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Professor David Roos

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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Shukla A, Olszewski KL, Llinás M, Rommereim LM, Fox BA, Bzik DJ, Xia D, Wastling J, Beiting D, Roos DS, Shanmugam D. Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondii. Int J Parasitol. 2018 10; 48(12):955-968. PMID: 30176233.
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    2. Basenko EY, Pulman JA, Shanmugasundram A, Harb OS, Crouch K, Starns D, Warrenfeltz S, Aurrecoechea C, Stoeckert CJ, Kissinger JC, Roos DS, Hertz-Fowler C. FungiDB: An Integrated Bioinformatic Resource for Fungi and Oomycetes. J Fungi (Basel). 2018 Mar 20; 4(1). PMID: 30152809.
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    3. Lorenzi H, Khan A, Behnke MS, Namasivayam S, Swapna LS, Hadjithomas M, Karamycheva S, Pinney D, Brunk BP, Ajioka JW, Ajzenberg D, Boothroyd JC, Boyle JP, Dardé ML, Diaz-Miranda MA, Dubey JP, Fritz HM, Gennari SM, Gregory BD, Kim K, Saeij JP, Su C, White MW, Zhu XQ, Howe DK, Rosenthal BM, Grigg ME, Parkinson J, Liu L, Kissinger JC, Roos DS, Sibley LD. Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes. Nat Commun. 2016 Jan 07; 7:10147. PMID: 26738725.
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    4. Carlton JM, Volkman SK, Uplekar S, Hupalo DN, Pereira Alves JM, Cui L, Donnelly M, Roos DS, Harb OS, Acosta M, Read A, Ribolla PEM, Singh OP, Valecha N, Wassmer SC, Ferreira M, Escalante AA. Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research. Am J Trop Med Hyg. 2015 Sep; 93(3 Suppl):87-98. PMID: 26259940.
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    5. Beiting DP, Hidano S, Baggs JE, Geskes JM, Fang Q, Wherry EJ, Hunter CA, Roos DS, Cherry S. The Orphan Nuclear Receptor TLX Is an Enhancer of STAT1-Mediated Transcription and Immunity to Toxoplasma gondii. PLoS Biol. 2015 Jul; 13(7):e1002200. PMID: 26196739.
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    6. Woo YH, Ansari H, Otto TD, Klinger CM, Kolisko M, Michálek J, Saxena A, Shanmugam D, Tayyrov A, Veluchamy A, Ali S, Bernal A, del Campo J, Cihlár J, Flegontov P, Gornik SG, Hajdušková E, Horák A, Janouškovec J, Katris NJ, Mast FD, Miranda-Saavedra D, Mourier T, Naeem R, Nair M, Panigrahi AK, Rawlings ND, Padron-Regalado E, Ramaprasad A, Samad N, Tomcala A, Wilkes J, Neafsey DE, Doerig C, Bowler C, Keeling PJ, Roos DS, Dacks JB, Templeton TJ, Waller RF, Lukeš J, Oborník M, Pain A. Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites. Elife. 2015 Jul 15; 4:e06974. PMID: 26175406.
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    7. Krishna R, Xia D, Sanderson S, Shanmugasundram A, Vermont S, Bernal A, Daniel-Naguib G, Ghali F, Brunk BP, Roos DS, Wastling JM, Jones AR. A large-scale proteogenomics study of apicomplexan pathogens-Toxoplasma gondii and Neospora caninum. Proteomics. 2015 Aug; 15(15):2618-28. PMID: 25867681.
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    8. Harb OS, Roos DS. The Eukaryotic Pathogen Databases: a functional genomic resource integrating data from human and veterinary parasites. Methods Mol Biol. 2015; 1201:1-18. PMID: 25388105.
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    9. Lynch M, Field MC, Goodson HV, Malik HS, Pereira-Leal JB, Roos DS, Turkewitz AP, Sazer S. Evolutionary cell biology: two origins, one objective. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):16990-4. PMID: 25404324.
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    10. Checkley W, White AC, Jaganath D, Arrowood MJ, Chalmers RM, Chen XM, Fayer R, Griffiths JK, Guerrant RL, Hedstrom L, Huston CD, Kotloff KL, Kang G, Mead JR, Miller M, Petri WA, Priest JW, Roos DS, Striepen B, Thompson RC, Ward HD, Van Voorhis WA, Xiao L, Zhu G, Houpt ER. A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium. Lancet Infect Dis. 2015 Jan; 15(1):85-94. PMID: 25278220.
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    11. Novais FO, Carvalho LP, Passos S, Roos DS, Carvalho EM, Scott P, Beiting DP. Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology. J Invest Dermatol. 2015 Jan; 135(1):94-101. PMID: 25036052.
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    12. Dugan VG, Emrich SJ, Giraldo-Calderón GI, Harb OS, Newman RM, Pickett BE, Schriml LM, Stockwell TB, Stoeckert CJ, Sullivan DE, Singh I, Ward DV, Yao A, Zheng J, Barrett T, Birren B, Brinkac L, Bruno VM, Caler E, Chapman S, Collins FH, Cuomo CA, Di Francesco V, Durkin S, Eppinger M, Feldgarden M, Fraser C, Fricke WF, Giovanni M, Henn MR, Hine E, Hotopp JD, Karsch-Mizrachi I, Kissinger JC, Lee EM, Mathur P, Mongodin EF, Murphy CI, Myers G, Neafsey DE, Nelson KE, Nierman WC, Puzak J, Rasko D, Roos DS, Sadzewicz L, Silva JC, Sobral B, Squires RB, Stevens RL, Tallon L, Tettelin H, Wentworth D, White O, Will R, Wortman J, Zhang Y, Scheuermann RH. Standardized metadata for human pathogen/vector genomic sequences. PLoS One. 2014; 9(6):e99979. PMID: 24936976.
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    13. Ouologuem DT, Roos DS. Dynamics of the Toxoplasma gondii inner membrane complex. J Cell Sci. 2014 Aug 01; 127(Pt 15):3320-30. PMID: 24928899.
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    14. Stelekati E, Shin H, Doering TA, Dolfi DV, Ziegler CG, Beiting DP, Dawson L, Liboon J, Wolski D, Ali MA, Katsikis PD, Shen H, Roos DS, Haining WN, Lauer GM, Wherry EJ. Bystander chronic infection negatively impacts development of CD8(+) T cell memory. Immunity. 2014 May 15; 40(5):801-13. PMID: 24837104.
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    15. Beiting DP, Peixoto L, Akopyants NS, Beverley SM, Wherry EJ, Christian DA, Hunter CA, Brodsky IE, Roos DS. Differential induction of TLR3-dependent innate immune signaling by closely related parasite species. PLoS One. 2014; 9(2):e88398. PMID: 24505488.
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    16. Klinger CM, Nisbet RE, Ouologuem DT, Roos DS, Dacks JB. Cryptic organelle homology in apicomplexan parasites: insights from evolutionary cell biology. Curr Opin Microbiol. 2013 Aug; 16(4):424-31. PMID: 23932202.
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    17. Novais FO, Carvalho LP, Graff JW, Beiting DP, Ruthel G, Roos DS, Betts MR, Goldschmidt MH, Wilson ME, de Oliveira CI, Scott P. Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis. PLoS Pathog. 2013; 9(7):e1003504. PMID: 23874205.
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    18. Gregg B, Taylor BC, John B, Tait-Wojno ED, Girgis NM, Miller N, Wagage S, Roos DS, Hunter CA. Replication and distribution of Toxoplasma gondii in the small intestine after oral infection with tissue cysts. Infect Immun. 2013 May; 81(5):1635-43. PMID: 23460516.
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    19. Aurrecoechea C, Barreto A, Brestelli J, Brunk BP, Cade S, Doherty R, Fischer S, Gajria B, Gao X, Gingle A, Grant G, Harb OS, Heiges M, Hu S, Iodice J, Kissinger JC, Kraemer ET, Li W, Pinney DF, Pitts B, Roos DS, Srinivasamoorthy G, Stoeckert CJ, Wang H, Warrenfeltz S. EuPathDB: the eukaryotic pathogen database. Nucleic Acids Res. 2013 Jan; 41(Database issue):D684-91. PMID: 23175615.
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    20. Zerlotini A, Aguiar ER, Yu F, Xu H, Li Y, Young ND, Gasser RB, Protasio AV, Berriman M, Roos DS, Kissinger JC, Oliveira G. SchistoDB: an updated genome resource for the three key schistosomes of humans. Nucleic Acids Res. 2013 Jan; 41(Database issue):D728-31. PMID: 23161692.
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    21. Jakobsen MA, Katzenstein TL, Valerius NH, Roos D, Fisker N, Mogensen TH, Jensen PØ, Barington T. Genetical analysis of all Danish patients diagnosed with chronic granulomatous disease. Scand J Immunol. 2012 Nov; 76(5):505-11. PMID: 22924696.
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    22. Hall AO, Beiting DP, Tato C, John B, Oldenhove G, Lombana CG, Pritchard GH, Silver JS, Bouladoux N, Stumhofer JS, Harris TH, Grainger J, Wojno ED, Wagage S, Roos DS, Scott P, Turka LA, Cherry S, Reiner SL, Cua D, Belkaid Y, Elloso MM, Hunter CA. The cytokines interleukin 27 and interferon-? promote distinct Treg cell populations required to limit infection-induced pathology. Immunity. 2012 Sep 21; 37(3):511-23. PMID: 22981537.
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    23. Ouologuem DT, Djimdé AA, Diallo N, Doumbo OK, Roos DS. Toxoplasma gondii seroprevalence in Mali. J Parasitol. 2013 Apr; 99(2):371-4. PMID: 22924926.
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    24. Reid AJ, Vermont SJ, Cotton JA, Harris D, Hill-Cawthorne GA, Könen-Waisman S, Latham SM, Mourier T, Norton R, Quail MA, Sanders M, Shanmugam D, Sohal A, Wasmuth JD, Brunk B, Grigg ME, Howard JC, Parkinson J, Roos DS, Trees AJ, Berriman M, Pain A, Wastling JM. Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy. PLoS Pathog. 2012; 8(3):e1002567. PMID: 22457617.
