. Expression of the human RNA-binding protein HuR in Trypanosoma brucei increases the abundance of mRNAs containing AU-rich regulatory elements. Nucleic Acids Res. 2002 Oct 15; 30(20):4414-24. PMID: 12384588; PMCID: PMC137141.
    83. Diehl S, Diehl F, El-Sayed NM, Clayton C, Hoheisel JD. Analysis of stage-specific gene expression in the bloodstream and the procyclic form of Trypanosoma brucei using a genomic DNA-microarray. Mol Biochem Parasitol. 2002 Aug 28; 123(2):115-23. PMID: 12270627.
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    84. Guerra-Giraldez C, Quijada L, Clayton CE. Compartmentation of enzymes in a microbody, the glycosome, is essential in Trypanosoma brucei. J Cell Sci. 2002 Jul 01; 115(Pt 13):2651-8. PMID: 12077356.
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    85. Drozdz M, Quijada L, Clayton CE. RNA interference in trypanosomes transfected with sense and antisense plasmids. Mol Biochem Parasitol. 2002 Apr 30; 121(1):149-52. PMID: 11985872.
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    86. Clayton CE. Life without transcriptional control? From fly to man and back again. EMBO J. 2002 Apr 15; 21(8):1881-8. PMID: 11953307; PMCID: PMC125970.
    87. Drozdz M, Palazzo SS, Salavati R, O'Rear J, Clayton C, Stuart K. TbMP81 is required for RNA editing in Trypanosoma brucei. EMBO J. 2002 Apr 02; 21(7):1791-9. PMID: 11927563; PMCID: PMC125959.
    88. Shahi SK, Krauth-Siegel RL, Clayton CE. Overexpression of the putative thiol conjugate transporter TbMRPA causes melarsoprol resistance in Trypanosoma brucei. Mol Microbiol. 2002 Mar; 43(5):1129-38. PMID: 11918801.
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    89. Stuart K, Panigrahi AK, Schnaufer A, Drozdz M, Clayton C, Salavati R. Composition of the editing complex of Trypanosoma brucei. Philos Trans R Soc Lond B Biol Sci. 2002 Jan 29; 357(1417):71-9. PMID: 11839184; PMCID: PMC1692915.
    90. Irmer H, Clayton C. Degradation of the unstable EP1 mRNA in Trypanosoma brucei involves initial destruction of the 3'-untranslated region. Nucleic Acids Res. 2001 Nov 15; 29(22):4707-15. PMID: 11713321; PMCID: PMC92565.
    91. Estévez AM, Kempf T, Clayton C. The exosome of Trypanosoma brucei. EMBO J. 2001 Jul 16; 20(14):3831-9. PMID: 11447124; PMCID: PMC125547.
    92. Helfert S, Estévez AM, Bakker B, Michels P, Clayton C. Roles of triosephosphate isomerase and aerobic metabolism in Trypanosoma brucei. Biochem J. 2001 Jul 01; 357(Pt 1):117-25. PMID: 11415442; PMCID: PMC1221934.
    93. Maier AG, Webb H, Ding M, Bremser M, Carrington M, Clayton C. The coatomer of Trypanosoma brucei. Mol Biochem Parasitol. 2001 Jun; 115(1):55-61. PMID: 11377739.
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    94. Maier A, Lorenz P, Voncken F, Clayton C. An essential dimeric membrane protein of trypanosome glycosomes. Mol Microbiol. 2001 Mar; 39(6):1443-51. PMID: 11260462.
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    95. van Deursen FJ, Shahi SK, Turner CM, Hartmann C, Guerra-Giraldez C, Matthews KR, Clayton CE. Characterisation of the growth and differentiation in vivo and in vitro-of bloodstream-form Trypanosoma brucei strain TREU 927. Mol Biochem Parasitol. 2001 Feb; 112(2):163-71. PMID: 11223123.
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    96. Maier AG, Schulreich S, Bremser M, Clayton C. Binding of coatomer by the PEX11 C-terminus is not required for function. FEBS Lett. 2000 Nov 03; 484(2):82-6. PMID: 11068037.
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    97. Ding M, Clayton C, Soldati D. Toxoplasma gondii catalase: are there peroxisomes in toxoplasma? J Cell Sci. 2000 Jul; 113 ( Pt 13):2409-19. PMID: 10852820.
