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Dr John Morrison Kelly

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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Francisco AF, Lewis MD, Jayawardhana S, Taylor MC, Chatelain E, Kelly JM. Reply to "Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs". Antimicrob Agents Chemother. 2015 Dec; 59(12):7925. PMID: 26578702.
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    2. Di Pietro O, Vicente-García E, Taylor MC, Berenguer D, Viayna E, Lanzoni A, Sola I, Sayago H, Riera C, Fisa R, Clos MV, Pérez B, Kelly JM, Lavilla R, Muñoz-Torrero D. Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity. Eur J Med Chem. 2015 Nov 13; 105:120-37. PMID: 26479031.
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    3. Francisco AF, Lewis MD, Jayawardhana S, Taylor MC, Chatelain E, Kelly JM. Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging. Antimicrob Agents Chemother. 2015 Aug; 59(8):4653-61. PMID: 26014936.
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    4. Taylor MC, Lewis MD, Fortes Francisco A, Wilkinson SR, Kelly JM. The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence. PLoS Negl Trop Dis. 2015 Apr; 9(4):e0003707. PMID: 25875298.
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    5. Sola I, Castellà S, Viayna E, Galdeano C, Taylor MC, Gbedema SY, Pérez B, Clos MV, Jones DC, Fairlamb AH, Wright CW, Kelly JM, Muñoz-Torrero D. Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity. Bioorg Med Chem. 2015 Aug 15; 23(16):5156-67. PMID: 25678015.
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    6. Sola I, Artigas A, Taylor MC, Gbedema SY, Pérez B, Clos MV, Wright CW, Kelly JM, Muñoz-Torrero D. Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines. Bioorg Med Chem Lett. 2014 Dec 01; 24(23):5435-8. PMID: 25454267.
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    7. Lewis MD, Francisco AF, Taylor MC, Kelly JM. A new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imaging. J Biomol Screen. 2015 Jan; 20(1):36-43. PMID: 25296657.
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    8. Lewis MD, Fortes Francisco A, Taylor MC, Burrell-Saward H, McLatchie AP, Miles MA, Kelly JM. Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection. Cell Microbiol. 2014 Sep; 16(9):1285-300. PMID: 24712539.
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    9. Taylor MC, Kelly JM. Optimizing bioluminescence imaging to study protozoan parasite infections. Trends Parasitol. 2014 Apr; 30(4):161-2. PMID: 24485045.
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    10. Campos MC, Leon LL, Taylor MC, Kelly JM. Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert. Mol Biochem Parasitol. 2014 Jan; 193(1):17-9. PMID: 24462750.
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    11. McLatchie AP, Burrell-Saward H, Myburgh E, Lewis MD, Ward TH, Mottram JC, Croft SL, Kelly JM, Taylor MC. Highly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferase. PLoS Negl Trop Dis. 2013 Nov; 7(11):e2571. PMID: 24278497.
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    12. Taylor MC, McLatchie AP, Kelly JM. Evidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue. Mol Microbiol. 2013 Aug; 89(3):420-32. PMID: 23750752.
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    13. Alsford S, Kelly JM, Baker N, Horn D. Genetic dissection of drug resistance in trypanosomes. Parasitology. 2013 Oct; 140(12):1478-91. PMID: 23552488.
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    14. Mejia AM, Hall BS, Taylor MC, Gómez-Palacio A, Wilkinson SR, Triana-Chávez O, Kelly JM. Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population. J Infect Dis. 2012 Jul 15; 206(2):220-8. PMID: 22551809.
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    15. Kelly JM, Taylor MC, Horn D, Loza E, Kalvinsh I, Björkling F. Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei. Bioorg Med Chem Lett. 2012 Mar 01; 22(5):1886-90. PMID: 22326398.
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    16. Echeverry MC, Bot C, Obado SO, Taylor MC, Kelly JM. Centromere-associated repeat arrays on Trypanosoma brucei chromosomes are much more extensive than predicted. BMC Genomics. 2012 Jan 18; 13:29. PMID: 22257693.
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    17. Torres E, Duque MD, López-Querol M, Taylor MC, Naesens L, Ma C, Pinto LH, Sureda FX, Kelly JM, Vázquez S. Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities. Bioorg Med Chem. 2012 Jan 15; 20(2):942-8. PMID: 22178660.
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    18. Fytas C, Zoidis G, Tzoutzas N, Taylor MC, Fytas G, Kelly JM. Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activity. J Med Chem. 2011 Jul 28; 54(14):5250-4. PMID: 21542562.
