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Professor Alicia Ponte-sucre

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    Alicia Ponte-Sucre was born in Caracas in 1955.
    Licence in Education (Biological Sciences) (1978), Catholic University “Andrés Bello”, Caracas, Venezuela.
    Magister Scientiarum in Biology (Physiology and Biophysics) (1981), Venezuelan Institute of Scientific Research (IVIC).
    Doctor of Sciences (Pharmacology) (1993), Central University of Venezuela (UCV).
    Alexander von Humboldt Foundation fellowship (1999-2000), University of Würzburg (Germany).
    Staff scientist (2003-2007), University of Würzburg, Germany.
    Full Professor (1998-until now) Central University of Venezuela

    Interests:
    The leitmotiv of her research has been to understand fundamental processes involved in essential functions for life homeostasis and preservation. APS main focus in research is the comprehension of the physiological mechanisms responsible for drug susceptibility or resistance in the metabolically flexible parasites Leishmania and Trypanosoma. Her integrated approach to such an important field of research originates from her broad training through areas of study including biochemistry, biophysics, cell biology, physiology and pharmacology in diverse model systems.

    Products: (on request)
    Publications 64
    Participations in seminars and symposiums 92
    Free communications 174
    Editor, “ABC transporters in microorganisms”, Horizon Scientific Press, Norwich, UK (2009)

    Additional issues, last ten years:
    President, Venezuelan Association for German-Venezuelan cultural exchange
    Full Professor in Human Physiology, Faculty of Medicine, UCV, Caracas, Venezuela.
    Coordinator for Scientific Affairs, Faculty of Medicine, UCV, Caracas, Venezuela
    Lecturer, Graduate Courses of Cellular Biology, Pharmacology and Physiological Sciences at the Universidad Central de Venezuela, Caracas, Venezuela.
    Advisor for projects related to the description of antiviral, anti-tumoral and immuno-modulatory activity of extracts from plants of the family Euphorbiaceae, and determination of the active compounds responsible for the biological activity, Medellin, Colombia.
    Coordinator of the central laboratory for the identification and characterization of natural products and compounds designed against specific targets (bacteria, fungi and parasites) as anti-infectious agents, within a multidisciplinary and multi-centric project financed by the German government in the City of Würzburg, Germany.
    Invited lecturer in courses and symposia and visiting Professor at the Institute of Molecular Biology of Infectious Diseases and the Institute Missio, Würzburg, Germany, Institute for Molecular and Cell Biology, Porto, Portugal, University of Antioquia, Medellín, Colombia.
    Member of academic commissions at the Faculty of Medicine, and the Council Research for Sciences and Humanities, UCV, Caracas, Venezuela
    Vice-president of the Directorate of the University Foundation Fundadiagnóstica, UCV, Caracas, Venezuela.
    Coordinator of the Graduate Program in Physiological Sciences, and Chair of Human Physiology, Faculty of Medicine, UCV, Caracas, Venezuela


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Febres A, Vanegas O, Giammarresi M, Gomes C, Díaz E, Ponte-Sucre A. Is the activity of CGRP and Adrenomedullin regulated by RAMP (-2) and (-3) in Trypanosomatidae? An in-silico approach. Infect Genet Evol. 2018 07; 61:197-206. PMID: 29626675.
      View in: PubMed
    2. Diaz E, Zacarias AK, Pérez S, Vanegas O, Köhidai L, Padrón-Nieves M, Ponte-Sucre A. Effect of aliphatic, monocarboxylic, dicarboxylic, heterocyclic and sulphur-containing amino acids on Leishmania spp. chemotaxis. Parasitology. 2015 Nov; 142(13):1621-30. PMID: 26396059.
