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Professor Sanjeev Krishna

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Slavic K, Krishna S, Lahree A, Bouyer G, Hanson KK, Vera I, Pittman JK, Staines HM, Mota MM. A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium. Nat Commun. 2016 Jan 20; 7:10403. PMID: 26786069; PMCID: PMC4735874.
    2. Kremsner PG, Adegnika AA, Hounkpatin AB, Zinsou JF, Taylor TE, Chimalizeni Y, Liomba A, Kombila M, Bouyou-Akotet MK, Mawili Mboumba DP, Agbenyega T, Ansong D, Sylverken J, Ogutu BR, Otieno GA, Wangwe A, Bojang KA, Okomo U, Sanya-Isijola F, Newton CR, Njuguna P, Kazungu M, Kerb R, Geditz M, Schwab M, Velavan TP, Nguetse C, Köhler C, Issifou S, Bolte S, Engleitner T, Mordmüller B, Krishna S. Intramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial. PLoS Med. 2016 Jan; 13(1):e1001938. PMID: 26757276; PMCID: PMC4710539.
    3. Augustin Y, Krishna S, Kumar D, Pantziarka P. The wisdom of crowds and the repurposing of artesunate as an anticancer drug. Ecancermedicalscience. 2015; 9:ed50. PMID: 26557887; PMCID: PMC4631583.
    4. Pulcini S, Staines HM, Lee AH, Shafik SH, Bouyer G, Moore CM, Daley DA, Hoke MJ, Altenhofen LM, Painter HJ, Mu J, Ferguson DJ, Llinás M, Martin RE, Fidock DA, Cooper RA, Krishna S. Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities. Sci Rep. 2015 Sep 30; 5:14552. PMID: 26420308; PMCID: PMC4588581.
    5. Schmutzhard J, Lackner P, Helbok R, Hurth HV, Aregger FC, Muigg V, Kegele J, Bunk S, Oberhammer L, Fischer N, Pinggera L, Otieno A, Ogutu B, Agbenyega T, Ansong D, Adegnika AA, Issifou S, Zorowka P, Krishna S, Mordmüller B, Schmutzhard E, Kremsner P. Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions--a prospective multicenter cohort study. BMC Med. 2015 May 28; 13:125. PMID: 26021376; PMCID: PMC4457990.
    6. Lanini S, Zumla A, Ioannidis JP, Di Caro A, Krishna S, Gostin L, Girardi E, Pletschette M, Strada G, Baritussio A, Portella G, Apolone G, Cavuto S, Satolli R, Kremsner P, Vairo F, Ippolito G. Are adaptive randomised trials or non-randomised studies the best way to address the Ebola outbreak in west Africa? Lancet Infect Dis. 2015 Jun; 15(6):738-45. PMID: 25881871.
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    7. Rolling T, Agbenyega T, Krishna S, Kremsner PG, Cramer JP. Delayed haemolysis after artesunate treatment of severe malaria - review of the literature and perspective. Travel Med Infect Dis. 2015 Mar-Apr; 13(2):143-9. PMID: 25812775.
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    8. Krishna S, Ganapathi S, Ster IC, Saeed ME, Cowan M, Finlayson C, Kovacsevics H, Jansen H, Kremsner PG, Efferth T, Kumar D. A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy for Colorectal Cancer. EBioMedicine. 2015 Jan; 2(1):82-90. PMID: 26137537; PMCID: PMC4484515.
    9. Zaloumis SG, Tarning J, Krishna S, Price RN, White NJ, Davis TM, McCaw JM, Olliaro P, Maude RJ, Kremsner P, Dondorp A, Gomes M, Barnes K, Simpson JA. Population pharmacokinetics of intravenous artesunate: a pooled analysis of individual data from patients with severe malaria. CPT Pharmacometrics Syst Pharmacol. 2014 Nov 05; 3:e145. PMID: 25372510; PMCID: PMC4259998.
    10. Rolling T, Agbenyega T, Issifou S, Adegnika AA, Sylverken J, Spahlinger D, Ansong D, Löhr SJ, Burchard GD, May J, Mordmüller B, Krishna S, Kremsner PG, Cramer JP. Delayed hemolysis after treatment with parenteral artesunate in African children with severe malaria--a double-center prospective study. J Infect Dis. 2014 Jun 15; 209(12):1921-8. PMID: 24376273.
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    11. Krishna S, Pulcini S, Moore CM, Teo BH, Staines HM. Pumped up: reflections on PfATP6 as the target for artemisinins. Trends Pharmacol Sci. 2014 Jan; 35(1):4-11. PMID: 24268763.