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    19. Defaux J, Sala M, Formosa X, Galdeano C, Taylor MC, Alobaid WA, Kelly JM, Wright CW, Camps P, Muñoz-Torrero D. Huprines as a new family of dual acting trypanocidal-antiplasmodial agents. Bioorg Med Chem. 2011 Mar 01; 19(5):1702-7. PMID: 21315611.
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    20. Taylor MC, Huang H, Kelly JM. Genetic techniques in Trypanosoma cruzi. Adv Parasitol. 2011; 75:231-50. PMID: 21820559.
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    21. Wilkinson SR, Bot C, Kelly JM, Hall BS. Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives. Curr Top Med Chem. 2011; 11(16):2072-84. PMID: 21619510.
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    22. Obado SO, Bot C, Echeverry MC, Bayona JC, Alvarez VE, Taylor MC, Kelly JM. Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei. Nucleic Acids Res. 2011 Feb; 39(3):1023-33. PMID: 20864447.
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    23. Patel S, Hussain S, Harris R, Sardiwal S, Kelly JM, Wilkinson SR, Driscoll PC, Djordjevic S. Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I). Biochem J. 2010 Jan 15; 425(3):513-22. PMID: 19886864.
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    24. Duque MD, Camps P, Torres E, Valverde E, Sureda FX, López-Querol M, Camins A, Prathalingam SR, Kelly JM, Vázquez S. New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities. Bioorg Med Chem. 2010 Jan 01; 18(1):46-57. PMID: 19954985.
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    25. Wilkinson SR, Kelly JM. Trypanocidal drugs: mechanisms, resistance and new targets. Expert Rev Mol Med. 2009 Oct 29; 11:e31. PMID: 19863838.
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    26. Papanastasiou I, Tsotinis A, Zoidis G, Kolocouris N, Prathalingam SR, Kelly JM. Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones. ChemMedChem. 2009 Jul; 4(7):1059-62. PMID: 19422003.
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    27. Duque MD, Camps P, Profire L, Montaner S, Vázquez S, Sureda FX, Mallol J, López-Querol M, Naesens L, De Clercq E, Prathalingam SR, Kelly JM. Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines. Bioorg Med Chem. 2009 Apr 15; 17(8):3198-206. PMID: 19251424.
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    28. Zoidis G, Tsotinis A, Kolocouris N, Kelly JM, Prathalingam SR, Naesens L, De Clercq E. Design and synthesis of bioactive 1,2-annulated adamantane derivatives. Org Biomol Chem. 2008 Sep 07; 6(17):3177-85. PMID: 18698478.
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    29. Wilkinson SR, Taylor MC, Horn D, Kelly JM, Cheeseman I. A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. Proc Natl Acad Sci U S A. 2008 Apr 01; 105(13):5022-7. PMID: 18367671.
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    30. Piacenza L, Peluffo G, Alvarez MN, Kelly JM, Wilkinson SR, Radi R. Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite. Biochem J. 2008 Mar 01; 410(2):359-68. PMID: 17973627.
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    31. Papanastasiou I, Tsotinis A, Kolocouris N, Prathalingam SR, Kelly JM. Design, synthesis, and trypanocidal activity of new aminoadamantane derivatives. J Med Chem. 2008 Mar 13; 51(5):1496-500. PMID: 18281929.
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    32. Taylor MC, Kaur H, Blessington B, Kelly JM, Wilkinson SR. Validation of spermidine synthase as a drug target in African trypanosomes. Biochem J. 2008 Jan 15; 409(2):563-9. PMID: 17916066.
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    33. Logan FJ, Taylor MC, Wilkinson SR, Kaur H, Kelly JM. The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase. Biochem J. 2007 Nov 01; 407(3):419-26. PMID: 17627608.
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    34. Kolocouris N, Zoidis G, Foscolos GB, Fytas G, Prathalingham SR, Kelly JM, Naesens L, De Clercq E. Design and synthesis of bioactive adamantane spiro heterocycles. Bioorg Med Chem Lett. 2007 Aug 01; 17(15):4358-62. PMID: 17588747.
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    35. Piacenza L, Irigoín F, Alvarez MN, Peluffo G, Taylor MC, Kelly JM, Wilkinson SR, Radi R. Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression. Biochem J. 2007 Apr 15; 403(2):323-34. PMID: 17168856.
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    36. Obado SO, Bot C, Nilsson D, Andersson B, Kelly JM. Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi. Genome Biol. 2007; 8(3):R37. PMID: 17352808.
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    37. Gluenz E, Taylor MC, Kelly JM. The Trypanosoma cruzi metacyclic-specific protein Met-III associates with the nucleolus and contains independent amino and carboxyl terminal targeting elements. Int J Parasitol. 2007 May; 37(6):617-25. PMID: 17239886.