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    98. Clayton C. Why do we need standard genetic nomenclature for parasite genes and gene products? Acta Trop. 2000 Feb 25; 75(1):119-22. PMID: 10708013.
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    99. Krieger S, Schwarz W, Ariyanayagam MR, Fairlamb AH, Krauth-Siegel RL, Clayton C. Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress. Mol Microbiol. 2000 Feb; 35(3):542-52. PMID: 10672177.
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    100. Clayton CE, Ha S, Rusché L, Hartmann C, Beverley SM. Tests of heterologous promoters and intergenic regions in Leishmania major. Mol Biochem Parasitol. 2000 Jan 05; 105(1):163-7. PMID: 10613709.
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    101. Drozdz M, Clayton C. Structure of a regulatory 3' untranslated region from Trypanosoma brucei. RNA. 1999 Dec; 5(12):1632-44. PMID: 10606273; PMCID: PMC1369884.
    102. Roditi I, Clayton C. An unambiguous nomenclature for the major surface glycoproteins of the procyclic form of Trypanosoma brucei. Mol Biochem Parasitol. 1999 Sep 20; 103(1):99-100. PMID: 10514084.
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    103. Clayton CE. Genetic manipulation of kinetoplastida. Parasitol Today. 1999 Sep; 15(9):372-8. PMID: 10461166.
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    104. Ansorge I, Steverding D, Melville S, Hartmann C, Clayton C. Transcription of 'inactive' expression sites in African trypanosomes leads to expression of multiple transferrin receptor RNAs in bloodstream forms. Mol Biochem Parasitol. 1999 Jun 25; 101(1-2):81-94. PMID: 10413045.
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    105. Clayton C, Adams M, Almeida R, Baltz T, Barrett M, Bastien P, Belli S, Beverley S, Biteau N, Blackwell J, Blaineau C, Boshart M, Bringaud F, Cross G, Cruz A, Degrave W, Donelson J, El-Sayed N, Fu G, Ersfeld K, Gibson W, Gull K, Ivens A, Kelly J, Vanhamme L, et al. Genetic nomenclature for Trypanosoma and Leishmania. Mol Biochem Parasitol. 1998 Nov 30; 97(1-2):221-4. PMID: 9879900.
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    106. Blattner J, Helfert S, Michels P, Clayton C. Compartmentation of phosphoglycerate kinase in Trypanosoma brucei plays a critical role in parasite energy metabolism. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11596-600. PMID: 9751711; PMCID: PMC21686.
    107. McAndrew M, Graham S, Hartmann C, Clayton C. Testing promoter activity in the trypanosome genome: isolation of a metacyclic-type VSG promoter, and unexpected insights into RNA polymerase II transcription. Exp Parasitol. 1998 Sep; 90(1):65-76. PMID: 9709032.
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    108. Lorenz P, Maier AG, Baumgart E, Erdmann R, Clayton C. Elongation and clustering of glycosomes in Trypanosoma brucei overexpressing the glycosomal Pex11p. EMBO J. 1998 Jul 01; 17(13):3542-55. PMID: 9649425; PMCID: PMC1170691.
    109. Hartmann C, Hotz HR, McAndrew M, Clayton C. Effect of multiple downstream splice sites on polyadenylation in Trypanosoma brucei. Mol Biochem Parasitol. 1998 May 15; 93(1):149-52. PMID: 9662038.
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    110. Hotz HR, Biebinger S, Flaspohler J, Clayton C. PARP gene expression: control at many levels. Mol Biochem Parasitol. 1998 Mar 01; 91(1):131-43. PMID: 9574931.
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    111. Hotz HR, Hartmann C, Huober K, Hug M, Clayton C. Mechanisms of developmental regulation in Trypanosoma brucei: a polypyrimidine tract in the 3'-untranslated region of a surface protein mRNA affects RNA abundance and translation. Nucleic Acids Res. 1997 Aug 01; 25(15):3017-26. PMID: 9224601; PMCID: PMC146859.
    112. Häusler T, Stierhof YD, Blattner J, Clayton C. Conservation of mitochondrial targeting sequence function in mitochondrial and hydrogenosomal proteins from the early-branching eukaryotes Crithidia, Trypanosoma and Trichomonas. Eur J Cell Biol. 1997 Jul; 73(3):240-51. PMID: 9243185.