      View in: PubMed
    3. Cecil A, Ohlsen K, Menzel T, François P, Schrenzel J, Fischer A, Dörries K, Selle M, Lalk M, Hantzschmann J, Dittrich M, Liang C, Bernhardt J, Ölschläger TA, Bringmann G, Bruhn H, Unger M, Ponte-Sucre A, Lehmann L, Dandekar T. Modelling antibiotic and cytotoxic isoquinoline effects in Staphylococcus aureus, Staphylococcus epidermidis and mammalian cells. Int J Med Microbiol. 2015 Jan; 305(1):96-109. PMID: 25500547.
      View in: PubMed
    4. Ponte-Sucre A, Bruhn H, Schirmeister T, Cecil A, Albert CR, Buechold C, Tischer M, Schlesinger S, Goebel T, Fuß A, Mathein D, Merget B, Sotriffer CA, Stich A, Krohne G, Engstler M, Bringmann G, Holzgrabe U. Anti-trypanosomal activities and structural chemical properties of selected compound classes. Parasitol Res. 2015 Feb; 114(2):501-12. PMID: 25416330.
      View in: PubMed
    5. Alcazar W, López AS, Alakurtti S, Tuononen ML, Yli-Kauhaluoma J, Ponte-Sucre A. Betulin derivatives impair Leishmania braziliensis viability and host-parasite interaction. Bioorg Med Chem. 2014 Nov 01; 22(21):6220-6. PMID: 25240731.
      View in: PubMed
    6. Vanaerschot M, Dumetz F, Roy S, Ponte-Sucre A, Arevalo J, Dujardin JC. Treatment failure in leishmaniasis: drug-resistance or another (epi-) phenotype? Expert Rev Anti Infect Ther. 2014 Aug; 12(8):937-46. PMID: 24802998.
      View in: PubMed
    7. Padrón-Nieves M, Machuca C, Díaz E, Cotrim P, Rodriguez N, Ponte-Sucre A. Correlation between glucose uptake and membrane potential in Leishmania parasites isolated from DCL patients with therapeutic failure: a proof of concept. Parasitol Res. 2014 Jun; 113(6):2121-8. PMID: 24671239.
      View in: PubMed
    8. Stich A, Ponte-Sucre A, Holzgrabe U. Do we need new drugs against human African trypanosomiasis? Lancet Infect Dis. 2013 Sep; 13(9):733-4. PMID: 23969207.
      View in: PubMed
    9. Díaz E, Köhidai L, Ríos A, Vanegas O, Silva A, Szabó R, Mezo G, Hudecz F, Ponte-Sucre A. Leishmania braziliensis: cytotoxic, cytostatic and chemotactic effects of poly-lysine-methotrexate-conjugates. Exp Parasitol. 2013 Sep; 135(1):134-41. PMID: 23816643.
      View in: PubMed
    10. Llanes-Coronel DS, Gámez-Díaz LY, Suarez-Quintero LP, Páez LJ, Torres F, Echeverri F, Ponte-Sucre A, Patiño PJ, Trujillo-Vargas CM. New promising Euphorbiaceae extracts with activity in human lymphocytes from primary cell cultures. Immunopharmacol Immunotoxicol. 2011 Jun; 33(2):279-90. PMID: 20670161.
      View in: PubMed
    11. Ponte-Sucre A, Gulder T, Gulder TA, Vollmers G, Bringmann G, Moll H. Alterations to the structure of Leishmania major induced by N-arylisoquinolines correlate with compound accumulation and disposition. J Med Microbiol. 2010 Jan; 59(Pt 1):69-75. PMID: 19745035.
      View in: PubMed
    12. Ponte-Sucre A, Gulder T, Wegehaupt A, Albert C, Rikanovic C, Schaeflein L, Frank A, Schultheis M, Unger M, Holzgrabe U, Bringmann G, Moll H. Structure-activity relationship and studies on the molecular mechanism of leishmanicidal N,C-coupled arylisoquinolinium salts. J Med Chem. 2009 Feb 12; 52(3):626-36. PMID: 19117415.
