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Dr Nancy Gore Saravia

TitleScientific Director
InstitutionCentro Internacional de Entrenamiento e Investigaciones Medicas, CIDEIM
AddressSantiago de Cali
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    Collapse Overview 
    Collapse overview
    My scientific career has largely been devoted to understanding the host-Leishmania relationship in the endemic context, from the natural history of infection and disease in affected human populations to the parasites, host cells and effector molecules involved. This has involved interdisciplinary research that has documented the epidemiologic importance of asymptomatic infection, reactivation of disease, and re-infection in endemic foci and identified populations that are clinically susceptible to chronic and recurrent leishmaniasis.

    Research capacity building has been a constant throughout my research career in tropical infectious disease. I have promoted and taken a multidisciplinary approach to research questions, in the training of Colombian investigators and the institutional development of CIDEIM.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Castro MD, Gomez MA, Kip AE, Cossio A, Ortiz E, Navas A, Dorlo TP, Saravia NG. Pharmacokinetics of Miltefosine in Children and Adults with Cutaneous Leishmaniasis. Antimicrob Agents Chemother. 2017 Mar; 61(3). PMID: 27956421.
      View in: PubMed
    2. Rosales-Chilama M, Gongora RE, Valderrama L, Jojoa J, Alexander N, Rubiano LC, Cossio A, Adams ER, Saravia NG, Gomez MA. Parasitological Confirmation and Analysis of Leishmania Diversity in Asymptomatic and Subclinical Infection following Resolution of Cutaneous Leishmaniasis. PLoS Negl Trop Dis. 2015 Dec; 9(12):e0004273. PMID: 26659114; PMCID: PMC4684356.
    3. Gonzalez-Fajardo L, Fernández OL, McMahon-Pratt D, Saravia NG. Ex vivo host and parasite response to antileishmanial drugs and immunomodulators. PLoS Negl Trop Dis. 2015 May; 9(5):e0003820. PMID: 26024228; PMCID: PMC4449175.
    4. Moreno M, Ferro C, Rosales-Chilama M, Rubiano L, Delgado M, Cossio A, Gómez MA, Ocampo C, Saravia NG. First report of Warileya rotundipennis (Psychodidae: Phlebotominae) naturally infected with Leishmania (Viannia) in a focus of cutaneous leishmaniasis in Colombia. Acta Trop. 2015 Aug; 148:191-6. PMID: 25917717; PMCID: PMC4654406.
    5. Adams ER, Gomez MA, Scheske L, Rios R, Marquez R, Cossio A, Albertini A, Schallig H, Saravia NG. Sensitive diagnosis of cutaneous leishmaniasis by lesion swab sampling coupled to qPCR. Parasitology. 2014 Dec; 141(14):1891-7. PMID: 25111885; PMCID: PMC4654403.
    6. Fernández OL, Diaz-Toro Y, Ovalle C, Valderrama L, Muvdi S, Rodríguez I, Gomez MA, Saravia NG. Miltefosine and antimonial drug susceptibility of Leishmania Viannia species and populations in regions of high transmission in Colombia. PLoS Negl Trop Dis. 2014 May; 8(5):e2871. PMID: 24853871; PMCID: PMC4031164.
    7. Navas A, Vargas DA, Freudzon M, McMahon-Pratt D, Saravia NG, Gómez MA. Chronicity of dermal leishmaniasis caused by Leishmania panamensis is associated with parasite-mediated induction of chemokine gene expression. Infect Immun. 2014 Jul; 82(7):2872-80. PMID: 24752514; PMCID: PMC4097649.
    8. Rodriguez-Pinto D, Saravia NG, McMahon-Pratt D. CD4 T cell activation by B cells in human Leishmania (Viannia) infection. BMC Infect Dis. 2014 Feb 25; 14:108. PMID: 24568275; PMCID: PMC3937821.
