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Dr Mark Carrington

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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Das A, Bellofatto V, Rosenfeld J, Carrington M, Romero-Zaliz R, del Val C, Estévez AM. High throughput sequencing analysis of Trypanosoma brucei DRBD3/PTB1-bound mRNAs. Mol Biochem Parasitol. 2015 Jan-Feb; 199(1-2):1-4. PMID: 25725478.
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    2. Fiebig M, Gluenz E, Carrington M, Kelly S. SLaP mapper: a webserver for identifying and quantifying spliced-leader addition and polyadenylation site usage in kinetoplastid genomes. Mol Biochem Parasitol. 2014 Sep; 196(2):71-4. PMID: 25111964.
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    3. Sunter J, Webb H, Carrington M. Determinants of GPI-PLC localisation to the flagellum and access to GPI-anchored substrates in trypanosomes. PLoS Pathog. 2013; 9(8):e1003566. PMID: 23990786.
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    4. Bilsland E, Sparkes A, Williams K, Moss HJ, de Clare M, Pir P, Rowland J, Aubrey W, Pateman R, Young M, Carrington M, King RD, Oliver SG. Yeast-based automated high-throughput screens to identify anti-parasitic lead compounds. Open Biol. 2013 Feb 27; 3(2):120158. PMID: 23446112.
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    5. Higgins MK, Tkachenko O, Brown A, Reed J, Raper J, Carrington M. Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):1905-10. PMID: 23319650.
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    6. Price HP, Hodgkinson MR, Wright MH, Tate EW, Smith BA, Carrington M, Stark M, Smith DF. A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei. Biochim Biophys Acta. 2012 Jul; 1823(7):1178-91. PMID: 22609302.
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    7. Sunter J, Wickstead B, Gull K, Carrington M. A new generation of T7 RNA polymerase-independent inducible expression plasmids for Trypanosoma brucei. PLoS One. 2012; 7(4):e35167. PMID: 22511983.
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    8. Kramer S, Marnef A, Standart N, Carrington M. Inhibition of mRNA maturation in trypanosomes causes the formation of novel foci at the nuclear periphery containing cytoplasmic regulators of mRNA fate. J Cell Sci. 2012 Jun 15; 125(Pt 12):2896-909. PMID: 22366449.
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    9. Price HP, Hodgkinson MR, Curwen RS, MacLean LM, Brannigan JA, Carrington M, Smith BA, Ashford DA, Stark M, Smith DF. The orthologue of Sjögren's syndrome nuclear autoantigen 1 (SSNA1) in Trypanosoma brucei is an immunogenic self-assembling molecule. PLoS One. 2012; 7(2):e31842. PMID: 22363749.
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    10. Schwede A, Kramer S, Carrington M. How do trypanosomes change gene expression in response to the environment? Protoplasma. 2012 Apr; 249(2):223-38. PMID: 21594757.
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    11. Leung KF, Riley FS, Carrington M, Field MC. Ubiquitylation and developmental regulation of invariant surface protein expression in trypanosomes. Eukaryot Cell. 2011 Jul; 10(7):916-31. PMID: 21571921.
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    12. Peacock L, Ferris V, Sharma R, Sunter J, Bailey M, Carrington M, Gibson W. Identification of the meiotic life cycle stage of Trypanosoma brucei in the tsetse fly. Proc Natl Acad Sci U S A. 2011 Mar 01; 108(9):3671-6. PMID: 21321215.
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    13. Freire ER, Dhalia R, Moura DM, da Costa Lima TD, Lima RP, Reis CR, Hughes K, Figueiredo RC, Standart N, Carrington M, de Melo Neto OP. The four trypanosomatid eIF4E homologues fall into two separate groups, with distinct features in primary sequence and biological properties. Mol Biochem Parasitol. 2011 Mar; 176(1):25-36. PMID: 21111007.
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    14. Schwede A, Jones N, Engstler M, Carrington M. The VSG C-terminal domain is inaccessible to antibodies on live trypanosomes. Mol Biochem Parasitol. 2011 Feb; 175(2):201-4. PMID: 21074579.
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    15. da Costa Lima TD, Moura DM, Reis CR, Vasconcelos JR, Ellis L, Carrington M, Figueiredo RC, de Melo Neto OP. Functional characterization of three leishmania poly(a) binding protein homologues with distinct binding properties to RNA and protein partners. Eukaryot Cell. 2010 Oct; 9(10):1484-94. PMID: 20675580.
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    16. Kramer S, Carrington M. Trans-acting proteins regulating mRNA maturation, stability and translation in trypanosomatids. Trends Parasitol. 2011 Jan; 27(1):23-30. PMID: 20609625.
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    17. Kramer S, Queiroz R, Ellis L, Hoheisel JD, Clayton C, Carrington M. The RNA helicase DHH1 is central to the correct expression of many developmentally regulated mRNAs in trypanosomes. J Cell Sci. 2010 Mar 01; 123(Pt 5):699-711. PMID: 20124414.