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    25. Dessimoz C, Gabaldón T, Roos DS, Sonnhammer EL, Herrero J. Toward community standards in the quest for orthologs. Bioinformatics. 2012 Mar 15; 28(6):900-4. PMID: 22332236.
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    26. Pszenny V, Davis PH, Zhou XW, Hunter CA, Carruthers VB, Roos DS. Targeted disruption of Toxoplasma gondii serine protease inhibitor 1 increases bradyzoite cyst formation in vitro and parasite tissue burden in mice. Infect Immun. 2012 Mar; 80(3):1156-65. PMID: 22202120.
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    27. Imam S, Chen Z, Roos DS, Pohlschröder M. Identification of surprisingly diverse type IV pili, across a broad range of gram-positive bacteria. PLoS One. 2011; 6(12):e28919. PMID: 22216142.
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    28. Magariños MP, Carmona SJ, Crowther GJ, Ralph SA, Roos DS, Shanmugam D, Van Voorhis WC, Agüero F. TDR Targets: a chemogenomics resource for neglected diseases. Nucleic Acids Res. 2012 Jan; 40(Database issue):D1118-27. PMID: 22116064.
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    29. Logan-Klumpler FJ, De Silva N, Boehme U, Rogers MB, Velarde G, McQuillan JA, Carver T, Aslett M, Olsen C, Subramanian S, Phan I, Farris C, Mitra S, Ramasamy G, Wang H, Tivey A, Jackson A, Houston R, Parkhill J, Holden M, Harb OS, Brunk BP, Myler PJ, Roos D, Carrington M, Smith DF, Hertz-Fowler C, Berriman M. GeneDB--an annotation database for pathogens. Nucleic Acids Res. 2012 Jan; 40(Database issue):D98-108. PMID: 22116062.
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    30. Khan A, Miller N, Roos DS, Dubey JP, Ajzenberg D, Dardé ML, Ajioka JW, Rosenthal B, Sibley LD. A monomorphic haplotype of chromosome Ia is associated with widespread success in clonal and nonclonal populations of Toxoplasma gondii. MBio. 2011; 2(6):e00228-11. PMID: 22068979.
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    31. Stajich JE, Harris T, Brunk BP, Brestelli J, Fischer S, Harb OS, Kissinger JC, Li W, Nayak V, Pinney DF, Stoeckert CJ, Roos DS. FungiDB: an integrated functional genomics database for fungi. Nucleic Acids Res. 2012 Jan; 40(Database issue):D675-81. PMID: 22064857.
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    32. Coyne RS, Hannick L, Shanmugam D, Hostetler JB, Brami D, Joardar VS, Johnson J, Radune D, Singh I, Badger JH, Kumar U, Saier M, Wang Y, Cai H, Gu J, Mather MW, Vaidya AB, Wilkes DE, Rajagopalan V, Asai DJ, Pearson CG, Findly RC, Dickerson HW, Wu M, Martens C, Van de Peer Y, Roos DS, Cassidy-Hanley DM, Clark TG. Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control. Genome Biol. 2011 Oct 17; 12(10):R100. PMID: 22004680.
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    33. Fischer S, Brunk BP, Chen F, Gao X, Harb OS, Iodice JB, Shanmugam D, Roos DS, Stoeckert CJ. Using OrthoMCL to assign proteins to OrthoMCL-DB groups or to cluster proteomes into new ortholog groups. Curr Protoc Bioinformatics. 2011 Sep; Chapter 6:Unit 6.12.1-19. PMID: 21901743.
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    34. Fernández Robledo JA, Caler E, Matsuzaki M, Keeling PJ, Shanmugam D, Roos DS, Vasta GR. The search for the missing link: a relic plastid in Perkinsus? Int J Parasitol. 2011 Oct; 41(12):1217-29. PMID: 21889509.
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    35. Gregg B, Dzierszinski F, Tait E, Jordan KA, Hunter CA, Roos DS. Subcellular antigen location influences T-cell activation during acute infection with Toxoplasma gondii. PLoS One. 2011; 6(7):e22936. PMID: 21829561.
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    36. Fischer S, Aurrecoechea C, Brunk BP, Gao X, Harb OS, Kraemer ET, Pennington C, Treatman C, Kissinger JC, Roos DS, Stoeckert CJ. The Strategies WDK: a graphical search interface and web development kit for functional genomics databases. Database (Oxford). 2011; 2011:bar027. PMID: 21705364.
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    37. Baumeister S, Wiesner J, Reichenberg A, Hintz M, Bietz S, Harb OS, Roos DS, Kordes M, Friesen J, Matuschewski K, Lingelbach K, Jomaa H, Seeber F. Fosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathways. PLoS One. 2011 May 04; 6(5):e19334. PMID: 21573242.
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    38. Parsons M, Myler PJ, Berriman M, Roos DS, Stuart KD. Identity crisis? The need for systematic gene IDs. Trends Parasitol. 2011 May; 27(5):183-4. PMID: 21474380.
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    39. Jaffe EK, Shanmugam D, Gardberg A, Dieterich S, Sankaran B, Stewart LJ, Myler PJ, Roos DS. Crystal structure of Toxoplasma gondii porphobilinogen synthase: insights on octameric structure and porphobilinogen formation. J Biol Chem. 2011 Apr 29; 286(17):15298-307. PMID: 21383008.
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    40. Beiting DP, Roos DS. A systems biological view of intracellular pathogens. Immunol Rev. 2011 Mar; 240(1):117-28. PMID: 21349090.
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    41. Roos D. David Roos. Interview by H. Craig Mak. Nat Biotechnol. 2011 Feb; 29(2):141-2. PMID: 21301442.
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    42. Jammallo L, Eidell K, Davis PH, Dufort FJ, Cronin C, Thirugnanam S, Chiles TC, Roos DS, Gubbels MJ. An insertional trap for conditional gene expression in Toxoplasma gondii: identification of TAF250 as an essential gene. Mol Biochem Parasitol. 2011 Feb; 175(2):133-43. PMID: 21035508.
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    43. Bahl A, Davis PH, Behnke M, Dzierszinski F, Jagalur M, Chen F, Shanmugam D, White MW, Kulp D, Roos DS. A novel multifunctional oligonucleotide microarray for Toxoplasma gondii. BMC Genomics. 2010 Oct 25; 11:603. PMID: 20974003.
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    44. Aurrecoechea C, Barreto A, Brestelli J, Brunk BP, Caler EV, Fischer S, Gajria B, Gao X, Gingle A, Grant G, Harb OS, Heiges M, Iodice J, Kissinger JC, Kraemer ET, Li W, Nayak V, Pennington C, Pinney DF, Pitts B, Roos DS, Srinivasamoorthy G, Stoeckert CJ, Treatman C, Wang H. AmoebaDB and MicrosporidiaDB: functional genomic resources for Amoebozoa and Microsporidia species. Nucleic Acids Res. 2011 Jan; 39(Database issue):D612-9. PMID: 20974635.
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    45. Crowther GJ, Shanmugam D, Carmona SJ, Doyle MA, Hertz-Fowler C, Berriman M, Nwaka S, Ralph SA, Roos DS, Van Voorhis WC, Agüero F. Identification of attractive drug targets in neglected-disease pathogens using an in silico approach. PLoS Negl Trop Dis. 2010 Aug 24; 4(8):e804. PMID: 20808766.
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    46. Peixoto L, Chen F, Harb OS, Davis PH, Beiting DP, Brownback CS, Ouloguem D, Roos DS. Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses. Cell Host Microbe. 2010 Aug 19; 8(2):208-18. PMID: 20709297.
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    47. Tait ED, Jordan KA, Dupont CD, Harris TH, Gregg B, Wilson EH, Pepper M, Dzierszinski F, Roos DS, Hunter CA. Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells. J Immunol. 2010 Aug 01; 185(3):1502-12. PMID: 20592284.
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    48. Zhang M, Fennell C, Ranford-Cartwright L, Sakthivel R, Gueirard P, Meister S, Caspi A, Doerig C, Nussenzweig RS, Tuteja R, Sullivan WJ, Roos DS, Fontoura BM, Ménard R, Winzeler EA, Nussenzweig V. The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands. J Exp Med. 2010 Jul 05; 207(7):1465-74. PMID: 20584882.
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    49. Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley PL, Castro S, Angulo-Barturen I, Ferrer S, Rosenthal PJ, Derisi JL, Sullivan DJ, Lazo JS, Roos DS, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM, Guy RK. Chemical genetics of Plasmodium falciparum. Nature. 2010 May 20; 465(7296):311-5. PMID: 20485428.
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    50. Shanmugam D, Wu B, Ramirez U, Jaffe EK, Roos DS. Plastid-associated porphobilinogen synthase from Toxoplasma gondii: kinetic and structural properties validate therapeutic potential. J Biol Chem. 2010 Jul 16; 285(29):22122-31. PMID: 20442414.
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    51. Aurrecoechea C, Brestelli J, Brunk BP, Fischer S, Gajria B, Gao X, Gingle A, Grant G, Harb OS, Heiges M, Innamorato F, Iodice J, Kissinger JC, Kraemer ET, Li W, Miller JA, Nayak V, Pennington C, Pinney DF, Roos DS, Ross C, Srinivasamoorthy G, Stoeckert CJ, Thibodeau R, Treatman C, Wang H. EuPathDB: a portal to eukaryotic pathogen databases. Nucleic Acids Res. 2010 Jan; 38(Database issue):D415-9. PMID: 19914931.
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    52. Aslett M, Aurrecoechea C, Berriman M, Brestelli J, Brunk BP, Carrington M, Depledge DP, Fischer S, Gajria B, Gao X, Gardner MJ, Gingle A, Grant G, Harb OS, Heiges M, Hertz-Fowler C, Houston R, Innamorato F, Iodice J, Kissinger JC, Kraemer E, Li W, Logan FJ, Miller JA, Mitra S, Myler PJ, Nayak V, Pennington C, Phan I, Pinney DF, Ramasamy G, Rogers MB, Roos DS, Ross C, Sivam D, Smith DF, Srinivasamoorthy G, Stoeckert CJ, Subramanian S, Thibodeau R, Tivey A, Treatman C, Velarde G, Wang H. TriTrypDB: a functional genomic resource for the Trypanosomatidae. Nucleic Acids Res. 2010 Jan; 38(Database issue):D457-62. PMID: 19843604.