      View in: PubMed
    13. Goebel T, Ulmer D, Projahn H, Kloeckner J, Heller E, Glaser M, Ponte-Sucre A, Specht S, Sarite SR, Hoerauf A, Kaiser A, Hauber I, Hauber J, Holzgrabe U. In search of novel agents for therapy of tropical diseases and human immunodeficiency virus. J Med Chem. 2008 Jan 24; 51(2):238-50. PMID: 18159921.
      View in: PubMed
    14. Ponte-Sucre A. Availability and applications of ATP-binding cassette (ABC) transporter blockers. Appl Microbiol Biotechnol. 2007 Aug; 76(2):279-86. PMID: 17522856.
      View in: PubMed
    15. Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC. Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro. Antimicrob Agents Chemother. 2007 Jun; 51(6):2164-72. PMID: 17371810.
      View in: PubMed
    16. Natera S, Machuca C, Padrón-Nieves M, Romero A, Díaz E, Ponte-Sucre A. Leishmania spp.: proficiency of drug-resistant parasites. Int J Antimicrob Agents. 2007 Jun; 29(6):637-42. PMID: 17353113.
      View in: PubMed
    17. Muth M, Hoerr V, Glaser M, Ponte-Sucre A, Moll H, Stich A, Holzgrabe U. Antitrypanosomal activity of quaternary naphthalimide derivatives. Bioorg Med Chem Lett. 2007 Mar 15; 17(6):1590-3. PMID: 17239596.
      View in: PubMed
    18. Bringmann G, Kajahn I, Reichert M, Pedersen SE, Faber JH, Gulder T, Brun R, Christensen SB, Ponte-Sucre A, Moll H, Heubl G, Mudogo V. Ancistrocladinium A and B, the first N,C-coupled naphthyldihydroisoquinoline alkaloids, from a Congolese ancistrocladus species. J Org Chem. 2006 Dec 08; 71(25):9348-56. PMID: 17137361.
      View in: PubMed
    19. Ponte-Sucre A, Faber JH, Gulder T, Kajahn I, Pedersen SE, Schultheis M, Bringmann G, Moll H. Activities of naphthylisoquinoline alkaloids and synthetic analogs against Leishmania major. Antimicrob Agents Chemother. 2007 Jan; 51(1):188-94. PMID: 17088484.
      View in: PubMed
    20. Ponte-Sucre A, Vicik R, Schultheis M, Schirmeister T, Moll H. Aziridine-2,3-dicarboxylates, peptidomimetic cysteine protease inhibitors with antileishmanial activity. Antimicrob Agents Chemother. 2006 Jul; 50(7):2439-47. PMID: 16801424.
      View in: PubMed
    21. Machuca C, Rodríguez A, Herrera M, Silva S, Ponte-Sucre A. Leishmania amazonensis: metabolic adaptations induced by resistance to an ABC transporter blocker. Exp Parasitol. 2006 Sep; 114(1):1-9. PMID: 16545807.
      View in: PubMed
    22. Vicik R, Hoerr V, Glaser M, Schultheis M, Hansell E, McKerrow JH, Holzgrabe U, Caffrey CR, Ponte-Sucre A, Moll H, Stich A, Schirmeister T. Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents. Bioorg Med Chem Lett. 2006 May 15; 16(10):2753-7. PMID: 16516467.
      View in: PubMed
    23. Uzcategui NL, Figarella K, Camacho N, Ponte-Sucre A. Substrate preferences and glucose uptake in glibenclamide-resistant Leishmania parasites. Comp Biochem Physiol C Toxicol Pharmacol. 2005 Mar-Apr; 140(3-4):395-402. PMID: 15886061.
      View in: PubMed
    24. Ponte-Sucre A, Moll H. Parasites, flies and men--21st Meeting of the German Society of Parasitology in Würzburg. Eur J Cell Biol. 2005 Jan; 84(1):7-13. PMID: 15724812.