    9. Gómez MA, Navas A, Márquez R, Rojas LJ, Vargas DA, Blanco VM, Koren R, Zilberstein D, Saravia NG. Leishmania panamensis infection and antimonial drugs modulate expression of macrophage drug transporters and metabolizing enzymes: impact on intracellular parasite survival. J Antimicrob Chemother. 2014 Jan; 69(1):139-49. PMID: 23975742; PMCID: PMC3861331.
    10. Blanco VM, Cossio A, Martinez JD, Saravia NG. Clinical and epidemiologic profile of cutaneous leishmaniasis in Colombian children: considerations for local treatment. Am J Trop Med Hyg. 2013 Aug; 89(2):359-64. PMID: 23798581; PMCID: PMC3741260.
    11. Zangger H, Ronet C, Desponds C, Kuhlmann FM, Robinson J, Hartley MA, Prevel F, Castiglioni P, Pratlong F, Bastien P, Müller N, Parmentier L, Saravia NG, Beverley SM, Fasel N. Detection of Leishmania RNA virus in Leishmania parasites. PLoS Negl Trop Dis. 2013; 7(1):e2006. PMID: 23326619; PMCID: PMC3542153.
    12. Ramírez C, Díaz-Toro Y, Tellez J, Castilho TM, Rojas R, Ettinger NA, Tikhonova I, Alexander ND, Valderrama L, Hager J, Wilson ME, Lin A, Zhao H, Saravia NG, McMahon-Pratt D. Human macrophage response to L. (Viannia) panamensis: microarray evidence for an early inflammatory response. PLoS Negl Trop Dis. 2012; 6(10):e1866. PMID: 23145196; PMCID: PMC3493378.
    13. Rodriguez-Pinto D, Navas A, Blanco VM, Ramírez L, Garcerant D, Cruz A, Craft N, Saravia NG. Regulatory T cells in the pathogenesis and healing of chronic human dermal leishmaniasis caused by Leishmania (Viannia) species. PLoS Negl Trop Dis. 2012; 6(4):e1627. PMID: 22545172; PMCID: PMC3335885.
    14. Fernández O, Diaz-Toro Y, Valderrama L, Ovalle C, Valderrama M, Castillo H, Perez M, Saravia NG. Novel approach to in vitro drug susceptibility assessment of clinical strains of Leishmania spp. J Clin Microbiol. 2012 Jul; 50(7):2207-11. PMID: 22518860; PMCID: PMC3405580.
    15. Walker J, Gongora R, Vasquez JJ, Drummelsmith J, Burchmore R, Roy G, Ouellette M, Gomez MA, Saravia NG. Discovery of factors linked to antimony resistance in Leishmania panamensis through differential proteome analysis. Mol Biochem Parasitol. 2012 Jun; 183(2):166-76. PMID: 22449941.
      View in: PubMed
    16. Santaella J, Ocampo CB, Saravia NG, Méndez F, Góngora R, Gomez MA, Munstermann LE, Quinnell RJ. Leishmania (Viannia) infection in the domestic dog in Chaparral, Colombia. Am J Trop Med Hyg. 2011 May; 84(5):674-80. PMID: 21540374; PMCID: PMC3083732.
    17. Gallego C, Golenbock D, Gomez MA, Saravia NG. Toll-like receptors participate in macrophage activation and intracellular control of Leishmania (Viannia) panamensis. Infect Immun. 2011 Jul; 79(7):2871-9. PMID: 21518783; PMCID: PMC3191987.
    18. Castilho TM, Goldsmith-Pestana K, Lozano C, Valderrama L, Saravia NG, McMahon-Pratt D. Murine model of chronic L. (Viannia) panamensis infection: role of IL-13 in disease. Eur J Immunol. 2010 Oct; 40(10):2816-29. PMID: 20827674; PMCID: PMC3289133.
    19. Díaz YR, Rojas R, Valderrama L, Saravia NG. T-bet, GATA-3, and Foxp3 expression and Th1/Th2 cytokine production in the clinical outcome of human infection with Leishmania (Viannia) species. J Infect Dis. 2010 Aug 15; 202(3):406-15. PMID: 20583921; PMCID: PMC4850829.