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    53. Köker MY, Sanal O, van Leeuwen K, de Boer M, Metin A, Patiroglu T, Ozgür TT, Tezcan I, Roos D. Four different NCF2 mutations in six families from Turkey and an overview of NCF2 gene mutations. Eur J Clin Invest. 2009 Oct; 39(10):942-51. PMID: 19624736.
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    54. John B, Harris TH, Tait ED, Wilson EH, Gregg B, Ng LG, Mrass P, Roos DS, Dzierszinski F, Weninger W, Hunter CA. Dynamic Imaging of CD8(+) T cells and dendritic cells during infection with Toxoplasma gondii. PLoS Pathog. 2009 Jul; 5(7):e1000505. PMID: 19578440.
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    55. Jordan KA, Wilson EH, Tait ED, Fox BA, Roos DS, Bzik DJ, Dzierszinski F, Hunter CA. Kinetics and phenotype of vaccine-induced CD8+ T-cell responses to Toxoplasma gondii. Infect Immun. 2009 Sep; 77(9):3894-901. PMID: 19528214.
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    56. Peterson ME, Chen F, Saven JG, Roos DS, Babbitt PC, Sali A. Evolutionary constraints on structural similarity in orthologs and paralogs. Protein Sci. 2009 Jun; 18(6):1306-15. PMID: 19472362.
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    57. Chandramohanadas R, Davis PH, Beiting DP, Harbut MB, Darling C, Velmourougane G, Lee MY, Greer PA, Roos DS, Greenbaum DC. Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells. Science. 2009 May 08; 324(5928):794-7. PMID: 19342550.
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    58. Köker MY, van Leeuwen K, de Boer M, Celmeli F, Metin A, Ozgür TT, Tezcan I, Sanal O, Roos D. Six different CYBA mutations including three novel mutations in ten families from Turkey, resulting in autosomal recessive chronic granulomatous disease. Eur J Clin Invest. 2009 Apr; 39(4):311-9. PMID: 19292887.
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    59. Wilson EH, Harris TH, Mrass P, John B, Tait ED, Wu GF, Pepper M, Wherry EJ, Dzierzinski F, Roos D, Haydon PG, Laufer TM, Weninger W, Hunter CA. Behavior of parasite-specific effector CD8+ T cells in the brain and visualization of a kinesis-associated system of reticular fibers. Immunity. 2009 Feb 20; 30(2):300-11. PMID: 19167248.
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    60. Maeda T, Saito T, Harb OS, Roos DS, Takeo S, Suzuki H, Tsuboi T, Takeuchi T, Asai T. Pyruvate kinase type-II isozyme in Plasmodium falciparum localizes to the apicoplast. Parasitol Int. 2009 Mar; 58(1):101-5. PMID: 19015045.
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    61. Chen Z, Harb OS, Roos DS. In silico identification of specialized secretory-organelle proteins in apicomplexan parasites and in vivo validation in Toxoplasma gondii. PLoS One. 2008; 3(10):e3611. PMID: 18974850.
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    62. Aurrecoechea C, Brestelli J, Brunk BP, Dommer J, Fischer S, Gajria B, Gao X, Gingle A, Grant G, Harb OS, Heiges M, Innamorato F, Iodice J, Kissinger JC, Kraemer E, Li W, Miller JA, Nayak V, Pennington C, Pinney DF, Roos DS, Ross C, Stoeckert CJ, Treatman C, Wang H. PlasmoDB: a functional genomic database for malaria parasites. Nucleic Acids Res. 2009 Jan; 37(Database issue):D539-43. PMID: 18957442.
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    63. Agüero F, Al-Lazikani B, Aslett M, Berriman M, Buckner FS, Campbell RK, Carmona S, Carruthers IM, Chan AW, Chen F, Crowther GJ, Doyle MA, Hertz-Fowler C, Hopkins AL, McAllister G, Nwaka S, Overington JP, Pain A, Paolini GV, Pieper U, Ralph SA, Riechers A, Roos DS, Sali A, Shanmugam D, Suzuki T, Van Voorhis WC, Verlinde CL. Genomic-scale prioritization of drug targets: the TDR Targets database. Nat Rev Drug Discov. 2008 11; 7(11):900-7. PMID: 18927591.
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    64. Liu Q, Crammer K, Pereira FC, Roos DS. Reranking candidate gene models with cross-species comparison for improved gene prediction. BMC Bioinformatics. 2008 Oct 14; 9:433. PMID: 18854050.
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    65. Aurrecoechea C, Brestelli J, Brunk BP, Carlton JM, Dommer J, Fischer S, Gajria B, Gao X, Gingle A, Grant G, Harb OS, Heiges M, Innamorato F, Iodice J, Kissinger JC, Kraemer E, Li W, Miller JA, Morrison HG, Nayak V, Pennington C, Pinney DF, Roos DS, Ross C, Stoeckert CJ, Sullivan S, Treatman C, Wang H. GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis. Nucleic Acids Res. 2009 Jan; 37(Database issue):D526-30. PMID: 18824479.
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    66. Xia D, Sanderson SJ, Jones AR, Prieto JH, Yates JR, Bromley E, Tomley FM, Lal K, Sinden RE, Brunk BP, Roos DS, Wastling JM. The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotation. Genome Biol. 2008; 9(7):R116. PMID: 18644147.
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    67. Pepper M, Dzierszinski F, Wilson E, Tait E, Fang Q, Yarovinsky F, Laufer TM, Roos D, Hunter CA. Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokines. J Immunol. 2008 May 01; 180(9):6229-36. PMID: 18424745.
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    68. Nishi M, Hu K, Murray JM, Roos DS. Organellar dynamics during the cell cycle of Toxoplasma gondii. J Cell Sci. 2008 May 01; 121(Pt 9):1559-68. PMID: 18411248.
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    69. Saito T, Nishi M, Lim MI, Wu B, Maeda T, Hashimoto H, Takeuchi T, Roos DS, Asai T. A novel GDP-dependent pyruvate kinase isozyme from Toxoplasma gondii localizes to both the apicoplast and the mitochondrion. J Biol Chem. 2008 May 16; 283(20):14041-52. PMID: 18326043.
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    70. Liu Q, Mackey AJ, Roos DS, Pereira FC. Evigan: a hidden variable model for integrating gene evidence for eukaryotic gene prediction. Bioinformatics. 2008 Mar 01; 24(5):597-605. PMID: 18187439.
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    71. Gajria B, Bahl A, Brestelli J, Dommer J, Fischer S, Gao X, Heiges M, Iodice J, Kissinger JC, Mackey AJ, Pinney DF, Roos DS, Stoeckert CJ, Wang H, Brunk BP. ToxoDB: an integrated Toxoplasma gondii database resource. Nucleic Acids Res. 2008 Jan; 36(Database issue):D553-6. PMID: 18003657.
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    72. Menard LC, Minns LA, Darche S, Mielcarz DW, Foureau DM, Roos D, Dzierszinski F, Kasper LH, Buzoni-Gatel D. B cells amplify IFN-gamma production by T cells via a TNF-alpha-mediated mechanism. J Immunol. 2007 Oct 01; 179(7):4857-66. PMID: 17878385.
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    73. Dzierszinski F, Pepper M, Stumhofer JS, LaRosa DF, Wilson EH, Turka LA, Halonen SK, Hunter CA, Roos DS. Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells. Infect Immun. 2007 Nov; 75(11):5200-9. PMID: 17846116.
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    74. Deitsch K, Duraisingh M, Dzikowski R, Gunasekera A, Khan S, Le Roch K, Llinás M, Mair G, McGovern V, Roos D, Shock J, Sims J, Wiegand R, Winzeler E. Mechanisms of gene regulation in Plasmodium. Am J Trop Med Hyg. 2007 Aug; 77(2):201-8. PMID: 17690387.
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    75. Chen F, Mackey AJ, Vermunt JK, Roos DS. Assessing performance of orthology detection strategies applied to eukaryotic genomes. PLoS One. 2007 Apr 18; 2(4):e383. PMID: 17440619.
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    76. Greene JM, Collins F, Lefkowitz EJ, Roos D, Scheuermann RH, Sobral B, Stevens R, White O, Di Francesco V. National Institute of Allergy and Infectious Diseases bioinformatics resource centers: new assets for pathogen informatics. Infect Immun. 2007 Jul; 75(7):3212-9. PMID: 17420237.
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    77. Cook T, Roos D, Morada M, Zhu G, Keithly JS, Feagin JE, Wu G, Yarlett N. Divergent polyamine metabolism in the Apicomplexa. Microbiology. 2007 Apr; 153(Pt 4):1123-30. PMID: 17379721.
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    78. Elsik CG, Mackey AJ, Reese JT, Milshina NV, Roos DS, Weinstock GM. Creating a honey bee consensus gene set. Genome Biol. 2007; 8(1):R13. PMID: 17241472.
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    79. Bourjea J, Lapègue S, Gagnevin L, Broderick D, Mortimer JA, Ciccione S, Roos D, Taquet C, Grizel H. Phylogeography of the green turtle, Chelonia mydas, in the Southwest Indian Ocean. Mol Ecol. 2007 Jan; 16(1):175-86. PMID: 17181729.
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    80. Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney GA, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, Mulichak A, Wernimont A, Bray J, Loppnau P, Plotnikova O, Newberry K, Sundararajan E, Houston S, Walker J, Tempel W, Bochkarev A, Kozieradzki I, Edwards A, Arrowsmith C, Roos D, Kain K, Hui R. Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol Biochem Parasitol. 2007 Jan; 151(1):100-10. PMID: 17125854.
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    81. Aurrecoechea C, Heiges M, Wang H, Wang Z, Fischer S, Rhodes P, Miller J, Kraemer E, Stoeckert CJ, Roos DS, Kissinger JC. ApiDB: integrated resources for the apicomplexan bioinformatics resource center. Nucleic Acids Res. 2007 Jan; 35(Database issue):D427-30. PMID: 17098930.
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    82. Stoeckert CJ, Fischer S, Kissinger JC, Heiges M, Aurrecoechea C, Gajria B, Roos DS. PlasmoDB v5: new looks, new genomes. Trends Parasitol. 2006 Dec; 22(12):543-6. PMID: 17029963.