      View in: PubMed
    25. Silva N, Camacho N, Figarella K, Ponte-Sucre A. Cell differentiation and infectivity of Leishmania mexicana are inhibited in a strain resistant to an ABC-transporter blocker. Parasitology. 2004 Jun; 128(Pt 6):629-34. PMID: 15206465.
      View in: PubMed
    26. Ponte-Sucre A, Scharner A, Moll H. [Leishmania major lipophosphoglycan modulates the expression of receptors involved in parasite internalization in skin Langerhans cells]. Acta Cient Venez. 2002; 53(3):218-24. PMID: 12658871.
      View in: PubMed
    27. Ponte-Sucre A, Heise D, Moll H. Leishmania major lipophosphoglycan modulates the phenotype and inhibits migration of murine Langerhans cells. Immunology. 2001 Dec; 104(4):462-7. PMID: 11899433.
      View in: PubMed
    28. Ponte-Sucre A, Figarella K, Moll H. Experimental leishmaniasis: the glibenclamide-triggered decrease in parasite growth correlates with changes in macrophage features. Immunopharmacol Immunotoxicol. 2001 Aug; 23(3):477-86. PMID: 11694036.
      View in: PubMed
    29. Ponte-Sucre A, Mendoza-León A, Moll H. Experimental leishmaniasis: synergistic effect of ion channel blockers and interferon-gamma on the clearance of Leishmania major by macrophages. Parasitol Res. 2001 Jan; 87(1):27-31. PMID: 11199845.
      View in: PubMed
    30. García N, Figarella K, Mendoza-León A, Ponte-Sucre A. Changes in the infectivity, pyruvate kinase activity, acid phosphatase activity and P-glycoprotein expression in glibenclamide-resistant Leishmania mexicana. Parasitol Res. 2000 Nov; 86(11):899-904. PMID: 11097297.
      View in: PubMed
    31. Ponte-Sucre A, Torrealba AT, González E. [Graduate Program on Physiological Sciences of the School of Medicine of the Central University of Venezuela: XXV years of history]. Acta Cient Venez. 1999; 50(4):220-6. PMID: 10974712.
      View in: PubMed
    32. Ponte-Sucre A, Campos Y, Fernandez M, Moll H, Mendoza-León A. Leishmania sp.: growth and survival are impaired by ion channel blockers. Exp Parasitol. 1998 Jan; 88(1):11-9. PMID: 9501844.
      View in: PubMed
    33. Ponte-Sucre A, Campos Y, Vázquez J, Moll H, Mendoza-León A. Sensitivity of Leishmania spp. to glibenclamide and 4-aminopyridine: a tool for the study of drug resistance development. Mem Inst Oswaldo Cruz. 1997 Sep-Oct; 92(5):601-6. PMID: 9566226.
      View in: PubMed
    34. DiFranco M, Villarroel A, Ponte-Sucre A, Quiñonez M, Drujan D, Dagger F. Incorporation of ion channels from the plasma membrane of Leishmania mexicana into planar bilayers. Acta Cient Venez. 1995; 46(3):206-7. PMID: 9334444.
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    35. Ponte-Sucre A, Ramirez JL. Fructose 2,6 bisphosphate promotes the monomer-tetramer conservation of Leishmania mexicana amazonensis pyruvate kinase type two. Biol Res. 1993; 26(1-2):131-4. PMID: 7670525.
      View in: PubMed
    36. Ponte-Sucre A, Alonso G, Martinez C, Hung A, Rivas L, Ramirez JL. Isolation of two pyruvate kinase activities in the parasitic protozoan Leishmania mexicana amazonensis. Arch Biochem Biophys. 1993 Jan; 300(1):466-71. PMID: 8424681.
      View in: PubMed
    37. Ponte-Sucre A. Muscarinic activation of phosphatidylinositol breakdown in neuroblastoma cells. Acta Cient Venez. 1987; 38(3):356-61. PMID: 3505151.
      View in: PubMed
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