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    12. Fatih FA, Staines HM, Siner A, Ahmed MA, Woon LC, Pasini EM, Kocken CH, Singh B, Cox-Singh J, Krishna S. Susceptibility of human Plasmodium knowlesi infections to anti-malarials. Malar J. 2013 Nov 19; 12:425. PMID: 24245918; PMCID: PMC3874596.
    13. Tjhin ET, Staines HM, van Schalkwyk DA, Krishna S, Saliba KJ. Studies with the Plasmodium falciparum hexokinase reveal that PfHT limits the rate of glucose entry into glycolysis. FEBS Lett. 2013 Oct 01; 587(19):3182-7. PMID: 23954294.
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    14. Newton PN, Stepniewska K, Dondorp A, Silamut K, Chierakul W, Krishna S, Davis TM, Suputtamongkol Y, Angus B, Pukrittayakamee S, Ruangveerayuth R, Hanson J, Day NP, White NJ. Prognostic indicators in adults hospitalized with falciparum malaria in Western Thailand. Malar J. 2013 Jul 08; 12:229. PMID: 23829311; PMCID: PMC3711784.
    15. Krishna S, Kremsner PG. Artemisinin resistance needs to be defined rigorously to be understood: response to Dondorp and Ringwald. Trends Parasitol. 2013 Aug; 29(8):361-2. PMID: 23809865.
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    16. Krishna S, Kremsner PG. Antidogmatic approaches to artemisinin resistance: reappraisal as treatment failure with artemisinin combination therapy. Trends Parasitol. 2013 Jul; 29(7):313-7. PMID: 23623760.
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    17. Pulcini S, Staines HM, Pittman JK, Slavic K, Doerig C, Halbert J, Tewari R, Shah F, Avery MA, Haynes RK, Krishna S. Expression in yeast links field polymorphisms in PfATP6 to in vitro artemisinin resistance and identifies new inhibitor classes. J Infect Dis. 2013 Aug 01; 208(3):468-78. PMID: 23599312.
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    18. Guttery DS, Pittman JK, Frénal K, Poulin B, McFarlane LR, Slavic K, Wheatley SP, Soldati-Favre D, Krishna S, Tewari R, Staines HM. The Plasmodium berghei Ca(2+)/H(+) exchanger, PbCAX, is essential for tolerance to environmental Ca(2+) during sexual development. PLoS Pathog. 2013 Feb; 9(2):e1003191. PMID: 23468629; PMCID: PMC3585132.
    19. Patzewitz EM, Salcedo-Sora JE, Wong EH, Sethia S, Stocks PA, Maughan SC, Murray JA, Krishna S, Bray PG, Ward SA, Müller S. Glutathione transport: a new role for PfCRT in chloroquine resistance. Antioxid Redox Signal. 2013 Sep 01; 19(7):683-95. PMID: 23256874; PMCID: PMC3739961.
    20. Ratzinger F, Bruckschwaiger H, Wischenbart M, Parschalk B, Fernandez-Reyes D, Lagler H, Indra A, Graninger W, Winkler S, Krishna S, Ramharter M. Rapid diagnostic algorithms as a screening tool for tuberculosis: an assessor blinded cross-sectional study. PLoS One. 2012; 7(11):e49658. PMID: 23185397; PMCID: PMC3504150.
    21. Willmann M, Ahmed A, Siner A, Wong IT, Woon LC, Singh B, Krishna S, Cox-Singh J. Laboratory markers of disease severity in Plasmodium knowlesi infection: a case control study. Malar J. 2012 Oct 30; 11:363. PMID: 23110615; PMCID: PMC3533741.
    22. Krishna S. Adjunctive management of malaria. Curr Opin Infect Dis. 2012 Oct; 25(5):484-8. PMID: 22907277.
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    23. Pillai DR, Lau R, Khairnar K, Lepore R, Via A, Staines HM, Krishna S. Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. Malar J. 2012 Apr 27; 11:131. PMID: 22540925; PMCID: PMC3422158.
    24. Fatih FA, Siner A, Ahmed A, Woon LC, Craig AG, Singh B, Krishna S, Cox-Singh J. Cytoadherence and virulence - the case of Plasmodium knowlesi malaria. Malar J. 2012 Feb 03; 11:33. PMID: 22305466; PMCID: PMC3330018.
    25. Kremsner PG, Taylor T, Issifou S, Kombila M, Chimalizeni Y, Kawaza K, Bouyou Akotet MK, Duscha M, Mordmüller B, Kösters K, Humberg A, Miller RS, Weina P, Duparc S, Möhrle J, Kun JF, Planche T, Teja-Isavadharm P, Simpson JA, Köhler C, Krishna S. A simplified intravenous artesunate regimen for severe malaria. J Infect Dis. 2012 Jan 15; 205(2):312-9. PMID: 22180622.