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    83. Tonkin CJ, Roos DS, McFadden GI. N-terminal positively charged amino acids, but not their exact position, are important for apicoplast transit peptide fidelity in Toxoplasma gondii. Mol Biochem Parasitol. 2006 Dec; 150(2):192-200. PMID: 16963133.
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    84. Khan A, Böhme U, Kelly KA, Adlem E, Brooks K, Simmonds M, Mungall K, Quail MA, Arrowsmith C, Chillingworth T, Churcher C, Harris D, Collins M, Fosker N, Fraser A, Hance Z, Jagels K, Moule S, Murphy L, O'Neil S, Rajandream MA, Saunders D, Seeger K, Whitehead S, Mayr T, Xuan X, Watanabe J, Suzuki Y, Wakaguri H, Sugano S, Sugimoto C, Paulsen I, Mackey AJ, Roos DS, Hall N, Berriman M, Barrell B, Sibley LD, Ajioka JW. Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii. Genome Res. 2006 Sep; 16(9):1119-25. PMID: 16902086.
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    85. Chaudhary K, Ting LM, Kim K, Roos DS. Toxoplasma gondii purine nucleoside phosphorylase biochemical characterization, inhibitor profiles, and comparison with the Plasmodium falciparum ortholog. J Biol Chem. 2006 Sep 01; 281(35):25652-8. PMID: 16829527.
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    86. Boyle JP, Rajasekar B, Saeij JPJ, Ajioka JW, Berriman M, Paulsen I, Roos DS, Sibley LD, White MW, Boothroyd JC. Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10514-10519. PMID: 16801557.
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    87. Crawford MJ, Thomsen-Zieger N, Ray M, Schachtner J, Roos DS, Seeber F. Toxoplasma gondii scavenges host-derived lipoic acid despite its de novo synthesis in the apicoplast. EMBO J. 2006 Jul 12; 25(13):3214-22. PMID: 16778769.
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    88. Hu K, Johnson J, Florens L, Fraunholz M, Suravajjala S, DiLullo C, Yates J, Roos DS, Murray JM. Cytoskeletal components of an invasion machine--the apical complex of Toxoplasma gondii. PLoS Pathog. 2006 Feb; 2(2):e13. PMID: 16518471.
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    89. Chen F, Mackey AJ, Stoeckert CJ, Roos DS. OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups. Nucleic Acids Res. 2006 Jan 01; 34(Database issue):D363-8. PMID: 16381887.
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    90. Radke JR, Behnke MS, Mackey AJ, Radke JB, Roos DS, White MW. The transcriptome of Toxoplasma gondii. BMC Biol. 2005 Dec 02; 3:26. PMID: 16324218.
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    91. Hartmann J, Hu K, He CY, Pelletier L, Roos DS, Warren G. Golgi and centrosome cycles in Toxoplasma gondii. Mol Biochem Parasitol. 2006 Jan; 145(1):125-7. PMID: 16266757.
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    92. Chaudhary K, Roos DS. Protozoan genomics for drug discovery. Nat Biotechnol. 2005 Sep; 23(9):1089-91. PMID: 16151400.
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    93. Shapira S, Harb OS, Margarit J, Matrajt M, Han J, Hoffmann A, Freedman B, May MJ, Roos DS, Hunter CA. Initiation and termination of NF-kappaB signaling by the intracellular protozoan parasite Toxoplasma gondii. J Cell Sci. 2005 Aug 01; 118(Pt 15):3501-8. PMID: 16079291.
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    94. Echeverria PC, Matrajt M, Harb OS, Zappia MP, Costas MA, Roos DS, Dubremetz JF, Angel SO. Toxoplasma gondii Hsp90 is a potential drug target whose expression and subcellular localization are developmentally regulated. J Mol Biol. 2005 Jul 22; 350(4):723-34. PMID: 15967463.
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    95. Roos DS. Genetics. Themes and variations in apicomplexan parasite biology. Science. 2005 Jul 01; 309(5731):72-3. PMID: 15994520.
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    96. Khan A, Taylor S, Su C, Mackey AJ, Boyle J, Cole R, Glover D, Tang K, Paulsen IT, Berriman M, Boothroyd JC, Pfefferkorn ER, Dubey JP, Ajioka JW, Roos DS, Wootton JC, Sibley LD. Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondii. Nucleic Acids Res. 2005; 33(9):2980-92. PMID: 15911631.
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    97. Chaudhary K, Donald RG, Nishi M, Carter D, Ullman B, Roos DS. Differential localization of alternatively spliced hypoxanthine-xanthine-guanine phosphoribosyltransferase isoforms in Toxoplasma gondii. J Biol Chem. 2005 Jun 10; 280(23):22053-9. PMID: 15814612.
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    98. Coppel RL, Roos DS, Bozdech Z. The genomics of malaria infection. Trends Parasitol. 2004 Dec; 20(12):553-7. PMID: 15522663.
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    99. Pepper M, Dzierszinski F, Crawford A, Hunter CA, Roos D. Development of a system to study CD4+-T-cell responses to transgenic ovalbumin-expressing Toxoplasma gondii during toxoplasmosis. Infect Immun. 2004 Dec; 72(12):7240-6. PMID: 15557649.
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    100. Berry AE, Gardner MJ, Caspers GJ, Roos DS, Berriman M. Curation of the Plasmodium falciparum genome. Trends Parasitol. 2004 Dec; 20(12):548-52. PMID: 15522662.
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    101. Tongren JE, Zavala F, Roos DS, Riley EM. Malaria vaccines: if at first you don't succeed... Trends Parasitol. 2004 Dec; 20(12):604-10. PMID: 15522671.
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    102. Hu K, Roos DS, Angel SO, Murray JM. Variability and heritability of cell division pathways in Toxoplasma gondii. J Cell Sci. 2004 Nov 01; 117(Pt 23):5697-705. PMID: 15494366.
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    103. Matrajt M, Platt CD, Sagar AD, Lindsay A, Moulton C, Roos DS. Transcript initiation, polyadenylation, and functional promoter mapping for the dihydrofolate reductase-thymidylate synthase gene of Toxoplasma gondii. Mol Biochem Parasitol. 2004 Oct; 137(2):229-38. PMID: 15383293.
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    104. Wang Q, Brown S, Roos DS, Nussenzweig V, Bhanot P. Transcriptome of axenic liver stages of Plasmodium yoelii. Mol Biochem Parasitol. 2004 Sep; 137(1):161-8. PMID: 15279962.
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    105. McKee AS, Dzierszinski F, Boes M, Roos DS, Pearce EJ. Functional inactivation of immature dendritic cells by the intracellular parasite Toxoplasma gondii. J Immunol. 2004 Aug 15; 173(4):2632-40. PMID: 15294980.
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    106. Dzierszinski F, Nishi M, Ouko L, Roos DS. Dynamics of Toxoplasma gondii differentiation. Eukaryot Cell. 2004 Aug; 3(4):992-1003. PMID: 15302832.
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    107. Gunasekera AM, Patankar S, Schug J, Eisen G, Kissinger J, Roos D, Wirth DF. Widespread distribution of antisense transcripts in the Plasmodium falciparum genome. Mol Biochem Parasitol. 2004 Jul; 136(1):35-42. PMID: 15138065.
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    108. Stwora-Wojczyk MM, Dzierszinski F, Roos DS, Spitalnik SL, Wojczyk BS. Functional characterization of a novel Toxoplasma gondii glycosyltransferase: UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T3. Arch Biochem Biophys. 2004 Jun 15; 426(2):231-40. PMID: 15158673.
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    109. Harb OS, Chatterjee B, Fraunholz MJ, Crawford MJ, Nishi M, Roos DS. Multiple functionally redundant signals mediate targeting to the apicoplast in the apicomplexan parasite Toxoplasma gondii. Eukaryot Cell. 2004 Jun; 3(3):663-74. PMID: 15189987.
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    110. Chaudhary K, Darling JA, Fohl LM, Sullivan WJ, Donald RG, Pfefferkorn ER, Ullman B, Roos DS. Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii. J Biol Chem. 2004 Jul 23; 279(30):31221-7. PMID: 15140885.
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    111. Wille U, Nishi M, Lieberman L, Wilson EH, Roos DS, Hunter CA. IL-10 is not required to prevent immune hyperactivity during memory responses to Toxoplasma gondii. Parasite Immunol. 2004 May; 26(5):229-36. PMID: 15491472.
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    112. Ralph SA, van Dooren GG, Waller RF, Crawford MJ, Fraunholz MJ, Foth BJ, Tonkin CJ, Roos DS, McFadden GI. Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast. Nat Rev Microbiol. 2004 Mar; 2(3):203-16. PMID: 15083156.
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    113. Li L, Crabtree J, Fischer S, Pinney D, Stoeckert CJ, Sibley LD, Roos DS. ApiEST-DB: analyzing clustered EST data of the apicomplexan parasites. Nucleic Acids Res. 2004 Jan 01; 32(Database issue):D326-8. PMID: 14681425.
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    114. Fohl LM, Roos DS. Fitness effects of DHFR-TS mutations associated with pyrimethamine resistance in apicomplexan parasites. Mol Microbiol. 2003 Nov; 50(4):1319-27. PMID: 14622418.
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    115. Wojczyk BS, Stwora-Wojczyk MM, Hagen FK, Striepen B, Hang HC, Bertozzi CR, Roos DS, Spitalnik SL. cDNA cloning and expression of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase T1 from Toxoplasma gondii. Mol Biochem Parasitol. 2003 Oct; 131(2):93-107. PMID: 14511808.
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    116. Li L, Stoeckert CJ, Roos DS. OrthoMCL: identification of ortholog groups for eukaryotic genomes. Genome Res. 2003 Sep; 13(9):2178-89. PMID: 12952885.
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    117. Li L, Brunk BP, Kissinger JC, Pape D, Tang K, Cole RH, Martin J, Wylie T, Dante M, Fogarty SJ, Howe DK, Liberator P, Diaz C, Anderson J, White M, Jerome ME, Johnson EA, Radke JA, Stoeckert CJ, Waterston RH, Clifton SW, Roos DS, Sibley LD. Gene discovery in the apicomplexa as revealed by EST sequencing and assembly of a comparative gene database. Genome Res. 2003 Mar; 13(3):443-54. PMID: 12618375.