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    18. Schwede A, Carrington M. Bloodstream form Trypanosome plasma membrane proteins: antigenic variation and invariant antigens. Parasitology. 2010 Dec; 137(14):2029-39. PMID: 20109254.
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    19. Field MC, Sergeenko T, Wang YN, Böhm S, Carrington M. Chaperone requirements for biosynthesis of the trypanosome variant surface glycoprotein. PLoS One. 2010 Jan 05; 5(1):e8468. PMID: 20052285.
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    20. Smith TK, Vasileva N, Gluenz E, Terry S, Portman N, Kramer S, Carrington M, Michaeli S, Gull K, Rudenko G. Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation. PLoS One. 2009 Oct 26; 4(10):e7532. PMID: 19855834.
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    21. Thomson R, Molina-Portela P, Mott H, Carrington M, Raper J. Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomes. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19509-14. PMID: 19858474.
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    22. Field MC, Carrington M. The trypanosome flagellar pocket. Nat Rev Microbiol. 2009 Nov; 7(11):775-86. PMID: 19806154.
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    23. Sharma R, Gluenz E, Peacock L, Gibson W, Gull K, Carrington M. The heart of darkness: growth and form of Trypanosoma brucei in the tsetse fly. Trends Parasitol. 2009 Nov; 25(11):517-24. PMID: 19747880.
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    24. Hanrahan O, Webb H, O'Byrne R, Brabazon E, Treumann A, Sunter JD, Carrington M, Voorheis HP. The glycosylphosphatidylinositol-PLC in Trypanosoma brucei forms a linear array on the exterior of the flagellar membrane before and after activation. PLoS Pathog. 2009 Jun; 5(6):e1000468. PMID: 19503825.
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    25. Kramer S, Queiroz R, Ellis L, Webb H, Hoheisel JD, Clayton C, Carrington M. Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2(alpha) phosphorylation at Thr169. J Cell Sci. 2008 Sep 15; 121(Pt 18):3002-14. PMID: 18713834.
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    26. Gluenz E, Sharma R, Carrington M, Gull K. Functional characterization of cohesin subunit SCC1 in Trypanosoma brucei and dissection of mutant phenotypes in two life cycle stages. Mol Microbiol. 2008 Aug; 69(3):666-80. PMID: 18554326.
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    27. Chung WL, Leung KF, Carrington M, Field MC. Ubiquitylation is required for degradation of transmembrane surface proteins in trypanosomes. Traffic. 2008 Sep; 9(10):1681-97. PMID: 18657071.
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    28. Field MC, Horn D, Carrington M. Analysis of small GTPase function in trypanosomes. Methods Enzymol. 2008; 438:57-76. PMID: 18413241.
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    29. Jones NG, Nietlispach D, Sharma R, Burke DF, Eyres I, Mues M, Mott HR, Carrington M. Structure of a glycosylphosphatidylinositol-anchored domain from a trypanosome variant surface glycoprotein. J Biol Chem. 2008 Feb 08; 283(6):3584-93. PMID: 18003615.
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    30. Sharma R, Peacock L, Gluenz E, Gull K, Gibson W, Carrington M. Asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes. Protist. 2008 Jan; 159(1):137-51. PMID: 17931969.
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    31. Hutchinson OC, Picozzi K, Jones NG, Mott H, Sharma R, Welburn SC, Carrington M. Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific. BMC Genomics. 2007 Jul 13; 8:234. PMID: 17629915.
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    32. Picozzi K, Carrington M, Welburn SC. A multiplex PCR that discriminates between Trypanosoma brucei brucei and zoonotic T. b. rhodesiense. Exp Parasitol. 2008 Jan; 118(1):41-6. PMID: 17643434.
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    33. Marcello L, Menon S, Ward P, Wilkes JM, Jones NG, Carrington M, Barry JD. VSGdb: a database for trypanosome variant surface glycoproteins, a large and diverse family of coiled coil proteins. BMC Bioinformatics. 2007 May 02; 8:143. PMID: 17474977.
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    34. Kelly S, Reed J, Kramer S, Ellis L, Webb H, Sunter J, Salje J, Marinsek N, Gull K, Wickstead B, Carrington M. Functional genomics in Trypanosoma brucei: a collection of vectors for the expression of tagged proteins from endogenous and ectopic gene loci. Mol Biochem Parasitol. 2007 Jul; 154(1):103-9. PMID: 17512617.
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    35. Dhalia R, Marinsek N, Reis CR, Katz R, Muniz JR, Standart N, Carrington M, de Melo Neto OP. The two eIF4A helicases in Trypanosoma brucei are functionally distinct. Nucleic Acids Res. 2006; 34(9):2495-507. PMID: 16687655.