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    26. Slavic K, Krishna S, Derbyshire ET, Staines HM. Plasmodial sugar transporters as anti-malarial drug targets and comparisons with other protozoa. Malar J. 2011 Jun 15; 10:165. PMID: 21676209; PMCID: PMC3135577.
    27. Cox-Singh J, Singh B, Daneshvar C, Planche T, Parker-Williams J, Krishna S. Anti-inflammatory cytokines predominate in acute human Plasmodium knowlesi infections. PLoS One. 2011; 6(6):e20541. PMID: 21687657; PMCID: PMC3110641.
    28. Slavic K, Delves MJ, Prudêncio M, Talman AM, Straschil U, Derbyshire ET, Xu Z, Sinden RE, Mota MM, Morin C, Tewari R, Krishna S, Staines HM. Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle. Antimicrob Agents Chemother. 2011 Jun; 55(6):2824-30. PMID: 21402842; PMCID: PMC3101457.
    29. Lubell Y, Staedke SG, Greenwood BM, Kamya MR, Molyneux M, Newton PN, Reyburn H, Snow RW, D'Alessandro U, English M, Day N, Kremsner P, Dondorp A, Mbacham W, Dorsey G, Owusu-Agyei S, Maitland K, Krishna S, Newton C, Pasvol G, Taylor T, von Seidlein L, White NJ, Binka F, Mills A, Whitty CJ. Likely health outcomes for untreated acute febrile illness in the tropics in decision and economic models; a Delphi survey. PLoS One. 2011 Feb 24; 6(2):e17439. PMID: 21390277; PMCID: PMC3044764.
    30. Pooley S, Fatih FA, Krishna S, Gerisch M, Haynes RK, Wong HN, Staines HM. Artemisone uptake in Plasmodium falciparum-infected erythrocytes. Antimicrob Agents Chemother. 2011 Feb; 55(2):550-6. PMID: 21135191; PMCID: PMC3028811.
    31. Planche T, Macallan DC, Sobande T, Borrmann S, Kun JF, Krishna S, Kremsner PG. Nitric oxide generation in children with malaria and the NOS2G-954C promoter polymorphism. Am J Physiol Regul Integr Comp Physiol. 2010 Nov; 299(5):R1248-53. PMID: 20811009.
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    32. Krishna S, Pulcini S, Fatih F, Staines H. Artemisinins and the biological basis for the PfATP6/SERCA hypothesis. Trends Parasitol. 2010 Nov; 26(11):517-23. PMID: 20638904.
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    33. Valderramos SG, Scanfeld D, Uhlemann AC, Fidock DA, Krishna S. Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance. Antimicrob Agents Chemother. 2010 Sep; 54(9):3842-52. PMID: 20566762; PMCID: PMC2935017.
    34. Cardi D, Pozza A, Arnou B, Marchal E, Clausen JD, Andersen JP, Krishna S, Møller JV, le Maire M, Jaxel C. Purified E255L mutant SERCA1a and purified PfATP6 are sensitive to SERCA-type inhibitors but insensitive to artemisinins. J Biol Chem. 2010 Aug 20; 285(34):26406-16. PMID: 20530490; PMCID: PMC2924071.
    35. Gravett AM, Liu WM, Krishna S, Chan WC, Haynes RK, Wilson NL, Dalgleish AG. In vitro study of the anti-cancer effects of artemisone alone or in combination with other chemotherapeutic agents. Cancer Chemother Pharmacol. 2011 Mar; 67(3):569-77. PMID: 20490800.
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    36. Staines HM, Derbyshire ET, Slavic K, Tattersall A, Vial H, Krishna S. Exploiting the therapeutic potential of Plasmodium falciparum solute transporters. Trends Parasitol. 2010 Jun; 26(6):284-96. PMID: 20392668.
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    37. Cowan ML, Rahman TM, Krishna S. Proteomic approaches in the search for biomarkers of liver fibrosis. Trends Mol Med. 2010 Apr; 16(4):171-83. PMID: 20304704.
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    38. Cox-Singh J, Hiu J, Lucas SB, Divis PC, Zulkarnaen M, Chandran P, Wong KT, Adem P, Zaki SR, Singh B, Krishna S. Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report. Malar J. 2010 Jan 11; 9:10. PMID: 20064229; PMCID: PMC2818646.