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    118. Wetzel DM, Håkansson S, Hu K, Roos D, Sibley LD. Actin filament polymerization regulates gliding motility by apicomplexan parasites. Mol Biol Cell. 2003 Feb; 14(2):396-406. PMID: 12589042.
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    119. Foth BJ, Ralph SA, Tonkin CJ, Struck NS, Fraunholz M, Roos DS, Cowman AF, McFadden GI. Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum. Science. 2003 Jan 31; 299(5607):705-8. PMID: 12560551.
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    120. Kissinger JC, Gajria B, Li L, Paulsen IT, Roos DS. ToxoDB: accessing the Toxoplasma gondii genome. Nucleic Acids Res. 2003 Jan 01; 31(1):234-6. PMID: 12519989.
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    121. Fraunholz MJ, Roos DS. PlasmoDB: exploring genomics and post-genomics data of the malaria parasite, Plasmodium falciparum. Redox Rep. 2003; 8(5):317-20. PMID: 14962373.
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    122. Bahl A, Brunk B, Crabtree J, Fraunholz MJ, Gajria B, Grant GR, Ginsburg H, Gupta D, Kissinger JC, Labo P, Li L, Mailman MD, Milgram AJ, Pearson DS, Roos DS, Schug J, Stoeckert CJ, Whetzel P. PlasmoDB: the Plasmodium genome resource. A database integrating experimental and computational data. Nucleic Acids Res. 2003 Jan 01; 31(1):212-5. PMID: 12519984.
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    123. Drozdowicz YM, Shaw M, Nishi M, Striepen B, Liwinski HA, Roos DS, Rea PA. Isolation and characterization of TgVP1, a type I vacuolar H+-translocating pyrophosphatase from Toxoplasma gondii. The dynamics of its subcellular localization and the cellular effects of a diphosphonate inhibitor. J Biol Chem. 2003 Jan 10; 278(2):1075-85. PMID: 12411435.
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    124. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 03; 419(6906):498-511. PMID: 12368864.
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    125. Kissinger JC, Brunk BP, Crabtree J, Fraunholz MJ, Gajria B, Milgram AJ, Pearson DS, Schug J, Bahl A, Diskin SJ, Ginsburg H, Grant GR, Gupta D, Labo P, Li L, Mailman MD, McWeeney SK, Whetzel P, Stoeckert CJ, Roos DS. The Plasmodium genome database. Nature. 2002 Oct 03; 419(6906):490-2. PMID: 12368860.
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    126. van der Geld YM, Tool AT, Videler J, de Haas M, Tervaert JW, Stegeman CA, Limburg PC, Kallenberg CG, Roos D. Interference of PR3-ANCA with the enzymatic activity of PR3: differences in patients during active disease or remission of Wegener's granulomatosis. Clin Exp Immunol. 2002 Sep; 129(3):562-70. PMID: 12197900.
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    127. Pelletier L, Stern CA, Pypaert M, Sheff D, Ngô HM, Roper N, He CY, Hu K, Toomre D, Coppens I, Roos DS, Joiner KA, Warren G. Golgi biogenesis in Toxoplasma gondii. Nature. 2002 Aug 01; 418(6897):548-52. PMID: 12152082.
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    128. Joiner KA, Roos DS. Secretory traffic in the eukaryotic parasite Toxoplasma gondii: less is more. J Cell Biol. 2002 May 13; 157(4):557-63. PMID: 12011107.
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    129. Matrajt M, Donald RG, Singh U, Roos DS. Identification and characterization of differentiation mutants in the protozoan parasite Toxoplasma gondii. Mol Microbiol. 2002 May; 44(3):735-47. PMID: 11994154.
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    130. Matrajt M, Nishi M, Fraunholz MJ, Peter O, Roos DS. Amino-terminal control of transgenic protein expression levels in Toxoplasma gondii. Mol Biochem Parasitol. 2002 Apr 09; 120(2):285-9. PMID: 11897133.
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    131. Hu K, Roos DS, Murray JM. A novel polymer of tubulin forms the conoid of Toxoplasma gondii. J Cell Biol. 2002 Mar 18; 156(6):1039-50. PMID: 11901169.
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    132. Swedlow JR, Hu K, Andrews PD, Roos DS, Murray JM. Measuring tubulin content in Toxoplasma gondii: a comparison of laser-scanning confocal and wide-field fluorescence microscopy. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2014-9. PMID: 11830634.
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    133. Hu K, Mann T, Striepen B, Beckers CJ, Roos DS, Murray JM. Daughter cell assembly in the protozoan parasite Toxoplasma gondii. Mol Biol Cell. 2002 Feb; 13(2):593-606. PMID: 11854415.
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    134. Shaw MK, Roos DS, Tilney LG. Cysteine and serine protease inhibitors block intracellular development and disrupt the secretory pathway of Toxoplasma gondii. Microbes Infect. 2002 Feb; 4(2):119-32. PMID: 11880042.
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    135. Roos DS, Crawford MJ, Donald RG, Fraunholz M, Harb OS, He CY, Kissinger JC, Shaw MK, Striepen B. Mining the Plasmodium genome database to define organellar function: what does the apicoplast do? Philos Trans R Soc Lond B Biol Sci. 2002 Jan 29; 357(1417):35-46. PMID: 11839180.
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    136. Bahl A, Brunk B, Coppel RL, Crabtree J, Diskin SJ, Fraunholz MJ, Grant GR, Gupta D, Huestis RL, Kissinger JC, Labo P, Li L, McWeeney SK, Milgram AJ, Roos DS, Schug J, Stoeckert CJ. PlasmoDB: the Plasmodium genome resource. An integrated database providing tools for accessing, analyzing and mapping expression and sequence data (both finished and unfinished). Nucleic Acids Res. 2002 Jan 01; 30(1):87-90. PMID: 11752262.
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    137. Dekker J, de Boer M, Roos D. Gene-scan method for the recognition of carriers and patients with p47(phox)-deficient autosomal recessive chronic granulomatous disease. Exp Hematol. 2001 Nov; 29(11):1319-25. PMID: 11698128.
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    138. Radke JR, Striepen B, Guerini MN, Jerome ME, Roos DS, White MW. Defining the cell cycle for the tachyzoite stage of Toxoplasma gondii. Mol Biochem Parasitol. 2001 Jul; 115(2):165-75. PMID: 11420103.
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    139. Middelhoven PJ, Van Buul JD, Hordijk PL, Roos D. Different proteolytic mechanisms involved in Fc gamma RIIIb shedding from human neutrophils. Clin Exp Immunol. 2001 Jul; 125(1):169-75. PMID: 11472441.
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    140. Wille U, Villegas EN, Striepen B, Roos DS, Hunter CA. Interleukin-10 does not contribute to the pathogenesis of a virulent strain of Toxoplasma gondii. Parasite Immunol. 2001 Jun; 23(6):291-6. PMID: 11412381.
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    141. He CY, Striepen B, Pletcher CH, Murray JM, Roos DS. Targeting and processing of nuclear-encoded apicoplast proteins in plastid segregation mutants of Toxoplasma gondii. J Biol Chem. 2001 Jul 27; 276(30):28436-42. PMID: 11319231.
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    142. Akopyants NS, Clifton SW, Martin J, Pape D, Wylie T, Li L, Kissinger JC, Roos DS, Beverley SM. A survey of the Leishmania major Friedlin strain V1 genome by shotgun sequencing: a resource for DNA microarrays and expression profiling. Mol Biochem Parasitol. 2001 Apr 06; 113(2):337-40. PMID: 11295190.
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    143. Shaw MK, Roos DS, Tilney LG. DNA replication and daughter cell budding are not tightly linked in the protozoan parasite Toxoplasma gondii. Microbes Infect. 2001 Apr; 3(5):351-62. PMID: 11369271.
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    144. Reynolds MG, Oh J, Roos DS. In vitro generation of novel pyrimethamine resistance mutations in the Toxoplasma gondii dihydrofolate reductase. Antimicrob Agents Chemother. 2001 Apr; 45(4):1271-7. PMID: 11257045.
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    145. Fast NM, Kissinger JC, Roos DS, Keeling PJ. Nuclear-encoded, plastid-targeted genes suggest a single common origin for apicomplexan and dinoflagellate plastids. Mol Biol Evol. 2001 Mar; 18(3):418-26. PMID: 11230543.
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    146. Striepen B, Soldati D, Garcia-Reguet N, Dubremetz JF, Roos DS. Targeting of soluble proteins to the rhoptries and micronemes in Toxoplasma gondii. Mol Biochem Parasitol. 2001 Mar; 113(1):45-53. PMID: 11254953.
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    147. Zuurbier AE, Liu L, Mul FP, Verhoeven AJ, Knol EF, Roos D. Neutrophils enhance eosinophil migration across monolayers of lung epithelial cells. Clin Exp Allergy. 2001 Mar; 31(3):444-52. PMID: 11260157.
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    148. Roos DS. Computational biology. Bioinformatics--trying to swim in a sea of data. Science. 2001 Feb 16; 291(5507):1260-1. PMID: 11233452.
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    149. Dekker J, Eppink MH, van Zwieten R, de Rijk T, Remacha AF, Law LK, Li AM, Cheung KL, van Berkel WJ, Roos D. Seven new mutations in the nicotinamide adenine dinucleotide reduced-cytochrome b(5) reductase gene leading to methemoglobinemia type I. Blood. 2001 Feb 15; 97(4):1106-14. PMID: 11159544.
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    150. Jelenska J, Crawford MJ, Harb OS, Zuther E, Haselkorn R, Roos DS, Gornicki P. Subcellular localization of acetyl-CoA carboxylase in the apicomplexan parasite Toxoplasma gondii. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2723-8. PMID: 11226307.
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    151. He CY, Shaw MK, Pletcher CH, Striepen B, Tilney LG, Roos DS. A plastid segregation defect in the protozoan parasite Toxoplasma gondii. EMBO J. 2001 Feb 01; 20(3):330-9. PMID: 11157740.
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    152. van den Berg JM, Mul FP, Schippers E, Weening JJ, Roos D, Kuijpers TW. Beta1 integrin activation on human neutrophils promotes beta2 integrin-mediated adhesion to fibronectin. Eur J Immunol. 2001 Jan; 31(1):276-84. PMID: 11265644.