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    113. Biebinger S, Wirtz LE, Lorenz P, Clayton C. Vectors for inducible expression of toxic gene products in bloodstream and procyclic Trypanosoma brucei. Mol Biochem Parasitol. 1997 Mar; 85(1):99-112. PMID: 9108552.
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    114. Clayton CE, Michels P. Metabolic compartmentation in African trypanosomes. Parasitol Today. 1996 Dec; 12(12):465-71. PMID: 15275265.
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    115. Biebinger S, Clayton C. A plasmid shuttle vector bearing an rRNA promoter is extrachromosomally maintained in Crithidia fasciculata. Exp Parasitol. 1996 Jul; 83(2):252-8. PMID: 8682194.
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    116. Clayton C, Hotz HR. Post-transcriptional control of PARP gene expression. Mol Biochem Parasitol. 1996 Apr; 77(1):1-6. PMID: 8784766.
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    117. Biebinger S, Rettenmaier S, Flaspohler J, Hartmann C, Peña-Diaz J, Wirtz LE, Hotz HR, Barry JD, Clayton C. The PARP promoter of Trypanosoma brucei is developmentally regulated in a chromosomal context. Nucleic Acids Res. 1996 Apr 01; 24(7):1202-11. PMID: 8614620; PMCID: PMC145797.
    118. Häusler T, Stierhof YD, Wirtz E, Clayton C. Import of a DHFR hybrid protein into glycosomes in vivo is not inhibited by the folate-analogue aminopterin. J Cell Biol. 1996 Feb; 132(3):311-24. PMID: 8636210; PMCID: PMC2120713.
    119. Häusler T, Clayton C. Post-transcriptional control of hsp70 mRNA in Trypanosoma brucei. Mol Biochem Parasitol. 1996 Feb-Mar; 76(1-2):57-71. PMID: 8919995.
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    120. Hotz HR, Lorenz P, Fischer R, Krieger S, Clayton C. Role of 3'-untranslated regions in the regulation of hexose transporter mRNAs in Trypanosoma brucei. Mol Biochem Parasitol. 1995 Dec; 75(1):1-14. PMID: 8720170.
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    121. Clayton C, Häusler T, Blattner J. Protein trafficking in kinetoplastid protozoa. Microbiol Rev. 1995 Sep; 59(3):325-44. PMID: 7565409; PMCID: PMC239364.
    122. Blattner J, Clayton CE. The 3'-untranslated regions from the Trypanosoma brucei phosphoglycerate kinase-encoding genes mediate developmental regulation. Gene. 1995 Aug 30; 162(1):153-6. PMID: 7557405.
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    123. Wirtz E, Clayton C. Inducible gene expression in trypanosomes mediated by a prokaryotic repressor. Science. 1995 May 26; 268(5214):1179-83. PMID: 7761835.
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    124. Clayton C. The cell biology of disease. Trends Microbiol. 1995 Feb; 3(2):39-40. PMID: 7728382.
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    125. Hug M, Hotz HR, Hartmann C, Clayton C. Hierarchies of RNA-processing signals in a trypanosome surface antigen mRNA precursor. Mol Cell Biol. 1994 Nov; 14(11):7428-35. PMID: 7935457; PMCID: PMC359278.
    126. Wirtz E, Hartmann C, Clayton C. Gene expression mediated by bacteriophage T3 and T7 RNA polymerases in transgenic trypanosomes. Nucleic Acids Res. 1994 Sep 25; 22(19):3887-94. PMID: 7937108; PMCID: PMC308385.
    127. Janz L, Clayton C. The PARP and rRNA promoters of Trypanosoma brucei are composed of dissimilar sequence elements that are functionally interchangeable. Mol Cell Biol. 1994 Sep; 14(9):5804-11. PMID: 8065315; PMCID: PMC359106.
    128. Janz L, Hug M, Clayton C. Factors that bind to RNA polymerase I promoter sequences of Trypanosoma brucei. Mol Biochem Parasitol. 1994 May; 65(1):99-108. PMID: 7935633.
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    129. Hug M, Carruthers VB, Hartmann C, Sherman DS, Cross GA, Clayton C. A possible role for the 3'-untranslated region in developmental regulation in Trypanosoma brucei. Mol Biochem Parasitol. 1993 Sep; 61(1):87-95. PMID: 8259136.