    39. Macallan DC, Abaye DA, Dottin S, Onanga M, Kombila M, Dzeing-Ella A, Kremsner PG, Krishna S, Planche T. Blood volume and red cell mass in children with moderate and severe malaria measured by chromium-53 dilution and gas chromatography/mass spectrometric analysis. Rapid Commun Mass Spectrom. 2009 Aug 30; 23(16):2467-75. PMID: 19603467.
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    40. Slavic K, Derbyshire ET, Naftalin RJ, Krishna S, Staines HM. Comparison of effects of green tea catechins on apicomplexan hexose transporters and mammalian orthologues. Mol Biochem Parasitol. 2009 Nov; 168(1):113-6. PMID: 19577593; PMCID: PMC2791876.
    41. Prudêncio M, Derbyshire ET, Marques CA, Krishna S, Mota MM, Staines HM. Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells. Cell Microbiol. 2009 Oct; 11(10):1492-501. PMID: 19496788; PMCID: PMC2774480.
    42. Slavic K, Straschil U, Reininger L, Doerig C, Morin C, Tewari R, Krishna S. Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality. Mol Microbiol. 2010 Mar; 75(6):1402-13. PMID: 20132450; PMCID: PMC2859251.
    43. Kremsner PG, Valim C, Missinou MA, Olola C, Krishna S, Issifou S, Kombila M, Bwanaisa L, Mithwani S, Newton CR, Agbenyega T, Pinder M, Bojang K, Wypij D, Taylor T. Prognostic value of circulating pigmented cells in African children with malaria. J Infect Dis. 2009 Jan 01; 199(1):142-50. PMID: 19086817; PMCID: PMC3755538.
    44. Gomes MF, Faiz MA, Gyapong JO, Warsame M, Agbenyega T, Babiker A, Baiden F, Yunus EB, Binka F, Clerk C, Folb P, Hassan R, Hossain MA, Kimbute O, Kitua A, Krishna S, Makasi C, Mensah N, Mrango Z, Olliaro P, Peto R, Peto TJ, Rahman MR, Ribeiro I, Samad R, White NJ. Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial. Lancet. 2009 Feb 14; 373(9663):557-66. PMID: 19059639; PMCID: PMC2646124.
    45. Planche T, Aghaizu A, Holliman R, Riley P, Poloniecki J, Breathnach A, Krishna S. Diagnosis of Clostridium difficile infection by toxin detection kits: a systematic review. Lancet Infect Dis. 2008 Dec; 8(12):777-84. PMID: 18977696.
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    46. Krishna S, Bustamante L, Haynes RK, Staines HM. Artemisinins: their growing importance in medicine. Trends Pharmacol Sci. 2008 Oct; 29(10):520-7. PMID: 18752857; PMCID: PMC2758403.
    47. Toovey S, Bustamante LY, Uhlemann AC, East JM, Krishna S. Effect of artemisinins and amino alcohol partner antimalarials on mammalian sarcoendoplasmic reticulum calcium adenosine triphosphatase activity. Basic Clin Pharmacol Toxicol. 2008 Sep; 103(3):209-13. PMID: 18684232.
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    48. Derbyshire ET, Franssen FJ, de Vries E, Morin C, Woodrow CJ, Krishna S, Staines HM. Identification, expression and characterisation of a Babesia bovis hexose transporter. Mol Biochem Parasitol. 2008 Oct; 161(2):124-9. PMID: 18638508; PMCID: PMC2688680.
    49. Rojas-Galeano S, Hsieh E, Agranoff D, Krishna S, Fernandez-Reyes D. Estimation of relevant variables on high-dimensional biological patterns using iterated weighted kernel functions. PLoS One. 2008 Mar 26; 3(3):e1806. PMID: 18509521; PMCID: PMC2396875.
    50. Patel AP, Staines HM, Krishna S. New antimalarial targets: the example of glucose transport. Travel Med Infect Dis. 2008 Jan-Mar; 6(1-2):58-66. PMID: 18342277.
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    51. Issifou S, Kendjo E, Missinou MA, Matsiegui PB, Dzeing-Ella A, Dissanami FA, Kombila M, Krishna S, Kremsner PG. Differences in presentation of severe malaria in urban and rural Gabon. Am J Trop Med Hyg. 2007 Dec; 77(6):1015-9. PMID: 18165514.
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    52. Haynes RK, Chan WC, Lung CM, Uhlemann AC, Eckstein U, Taramelli D, Parapini S, Monti D, Krishna S. The Fe2+-mediated decomposition, PfATP6 binding, and antimalarial activities of artemisone and other artemisinins: the unlikelihood of C-centered radicals as bioactive intermediates. ChemMedChem. 2007 Oct; 2(10):1480-97. PMID: 17768732.