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    153. Heyworth PG, Curnutte JT, Rae J, Noack D, Roos D, van Koppen E, Cross AR. Hematologically important mutations: X-linked chronic granulomatous disease (second update). Blood Cells Mol Dis. 2001 Jan-Feb; 27(1):16-26. PMID: 11162142.
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    154. Striepen B, Crawford MJ, Shaw MK, Tilney LG, Seeber F, Roos DS. The plastid of Toxoplasma gondii is divided by association with the centrosomes. J Cell Biol. 2000 Dec 25; 151(7):1423-34. PMID: 11134072.
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    155. Burritt JB, Fritel GN, Dahan I, Pick E, Roos D, Jesaitis AJ. Epitope identification for human neutrophil flavocytochrome b monoclonals 48 and 449. Eur J Haematol. 2000 Dec; 65(6):407-13. PMID: 11168498.
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    156. van Dooren GG, Waller RF, Joiner KA, Roos DS, McFadden GI. Traffic jams: protein transport in Plasmodium falciparum. Parasitol Today. 2000 Oct; 16(10):421-7. PMID: 11006473.
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    157. Meischl C, Boer M, Ahlin A, Roos D. A new exon created by intronic insertion of a rearranged LINE-1 element as the cause of chronic granulomatous disease. Eur J Hum Genet. 2000 Sep; 8(9):697-703. PMID: 10980575.
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    158. Shaw MK, He CY, Roos DS, Tilney LG. Proteasome inhibitors block intracellular growth and replication of Toxoplasma gondii. Parasitology. 2000 Jul; 121 ( Pt 1):35-47. PMID: 11085223.
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    159. Baldi DL, Andrews KT, Waller RF, Roos DS, Howard RF, Crabb BS, Cowman AF. RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparum. EMBO J. 2000 Jun 01; 19(11):2435-43. PMID: 10835342.
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    160. Lie WJ, Van Der Veen MJ, Knol EF, Mul FP, Jansen HM, Roos D, Van Der Zee JS. Influence of bronchial allergen challenge on histamine release by human basophils. Clin Exp Allergy. 2000 Jun; 30(6):882-90. PMID: 10848908.
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    161. Schumacher MA, Scott DM, Mathews II, Ealick SE, Roos DS, Ullman B, Brennan RG. Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. J Mol Biol. 2000 May 19; 298(5):875-93. PMID: 10801355.
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    162. Banerjee R, Anguita J, Roos D, Fikrig E. Cutting edge: infection by the agent of human granulocytic ehrlichiosis prevents the respiratory burst by down-regulating gp91phox. J Immunol. 2000 Apr 15; 164(8):3946-9. PMID: 10754283.
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    163. Shaw MK, Compton HL, Roos DS, Tilney LG. Microtubules, but not actin filaments, drive daughter cell budding and cell division in Toxoplasma gondii. J Cell Sci. 2000 Apr; 113 ( Pt 7):1241-54. PMID: 10704375.
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    164. Schumacher MA, Scott DM, Mathews II, Ealick SE, Roos DS, Ullman B, Brennan RG. Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. J Mol Biol. 2000 Feb 18; 296(2):549-67. PMID: 10669608.
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    165. Leusen JH, Meischl C, Eppink MH, Hilarius PM, de Boer M, Weening RS, Ahlin A, Sanders L, Goldblatt D, Skopczynska H, Bernatowska E, Palmblad J, Verhoeven AJ, van Berkel WJ, Roos D. Four novel mutations in the gene encoding gp91-phox of human NADPH oxidase: consequences for oxidase assembly. Blood. 2000 Jan 15; 95(2):666-73. PMID: 10627478.
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    166. Chiang CW, Carter N, Sullivan WJ, Donald RG, Roos DS, Naguib FN, el Kouni MH, Ullman B, Wilson CM. The adenosine transporter of Toxoplasma gondii. Identification by insertional mutagenesis, cloning, and recombinant expression. J Biol Chem. 1999 Dec 03; 274(49):35255-61. PMID: 10575012.
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    167. Darling JA, Sullivan WJ, Carter D, Ullman B, Roos DS. Recombinant expression, purification, and characterization of Toxoplasma gondii adenosine kinase. Mol Biochem Parasitol. 1999 Sep 20; 103(1):15-23. PMID: 10514077.
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    168. Sullivan WJ, Chiang CW, Wilson CM, Naguib FN, el Kouni MH, Donald RG, Roos DS. Insertional tagging of at least two loci associated with resistance to adenine arabinoside in Toxoplasma gondii, and cloning of the adenosine kinase locus. Mol Biochem Parasitol. 1999 Sep 20; 103(1):1-14. PMID: 10514076.
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    169. Roos DS, Crawford MJ, Donald RG, Kissinger JC, Klimczak LJ, Striepen B. Origin, targeting, and function of the apicomplexan plastid. Curr Opin Microbiol. 1999 Aug; 2(4):426-32. PMID: 10458993.
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    170. Hager KM, Striepen B, Tilney LG, Roos DS. The nuclear envelope serves as an intermediary between the ER and Golgi complex in the intracellular parasite Toxoplasma gondii. J Cell Sci. 1999 Aug; 112 ( Pt 16):2631-8. PMID: 10413671.
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    171. McFadden GI, Roos DS. Apicomplexan plastids as drug targets. Trends Microbiol. 1999 Aug; 7(8):328-33. PMID: 10431206.
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    172. Hordijk PL, Anthony E, Mul FP, Rientsma R, Oomen LC, Roos D. Vascular-endothelial-cadherin modulates endothelial monolayer permeability. J Cell Sci. 1999 Jun; 112 ( Pt 12):1915-23. PMID: 10341210.
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    173. Tool AT, Blom M, Roos D, Verhoeven AJ. Phospholipase D-derived phosphatidic acid is involved in the activation of the CD11b/CD18 integrin in human eosinophils. Biochem J. 1999 May 15; 340 ( Pt 1):95-101. PMID: 10229663.
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    174. Matrajt M, Angel SO, Pszenny V, Guarnera E, Roos DS, Garberi JC. Arrays of repetitive DNA elements in the largest chromosomes of Toxoplasma gondii. Genome. 1999 Apr; 42(2):265-9. PMID: 10231960.
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    175. Chaturvedi S, Qi H, Coleman D, Rodriguez A, Hanson PI, Striepen B, Roos DS, Joiner KA. Constitutive calcium-independent release of Toxoplasma gondii dense granules occurs through the NSF/SNAP/SNARE/Rab machinery. J Biol Chem. 1999 Jan 22; 274(4):2424-31. PMID: 9891012.
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    176. Keeling PJ, Palmer JD, Donald RG, Roos DS, Waller RF, McFadden GI. Shikimate pathway in apicomplexan parasites. Nature. 1999 Jan 21; 397(6716):219-20. PMID: 9930696.
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    177. Roos DS, Crawford MJ, Donald RG, Fohl LM, Hager KM, Kissinger JC, Reynolds MG, Striepen B, Sullivan WJ. Transport and trafficking: Toxoplasma as a model for Plasmodium. Novartis Found Symp. 1999; 226:176-95; discussion 195-8. PMID: 10645546.
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    178. Roos DS. The apicoplast as a potential therapeutic target in Toxoplasma and other apicomplexan parasites: some additional thoughts. Parasitol Today. 1999 Jan; 15(1):41. PMID: 10234180.
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    179. Dusi S, Nadalini KA, Donini M, Zentilin L, Wientjes FB, Roos D, Giacca M, Rossi F. Nicotinamide-adenine dinucleotide phosphate oxidase assembly and activation in EBV-transformed B lymphoblastoid cell lines of normal and chronic granulomatous disease patients. J Immunol. 1998 Nov 01; 161(9):4968-74. PMID: 9794433.
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    180. Shaw MK, Roos DS, Tilney LG. Acidic compartments and rhoptry formation in Toxoplasma gondii. Parasitology. 1998 Nov; 117 ( Pt 5):435-43. PMID: 9836308.
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    181. Waller RF, Keeling PJ, Donald RG, Striepen B, Handman E, Lang-Unnasch N, Cowman AF, Besra GS, Roos DS, McFadden GI. Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12352-7. PMID: 9770490.
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    182. Jerome ME, Radke JR, Bohne W, Roos DS, White MW. Toxoplasma gondii bradyzoites form spontaneously during sporozoite-initiated development. Infect Immun. 1998 Oct; 66(10):4838-44. PMID: 9746587.
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    183. Liu L, Zuurbier AE, Mul FP, Verhoeven AJ, Lutter R, Knol EF, Roos D. Triple role of platelet-activating factor in eosinophil migration across monolayers of lung epithelial cells: eosinophil chemoattractant and priming agent and epithelial cell activator. J Immunol. 1998 Sep 15; 161(6):3064-70. PMID: 9743372.
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    184. Morrissette NS, Roos DS. Toxoplasma gondii: a family of apical antigens associated with the cytoskeleton. Exp Parasitol. 1998 Jul; 89(3):296-303. PMID: 9676707.
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    185. Schumacher MA, Carter D, Scott DM, Roos DS, Ullman B, Brennan RG. Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. EMBO J. 1998 Jun 15; 17(12):3219-32. PMID: 9628859.
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    186. Suzuki S, Kumatori A, Haagen IA, Fujii Y, Sadat MA, Jun HL, Tsuji Y, Roos D, Nakamura M. PU.1 as an essential activator for the expression of gp91(phox) gene in human peripheral neutrophils, monocytes, and B lymphocytes. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6085-90. PMID: 9600921.
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    187. Bohne W, Hunter CA, White MW, Ferguson DJ, Gross U, Roos DS. Targeted disruption of the bradyzoite-specific gene BAG1 does not prevent tissue cyst formation in Toxoplasma gondii. Mol Biochem Parasitol. 1998 May 01; 92(2):291-301. PMID: 9657333.
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    188. Striepen B, He CY, Matrajt M, Soldati D, Roos DS. Expression, selection, and organellar targeting of the green fluorescent protein in Toxoplasma gondii. Mol Biochem Parasitol. 1998 May 01; 92(2):325-38. PMID: 9657336.