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    130. Beverley SM, Clayton CE. Transfection of Leishmania and Trypanosoma brucei by electroporation. Methods Mol Biol. 1993; 21:333-48. PMID: 8220725.
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    131. Blattner J, Swinkels B, Dörsam H, Prospero T, Subramani S, Clayton C. Glycosome assembly in trypanosomes: variations in the acceptable degeneracy of a COOH-terminal microbody targeting signal. J Cell Biol. 1992 Dec; 119(5):1129-36. PMID: 1447292; PMCID: PMC2289717.
    132. Clayton C. Developmental regulation of nuclear gene expression in Trypanosoma brucei. Prog Nucleic Acid Res Mol Biol. 1992; 43:37-66. PMID: 1410447.
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    133. Sherman DR, Janz L, Hug M, Clayton C. Anatomy of the parp gene promoter of Trypanosoma brucei. EMBO J. 1991 Nov; 10(11):3379-86. PMID: 1840521; PMCID: PMC453066.
    134. Fung K, Clayton C. Recognition of a peroxisomal tripeptide entry signal by the glycosomes of Trypanosoma brucei. Mol Biochem Parasitol. 1991 Apr; 45(2):261-4. PMID: 2038359.
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    135. Cross GA, Bellofatto V, Clayton CE, Sherman DR. Using transfection to study gene expression in trypanosomes. Biochem Soc Trans. 1990 Oct; 18(5):714-6. PMID: 2128058.
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    136. Zomerdijk JC, Ouellette M, ten Asbroek AL, Kieft R, Bommer AM, Clayton CE, Borst P. The promoter for a variant surface glycoprotein gene expression site in Trypanosoma brucei. EMBO J. 1990 Sep; 9(9):2791-801. PMID: 1697265; PMCID: PMC551989.
    137. Clayton CE, Fueri JP, Itzhaki JE, Bellofatto V, Sherman DR, Wisdom GS, Vijayasarathy S, Mowatt MR. Transcription of the procyclic acidic repetitive protein genes of Trypanosoma brucei. Mol Cell Biol. 1990 Jun; 10(6):3036-47. PMID: 2342468; PMCID: PMC360668.
    138. Vijayasarathy S, Ernest I, Itzhaki JE, Sherman D, Mowatt MR, Michels PA, Clayton CE. The genes encoding fructose bisphosphate aldolase in Trypanosoma brucei are interspersed with unrelated genes. Nucleic Acids Res. 1990 May 25; 18(10):2967-75. PMID: 2349093; PMCID: PMC330826.
    139. Clayton CE, Mowatt MR. The procyclic acidic repetitive proteins of Trypanosoma brucei. Purification and post-translational modification. J Biol Chem. 1989 Sep 05; 264(25):15088-93. PMID: 2475493.
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    140. Mowatt MR, Wisdom GS, Clayton CE. Variation of tandem repeats in the developmentally regulated procyclic acidic repetitive proteins of Trypanosoma brucei. Mol Cell Biol. 1989 Mar; 9(3):1332-5. PMID: 2725502; PMCID: PMC362727.
    141. Clayton CE, Fox JA. Phosphorylation of fructose bisphosphate aldolase in Trypanosoma brucei. Mol Biochem Parasitol. 1989 Feb; 33(1):73-9. PMID: 2710165.
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    142. Mowatt MR, Clayton CE. Polymorphism in the procyclic acidic repetitive protein gene family of Trypanosoma brucei. Mol Cell Biol. 1988 Oct; 8(10):4055-62. PMID: 3185541; PMCID: PMC365474.
    143. Wren BW, Mullany P, Clayton C, Tabaqchali S. Molecular cloning and genetic analysis of a chloramphenicol acetyltransferase determinant from Clostridium difficile. Antimicrob Agents Chemother. 1988 Aug; 32(8):1213-7. PMID: 2847649; PMCID: PMC172379.
    144. Clayton CE. Most proteins, including fructose bisphosphate aldolase, are stable in the procyclic trypomastigote form of Trypanosoma brucei. Mol Biochem Parasitol. 1988 Feb; 28(1):43-6. PMID: 3374524.
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    145. Clayton CE. The molecular biology of the Kinetoplastidae. Genet Eng. 1988; (7):1-56. PMID: 2483088.