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    53. Woodrow CJ, Abel PM, Krishna S. Randomized, controlled trial of treatments for second-stage sleeping sickness. J Infect Dis. 2007 Aug 15; 196(4):650-1. PMID: 17624857.
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    54. Ionita M, Krishna S, Léo PM, Morin C, Patel AP. Interaction of O-(undec-10-en)-yl-D-glucose derivatives with the Plasmodium falciparum hexose transporter (PfHT). Bioorg Med Chem Lett. 2007 Sep 01; 17(17):4934-7. PMID: 17587575.
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    55. Sisowath C, Ferreira PE, Bustamante LY, Dahlström S, Mårtensson A, Björkman A, Krishna S, Gil JP. The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa. Trop Med Int Health. 2007 Jun; 12(6):736-42. PMID: 17550470.
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    56. Price L, Planche T, Rayner C, Krishna S. Acute respiratory distress syndrome in Plasmodium vivax malaria: case report and review of the literature. Trans R Soc Trop Med Hyg. 2007 Jul; 101(7):655-9. PMID: 17433389.
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    57. Mishina YV, Krishna S, Haynes RK, Meade JC. Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth. Antimicrob Agents Chemother. 2007 May; 51(5):1852-4. PMID: 17339374; PMCID: PMC1855540.
    58. Ramharter M, Adegnika AA, Agnandji ST, Matsiegui PB, Grobusch MP, Winkler S, Graninger W, Krishna S, Yazdanbakhsh M, Mordmüller B, Lell B, Missinou MA, Mavoungou E, Issifou S, Kremsner PG. History and perspectives of medical research at the Albert Schweitzer Hospital in Lambaréné, Gabon. Wien Klin Wochenschr. 2007; 119(19-20 Suppl 3):8-12. PMID: 17987353.
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    59. Burkhardt D, Wiesner J, Stoesser N, Ramharter M, Uhlemann AC, Issifou S, Jomaa H, Krishna S, Kremsner PG, Borrmann S. Delayed parasite elimination in human infections treated with clindamycin parallels 'delayed death' of Plasmodium falciparum in vitro. Int J Parasitol. 2007 Jun; 37(7):777-85. PMID: 17280676.
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    60. Jeffares DC, Pain A, Berry A, Cox AV, Stalker J, Ingle CE, Thomas A, Quail MA, Siebenthall K, Uhlemann AC, Kyes S, Krishna S, Newbold C, Dermitzakis ET, Berriman M. Genome variation and evolution of the malaria parasite Plasmodium falciparum. Nat Genet. 2007 Jan; 39(1):120-5. PMID: 17159978; PMCID: PMC2663918.
    61. Uhlemann AC, Wittlin S, Matile H, Bustamante LY, Krishna S. Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277). Antimicrob Agents Chemother. 2007 Feb; 51(2):667-72. PMID: 17145800; PMCID: PMC1797759.
    62. Vera J, Hensiek A, Woodrow C, Crawley F, Krishna S. Ophthalmoplegia and slurred speech in an intravenous drug user. PLoS Med. 2006 Dec; 3(12):e453. PMID: 17194180; PMCID: PMC1762052.
    63. Krishna S. Drug development papers in PLoS Medicine: how we try to spot a winner. PLoS Med. 2006 Dec; 3(12):e547. PMID: 17526082; PMCID: PMC1762067.
    64. Nair S, Nash D, Sudimack D, Jaidee A, Barends M, Uhlemann AC, Krishna S, Nosten F, Anderson TJ. Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasites. Mol Biol Evol. 2007 Feb; 24(2):562-73. PMID: 17124182.
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    65. Uhlemann AC, McGready R, Ashley EA, Brockman A, Singhasivanon P, Krishna S, White NJ, Nosten F, Price RN. Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand. J Infect Dis. 2007 Jan 01; 195(1):134-41. PMID: 17152017; PMCID: PMC4337981.
    66. Simpson JA, Agbenyega T, Barnes KI, Di Perri G, Folb P, Gomes M, Krishna S, Krudsood S, Looareesuwan S, Mansor S, McIlleron H, Miller R, Molyneux M, Mwenechanya J, Navaratnam V, Nosten F, Olliaro P, Pang L, Ribeiro I, Tembo M, van Vugt M, Ward S, Weerasuriya K, Win K, White NJ. Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients. PLoS Med. 2006 Nov; 3(11):e444. PMID: 17132053; PMCID: PMC1664603.