    20. Figueroa RA, Lozano LE, Romero IC, Cardona MT, Prager M, Pacheco R, Diaz YR, Tellez JA, Saravia NG. Detection of Leishmania in unaffected mucosal tissues of patients with cutaneous leishmaniasis caused by Leishmania (Viannia) species. J Infect Dis. 2009 Aug 15; 200(4):638-46. PMID: 19569974.
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    21. Goyeneche-Patino DA, Valderrama L, Walker J, Saravia NG. Antimony resistance and trypanothione in experimentally selected and clinical strains of Leishmania panamensis. Antimicrob Agents Chemother. 2008 Dec; 52(12):4503-6. PMID: 18824610; PMCID: PMC2592887.
    22. Rodríguez-Barraquer I, Góngora R, Prager M, Pacheco R, Montero LM, Navas A, Ferro C, Miranda MC, Saravia NG. Etiologic agent of an epidemic of cutaneous leishmaniasis in Tolima, Colombia. Am J Trop Med Hyg. 2008 Feb; 78(2):276-82. PMID: 18256429.
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    23. Salazar JC, Cruz AR, Pope CD, Valderrama L, Trujillo R, Saravia NG, Radolf JD. Treponema pallidum elicits innate and adaptive cellular immune responses in skin and blood during secondary syphilis: a flow-cytometric analysis. J Infect Dis. 2007 Mar 15; 195(6):879-87. PMID: 17299719; PMCID: PMC2131710.
    24. Cruz A, Rainey PM, Herwaldt BL, Stagni G, Palacios R, Trujillo R, Saravia NG. Pharmacokinetics of antimony in children treated for leishmaniasis with meglumine antimoniate. J Infect Dis. 2007 Feb 15; 195(4):602-8. PMID: 17230422.
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    25. Saravia NG, Nicholls RS. [Leishmaniasis: a public health challenge that demands concerted effort and will (editorial)]. Biomedica. 2006 Oct; 26 Suppl 1:7-9. PMID: 17361835.
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    26. Guarín N, Palma GI, Pirmez C, Valderrama L, Tovar R, Saravia NG. Comparative immunohistological analysis of the Montenegro skin test reaction in asymptomatic infection and in acute and chronic cutaneous leishmaniasis. Biomedica. 2006 Oct; 26 Suppl 1:38-48. PMID: 17361840.
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    27. Acestor N, Masina S, Ives A, Walker J, Saravia NG, Fasel N. Resistance to oxidative stress is associated with metastasis in mucocutaneous leishmaniasis. J Infect Dis. 2006 Oct 15; 194(8):1160-7. PMID: 16991092.
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    28. Vergel C, Palacios R, Cadena H, Posso CJ, Valderrama L, Perez M, Walker J, Travi BL, Saravia NG. Evidence for leishmania (viannia) parasites in the skin and blood of patients before and after treatment. J Infect Dis. 2006 Aug 15; 194(4):503-11. PMID: 16845635.
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    29. Rojas R, Valderrama L, Valderrama M, Varona MX, Ouellette M, Saravia NG. Resistance to antimony and treatment failure in human Leishmania (Viannia) infection. J Infect Dis. 2006 May 15; 193(10):1375-83. PMID: 16619185.
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    30. Romero IC, Saravia NG, Walker J. Selective action of fluoroquinolones against intracellular amastigotes of Leishmania (Viannia) panamensis in vitro. J Parasitol. 2005 Dec; 91(6):1474-9. PMID: 16539034.
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    31. Walker J, Acestor N, Gongora R, Quadroni M, Segura I, Fasel N, Saravia NG. Comparative protein profiling identifies elongation factor-1beta and tryparedoxin peroxidase as factors associated with metastasis in Leishmania guyanensis. Mol Biochem Parasitol. 2006 Feb; 145(2):254-64. PMID: 16325936.
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    32. Saravia NG, Escorcia B, Osorio Y, Valderrama L, Brooks D, Arteaga L, Coombs G, Mottram J, Travi BL. Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models. Vaccine. 2006 May 08; 24(19):4247-59. PMID: 16216395.