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    146. Clayton CE. Import of fructose bisphosphate aldolase into the glycosomes of Trypanosoma brucei. J Cell Biol. 1987 Dec; 105(6 Pt 1):2649-54. PMID: 3320052; PMCID: PMC2114687.
    147. Mowatt MR, Clayton CE. Developmental regulation of a novel repetitive protein of Trypanosoma brucei. Mol Cell Biol. 1987 Aug; 7(8):2838-44. PMID: 3670296; PMCID: PMC367901.
    148. Clayton CE. Structure and regulated expression of genes encoding fructose biphosphate aldolase in Trypanosoma brucei. EMBO J. 1985 Nov; 4(11):2997-3003. PMID: 2998772; PMCID: PMC554610.
    149. Bhasin VK, Clayton C, Trager W, Cross GA. Variations in the organization of repetitive DNA sequences in the genomes of Plasmodium falciparum clones. Mol Biochem Parasitol. 1985 May; 15(2):149-58. PMID: 3892291.
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    150. Zieg J, Clayton CE, Ardeshir F, Giulotto E, Swyryd EA, Stark GR. Properties of single-step mutants of Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate. Mol Cell Biol. 1983 Nov; 3(11):2089-98. PMID: 6656764; PMCID: PMC370075.
    151. Clayton CE, Lovett M, Rigby PW. Functional analysis of a simian virus 40 super T-antigen. J Virol. 1982 Dec; 44(3):974-82. PMID: 6294345; PMCID: PMC256357.
    152. Lovett M, Clayton CE, Murphy D, Rigby PW, Smith AE, Chaudry F. Structure and synthesis of a simian virus 40 super T-antigen. J Virol. 1982 Dec; 44(3):963-73. PMID: 6294344; PMCID: PMC256356.
    153. Clayton CE, Murphy D, Lovett M, Rigby PW. A fragment of the SV40 large T-antigen gene transforms. Nature. 1982 Sep 02; 299(5878):59-61. PMID: 6287280.
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    154. Clayton CE, Rigby PW. Cloning and characterization of the integrated viral DNA from three lines of SV40-transformed mouse cells. Cell. 1981 Aug; 25(2):547-59. PMID: 6269750.
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    155. Rigby PW, Chia W, Clayton CE, Lovett M. The structure and expression of the integrated viral DNA in mouse cells transformed by simian virus 40. Proc R Soc Lond B Biol Sci. 1980 Nov 19; 210(1180):437-50. PMID: 6109304.
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    156. Clayton CE, Selkirk ME, Corsini CA, Ogilvie BM, Askonas BA. Murine trypanosomiasis: cellular proliferation and functional depletion in the blood, peritoneum, and spleen related to changes in bone marrow stem cells. Infect Immun. 1980 Jun; 28(3):824-31. PMID: 7399696; PMCID: PMC551024.
    157. Clayton CE. A culture system for in vitro studies of immunity to Trypanosoma (Herpetosoma) musculi. Trans R Soc Trop Med Hyg. 1980; 74(1):125-6. PMID: 7434406.
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    158. Askonas BA, Corsini AC, Clayton CE, Ogilvie BM. Functional depletion of T- and B-memory cells and other lymphoid cell subpopulations-during trypanosomiasis. Immunology. 1979 Feb; 36(2):313-21. PMID: 155650; PMCID: PMC1457484.
    159. Clayton CE, Ogilvie BM, Askonas BA. Trypanosoma brucei infection in nude mice: B lymphocyte function is suppressed in the absence of T lymphocytes. Parasite Immunol. 1979; 1(1):39-48. PMID: 45125.
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    160. Clayton CE, Sacks DL, Ogilvie BM, Askonas BA. Membrane fractions of trypanosomes mimic the immunosuppressive and mitogenic effects of living parasites on the host. Parasite Immunol. 1979; 1(3):241-9. PMID: 399337.
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    161. Mayor-Withey KS, Clayton CE, Roelants GE, Askonas BA. Trypanosomiasis leads to extensive proliferation of B, T and null cells in spleen and bone marrow. Clin Exp Immunol. 1978 Dec; 34(3):359-63. PMID: 311257; PMCID: PMC1537537.
    162. Clayton CE. Trypanosoma brucei: influence of host strain and parasite antigenic type on infections in mice. Exp Parasitol. 1978 Apr; 44(2):202-8. PMID: 658218.
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