    67. Agranoff D, Fernandez-Reyes D, Papadopoulos MC, Rojas SA, Herbster M, Loosemore A, Tarelli E, Sheldon J, Schwenk A, Pollok R, Rayner CF, Krishna S. Identification of diagnostic markers for tuberculosis by proteomic fingerprinting of serum. Lancet. 2006 Sep 16; 368(9540):1012-21. PMID: 16980117.
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    68. Sidhu AB, Uhlemann AC, Valderramos SG, Valderramos JC, Krishna S, Fidock DA. Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin. J Infect Dis. 2006 Aug 15; 194(4):528-35. PMID: 16845638; PMCID: PMC2978021.
    69. Price RN, Uhlemann AC, van Vugt M, Brockman A, Hutagalung R, Nair S, Nash D, Singhasivanon P, Anderson TJ, Krishna S, White NJ, Nosten F. Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria. Clin Infect Dis. 2006 Jun 01; 42(11):1570-7. PMID: 16652314; PMCID: PMC4337983.
    70. Krishna S, Woodrow CJ, Staines HM, Haynes RK, Mercereau-Puijalon O. Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance. Trends Mol Med. 2006 May; 12(5):200-5. PMID: 16616639; PMCID: PMC2682190.
    71. Kreidenweiss A, Mordmüller B, Krishna S, Kremsner PG. Antimalarial activity of a synthetic endoperoxide (RBx-11160/OZ277) against Plasmodium falciparum isolates from Gabon. Antimicrob Agents Chemother. 2006 Apr; 50(4):1535-7. PMID: 16569877; PMCID: PMC1426938.
    72. Taylor T, Olola C, Valim C, Agbenyega T, Kremsner P, Krishna S, Kwiatkowski D, Newton C, Missinou M, Pinder M, Wypij D. Standardized data collection for multi-center clinical studies of severe malaria in African children: establishing the SMAC network. Trans R Soc Trop Med Hyg. 2006 Jul; 100(7):615-22. PMID: 16551469; PMCID: PMC1459261.
    73. Woodrow CJ, Planche T, Krishna S. Artesunate versus quinine for severe falciparum malaria. Lancet. 2006 Jan 14; 367(9505):110-1; author reply 111-2. PMID: 16413871.
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    74. Fayolle M, Ionita M, Krishna S, Morin C, Patel AP. Probing structure/affinity relationships for the Plasmodium falciparum hexose transporter with glucose derivatives. Bioorg Med Chem Lett. 2006 Mar 01; 16(5):1267-71. PMID: 16361099.
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    75. Uhlemann AC, Ramharter M, Lell B, Kremsner PG, Krishna S. Amplification of Plasmodium falciparum multidrug resistance gene 1 in isolates from Gabon. J Infect Dis. 2005 Nov 15; 192(10):1830-5. PMID: 16235185.
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    76. Planche T, Krishna S. The relevance of malaria pathophysiology to strategies of clinical management. Curr Opin Infect Dis. 2005 Oct; 18(5):369-75. PMID: 16148522.
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    77. Newton CR, Valim C, Krishna S, Wypij D, Olola C, Agbenyega T, Taylor TE. The prognostic value of measures of acid/base balance in pediatric falciparum malaria, compared with other clinical and laboratory parameters. Clin Infect Dis. 2005 Oct 01; 41(7):948-57. PMID: 16142658; PMCID: PMC1388262.
    78. Stewart ML, Krishna S, Burchmore RJ, Brun R, de Koning HP, Boykin DW, Tidwell RR, Hall JE, Barrett MP. Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet. 2005 Aug 6-12; 366(9484):486-7. PMID: 16084257.
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    79. Uhlemann AC, Cameron A, Eckstein-Ludwig U, Fischbarg J, Iserovich P, Zuniga FA, East M, Lee A, Brady L, Haynes RK, Krishna S. A single amino acid residue can determine the sensitivity of SERCAs to artemisinins. Nat Struct Mol Biol. 2005 Jul; 12(7):628-9. PMID: 15937493.
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    80. Ramharter M, Oyakhirome S, Klein Klouwenberg P, Adégnika AA, Agnandji ST, Missinou MA, Matsiégui PB, Mordmüller B, Borrmann S, Kun JF, Lell B, Krishna S, Graninger W, Issifou S, Kremsner PG. Artesunate-clindamycin versus quinine-clindamycin in the treatment of Plasmodium falciparum malaria: a randomized controlled trial. Clin Infect Dis. 2005 Jun 15; 40(12):1777-84. PMID: 15909266.
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    81. Agranoff D, Stich A, Abel P, Krishna S. Proteomic fingerprinting for the diagnosis of human African trypanosomiasis. Trends Parasitol. 2005 Apr; 21(4):154-7. PMID: 15780834.