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    33. Murray HW, Berman JD, Davies CR, Saravia NG. Advances in leishmaniasis. Lancet. 2005 Oct 29-Nov 4; 366(9496):1561-77. PMID: 16257344.
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    34. El Fadili K, Messier N, Leprohon P, Roy G, Guimond C, Trudel N, Saravia NG, Papadopoulou B, Légaré D, Ouellette M. Role of the ABC transporter MRPA (PGPA) in antimony resistance in Leishmania infantum axenic and intracellular amastigotes. Antimicrob Agents Chemother. 2005 May; 49(5):1988-93. PMID: 15855523; PMCID: PMC1087671.
    35. Vergel C, Walker J, Saravia NG. Amplification of human DNA by primers targeted to Leishmania kinetoplast DNA and post-genome considerations in the detection of parasites by a polymerase chain reaction. Am J Trop Med Hyg. 2005 Apr; 72(4):423-9. PMID: 15827280.
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    36. Saravia NG, Hazbón MH, Osorio Y, Valderrama L, Walker J, Santrich C, Cortázar T, Lebowitz JH, Travi BL. Protective immunogenicity of the paraflagellar rod protein 2 of Leishmania mexicana. Vaccine. 2005 Jan 11; 23(8):984-95. PMID: 15620471.
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    37. Henao HH, Osorio Y, Saravia NG, Gómez A, Travi B. [Efficacy and toxicity of pentavalent antimonials (Glucantime and Pentostam) in an American cutaneous leishmaniasis animal model: luminometry application]. Biomedica. 2004 Dec; 24(4):393-402. PMID: 15678803.
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    38. Walker J, Saravia NG. Inhibition of Leishmania donovani promastigote DNA topoisomerase I and human monocyte DNA topoisomerases I and II by antimonial drugs and classical antitopoisomerase agents. J Parasitol. 2004 Oct; 90(5):1155-62. PMID: 15562618.
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    39. Saravia NG, Miranda JF. Plumbing the brain drain. Bull World Health Organ. 2004 Aug; 82(8):608-15. PMID: 15375451; PMCID: PMC2622935.
    40. Cuervo P, Cupolillo E, Nehme N, Hernandez V, Saravia N, Fernandes O. Leishmania (Viannia): genetic analysis of cutaneous and mucosal strains isolated from the same patient. Exp Parasitol. 2004 Sep-Oct; 108(1-2):59-66. PMID: 15491550.
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    41. Brochu C, Wang J, Roy G, Messier N, Wang XY, Saravia NG, Ouellette M. Antimony uptake systems in the protozoan parasite Leishmania and accumulation differences in antimony-resistant parasites. Antimicrob Agents Chemother. 2003 Oct; 47(10):3073-9. PMID: 14506011; PMCID: PMC201146.
    42. Góngora R, Acestor N, Quadroni M, Fasel N, Saravia NG, Walker J. Mapping the proteome of Leishmania Viannia parasites using two-dimensional polyacrylamide gel electrophoresis and associated technologies. Biomedica. 2003 Jun; 23(2):153-60. PMID: 12872554.
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    43. González IJ, Varela RE, Murillo C, Ferro BE, Salas J, Giraldo LE, Zalis MG, Saravia NG. Polymorphisms in cg2 and pfcrt genes and resistance to chloroquine and other antimalarials in vitro in Plasmodium falciparum isolates from Colombia. Trans R Soc Trop Med Hyg. 2003 May-Jun; 97(3):318-24. PMID: 15228252.
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    44. González IJ, Padilla JO, Giraldo LE, Saravia NG. [Efficacy of amodiaquine and sulfadoxine/pyrimethamine in the treatment of malaria not complicated by Plasmodium falciparum in Nariño, Colombia, 1999-2002]. Biomedica. 2003 Mar; 23(1):38-46. PMID: 12696398.
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    45. Cuervo P, Cupolillo E, Segura I, Saravia N, Fernandes O. Genetic diversity of Colombian sylvatic Trypanosoma cruzi isolates revealed by the ribosomal DNA. Mem Inst Oswaldo Cruz. 2002 Sep; 97(6):877-80. PMID: 12386714.