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    189. Donald RG, Roos DS. Gene knock-outs and allelic replacements in Toxoplasma gondii: HXGPRT as a selectable marker for hit-and-run mutagenesis. Mol Biochem Parasitol. 1998 Mar 15; 91(2):295-305. PMID: 9566522.
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    190. Reynolds MG, Roos DS. A biochemical and genetic model for parasite resistance to antifolates. Toxoplasma gondii provides insights into pyrimethamine and cycloguanil resistance in Plasmodium falciparum. J Biol Chem. 1998 Feb 06; 273(6):3461-9. PMID: 9452469.
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    191. Ajioka JW, Boothroyd JC, Brunk BP, Hehl A, Hillier L, Manger ID, Marra M, Overton GC, Roos DS, Wan KL, Waterston R, Sibley LD. Gene discovery by EST sequencing in Toxoplasma gondii reveals sequences restricted to the Apicomplexa. Genome Res. 1998 Jan; 8(1):18-28. PMID: 9445484.
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    192. Meischl C, Roos D. The molecular basis of chronic granulomatous disease. Springer Semin Immunopathol. 1998; 19(4):417-34. PMID: 9618766.
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    193. Fichera ME, Roos DS. A plastid organelle as a drug target in apicomplexan parasites. Nature. 1997 Nov 27; 390(6658):407-9. PMID: 9389481.
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    194. Tilley M, Fichera ME, Jerome ME, Roos DS, White MW. Toxoplasma gondii sporozoites form a transient parasitophorous vacuole that is impermeable and contains only a subset of dense-granule proteins. Infect Immun. 1997 Nov; 65(11):4598-605. PMID: 9353039.
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    195. Roos DS, Sullivan WJ, Striepen B, Bohne W, Donald RG. Tagging genes and trapping promoters in Toxoplasma gondii by insertional mutagenesis. Methods. 1997 Oct; 13(2):112-22. PMID: 9405195.
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    196. Bohne W, Roos DS. Stage-specific expression of a selectable marker in Toxoplasma gondii permits selective inhibition of either tachyzoites or bradyzoites. Mol Biochem Parasitol. 1997 Sep; 88(1-2):115-26. PMID: 9274873.
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    197. Carter D, Donald RG, Roos D, Ullman B. Expression, purification, and characterization of uracil phosphoribosyltransferase from Toxoplasma gondii. Mol Biochem Parasitol. 1997 Aug; 87(2):137-44. PMID: 9247925.
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    198. Köhler S, Delwiche CF, Denny PW, Tilney LG, Webster P, Wilson RJ, Palmer JD, Roos DS. A plastid of probable green algal origin in Apicomplexan parasites. Science. 1997 Mar 07; 275(5305):1485-9. PMID: 9045615.
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    199. Morrissette NS, Murray JM, Roos DS. Subpellicular microtubules associate with an intramembranous particle lattice in the protozoan parasite Toxoplasma gondii. J Cell Sci. 1997 Jan; 110 ( Pt 1):35-42. PMID: 9010782.
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    200. Beutler E, Westwood B, van Zwieten R, Roos D. G-->T transition at cDNA nt 110 (K37Q) in the PKLR (pyruvate kinase) gene is the molecular basis of a case of hereditary increase of red blood cell ATP. Hum Mutat. 1997; 9(3):282-5. PMID: 9090535.
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    201. Liu L, Mul FP, Lutter R, Roos D, Knol EF. Transmigration of human neutrophils across airway epithelial cell monolayers is preferentially in the physiologic basolateral-to-apical direction. Am J Respir Cell Mol Biol. 1996 Dec; 15(6):771-80. PMID: 8969272.
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    202. Stokkermans TJ, Schwartzman JD, Keenan K, Morrissette NS, Tilney LG, Roos DS. Inhibition of Toxoplasma gondii replication by dinitroaniline herbicides. Exp Parasitol. 1996 Dec; 84(3):355-70. PMID: 8948325.
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    203. Liu L, Mul FP, Kuijpers TW, Lutter R, Roos D, Knol EF. Neutrophil transmigration across monolayers of endothelial cells and airway epithelial cells is regulated by different mechanisms. Ann N Y Acad Sci. 1996 Oct 31; 796:21-9. PMID: 8906208.
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    204. Leusen JH, de Klein A, Hilarius PM, Ahlin A, Palmblad J, Smith CI, Diekmann D, Hall A, Verhoeven AJ, Roos D. Disturbed interaction of p21-rac with mutated p67-phox causes chronic granulomatous disease. J Exp Med. 1996 Oct 01; 184(4):1243-9. PMID: 8879195.
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    205. Schumacher MA, Carter D, Roos DS, Ullman B, Brennan RG. Crystal structures of Toxoplasma gondii HGXPRTase reveal the catalytic role of a long flexible loop. Nat Struct Biol. 1996 Oct; 3(10):881-7. PMID: 8836106.
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    206. Leusen JH, Verhoeven AJ, Roos D. Interactions between the components of the human NADPH oxidase: a review about the intrigues in the phox family. Front Biosci. 1996 Jul 01; 1:d72-90. PMID: 9159214.
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    207. Donald RG, Carter D, Ullman B, Roos DS. Insertional tagging, cloning, and expression of the Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyltransferase gene. Use as a selectable marker for stable transformation. J Biol Chem. 1996 Jun 14; 271(24):14010-9. PMID: 8662859.
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    208. Trujillo M, Donald RG, Roos DS, Greene PJ, Santi DV. Heterologous expression and characterization of the bifunctional dihydrofolate reductase-thymidylate synthase enzyme of Toxoplasma gondii. Biochemistry. 1996 May 21; 35(20):6366-74. PMID: 8639582.
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    209. de Haas M, Koene HR, Kleijer M, de Vries E, Simsek S, van Tol MJ, Roos D, von dem Borne AE. A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa. J Immunol. 1996 Apr 15; 156(8):2948-55. PMID: 8609432.
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    210. Schlichtherle IM, Roos DS, Van Houten JL. Cloning and molecular analysis of the bifunctional dihydrofolate reductase-thymidylate synthase gene in the ciliated protozoan Paramecium tetraurelia. Mol Gen Genet. 1996 Apr 10; 250(6):665-73. PMID: 8628226.
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    211. Roos DS. Molecular genetic tools for the identification and analysis of drug targets in Toxoplasma gondii. Curr Top Microbiol Immunol. 1996; 219:247-59. PMID: 8791705.
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    212. Fichera ME, Bhopale MK, Roos DS. In vitro assays elucidate peculiar kinetics of clindamycin action against Toxoplasma gondii. Antimicrob Agents Chemother. 1995 Jul; 39(7):1530-7. PMID: 7492099.
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    213. Donald RG, Roos DS. Insertional mutagenesis and marker rescue in a protozoan parasite: cloning of the uracil phosphoribosyltransferase locus from Toxoplasma gondii. Proc Natl Acad Sci U S A. 1995 Jun 06; 92(12):5749-53. PMID: 7777580.
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    214. Leusen JH, Fluiter K, Hilarius PM, Roos D, Verhoeven AJ, Bolscher BG. Interactions between the cytosolic components p47phox and p67phox of the human neutrophil NADPH oxidase that are not required for activation in the cell-free system. J Biol Chem. 1995 May 12; 270(19):11216-21. PMID: 7744754.
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    215. Beckers CJ, Roos DS, Donald RG, Luft BJ, Schwab JC, Cao Y, Joiner KA. Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii. Implications for the target of macrolide antibiotics. J Clin Invest. 1995 Jan; 95(1):367-76. PMID: 7814637.
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    216. Leusen JH, Bolscher BG, Hilarius PM, Weening RS, Kaulfersch W, Seger RA, Roos D, Verhoeven AJ. 156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox. J Exp Med. 1994 Dec 01; 180(6):2329-34. PMID: 7964505.
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    217. Morrissette NS, Bedian V, Webster P, Roos DS. Characterization of extreme apical antigens from Toxoplasma gondii. Exp Parasitol. 1994 Nov; 79(3):445-59. PMID: 7525339.
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    218. Kuijpers TW, Raleigh M, Kavanagh T, Janssen H, Calafat J, Roos D, Harlan JM. Cytokine-activated endothelial cells internalize E-selectin into a lysosomal compartment of vesiculotubular shape. A tubulin-driven process. J Immunol. 1994 May 15; 152(10):5060-9. PMID: 7513727.
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    219. Roos D. The genetic basis of chronic granulomatous disease. Immunol Rev. 1994 Apr; 138:121-57. PMID: 8070813.
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    220. Donald RG, Roos DS. Homologous recombination and gene replacement at the dihydrofolate reductase-thymidylate synthase locus in Toxoplasma gondii. Mol Biochem Parasitol. 1994 Feb; 63(2):243-53. PMID: 8008022.
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    221. de Haas M, Kleijer M, Minchinton RM, Roos D, von dem Borne AE. Soluble Fc gamma RIIIa is present in plasma and is derived from natural killer cells. J Immunol. 1994 Jan 15; 152(2):900-7. PMID: 8283059.
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    222. Roos DS, Donald RG, Morrissette NS, Moulton AL. Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii. Methods Cell Biol. 1994; 45:27-63. PMID: 7707991.
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    223. Masuda M, Roos D. Association of all three types of Fc gamma R (CD64, CD32, and CD16) with a gamma-chain homodimer in cultured human monocytes. J Immunol. 1993 Dec 15; 151(12):7188-95. PMID: 8258719.
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    224. Donald RG, Roos DS. Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11703-7. PMID: 8265612.
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    225. Masuda M, Verhoeven AJ, Roos D. Tyrosine phosphorylation of a gamma-chain homodimer associated with Fc gamma RIII (CD16) in cultured human monocytes. J Immunol. 1993 Dec 01; 151(11):6382-8. PMID: 8245472.
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    226. Knol EF, Kuijpers TW, Mul FP, Roos D. Stimulation of human basophils results in homotypic aggregation. A response independent of degranulation. J Immunol. 1993 Nov 01; 151(9):4926-33. PMID: 7691958.
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    227. Kuijpers TW, van der Schoot CE, Hoogerwerf M, Roos D. Cross-linking of the carcinoembryonic antigen-like glycoproteins CD66 and CD67 induces neutrophil aggregation. J Immunol. 1993 Nov 01; 151(9):4934-40. PMID: 8104998.