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    82. Dzeing-Ella A, Nze Obiang PC, Tchoua R, Planche T, Mboza B, Mbounja M, Muller-Roemer U, Jarvis J, Kendjo E, Ngou-Milama E, Kremsner PG, Krishna S, Kombila M. Severe falciparum malaria in Gabonese children: clinical and laboratory features. Malar J. 2005 Jan 09; 4:1. PMID: 15638948; PMCID: PMC546207.
    83. Agranoff D, Collins L, Kehres D, Harrison T, Maguire M, Krishna S. The Nramp orthologue of Cryptococcus neoformans is a pH-dependent transporter of manganese, iron, cobalt and nickel. Biochem J. 2005 Jan 01; 385(Pt 1):225-32. PMID: 15350193; PMCID: PMC1134691.
    84. Borrmann S, Oyakhirome S, Esser G, Trinkle C, Issifou S, Grobusch MP, Krishna S, Kremsner PG. Short report: evaluation of a simple and inexpensive photometric device for the measurement of hemoglobin. Am J Trop Med Hyg. 2004 Nov; 71(5):691-2. PMID: 15569807.
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    85. Haynes RK, Krishna S. Artemisinins: activities and actions. Microbes Infect. 2004 Nov; 6(14):1339-46. PMID: 15555542.
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    86. Planche T, Onanga M, Schwenk A, Dzeing A, Borrmann S, Faucher JF, Wright A, Bluck L, Ward L, Kombila M, Kremsner PG, Krishna S. Assessment of volume depletion in children with malaria. PLoS Med. 2004 Oct; 1(1):e18. PMID: 15526044; PMCID: PMC523837.
    87. Agranoff D, Krishna S. Metal ion transport and regulation in Mycobacterium tuberculosis. Front Biosci. 2004 Sep 01; 9:2996-3006. PMID: 15353332.
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    88. Joët T, Chotivanich K, Silamut K, Patel AP, Morin C, Krishna S. Analysis of Plasmodium vivax hexose transporters and effects of a parasitocidal inhibitor. Biochem J. 2004 Aug 01; 381(Pt 3):905-9. PMID: 15107012; PMCID: PMC1133902.
    89. Krishna S, Uhlemann AC, Haynes RK. Artemisinins: mechanisms of action and potential for resistance. Drug Resist Updat. 2004 Aug-Oct; 7(4-5):233-44. PMID: 15533761.
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    90. Price RN, Uhlemann AC, Brockman A, McGready R, Ashley E, Phaipun L, Patel R, Laing K, Looareesuwan S, White NJ, Nosten F, Krishna S. Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. Lancet. 2004 Jul 31-Aug 6; 364(9432):438-447. PMID: 15288742; PMCID: PMC4337987.
    91. Kremsner PG, Krishna S. Antimalarial combinations. Lancet. 2004 Jul 17-23; 364(9430):285-94. PMID: 15262108.
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    92. Papadopoulos MC, Manley GT, Krishna S, Verkman AS. Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J. 2004 Aug; 18(11):1291-3. PMID: 15208268.
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    93. Papadopoulos MC, Abel PM, Agranoff D, Stich A, Tarelli E, Bell BA, Planche T, Loosemore A, Saadoun S, Wilkins P, Krishna S. A novel and accurate diagnostic test for human African trypanosomiasis. Lancet. 2004 Apr 24; 363(9418):1358-63. PMID: 15110493.
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    94. Joët T, Krishna S. The hexose transporter of Plasmodium falciparum is a worthy drug target. Acta Trop. 2004 Feb; 89(3):371-4. PMID: 14744563.
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    95. Kumar R, Musiyenko A, Cioffi E, Oldenburg A, Adams B, Bitko V, Krishna SS, Barik S. A zinc-binding dual-specificity YVH1 phosphatase in the malaria parasite, Plasmodium falciparum, and its interaction with the nuclear protein, pescadillo. Mol Biochem Parasitol. 2004 Feb; 133(2):297-310. PMID: 14698441.
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    96. Abel PM, Kiala G, Lôa V, Behrend M, Musolf J, Fleischmann H, Théophile J, Krishna S, Stich A. Retaking sleeping sickness control in Angola. Trop Med Int Health. 2004 Jan; 9(1):141-8. PMID: 14728618.
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    97. Barrett MP, Burchmore RJ, Stich A, Lazzari JO, Frasch AC, Cazzulo JJ, Krishna S. The trypanosomiases. Lancet. 2003 Nov 01; 362(9394):1469-80. PMID: 14602444.