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    46. Acestor N, Masina S, Walker J, Saravia NG, Fasel N, Quadroni M. Establishing two-dimensional gels for the analysis of Leishmania proteomes. Proteomics. 2002 Jul; 2(7):877-9. PMID: 12124933.
      View in: PubMed
    47. Ferro BE, Gonzalez IJ, Carvajal Fd, Palma GI, Saravia NG. Performance of OptiMAL(R) in the diagnosis of Plasmodium vivax and Plasmodium falciparum infections in a malaria referral center in Colombia. Mem Inst Oswaldo Cruz. 2002 Jul; 97(5):731-5. PMID: 12219143.
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    48. Saravia NG, Weigle K, Navas C, Segura I, Valderrama L, Valencia AZ, Escorcia B, McMahon-Pratt D. Heterogeneity, geographic distribution, and pathogenicity of serodemes of Leishmania viannia in Colombia. Am J Trop Med Hyg. 2002 Jun; 66(6):738-44. PMID: 12224583.
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    49. Travi BL, Osorio Y, Melby PC, Chandrasekar B, Arteaga L, Saravia NG. Gender is a major determinant of the clinical evolution and immune response in hamsters infected with Leishmania spp. Infect Immun. 2002 May; 70(5):2288-96. PMID: 11953362; PMCID: PMC127932.
    50. Pacheco RS, Fernandes O, Salinas G, Segura I, Momen H, Degrave W, Saravia NG, Campbell DA. Intraspecific heterogeneity in the mini-exon gene localization of Leishmania (Viannia) panamensis and Leishmania (Viannia) guyanensis from Colombia. J Parasitol. 2000 Dec; 86(6):1250-3. PMID: 11191900.
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    51. Villegas MV, Labrada LA, Saravia NG. Evaluation of polymerase chain reaction, adenosine deaminase, and interferon-gamma in pleural fluid for the differential diagnosis of pleural tuberculosis. Chest. 2000 Nov; 118(5):1355-64. PMID: 11083686.
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    52. Martínez JE, Valderrama L, Gama V, Leiby DA, Saravia NG. Clonal diversity in the expression and stability of the metastatic capability of Leishmania guyanensis in the golden hamster. J Parasitol. 2000 Aug; 86(4):792-9. PMID: 10958458.
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    53. Bosque F, Saravia NG, Valderrama L, Milon G. Distinct innate and acquired immune responses to Leishmania in putative susceptible and resistant human populations endemically exposed to L. (Viannia) panamensis infection. Scand J Immunol. 2000 May; 51(5):533-41. PMID: 10792848.
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    54. Fernandes O, Catanho MP, Segura I, Labrada LA, Derré R, Saravia N, Degrave W. Minicircle variable region probes for characterization of Leishmania (Viannia) species. J Parasitol. 1999 Jun; 85(3):563-8. PMID: 10386456.
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    55. Robledo SM, Valencia AZ, Saravia NG. Sensitivity to Glucantime of Leishmania viannia isolated from patients prior to treatment. J Parasitol. 1999 Apr; 85(2):360-6. PMID: 10219320.
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    56. Lenis AM, Blank A, Valderrama L, Saravia NG. Relationship between the human T-lymphotropic virus type 1 infection and clinical manifestations of tegumentary leishmaniasis in the Colombian Pacific Coast. Mem Inst Oswaldo Cruz. 1999 Jan-Feb; 94(1):19-20. PMID: 10029908.
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    57. Bosque F, Milon G, Valderrama L, Saravia NG. Permissiveness of human monocytes and monocyte-derived macrophages to infection by promastigotes of Leishmania (Viannia) panamensis. J Parasitol. 1998 Dec; 84(6):1250-6. PMID: 9920322.
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    58. Lucumi A, Robledo S, Gama V, Saravia NG. Sensitivity of Leishmania viannia panamensis to pentavalent antimony is correlated with the formation of cleavable DNA-protein complexes. Antimicrob Agents Chemother. 1998 Aug; 42(8):1990-5. PMID: 9687395; PMCID: PMC105721.