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    36. Berriman M, Ghedin E, Hertz-Fowler C, Blandin G, Renauld H, Bartholomeu DC, Lennard NJ, Caler E, Hamlin NE, Haas B, Böhme U, Hannick L, Aslett MA, Shallom J, Marcello L, Hou L, Wickstead B, Alsmark UC, Arrowsmith C, Atkin RJ, Barron AJ, Bringaud F, Brooks K, Carrington M, Cherevach I, Chillingworth TJ, Churcher C, Clark LN, Corton CH, Cronin A, Davies RM, Doggett J, Djikeng A, Feldblyum T, Field MC, Fraser A, Goodhead I, Hance Z, Harper D, Harris BR, Hauser H, Hostetler J, Ivens A, Jagels K, Johnson D, Johnson J, Jones K, Kerhornou AX, Koo H, Larke N, Landfear S, Larkin C, Leech V, Line A, Lord A, Macleod A, Mooney PJ, Moule S, Martin DM, Morgan GW, Mungall K, Norbertczak H, Ormond D, Pai G, Peacock CS, Peterson J, Quail MA, Rabbinowitsch E, Rajandream MA, Reitter C, Salzberg SL, Sanders M, Schobel S, Sharp S, Simmonds M, Simpson AJ, Tallon L, Turner CM, Tait A, Tivey AR, Van Aken S, Walker D, Wanless D, Wang S, White B, White O, Whitehead S, Woodward J, Wortman J, Adams MD, Embley TM, Gull K, Ullu E, Barry JD, Fairlamb AH, Opperdoes F, Barrell BG, Donelson JE, Hall N, Fraser CM, Melville SE, El-Sayed NM. The genome of the African trypanosome Trypanosoma brucei. Science. 2005 Jul 15; 309(5733):416-22. PMID: 16020726.
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    37. Webb H, Burns R, Kimblin N, Ellis L, Carrington M. A novel strategy to identify the location of necessary and sufficient cis-acting regulatory mRNA elements in trypanosomes. RNA. 2005 Jul; 11(7):1108-16. PMID: 15928343.
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    38. Webb H, Burns R, Ellis L, Kimblin N, Carrington M. Developmentally regulated instability of the GPI-PLC mRNA is dependent on a short-lived protein factor. Nucleic Acids Res. 2005; 33(5):1503-12. PMID: 15755751.
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    39. Chattopadhyay A, Jones NG, Nietlispach D, Nielsen PR, Voorheis HP, Mott HR, Carrington M. Structure of the C-terminal domain from Trypanosoma brucei variant surface glycoprotein MITat1.2. J Biol Chem. 2005 Feb 25; 280(8):7228-35. PMID: 15557330.
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    40. Hutchinson OC, Webb H, Picozzi K, Welburn S, Carrington M. Candidate protein selection for diagnostic markers of African trypanosomiasis. Trends Parasitol. 2004 Nov; 20(11):519-23. PMID: 15471703.
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    41. Chung WL, Carrington M, Field MC. Cytoplasmic targeting signals in transmembrane invariant surface glycoproteins of trypanosomes. J Biol Chem. 2004 Dec 24; 279(52):54887-95. PMID: 15342636.
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    42. Hutchinson OC, Smith W, Jones NG, Chattopadhyay A, Welburn SC, Carrington M. VSG structure: similar N-terminal domains can form functional VSGs with different types of C-terminal domain. Mol Biochem Parasitol. 2003 Aug 31; 130(2):127-31. PMID: 12946849.
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    43. Campillo N, Carrington M. The origin of the serum resistance associated (SRA) gene and a model of the structure of the SRA polypeptide from Trypanosoma brucei rhodesiense. Mol Biochem Parasitol. 2003 Mar; 127(1):79-84. PMID: 12615339.
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    44. Morgan GW, Hall BS, Denny PW, Field MC, Carrington M. The endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system. Trends Parasitol. 2002 Dec; 18(12):540-6. PMID: 12482539.
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    45. Morgan GW, Hall BS, Denny PW, Carrington M, Field MC. The kinetoplastida endocytic apparatus. Part I: a dynamic system for nutrition and evasion of host defences. Trends Parasitol. 2002 Nov; 18(11):491-6. PMID: 12473365.
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    46. Paturiaux-Hanocq F, Hanocq-Quertier J, de Almeida ML, Nolan DP, Pays A, Vanhamme L, Van den Abbeele J, Wasunna CL, Carrington M, Pays E. A role for the dynamic acylation of a cluster of cysteine residues in regulating the activity of the glycosylphosphatidylinositol-specific phospholipase C of Trypanosoma brucei. J Biol Chem. 2000 Apr 21; 275(16):12147-55. PMID: 10766850.
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    47. Carrington M, Carnall N, Crow MS, Gaud A, Redpath MB, Wasunna CL, Webb H. The properties and function of the glycosylphosphatidylinositol-phospholipase C in Trypanosoma brucei. Mol Biochem Parasitol. 1998 Mar 01; 91(1):153-64. PMID: 9574933.
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    48. Carrington M, Shochat Y, Gurnett AM. Selective metabolic labelling of intracellular parasite proteins using ricin. Parasitol Today. 1996 Dec; 12(12):492-5. PMID: 15275269.
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    49. Carrington M, Boothroyd J. Implications of conserved structural motifs in disparate trypanosome surface proteins. Mol Biochem Parasitol. 1996 Oct 30; 81(2):119-26. PMID: 8898328.
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