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    98. Planche T, Agbenyega T, Bedu-Addo G, Ansong D, Owusu-Ofori A, Micah F, Anakwa C, Asafo-Agyei E, Hutson A, Stacpoole PW, Krishna S. A prospective comparison of malaria with other severe diseases in African children: prognosis and optimization of management. Clin Infect Dis. 2003 Oct 01; 37(7):890-7. PMID: 13130399.
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    99. Lawn SD, Krishna S, Jarvis JN, Joet T, Macallan DC. Case reports: pernicious complications of benign tertian malaria. Trans R Soc Trop Med Hyg. 2003 Sep-Oct; 97(5):551-3. PMID: 15307424.
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    100. Joet T, Eckstein-Ludwig U, Morin C, Krishna S. Validation of the hexose transporter of Plasmodium falciparum as a novel drug target. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7476-9. PMID: 12792024; PMCID: PMC164611.
    101. Stich A, Barrett MP, Krishna S. Waking up to sleeping sickness. Trends Parasitol. 2003 May; 19(5):195-7. PMID: 12763420.
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    102. Agbenyega T, Planche T, Bedu-Addo G, Ansong D, Owusu-Ofori A, Bhattaram VA, Nagaraja NV, Shroads AL, Henderson GN, Hutson AD, Derendorf H, Krishna S, Stacpoole PW. Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children. J Clin Pharmacol. 2003 Apr; 43(4):386-96. PMID: 12723459.
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    103. Muhia DK, Swales CA, Eckstein-Ludwig U, Saran S, Polley SD, Kelly JM, Schaap P, Krishna S, Baker DA. Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum. J Biol Chem. 2003 Jun 13; 278(24):22014-22. PMID: 12668669.
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    104. Borrmann S, Adegnika AA, Missinou MA, Binder RK, Issifou S, Schindler A, Matsiegui PB, Kun JF, Krishna S, Lell B, Kremsner PG. Short-course artesunate treatment of uncomplicated Plasmodium falciparum malaria in Gabon. Antimicrob Agents Chemother. 2003 Mar; 47(3):901-4. PMID: 12604519; PMCID: PMC149309.
    105. Joët T, Holterman L, Stedman TT, Kocken CH, Van Der Wel A, Thomas AW, Krishna S. Comparative characterization of hexose transporters of Plasmodium knowlesi, Plasmodium yoelii and Toxoplasma gondii highlights functional differences within the apicomplexan family. Biochem J. 2002 Dec 15; 368(Pt 3):923-9. PMID: 12238947; PMCID: PMC1223042.
    106. Krishna S, Eckstein-Ludwig U, Joët T, Uhlemann AC, Morin C, Webb R, Woodrow C, Kun JF, Kremsner PG. Transport processes in Plasmodium falciparum-infected erythrocytes: potential as new drug targets. Int J Parasitol. 2002 Dec 04; 32(13):1567-73. PMID: 12435441.
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    107. Nealon C, Dzeing A, Müller-Römer U, Planche T, Sinou V, Kombila M, Kremsner PG, Parzy D, Krishna S. Intramuscular bioavailability and clinical efficacy of artesunate in gabonese children with severe malaria. Antimicrob Agents Chemother. 2002 Dec; 46(12):3933-9. PMID: 12435698; PMCID: PMC132755.
    108. Kremsner PG, Krishna S. Antimalarial cocktails--tropical flavours of the month. Lancet. 2002 Dec 21-28; 360(9350):1998-9. PMID: 12504391.
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    109. Papadopoulos MC, Krishna S, Verkman AS. Aquaporin water channels and brain edema. Mt Sinai J Med. 2002 Sep; 69(4):242-8. PMID: 12357265.
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    110. Stich A, Abel PM, Krishna S. Human African trypanosomiasis. BMJ. 2002 Jul 27; 325(7357):203-6. PMID: 12142311; PMCID: PMC1123723.
    111. Manning SK, Woodrow C, Zuniga FA, Iserovich P, Fischbarg J, Louw AI, Krishna S. Mutational analysis of the hexose transporter of Plasmodium falciparum and development of a three-dimensional model. J Biol Chem. 2002 Aug 23; 277(34):30942-9. PMID: 12042321.
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    112. Adjuik M, Agnamey P, Babiker A, Borrmann S, Brasseur P, Cisse M, Cobelens F, Diallo S, Faucher JF, Garner P, Gikunda S, Kremsner PG, Krishna S, Lell B, Loolpapit M, Matsiegui PB, Missinou MA, Mwanza J, Ntoumi F, Olliaro P, Osimbo P, Rezbach P, Some E, Taylor WR. Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial. Lancet. 2002 Apr 20; 359(9315):1365-72. PMID: 11978332.
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