    59. Saravia NG, Segura I, Holguin AF, Santrich C, Valderrama L, Ocampo C. Epidemiologic, genetic, and clinical associations among phenotypically distinct populations of Leishmania (Viannia) in Colombia. Am J Trop Med Hyg. 1998 Jul; 59(1):86-94. PMID: 9684634.
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    60. Giraldo LE, Acosta MC, Labrada LA, Praba A, Montenegro-James S, Saravia NG, Krogstad DJ. Frequency of the Asn-108 and Thr-108 point mutations in the dihydrofolate reductase gene in Plasmodium falciparum from southwest Colombia. Am J Trop Med Hyg. 1998 Jul; 59(1):124-8. PMID: 9684639.
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    61. Zea AH, Ochoa MT, Ghosh P, Longo DL, Alvord WG, Valderrama L, Falabella R, Harvey LK, Saravia N, Moreno LH, Ochoa AC. Changes in expression of signal transduction proteins in T lymphocytes of patients with leprosy. Infect Immun. 1998 Feb; 66(2):499-504. PMID: 9453602; PMCID: PMC107934.
    62. Palma GI, Saravia NG. In situ characterization of the human host response to Leishmania panamensis. Am J Dermatopathol. 1997 Dec; 19(6):585-90. PMID: 9415615.
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    63. Muskus C, Segura I, Oddone R, Turco SJ, Leiby DA, Toro L, Robledo S, Saravia NG. Carbohydrate and LPG expression in Leishmania viannia subgenus. J Parasitol. 1997 Aug; 83(4):671-8. PMID: 9267410.
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    64. Escobar MA, Saravia NG, Weigle KA. Concurrent mucosal leishmaniasis and pulmonary tuberculosis. Clin Infect Dis. 1996 Oct; 23(4):836-7. PMID: 8909860.
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    65. Weigle K, Saravia NG. Natural history, clinical evolution, and the host-parasite interaction in New World cutaneous Leishmaniasis. Clin Dermatol. 1996 Sep-Oct; 14(5):433-50. PMID: 8889321.
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    66. Travi BL, Osorio Y, Saravia NG. The inflammatory response promotes cutaneous metastasis in hamsters infected with Leishmania (Viannia) panamensis. J Parasitol. 1996 Jun; 82(3):454-7. PMID: 8636852.
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    67. Salinas G, Zamora M, Stuart K, Saravia N. Leishmania RNA viruses in Leishmania of the Viannia subgenus. Am J Trop Med Hyg. 1996 Apr; 54(4):425-9. PMID: 8615459.
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    68. Osorio Y, Travi BL, Palma GI, Saravia NG. Infectivity of Trypanosoma rangeli in a promonocytic mammalian cell line. J Parasitol. 1995 Oct; 81(5):687-93. PMID: 7472856.
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    69. Pacheco RS, Martinez JE, Valderrama L, Momen H, Saravia NG. Genotypic polymorphisms in experimental metastatic dermal leishmaniasis. Mol Biochem Parasitol. 1995 Feb; 69(2):197-209. PMID: 7770084.
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    70. Robledo S, Wozencraft A, Valencia AZ, Saravia N. Human monocyte infection by Leishmania (Viannia) panamensis. Role of complement receptors and correlation of susceptibility in vitro with clinical phenotype. J Immunol. 1994 Feb 01; 152(3):1265-76. PMID: 8301130.
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    71. Weigle KA, Santrich C, Martinez F, Valderrama L, Saravia NG. Epidemiology of cutaneous leishmaniasis in Colombia: environmental and behavioral risk factors for infection, clinical manifestations, and pathogenicity. J Infect Dis. 1993 Sep; 168(3):709-14. PMID: 8354913.
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    72. Weigle KA, Santrich C, Martinez F, Valderrama L, Saravia NG. Epidemiology of cutaneous leishmaniasis in Colombia: a longitudinal study of the natural history, prevalence, and incidence of infection and clinical manifestations. J Infect Dis. 1993 Sep; 168(3):699-708. PMID: 8354912.