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    38. Prathalingham SR, Wilkinson SR, Horn D, Kelly JM. Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole. Antimicrob Agents Chemother. 2007 Feb; 51(2):755-8. PMID: 17145786.
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    39. Taylor MC, Kelly JM. pTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruzi. BMC Biotechnol. 2006 Jul 06; 6:32. PMID: 16824206.
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    40. Kelly JM, McRobert L, Baker DA. Evidence on the chromosomal location of centromeric DNA in Plasmodium falciparum from etoposide-mediated topoisomerase-II cleavage. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6706-11. PMID: 16617116.
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    41. MacRae JI, Obado SO, Turnock DC, Roper JR, Kierans M, Kelly JM, Ferguson MA. The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology. Mol Biochem Parasitol. 2006 May; 147(1):126-36. PMID: 16569451.
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    42. Wilkinson SR, Prathalingam SR, Taylor MC, Ahmed A, Horn D, Kelly JM. Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei. Free Radic Biol Med. 2006 Jan 15; 40(2):198-209. PMID: 16413403.
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    43. Wilkinson SR, Prathalingam SR, Taylor MC, Horn D, Kelly JM. Vitamin C biosynthesis in trypanosomes: a role for the glycosome. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11645-50. PMID: 16087875.
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    44. Obado SO, Taylor MC, Wilkinson SR, Bromley EV, Kelly JM. Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature. Genome Res. 2005 Jan; 15(1):36-43. PMID: 15632088.
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    45. Baker DA, Kelly JM. Structure, function and evolution of microbial adenylyl and guanylyl cyclases. Mol Microbiol. 2004 Jun; 52(5):1229-42. PMID: 15165228.
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    46. Wu Z, Roberts M, Porter M, Walker F, Wherry EJ, Kelly J, Gadina M, Silva EM, DosReis GA, Lopes MF, O'Shea J, Leonard WJ, Ahmed R, Siegel RM. Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory. J Immunol. 2004 May 15; 172(10):6313-23. PMID: 15128821.
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    47. Baker DA, Kelly JM. Purine nucleotide cyclases in the malaria parasite. Trends Parasitol. 2004 May; 20(5):227-32. PMID: 15105023.
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    48. Bromley EV, Taylor MC, Wilkinson SR, Kelly JM. The amino terminal domain of a novel WD repeat protein from Trypanosoma cruzi contains a non-canonical mitochondrial targeting signal. Int J Parasitol. 2004 Jan; 34(1):63-71. PMID: 14711591.
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    49. Wilkinson SR, Horn D, Prathalingam SR, Kelly JM. RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the african trypanosome. J Biol Chem. 2003 Aug 22; 278(34):31640-6. PMID: 12791697.
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    50. Wilkinson SR, Kelly JM. The role of glutathione peroxidases in trypanosomatids. Biol Chem. 2003 Apr; 384(4):517-25. PMID: 12751782.
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    51. Muhia DK, Swales CA, Eckstein-Ludwig U, Saran S, Polley SD, Kelly JM, Schaap P, Krishna S, Baker DA. Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum. J Biol Chem. 2003 Jun 13; 278(24):22014-22. PMID: 12668669.
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    52. Wilkinson SR, Obado SO, Mauricio IL, Kelly JM. Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13453-8. PMID: 12351682.
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    53. Wilkinson SR, Taylor MC, Touitha S, Mauricio IL, Meyer DJ, Kelly JM. TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum. Biochem J. 2002 Jun 15; 364(Pt 3):787-94. PMID: 12049643.
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    54. Wilkinson SR, Meyer DJ, Taylor MC, Bromley EV, Miles MA, Kelly JM. The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. J Biol Chem. 2002 May 10; 277(19):17062-71. PMID: 11842085.
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    55. Kelly JM, Miles MA, Skinner AC. The anti-influenza virus drug rimantadine has trypanocidal activity. Antimicrob Agents Chemother. 1999 Apr; 43(4):985-7. PMID: 10103219.
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    56. Clayton C, Adams M, Almeida R, Baltz T, Barrett M, Bastien P, Belli S, Beverley S, Biteau N, Blackwell J, Blaineau C, Boshart M, Bringaud F, Cross G, Cruz A, Degrave W, Donelson J, El-Sayed N, Fu G, Ersfeld K, Gibson W, Gull K, Ivens A, Kelly J, Vanhamme L, et al. Genetic nomenclature for Trypanosoma and Leishmania. Mol Biochem Parasitol. 1998 Nov 30; 97(1-2):221-4. PMID: 9879900.
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    57. Kelly JM. Trypanosomatid shuttle vectors: new tools for the functional dissection of parasite genomes. Parasitol Today. 1995 Dec; 11(12):447-51. PMID: 15275381.
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