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    228. Kuijpers TW, Roos D. Leukocyte extravasation: mechanisms and consequences. Behring Inst Mitt. 1993 Aug; (92):107-37. PMID: 8250806.
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    229. Calafat J, Kuijpers TW, Janssen H, Borregaard N, Verhoeven AJ, Roos D. Evidence for small intracellular vesicles in human blood phagocytes containing cytochrome b558 and the adhesion molecule CD11b/CD18. Blood. 1993 Jun 01; 81(11):3122-9. PMID: 8098969.
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    230. Roos DS. Primary structure of the dihydrofolate reductase-thymidylate synthase gene from Toxoplasma gondii. J Biol Chem. 1993 Mar 25; 268(9):6269-80. PMID: 8454599.
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    231. Blom M, Tool AT, Roos D, Verhoeven AJ. Priming of human eosinophils by platelet-activating factor enhances the number of cells able to bind and respond to opsonized particles. J Immunol. 1992 Dec 01; 149(11):3672-7. PMID: 1431137.
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    232. Kuijpers TW, Hoogerwerf M, van der Laan LJ, Nagel G, van der Schoot CE, Grunert F, Roos D. CD66 nonspecific cross-reacting antigens are involved in neutrophil adherence to cytokine-activated endothelial cells. J Cell Biol. 1992 Jul; 118(2):457-66. PMID: 1378450.
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    233. Kuijpers TW, Hakkert BC, Hart MH, Roos D. Neutrophil migration across monolayers of cytokine-prestimulated endothelial cells: a role for platelet-activating factor and IL-8. J Cell Biol. 1992 May; 117(3):565-72. PMID: 1315317.
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    234. Kuijpers TW, Hoogerwerf M, Roos D. Neutrophil migration across monolayers of resting or cytokine-activated endothelial cells. Role of intracellular calcium changes and fusion of specific granules with the plasma membrane. J Immunol. 1992 Jan 01; 148(1):72-7. PMID: 1370172.
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    235. Kuijpers TW, Hakkert BC, Hoogerwerf M, Leeuwenberg JF, Roos D. Role of endothelial leukocyte adhesion molecule-1 and platelet-activating factor in neutrophil adherence to IL-1-prestimulated endothelial cells. Endothelial leukocyte adhesion molecule-1-mediated CD18 activation. J Immunol. 1991 Aug 15; 147(4):1369-76. PMID: 1714481.
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    236. Koenderman L, Tool AT, Roos D, Verhoeven AJ. Priming of the respiratory burst in human eosinophils is accompanied by changes in signal transduction. J Immunol. 1990 Dec 01; 145(11):3883-8. PMID: 2246518.
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    237. Kuijpers TW, Hakkert BC, van Mourik JA, Roos D. Distinct adhesive properties of granulocytes and monocytes to endothelial cells under static and stirred conditions. J Immunol. 1990 Oct 15; 145(8):2588-94. PMID: 1976697.
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    238. Huizinga TW, Dolman KM, van der Linden NJ, Kleijer M, Nuijens JH, von dem Borne AE, Roos D. Phosphatidylinositol-linked FcRIII mediates exocytosis of neutrophil granule proteins, but does not mediate initiation of the respiratory burst. J Immunol. 1990 Feb 15; 144(4):1432-7. PMID: 2137491.
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    239. Marijnen YM, de Korte D, Haverkort WA, den Breejen EJ, van Gennip AH, Roos D. Studies on the incorporation of precursors into purine and pyrimidine nucleotides via 'de novo' and 'salvage' pathways in normal lymphocytes and lymphoblastic cell-line cells. Biochim Biophys Acta. 1989 Jul 11; 1012(2):148-55. PMID: 2787169.
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    240. Huizinga TW, Kerst M, Nuyens JH, Vlug A, von dem Borne AE, Roos D, Tetteroo PA. Binding characteristics of dimeric IgG subclass complexes to human neutrophils. J Immunol. 1989 Apr 01; 142(7):2359-64. PMID: 2784461.
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    241. Huizinga TW, van Kemenade F, Koenderman L, Dolman KM, von dem Borne AE, Tetteroo PA, Roos D. The 40-kDa Fc gamma receptor (FcRII) on human neutrophils is essential for the IgG-induced respiratory burst and IgG-induced phagocytosis. J Immunol. 1989 Apr 01; 142(7):2365-9. PMID: 2538508.
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    242. Koenderman L, Yazdanbakhsh M, Roos D, Verhoeven AJ. Dual mechanisms in priming of the chemoattractant-induced respiratory burst in human granulocytes. A Ca2+-dependent and a Ca2+-independent route. J Immunol. 1989 Jan 15; 142(2):623-8. PMID: 2911014.
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    243. Roos DS, Schimke RT. Toxicity of folic acid analogs in cultured human cells: a microtiter assay for the analysis of drug competition. Proc Natl Acad Sci U S A. 1987 Jul; 84(14):4860-4. PMID: 3496598.
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    244. Yazdanbakhsh M, Eckmann CM, Roos D. Killing of schistosomula by taurine chloramine and taurine bromamine. Am J Trop Med Hyg. 1987 Jul; 37(1):106-10. PMID: 3605492.
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    245. Yazdanbakhsh M, Tai PC, Spry CJ, Gleich GJ, Roos D. Synergism between eosinophil cationic protein and oxygen metabolites in killing of schistosomula of Schistosoma mansoni. J Immunol. 1987 May 15; 138(10):3443-7. PMID: 3571976.
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    246. Yazdanbakhsh M, Eckmann CM, Bot AA, Roos D. Bactericidal action of eosinophils from normal human blood. Infect Immun. 1986 Jul; 53(1):192-8. PMID: 3522428.
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    247. de Boer M, Roos D. Metabolic comparison between basophils and other leukocytes from human blood. J Immunol. 1986 May 01; 136(9):3447-54. PMID: 3007619.
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    248. Roos DS, Choppin PW. Biochemical studies on cell fusion. II. Control of fusion response by lipid alteration. J Cell Biol. 1985 Oct; 101(4):1591-8. PMID: 4044646.
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    249. Roos DS, Choppin PW. Biochemical studies on cell fusion. I. Lipid composition of fusion-resistant cells. J Cell Biol. 1985 Oct; 101(4):1578-90. PMID: 4044645.
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    250. Yazdanbakhsh M, Eckmann CM, Roos D. Characterization of the interaction of human eosinophils and neutrophils with opsonized particles. J Immunol. 1985 Aug; 135(2):1378-84. PMID: 4008927.
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    251. Miedema F, Tetteroo PA, Terpstra FG, Keizer G, Roos M, Weening RS, Weemaes CM, Roos D, Melief CJ. Immunologic studies with LFA-1- and Mo1-deficient lymphocytes from a patient with recurrent bacterial infections. J Immunol. 1985 May; 134(5):3075-81. PMID: 3156928.
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    252. Gallin JI, Metcalf JA, Roos D, Seligmann B, Friedman MM. Organelle-depleted human neutrophil cytoplasts used to study fmet-leu-phe receptor modulation and cell function. J Immunol. 1984 Jul; 133(1):415-21. PMID: 6327824.
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    253. Roos DS, Robinson JM, Davidson RL. Cell fusion and intramembrane particle distribution in polyethylene glycol-resistant cells. J Cell Biol. 1983 Sep; 97(3):909-17. PMID: 6885925.
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    254. Roos D, Voetman AA, Meerhof LJ. Functional activity of enucleated human polymorphonuclear leukocytes. J Cell Biol. 1983 Aug; 97(2):368-77. PMID: 6309859.
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    255. van de Griend RJ, ten Berge I, Tanke HJ, Roos D, Schellekens PT, Melief CJ, Zeijlemaker WP, Astaldi A. Characterization of two subsets of human T gamma cells. J Immunol. 1982 May; 128(5):1979-85. PMID: 6977578.
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    256. Oort M, Heerspink W, Roos D, Flavell RA, Bernini LF. Haemolytic disease of the newborn and chronic anaemia induced by gamma beta thalassaemia in a Dutch family. Br J Haematol. 1981 Jun; 48(2):251-62. PMID: 7195273.
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    257. Bos AJ, Wever R, Hamers MN, Roos D. Some enzymatic characteristics of eosinophil peroxidase from patients with eosinophilia and from healthy donors. Infect Immun. 1981 May; 32(2):427-31. PMID: 6265355.
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    258. Roos D, Bot AA, van Schaik ML, de Boer M, Daha MR. Interaction between human neutrophils and zymosan particles: the role of opsonins and divalent cations. J Immunol. 1981 Feb; 126(2):433-40. PMID: 7005337.
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    259. van de Griend RJ, Astaldi A, Vossen JM, Dooren LJ, Schellekens PT, Zwaan FE, van den Ende A, Roos M, Roos D. T lymphocyte characteristics in bone marrow-transplanted patients. I. Changes in biochemical properties that correlate with the immunologic reconstitution. J Immunol. 1981 Feb; 126(2):636-40. PMID: 7005340.
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    260. Roos DS, Davidson RL. Isolation of mouse cell lines resistant to the fusion-inducing effect of polyethylene glycol. Somatic Cell Genet. 1980 May; 6(3):381-90. PMID: 7404269.
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    261. Robinson JM, Roos DS, Davidson RL, Karnovsky MJ. Membrane alterations and other morphological features associated with polyethylene glycol-induced cell fusion. J Cell Sci. 1979 Dec; 40:63-75. PMID: 536393.
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    262. van Schaik ML, Weening RS, Roos D. Phenylglyoxal is not a selective inhibitor of phagocytosis. J Cell Sci. 1979 Aug; 38:331-43. PMID: 521469.
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    263. Carapella-de Luca E, Aiuti F, Lucarelli P, Bruni L, Baroni CD, Imperato C, Roos D, Astaldi A. A patient with nucleoside phosphorylase deficiency, selective t-cell deficiency, and autoimmune hemolytic anemia. J Pediatr. 1978 Dec; 93(6):1000-3. PMID: 102751.
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    264. Goldstein IM, Roos D, Weissmann G, Kaplan HB. Influence of corticosteroids on human polymorphonuclear leukocyte function in vitro : Reduction of lysosomal enzyme release and superoxide production. Inflammation. 1976 Jun; 1(3):305-15. PMID: 24194453.
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