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    73. O'Neil CE, Labrada M, Saravia NG. Leishmania (Viannia) panamensis-specific IgE and IgA antibodies in relation to expression of human tegumentary leishmaniasis. Am J Trop Med Hyg. 1993 Aug; 49(2):181-8. PMID: 8357080.
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    74. Martinez JE. Haemoculture of Leishmania (Viannia) braziliensis from two cases of mucosal leishmaniasis: re-examination of haematogenous dissemination. Trans R Soc Trop Med Hyg. 1992 Jul-Aug; 86(4):392-4. PMID: 1440813.
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    75. Gonçalves AM, Nehme NS, Saravia N, Segura I, Morel CM. Schizodeme analysis with the restriction endonuclease RSA I differentiates between Trypanosoma rangeli and Trypanosoma cruzi. Mem Inst Oswaldo Cruz. 1991 Oct-Dec; 86(4):477-8. PMID: 1842443.
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    76. Martinez JE, Travi BL, Valencia AZ, Saravia NG. Metastatic capability of Leishmania (Viannia) panamensis and Leishmania (Viannia) guyanensis in golden hamsters. J Parasitol. 1991 Oct; 77(5):762-8. PMID: 1919926.
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    77. Gutierrez Y, Salinas GH, Palma G, Valderrama LB, Santrich CV, Saravia NG. Correlation between histopathology, immune response, clinical presentation, and evolution in Leishmania braziliensis infection. Am J Trop Med Hyg. 1991 Sep; 45(3):281-9. PMID: 1928562.
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    78. Weigle KA, Valderrama L, Arias AL, Santrich C, Saravia NG. Leishmanin skin test standardization and evaluation of safety, dose, storage, longevity of reaction and sensitization. Am J Trop Med Hyg. 1991 Mar; 44(3):260-71. PMID: 2035747.
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    79. Rey JA, Travi BL, Valencia AZ, Saravia NG. Infectivity of the subspecies of the Leishmania braziliensis complex in vivo and in vitro. Am J Trop Med Hyg. 1990 Dec; 43(6):623-31. PMID: 2267967.
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    80. González de Polanía LA, Alzate A, Saravia N. [Experimental behavior of Sporothrix schenckii and Leishmania mexicana in hamsters]. Rev Inst Med Trop Sao Paulo. 1990 Sep-Oct; 32(5):319-24. PMID: 2135471.
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    81. Saravia NG, Weigle K, Segura I, Giannini SH, Pacheco R, Labrada LA, Goncalves A. Recurrent lesions in human Leishmania braziliensis infection--reactivation or reinfection? Lancet. 1990 Aug 18; 336(8712):398-402. PMID: 1974943.
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    82. Santrich C, Segura I, Arias AL, Saravia NG. Mucosal disease caused by Leishmania braziliensis guyanensis. Am J Trop Med Hyg. 1990 Jan; 42(1):51-5. PMID: 2301705.
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    83. Labrada M, Weigle K, Valderrama L, Saravia NG. [Evaluation of immunoglobin isotype specific to Leishmania in tegumentary American leishmaniasis]. Mem Inst Oswaldo Cruz. 1989 Jul-Sep; 84(3):409-16. PMID: 2520833.
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    84. Saravia NG, Valderrama L, Labrada M, Holguín AF, Navas C, Palma G, Weigle KA. The relationship of Leishmania braziliensis subspecies and immune response to disease expression in New World leishmaniasis. J Infect Dis. 1989 Apr; 159(4):725-35. PMID: 2647862.
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    85. Salinas G, Valderrama L, Palma G, Montes G, Saravia NG. [Detection of amastigotes in cutaneous and mucocutaneous leishmaniasis using the immunoperoxidase method, using polyclonal antibody: sensibility and specificity compared with conventional methods of diagnosis]. Mem Inst Oswaldo Cruz. 1989 Jan-Mar; 84(1):53-60. PMID: 2181244.
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    86. Travi B, Rey-Ladino J, Saravia NG. Behavior of Leishmania braziliensis s.l. in golden hamsters: evolution of the infection under different experimental conditions. J Parasitol. 1988 Dec; 74(6):1059-62. PMID: 3193329.
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    87. Reyes MA, de Borrero MF, Roa J, Bergonzoli G, Saravia NG. Measles vaccine failure after documented seroconversion. Pediatr Infect Dis J. 1987 Sep; 6(9):848-51. PMID: 3670952.
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    88. Weigle KA, de Dávalos M, Heredia P, Molineros R, Saravia NG, D'Alessandro A. Diagnosis of cutaneous and mucocutaneous leishmaniasis in Colombia: a comparison of seven methods. Am J Trop Med Hyg. 1987 May; 36(3):489-96. PMID: 2437815.
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    89. Holguín AF, Saravia NG, D'Alessandro A. Lack of enzyme polymorphism in Trypanosoma rangeli stocks from sylvatic and domiciliary transmission cycles in Colombia. Am J Trop Med Hyg. 1987 Jan; 36(1):53-8. PMID: 3812885.
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    90. Saravia NG, Holguín AF, Cibulskis RE, D'Alessandro A. Divergent isoenzyme profiles of sylvatic and domiciliary Trypanosoma cruzi in the eastern plains, piedmont, and highlands of Colombia. Am J Trop Med Hyg. 1987 Jan; 36(1):59-69. PMID: 3544893.
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    91. Weigle KA, Saravia NG, de Dávalos M, Moreno LH, D'Alessandro A. Leishmania braziliensis from the Pacific coast region of Colombia: foci of transmission, clinical spectrum and isoenzyme phenotypes. Am J Trop Med Hyg. 1986 Jul; 35(4):722-31. PMID: 3728793.
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    92. Weigle KA, Valderrama L, Santrich C, Saravia NG. Recurrences of tegumentary leishmaniasis. Lancet. 1985 Sep 07; 2(8454):557-8. PMID: 2863579.
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    93. Saravia NG, Holguín AF, McMahon-Pratt D, D'Alessandro A. Mucocutaneous leishmaniasis in Colombia: Leishmania braziliensis subspecies diversity. Am J Trop Med Hyg. 1985 Jul; 34(4):714-20. PMID: 4025684.
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    94. Saravia NG, Gemmell MA, Nance SL, Anderson NL. Two-dimensional electrophoresis used to differentiate the causal agents of American tegumentary leishmaniasis. Clin Chem. 1984 Dec; 30(12 Pt 1):2048-52. PMID: 6499179.
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    95. D'Alessandro A, Barreto P, Saravia N, Barreto M. Epidemiology of Trypanosoma cruzi in the oriental plains of Colombia. Am J Trop Med Hyg. 1984 Nov; 33(6):1084-95. PMID: 6439062.
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    96. Miranda R, Saravia NG, Ackerman R, Murphy N, Berman S, McMurray DN. Effect of maternal nutritional status on immunological substances in human colostrum and milk. Am J Clin Nutr. 1983 Apr; 37(4):632-40. PMID: 6837495.
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    97. Reyes MA, Saravia NG, Watson RR, McMurray DN. Effect of moderate malnutrition on immediate hypersensitivity and immunoglobulin E levels in asthmatic children. J Allergy Clin Immunol. 1982 Aug; 70(2):94-100. PMID: 6980237.
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    98. Saravia NG, Derryberry S, Robinson JP. The association of serum proteins with peripheral blood cells at low ionic strength: ultrastructural examination. Mol Cell Biochem. 1978 Aug 16; 20(3):167-72. PMID: 309063.
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    99. Saravia N, DeMars RI, Bollum FJ, Bach FH. Phenotypic expression in T-lymphocyte x "fibroblast" cell hybrids. Curr Top Microbiol Immunol. 1978; 81:224-31. PMID: 80307.
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    100. Saravia N, Demars R, Dunlap B, Bach FH. A T-cell marker in mouse fibroblast x T-lymphocyte somatic cell hybrids. Scand J Immunol. 1977; 6(12):1333-7. PMID: 305108.
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